DK0576623T4 - Bindingsdomæner i Notch-proteiner - Google Patents

Bindingsdomæner i Notch-proteiner

Info

Publication number
DK0576623T4
DK0576623T4 DK92911557T DK92911557T DK0576623T4 DK 0576623 T4 DK0576623 T4 DK 0576623T4 DK 92911557 T DK92911557 T DK 92911557T DK 92911557 T DK92911557 T DK 92911557T DK 0576623 T4 DK0576623 T4 DK 0576623T4
Authority
DK
Denmark
Prior art keywords
binding domains
toporythmic protein
notch proteins
fragment
cell
Prior art date
Application number
DK92911557T
Other languages
Danish (da)
English (en)
Other versions
DK0576623T3 (da
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Ilaria Rebay
Christine Marie Blaumueller
Scott Brockewell Shepard
Original Assignee
Univ Yale
Advanced Res & Tech Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0576623(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale, Advanced Res & Tech Inst filed Critical Univ Yale
Application granted granted Critical
Publication of DK0576623T3 publication Critical patent/DK0576623T3/da
Publication of DK0576623T4 publication Critical patent/DK0576623T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK92911557T 1991-05-03 1992-05-01 Bindingsdomæner i Notch-proteiner DK0576623T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14
PCT/US1992/003651 WO1992019734A1 (en) 1991-05-03 1992-05-01 Binding domains in notch and delta proteins

Publications (2)

Publication Number Publication Date
DK0576623T3 DK0576623T3 (da) 2003-02-24
DK0576623T4 true DK0576623T4 (da) 2008-01-02

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
DK92911557T DK0576623T4 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Notch-proteiner
DK99101563T DK0930366T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Delta-proteiner
DK99101561.1T DK0933082T3 (da) 1991-05-03 1992-05-01 Fremgangsmåde til manipulation af celledifferentiering
DK99101562T DK0930365T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Serrate-protein

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK99101563T DK0930366T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Delta-proteiner
DK99101561.1T DK0933082T3 (da) 1991-05-03 1992-05-01 Fremgangsmåde til manipulation af celledifferentiering
DK99101562T DK0930365T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Serrate-protein

Country Status (12)

Country Link
US (1) US5849869A (ja)
EP (4) EP0930365B1 (ja)
JP (7) JPH07503123A (ja)
AT (4) ATE226633T1 (ja)
AU (1) AU675203B2 (ja)
CA (1) CA2102208C (ja)
DE (4) DE69232832T3 (ja)
DK (4) DK0576623T4 (ja)
ES (4) ES2303363T3 (ja)
IE (2) IE921367A1 (ja)
IL (1) IL101728A (ja)
WO (1) WO1992019734A1 (ja)

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US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
WO1997001571A1 (en) 1995-06-28 1997-01-16 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
ATE319827T1 (de) 1995-11-17 2006-03-15 Asahi Chemical Ind Polypeptid, das die differenzierung unterdrueckt
CA2238404A1 (en) * 1995-11-22 1997-05-29 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
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US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
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ATE342358T1 (de) 1997-04-04 2006-11-15 Millennium Biotherapeutics Inc Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen
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US6436650B1 (en) * 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
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US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US20020151487A1 (en) * 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
US7399633B2 (en) * 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
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US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
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EP2610267A1 (en) 2006-12-18 2013-07-03 Genentech, Inc. Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
EP2106439B1 (en) 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
EP2125887A4 (en) 2007-01-24 2010-11-10 Oncomed Pharm Inc COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF CANCER
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US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
KR101574958B1 (ko) 2007-11-12 2015-12-07 가부시키가이샤 지에스 유아사 리튬 이차전지용 활물질, 리튬 이차전지 및 그 제조방법
JP5560270B2 (ja) 2008-07-08 2014-07-23 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｎｏｔｃｈ結合剤およびアンタゴニストならびにその使用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
JP5792621B2 (ja) 2008-09-26 2015-10-14 オンコメッド ファーマシューティカルズ インコーポレイテッド ｆｒｉｚｚｌｅｄ結合剤およびその使用
DK2488204T3 (en) 2009-10-16 2016-06-06 Oncomed Pharm Inc Therapeutic combination and use of DLL4 antagonist antibodies and blood pressure lowering agents
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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
ATE194653T1 (de) * 1992-12-11 2000-07-15 Us Health Delta ähnliches gen welches in neuroendokrinen tumoren exprimiert wird

Also Published As

Publication number Publication date
DE69233724D1 (de) 2008-03-27
IE921367A1 (en) 1992-11-04
ES2303363T3 (es) 2008-08-01
ES2310933T3 (es) 2009-01-16
DE69233791D1 (de) 2010-08-26
EP0930365A3 (en) 1999-07-28
IL101728A0 (en) 1992-12-30
IL101728A (en) 2007-08-19
IE20030774A1 (en) 2003-12-10
WO1992019734A1 (en) 1992-11-12
DK0930366T3 (da) 2008-10-13
AU1919792A (en) 1992-12-21
EP0576623B2 (en) 2007-10-03
EP0930366B1 (en) 2008-06-04
JP4604227B2 (ja) 2011-01-05
JP4430891B2 (ja) 2010-03-10
EP0930366A3 (en) 1999-07-28
ATE473754T1 (de) 2010-07-15
EP0576623B1 (en) 2002-10-23
JP2008005843A (ja) 2008-01-17
DE69233735D1 (de) 2008-07-17
EP0933082B1 (en) 2010-07-14
EP0930365A2 (en) 1999-07-21
EP0933082A1 (en) 1999-08-04
JP2011135886A (ja) 2011-07-14
ATE226633T1 (de) 2002-11-15
ES2348919T3 (es) 2010-12-16
JP2007330258A (ja) 2007-12-27
JP2004065243A (ja) 2004-03-04
DK0933082T3 (da) 2010-10-25
DK0576623T3 (da) 2003-02-24
IE85350B1 (en) 2009-10-14
US5849869A (en) 1998-12-15
JPH07503123A (ja) 1995-04-06
ATE386116T1 (de) 2008-03-15
DE69233724T2 (de) 2009-04-02
JP4604228B2 (ja) 2011-01-05
DE69232832T2 (de) 2003-06-18
CA2102208A1 (en) 1992-11-12
CA2102208C (en) 2003-04-29
DK0930365T3 (da) 2008-06-02
EP0930366A2 (en) 1999-07-21
EP0576623A1 (en) 1994-01-05
JP2007330259A (ja) 2007-12-27
ES2181674T3 (es) 2003-03-01
JP2011155979A (ja) 2011-08-18
DE69232832T3 (de) 2008-02-28
DE69232832D1 (de) 2002-11-28
ES2181674T5 (es) 2008-03-01
AU675203B2 (en) 1997-01-30
ATE397661T1 (de) 2008-06-15
EP0930365B1 (en) 2008-02-13
EP0576623A4 (en) 1995-01-18

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