DK0570518T3 - Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays - Google Patents

Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays

Info

Publication number
DK0570518T3
DK0570518T3 DK92906820T DK92906820T DK0570518T3 DK 0570518 T3 DK0570518 T3 DK 0570518T3 DK 92906820 T DK92906820 T DK 92906820T DK 92906820 T DK92906820 T DK 92906820T DK 0570518 T3 DK0570518 T3 DK 0570518T3
Authority
DK
Denmark
Prior art keywords
electrochemiluminescence
working electrode
analyte
interest
electrode surface
Prior art date
Application number
DK92906820T
Other languages
Danish (da)
English (en)
Inventor
K Leland John
P Shah Haresh
H Kenten John
E Goodman Jack
E Lowke George
F Blackburn Gary
J Massey Richard
Original Assignee
Igen Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igen Int Inc filed Critical Igen Int Inc
Application granted granted Critical
Publication of DK0570518T3 publication Critical patent/DK0570518T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
DK92906820T 1991-02-06 1992-02-05 Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays DK0570518T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65242791A 1991-02-06 1991-02-06
US82727092A 1992-02-03 1992-02-03
US82726992A 1992-02-03 1992-02-03
PCT/US1992/000992 WO1992014139A1 (en) 1991-02-06 1992-02-05 Methods and apparatus for improved luminescence assays

Publications (1)

Publication Number Publication Date
DK0570518T3 true DK0570518T3 (da) 1999-08-02

Family

ID=27417877

Family Applications (2)

Application Number Title Priority Date Filing Date
DK92906820T DK0570518T3 (da) 1991-02-06 1992-02-05 Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays
DK98200764T DK0877252T3 (da) 1991-02-06 1992-02-05 Fremgangsmåde og apparat til luminescensassays

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98200764T DK0877252T3 (da) 1991-02-06 1992-02-05 Fremgangsmåde og apparat til luminescensassays

Country Status (17)

Country Link
EP (3) EP1286164B1 (de)
JP (2) JP3061416B2 (de)
KR (1) KR100226231B1 (de)
CN (2) CN1094593C (de)
AT (2) ATE173542T1 (de)
AU (1) AU668085B2 (de)
CA (1) CA2103674C (de)
DE (3) DE69233675T2 (de)
DK (2) DK0570518T3 (de)
ES (3) ES2126591T3 (de)
GR (1) GR3029446T3 (de)
HK (3) HK1017970A1 (de)
IE (1) IE69060B1 (de)
IL (1) IL100867A (de)
NZ (1) NZ241537A (de)
TW (1) TW316291B (de)
WO (1) WO1992014139A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001308A1 (en) * 1991-07-10 1993-01-21 Igen, Inc. Methods and apparatus for improved luminescence assays using particle concentration and chemiluminescence detection
ZA929351B (en) * 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
US5466416A (en) * 1993-05-14 1995-11-14 Ghaed; Ali Apparatus and methods for carrying out electrochemiluminescence test measurements
DE59507438D1 (de) * 1994-07-25 2000-01-20 Roche Diagnostics Gmbh Hydrophile metallkomplexe
US5744367A (en) * 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6066448A (en) * 1995-03-10 2000-05-23 Meso Sclae Technologies, Llc. Multi-array, multi-specific electrochemiluminescence testing
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US7314711B2 (en) 1997-05-23 2008-01-01 Bioveris Corporation Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers
JP3366842B2 (ja) * 1997-08-29 2003-01-14 エーザイ株式会社 電気化学発光測定用セル
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
US6136268A (en) * 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
CA2459893C (en) * 2001-09-10 2014-01-21 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
US20030180814A1 (en) * 2002-03-21 2003-09-25 Alastair Hodges Direct immunosensor assay
KR20050013592A (ko) 2002-06-20 2005-02-04 아이젠인터내셔널인코포레이티드 전기화학발광 유동 셀 및 유동 셀 성분
JP4732755B2 (ja) 2002-11-07 2011-07-27 三菱化学メディエンス株式会社 磁性粒子捕集用磁力体及びその利用
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
AU2005326758B2 (en) 2004-06-23 2011-07-14 Board Of Regents Of The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex
US20070045902A1 (en) 2004-07-13 2007-03-01 Brauker James H Analyte sensor
US8170803B2 (en) 2004-07-13 2012-05-01 Dexcom, Inc. Transcutaneous analyte sensor
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
WO2007053191A2 (en) 2005-06-03 2007-05-10 University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
WO2007148762A1 (ja) * 2006-06-22 2007-12-27 Masahiko Kuroda ヒトパピローマウイルス（ｈｐｖ）の検出方法、それに用いるプライマーセットおよび検出キット
SI2271938T1 (sl) 2008-04-11 2014-07-31 Board Of Regents Of The University Of Texas System Postopek in naprava za ojačenje električno generirane kemiluminiscence nanodelcev
EP2626693A3 (de) 2008-05-08 2014-10-01 Board of Regents of the University of Texas System Nanostrukturierte lumineszente Materialien zur Verwendung in elektrogenerierter Chemolumineszenz
AU2009296662B2 (en) 2008-09-24 2016-08-11 First Light Diagnostics, Inc. Kits and devices for detecting analytes
US20100261292A1 (en) * 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
JP6059718B2 (ja) * 2011-06-15 2017-01-11 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 生物試料成分の処理
CN104067123B (zh) * 2011-12-28 2016-02-17 株式会社日立高新技术 试样分析装置以及试样分析方法
EP3338094B1 (de) 2015-08-20 2019-05-08 H. Hoffnabb-La Roche Ag Partikelbasierter immunoassay unter verwendung eines pegylierten analytspezifischen bindemittels
WO2017153336A1 (en) 2016-03-07 2017-09-14 F. Hoffmann-La Roche Ag Detection of anti-p53 antibodies
WO2017153574A1 (en) 2016-03-11 2017-09-14 Roche Diagnostics Gmbh Branched-chain amines in electrochemiluminescence detection
RU2711158C1 (ru) * 2016-09-14 2020-01-15 Филип Моррис Продактс С.А. Система, генерирующая аэрозоль, и способ управления ею
JP7068323B2 (ja) 2017-02-02 2022-05-16 エフ．ホフマン－ラ ロシュ アーゲー 少なくとも２種のペグ化された分析物特異的結合剤を使用する免疫アッセイ
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor
EP3697927B1 (de) * 2017-10-19 2022-12-14 Bio-Rad Laboratories, Inc. Digitale amplifikationsassays mit unkonventionellen und/oder inversen änderungen in der photolumineszenz
CN111936522B (zh) 2018-04-18 2024-07-02 豪夫迈·罗氏有限公司 新型抗胸苷激酶抗体
CN112639475A (zh) 2018-08-31 2021-04-09 豪夫迈·罗氏有限公司 Dlbcl的预后指数中的胸苷激酶(tk-1)
CN111351781B (zh) * 2018-12-20 2023-11-24 麦德龙生物株式会社 电化学发光分析装置和使用其分析样品的方法
CN111007593B (zh) * 2019-05-12 2022-05-13 桂林电子科技大学 基于热扩散融嵌芯毛细管光纤微小粒子输运装置
BR112022001140A2 (pt) 2019-07-22 2022-03-15 Hoffmann La Roche Métodos para avaliar se um paciente tem endometriose ou está em risco de desenvolver endometriose, selecionar um paciente para terapia e monitorar um paciente que sofre de endometriose ou que está sendo tratado para endometriose
CN114144673A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 S100a8作为血液生物标志物用于子宫内膜异位症的非侵入性诊断
EP4004554A1 (de) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a9 als blutbiomarker zur nichtinvasiven diagnose von endometriose
CN114144674A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 P物质作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物
EP4004555A1 (de) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a6 als blutbiomarker zur nichtinvasiven diagnose von endometriose
KR20220100883A (ko) 2019-11-15 2022-07-18 에프. 호프만-라 로슈 아게 환자 샘플의 질량분석법 측정을 위한 베타-락탐 항생제의 유도체화
CN111693515B (zh) * 2020-05-07 2022-06-17 四川轻化工大学 一种流式电化学发光实时检测装置及检测方法
CN111693516B (zh) * 2020-05-07 2023-04-21 四川轻化工大学 一种气液相电化学发光检测装置及检测方法
JP2023547505A (ja) 2020-11-02 2023-11-10 エフ． ホフマン－ラ ロシュ アーゲー ＳＡＲＳ－ＣｏＶ－２ヌクレオカプシド抗体
CN113030068A (zh) * 2021-02-01 2021-06-25 苏州易莱生物技术有限公司 电化学发光的检测设备
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
EP4314838A1 (de) 2021-04-01 2024-02-07 F. Hoffmann-La Roche AG Psp94 als blutbiomarker zur nichtinvasiven diagnose von endometriose
JP2024518180A (ja) 2021-05-17 2024-04-25 エフ． ホフマン－ラ ロシュ アーゲー 腺筋症の非侵襲的診断のための血液バイオマーカーとしてのｓＦＲＰ４
WO2023072904A1 (en) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Monoclonal antibodies specific for sars-cov-2 rbd
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
WO2023247752A1 (en) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Method for diagnosing endometriosis and for classifying the stage of endometriosis
WO2024017983A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2024017985A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2024017982A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030087A1 (de) * 1979-11-13 1981-06-10 Technicon Instruments Company Limited Immunoassay-Verfahren und -Vorrichtung und Ausrüstung zur Durchführung des Verfahrens
DE3013765A1 (de) * 1980-04-10 1981-10-15 Philips Patentverwaltung Gmbh, 2000 Hamburg Detektroranordnung, insbesondere fuer die fluessigkeitschromatografie
US4652533A (en) * 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
IL75749A (en) * 1984-07-10 1990-02-09 Serono Diagnostics Ltd Electrochemical specific-binding assay of ligand with a labelled component and kit for carrying out such assay
FI844027A (fi) * 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.
GB8507706D0 (en) * 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
ATE127923T1 (de) * 1986-04-30 1995-09-15 Igen Inc Elektrochemilumineszenz-testverfahren.
AU7399487A (en) * 1986-05-22 1987-12-22 Unilever Plc Solid phase immunoassay method
GB8620893D0 (en) * 1986-08-29 1986-10-08 Unilever Plc Assays
US5093268A (en) * 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5061445A (en) * 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
KR0143993B1 (ko) * 1988-11-03 1998-07-15 리차아드 제이 매씨이 전기화학 발광성 분석
CA2002083C (en) * 1988-11-03 2001-01-09 Haresh P. Shah Enhanced electrochemiluminescence
US5068088A (en) * 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements

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NZ241537A (en) 1993-06-25
DE69233703T2 (de) 2008-05-29
HK1015878A1 (en) 1999-10-22
EP0570518B1 (de) 1998-11-18
ATE173542T1 (de) 1998-12-15
TW316291B (de) 1997-09-21
EP0877252A2 (de) 1998-11-11
IL100867A (en) 1995-12-08
ATE368224T1 (de) 2007-08-15
JPH11148901A (ja) 1999-06-02
DE69233703D1 (de) 2007-09-06
JPH06509412A (ja) 1994-10-20
CN1495425A (zh) 2004-05-12
WO1992014139A1 (en) 1992-08-20
JP3061416B2 (ja) 2000-07-10
AU668085B2 (en) 1996-04-26
JP3182515B2 (ja) 2001-07-03
EP0570518A4 (en) 1994-05-18
EP1286164A3 (de) 2003-10-22
AU1420692A (en) 1992-09-07
EP1286164A2 (de) 2003-02-26
CN1094593C (zh) 2002-11-20
EP1286164B1 (de) 2007-07-25
DE69233675D1 (de) 2007-02-22
CN1064945A (zh) 1992-09-30
IE69060B1 (en) 1996-08-07
ES2291407T3 (es) 2008-03-01
IE920380A1 (en) 1992-08-12
DE69227624D1 (de) 1998-12-24
EP0877252A3 (de) 1999-02-17
CA2103674C (en) 2002-04-09
ES2126591T3 (es) 1999-04-01
HK1066059A1 (en) 2005-03-11
CA2103674A1 (en) 1992-08-07
DE69233675T2 (de) 2007-11-15
HK1017970A1 (en) 1999-12-03
IL100867A0 (en) 1992-11-15
DE69227624T2 (de) 1999-07-08
EP0877252B1 (de) 2007-01-10
GR3029446T3 (en) 1999-05-28
KR100226231B1 (ko) 1999-10-15
ES2281119T3 (es) 2007-09-16
DK0877252T3 (da) 2007-05-07
EP0570518A1 (de) 1993-11-24

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