DK0877252T3 - Fremgangsmåde og apparat til luminescensassays - Google Patents

Fremgangsmåde og apparat til luminescensassays

Info

Publication number
DK0877252T3
DK0877252T3 DK98200764T DK98200764T DK0877252T3 DK 0877252 T3 DK0877252 T3 DK 0877252T3 DK 98200764 T DK98200764 T DK 98200764T DK 98200764 T DK98200764 T DK 98200764T DK 0877252 T3 DK0877252 T3 DK 0877252T3
Authority
DK
Denmark
Prior art keywords
electrochemiluminescence
working electrode
analyte
interest
electrode surface
Prior art date
Application number
DK98200764T
Other languages
English (en)
Inventor
Gary F Blackburn
John K Leland
George E Lowke
Jack E Goodman
Richard J Massey
John H Kenten
Haresh P Shah
Original Assignee
Bioveris Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioveris Corp filed Critical Bioveris Corp
Application granted granted Critical
Publication of DK0877252T3 publication Critical patent/DK0877252T3/da

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK98200764T 1991-02-06 1992-02-05 Fremgangsmåde og apparat til luminescensassays DK0877252T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65242791A 1991-02-06 1991-02-06
US82726992A 1992-02-03 1992-02-03
US82727092A 1992-02-03 1992-02-03
EP92906820A EP0570518B1 (en) 1991-02-06 1992-02-05 Methods and apparatus for improved electrochemi-luminescence assays

Publications (1)

Publication Number Publication Date
DK0877252T3 true DK0877252T3 (da) 2007-05-07

Family

ID=27417877

Family Applications (2)

Application Number Title Priority Date Filing Date
DK92906820T DK0570518T3 (da) 1991-02-06 1992-02-05 Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays
DK98200764T DK0877252T3 (da) 1991-02-06 1992-02-05 Fremgangsmåde og apparat til luminescensassays

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK92906820T DK0570518T3 (da) 1991-02-06 1992-02-05 Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays

Country Status (17)

Country Link
EP (3) EP1286164B1 (da)
JP (2) JP3061416B2 (da)
KR (1) KR100226231B1 (da)
CN (2) CN1495425A (da)
AT (2) ATE368224T1 (da)
AU (1) AU668085B2 (da)
CA (1) CA2103674C (da)
DE (3) DE69227624T2 (da)
DK (2) DK0570518T3 (da)
ES (3) ES2281119T3 (da)
GR (1) GR3029446T3 (da)
HK (3) HK1017970A1 (da)
IE (1) IE69060B1 (da)
IL (1) IL100867A (da)
NZ (1) NZ241537A (da)
TW (1) TW316291B (da)
WO (1) WO1992014139A1 (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE184320T1 (de) * 1991-07-10 1999-09-15 Igen Int Inc Verfahren für verbesserte lumineszenz-assays unter verwendung von teilchenkonzentration und chemilumineszenznachweis
ZA929351B (en) * 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
US5466416A (en) * 1993-05-14 1995-11-14 Ghaed; Ali Apparatus and methods for carrying out electrochemiluminescence test measurements
US5981286A (en) * 1994-07-25 1999-11-09 Roche Diagnostics, Gmbh Hydrophilic metal complexes
US5744367A (en) * 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
WO1996028538A1 (en) * 1995-03-10 1996-09-19 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US7314711B2 (en) 1997-05-23 2008-01-01 Bioveris Corporation Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers
JP3366842B2 (ja) * 1997-08-29 2003-01-14 エーザイ株式会社 電気化学発光測定用セル
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
US6136268A (en) * 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
JP4768224B2 (ja) * 2001-09-10 2011-09-07 メソ スケイル テクノロジーズ，エルエルシー １つの試料について複数の測定を実施する方法及び装置
US20030180814A1 (en) * 2002-03-21 2003-09-25 Alastair Hodges Direct immunosensor assay
AU2003249350A1 (en) 2002-06-20 2004-01-06 Igen International, Inc Electrochemiluminescence flow cell and flow cell components
WO2004042400A1 (ja) 2002-11-07 2004-05-21 Mitsubishi Kagaku Iatron, Inc. 磁性粒子捕集用磁力体及びその利用
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
JP5118964B2 (ja) 2004-06-23 2013-01-16 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム ２粒子複合体を用いた生物学的分子の検出のための方法及び組成物
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
US7713574B2 (en) 2004-07-13 2010-05-11 Dexcom, Inc. Transcutaneous analyte sensor
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US8211279B2 (en) 2005-06-03 2012-07-03 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
JPWO2007148762A1 (ja) * 2006-06-22 2009-11-19 雅彦 黒田 ヒトパピローマウイルス（ｈｐｖ）の検出方法、それに用いるプライマーセットおよび検出キット
SI2271938T1 (sl) 2008-04-11 2014-07-31 Board Of Regents Of The University Of Texas System Postopek in naprava za ojačenje električno generirane kemiluminiscence nanodelcev
US8372652B2 (en) 2008-05-08 2013-02-12 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
CA2738317C (en) 2008-09-24 2020-01-14 Straus Holdings Inc. Imaging analyzer for testing analytes
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
EP2720798B1 (en) * 2011-06-15 2020-01-01 Koninklijke Philips N.V. Processing of biological sample components
JP6313977B2 (ja) * 2011-12-28 2018-04-18 株式会社日立ハイテクノロジーズ 試料分析装置及び試料分析方法
CN107923911A (zh) 2015-08-20 2018-04-17 豪夫迈·罗氏有限公司 使用聚乙二醇化分析物特异性结合剂的基于颗粒的免疫测定法
KR102437995B1 (ko) 2016-03-07 2022-08-29 에프. 호프만-라 로슈 아게 항-p53 항체의 검출
ES2974284T3 (es) 2016-03-11 2024-06-26 Roche Diagnostics Gmbh Aminas de cadena ramificada en la detección de electroquimioluminiscencia
RU2711158C1 (ru) 2016-09-14 2020-01-15 Филип Моррис Продактс С.А. Система, генерирующая аэрозоль, и способ управления ею
ES2865511T3 (es) 2017-02-02 2021-10-15 Hoffmann La Roche Inmunoanálisis que usa al menos dos agentes de unión específica a analito pegilado
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor
WO2019079125A2 (en) * 2017-10-19 2019-04-25 Bio-Rad Laboratories, Inc. DIGITAL AMPLIFICATION TESTS WITH UNCONVENTIONAL AND / OR INVERTED PHOTOLUMINESCENCE CHANGES
JP2021522192A (ja) 2018-04-18 2021-08-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規抗チミジンキナーゼ抗体
CN112639475A (zh) 2018-08-31 2021-04-09 豪夫迈·罗氏有限公司 Dlbcl的预后指数中的胸苷激酶(tk-1)
CN111351781B (zh) * 2018-12-20 2023-11-24 麦德龙生物株式会社 电化学发光分析装置和使用其分析样品的方法
CN111007593B (zh) * 2019-05-12 2022-05-13 桂林电子科技大学 基于热扩散融嵌芯毛细管光纤微小粒子输运装置
WO2021013786A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis
KR20220016210A (ko) 2019-07-22 2022-02-08 에프. 호프만-라 로슈 아게 자궁내막증의 비-침습적 진단용 혈액 생물표지자로써 s100a9
BR112022000945A2 (pt) 2019-07-22 2022-03-08 Hoffmann La Roche Métodos para avaliar se uma paciente tem endometriose ou está em risco de desenvolver endometriose, para selecionar uma paciente para terapia e para monitorar uma paciente que sofre de endometriose ou que está sendo tratada para endometriose
CN114144674A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 P物质作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物
JP7315781B2 (ja) 2019-07-22 2023-07-26 エフ． ホフマン－ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ１２
EP4058459A1 (en) 2019-11-15 2022-09-21 F. Hoffmann-La Roche AG Derivatization of beta-lactam antibiotics for massspec measurements in patient samples
CN111693515B (zh) * 2020-05-07 2022-06-17 四川轻化工大学 一种流式电化学发光实时检测装置及检测方法
CN111693516B (zh) * 2020-05-07 2023-04-21 四川轻化工大学 一种气液相电化学发光检测装置及检测方法
EP4237441A1 (en) 2020-11-02 2023-09-06 F. Hoffmann-La Roche AG Sars-cov-2 nucleocapsid antibodies
CN113030068A (zh) * 2021-02-01 2021-06-25 苏州易莱生物技术有限公司 电化学发光的检测设备
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
WO2022207685A1 (en) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis
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WO2023072904A1 (en) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Monoclonal antibodies specific for sars-cov-2 rbd
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
WO2023247752A1 (en) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Method for diagnosing endometriosis and for classifying the stage of endometriosis
WO2024017985A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2024017983A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2024017982A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030087A1 (en) * 1979-11-13 1981-06-10 Technicon Instruments Company Limited Immunoassay method and apparatus and kit for carrying out the method
DE3013765A1 (de) * 1980-04-10 1981-10-15 Philips Patentverwaltung Gmbh, 2000 Hamburg Detektroranordnung, insbesondere fuer die fluessigkeitschromatografie
US4652533A (en) * 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
AU596946B2 (en) * 1984-07-10 1990-05-24 F. Hoffmann-La Roche Ltd Methods of assay
FI844027A (fi) * 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.
GB8507706D0 (en) * 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
JPH0737464B2 (ja) * 1986-04-30 1995-04-26 イゲン，インコーポレーテッド エレクトロ化学ルミネセンスアツセイ
WO1987007386A1 (en) * 1986-05-22 1987-12-03 Unilever Plc Solid phase immunoassay method
GB8620893D0 (en) * 1986-08-29 1986-10-08 Unilever Plc Assays
US5093268A (en) * 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
KR0143993B1 (ko) * 1988-11-03 1998-07-15 리차아드 제이 매씨이 전기화학 발광성 분석
US5061445A (en) * 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
CA2002083C (en) * 1988-11-03 2001-01-09 Haresh P. Shah Enhanced electrochemiluminescence
US5068088A (en) * 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements

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DE69233703T2 (de) 2008-05-29
AU1420692A (en) 1992-09-07
IE920380A1 (en) 1992-08-12
CA2103674A1 (en) 1992-08-07
DE69233675D1 (de) 2007-02-22
DE69227624D1 (de) 1998-12-24
EP0877252A3 (en) 1999-02-17
EP0877252B1 (en) 2007-01-10
JPH06509412A (ja) 1994-10-20
JP3061416B2 (ja) 2000-07-10
CA2103674C (en) 2002-04-09
ES2126591T3 (es) 1999-04-01
EP0570518B1 (en) 1998-11-18
DK0570518T3 (da) 1999-08-02
EP0877252A2 (en) 1998-11-11
IL100867A (en) 1995-12-08
ATE173542T1 (de) 1998-12-15
IE69060B1 (en) 1996-08-07
ES2281119T3 (es) 2007-09-16
JP3182515B2 (ja) 2001-07-03
AU668085B2 (en) 1996-04-26
HK1015878A1 (en) 1999-10-22
HK1017970A1 (en) 1999-12-03
TW316291B (da) 1997-09-21
ES2291407T3 (es) 2008-03-01
DE69233703D1 (de) 2007-09-06
WO1992014139A1 (en) 1992-08-20
EP1286164B1 (en) 2007-07-25
EP1286164A3 (en) 2003-10-22
GR3029446T3 (en) 1999-05-28
CN1064945A (zh) 1992-09-30
HK1066059A1 (en) 2005-03-11
EP1286164A2 (en) 2003-02-26
KR100226231B1 (ko) 1999-10-15
JPH11148901A (ja) 1999-06-02
CN1094593C (zh) 2002-11-20
DE69233675T2 (de) 2007-11-15
DE69227624T2 (de) 1999-07-08
EP0570518A4 (en) 1994-05-18
IL100867A0 (en) 1992-11-15
EP0570518A1 (en) 1993-11-24
ATE368224T1 (de) 2007-08-15
CN1495425A (zh) 2004-05-12
NZ241537A (en) 1993-06-25

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