DK0556213T3 - Fremstilling af hyarulonsyre - Google Patents

Fremstilling af hyarulonsyre

Info

Publication number
DK0556213T3
DK0556213T3 DK91918590T DK91918590T DK0556213T3 DK 0556213 T3 DK0556213 T3 DK 0556213T3 DK 91918590 T DK91918590 T DK 91918590T DK 91918590 T DK91918590 T DK 91918590T DK 0556213 T3 DK0556213 T3 DK 0556213T3
Authority
DK
Denmark
Prior art keywords
pct
sec
date
hyaluronic acid
streptococcus
Prior art date
Application number
DK91918590T
Other languages
Danish (da)
English (en)
Inventor
Derek Clifford Ellwood
Charles Gervase Evans
Geoffrey Michael Dunn
Neil Mcinnes
Richard Grenville Yeo
Keith James Smith
Original Assignee
Fermentech Med Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fermentech Med Ltd filed Critical Fermentech Med Ltd
Application granted granted Critical
Publication of DK0556213T3 publication Critical patent/DK0556213T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91918590T 1990-11-07 1991-11-04 Fremstilling af hyarulonsyre DK0556213T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909024223A GB9024223D0 (en) 1990-11-07 1990-11-07 Production of hyaluronic acid
PCT/GB1991/001927 WO1992008799A1 (fr) 1990-11-07 1991-11-04 Production d'acide hyaluronique

Publications (1)

Publication Number Publication Date
DK0556213T3 true DK0556213T3 (da) 1998-12-21

Family

ID=10685019

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91918590T DK0556213T3 (da) 1990-11-07 1991-11-04 Fremstilling af hyarulonsyre

Country Status (9)

Country Link
US (2) US5411874A (fr)
EP (1) EP0556213B1 (fr)
JP (1) JP3159983B2 (fr)
AT (1) ATE164185T1 (fr)
DE (1) DE69129118T2 (fr)
DK (1) DK0556213T3 (fr)
ES (1) ES2115620T3 (fr)
GB (1) GB9024223D0 (fr)
WO (1) WO1992008799A1 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid
IT1263393B (it) * 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
SE9401806D0 (sv) * 1994-05-26 1994-05-26 Pharmacia Ab Method and means for the production of hyaluronic acid
IT1271001B (it) * 1994-07-26 1997-05-26 Poli Ind Chimica Spa Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
IT1295935B1 (it) 1997-10-30 1999-05-28 Acs Dobfar Spa Derivati aminotiazolici utili nella preparazione di antibiotici b -lattamici
WO1999050389A1 (fr) 1998-03-30 1999-10-07 Metabolix, Inc. Souches microbiennes et procedes de production de biomateriaux
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
GB9902652D0 (en) 1999-02-05 1999-03-31 Fermentech Med Ltd Process
DE60121027T3 (de) 2000-11-03 2011-06-09 Xvivo Perfusion Ab Lösung zur evaluierung und konservierung
US6660853B2 (en) * 2000-12-15 2003-12-09 Al Prescott Method for purifying high molecular weight hyaluronic acid
US20080063677A1 (en) * 2004-03-10 2008-03-13 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
US20040180025A1 (en) * 2003-03-12 2004-09-16 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
US6946551B2 (en) * 2003-03-12 2005-09-20 New Life Resources, Llc Preparation of hyaluronic acid from eggshell membrane
AU2003901834A0 (en) 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
ES2341863T3 (es) * 2003-09-11 2010-06-29 De Staat Der Nederlanden, Vert. Door De Minister Van Vws Proceso para la produccion de un polisacarido capsular para su uso en vacunas de conjugado.
US8580315B2 (en) * 2004-03-10 2013-11-12 Esm Technologies, Llc Anti-inflammatory activity of eggshell membrane and processed eggshell membrane preparations
CN1293197C (zh) * 2004-03-23 2007-01-03 中国农业大学 一种用于乳酸菌发酵的增效剂
CA2567532C (fr) * 2004-05-20 2013-10-01 Mentor Corporation Procede de preparation d'hydrogels polymeres injectables
WO2005113608A1 (fr) * 2004-05-20 2005-12-01 Mentor Corporation Méthode pour lier covalemment l’hyaluronan et le chitosan
CN100431431C (zh) * 2004-05-25 2008-11-12 中国科学院南海海洋研究所 一种富含海洋天然牛磺酸的保健型味精及其制备方法
US7002007B2 (en) * 2004-05-28 2006-02-21 Calcigen Corporation Production of high molecular weight hyaluronates
AU2007298454B2 (en) * 2006-07-06 2014-01-16 Reliance Life Sciences Pvt Ltd Efficient process for purification of high molecular weight hyaluronic acid
KR101509139B1 (ko) * 2006-11-23 2015-04-08 주식회사 엘지생명과학 히알루론산의 정제방법
WO2008094910A2 (fr) * 2007-01-30 2008-08-07 Cypress Pharmaceutical, Inc. Compositions de hyaluronate
US8759321B2 (en) * 2007-06-13 2014-06-24 Bausch & Lomb Incorporated Ophthalmic composition with hyaluronic acid and polymeric biguanide
CN101089021B (zh) * 2007-07-12 2010-04-14 华东理工大学 从微生物发酵液中分离提取透明质酸的方法
KR20100094982A (ko) 2007-11-13 2010-08-27 바이오-테크널러지 제너럴 (이스라엘) 리미티드 점탄성 바이오폴리머의 희석식 여과 멸균 방법
WO2011148116A2 (fr) 2010-05-27 2011-12-01 Laboratoire Idenov Acide hyaluronique modifie, procede de fabrication et utilisations
DE102011077393A1 (de) 2011-06-10 2012-12-13 Johannes Reinmüller Antiinfektives Mittel
CN102504047A (zh) * 2011-11-30 2012-06-20 上海景峰制药有限公司 一种玻璃酸钠发酵液的超滤方法
CN105504091A (zh) * 2013-07-30 2016-04-20 青岛九龙生物医药有限公司 从猪皮中提取透明质酸的方法
ITMI20131654A1 (it) * 2013-10-07 2015-04-08 Rosa Mario De Downstream di purificazione di acido ialuronico da brodi di coltura microbici
CA2896038C (fr) 2015-07-03 2022-08-09 Glycobiosciences Inc. Compositions de matrice polymere renfermant une concentration elevee d'hyalluonate de sodium bio-fermente et leurs utilisations
CN112553272B (zh) * 2020-12-24 2022-08-09 华熙生物科技股份有限公司 一种提高透明质酸产率的方法
KR102485521B1 (ko) 2021-03-04 2023-01-10 주식회사 금오시설안전 고소 콘크리트 비파괴점검을 위한 슈미트해머 거치장치
CN117915933A (zh) 2021-09-01 2024-04-19 上海其胜生物制剂有限公司 使用含有软骨细胞或干细胞的可注射可原位聚合胶原组合物进行软骨再生
CN115215949B (zh) * 2022-06-09 2024-01-05 浙江驭远生物科技有限公司 透明质酸钠及其提纯方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
NO161573C (no) * 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
JPS60251898A (ja) * 1984-05-25 1985-12-12 Shiseido Co Ltd 醗酵法によるヒアルロン酸の製造方法
FR2569724B1 (fr) * 1984-09-04 1991-02-08 Chisso Corp Procede pour la preparation d'acide hyaluronique
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
JPS6232893A (ja) * 1985-08-01 1987-02-12 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
US4946780A (en) * 1988-10-12 1990-08-07 Denkl Kagaku Kogyo Kabushiki Kaisha Method for producing sodium hyaluronate by fermentation method
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid

Also Published As

Publication number Publication date
EP0556213B1 (fr) 1998-03-18
DE69129118D1 (de) 1998-04-23
GB9024223D0 (en) 1990-12-19
US5411874A (en) 1995-05-02
JPH06505146A (ja) 1994-06-16
ES2115620T3 (es) 1998-07-01
US5563051A (en) 1996-10-08
JP3159983B2 (ja) 2001-04-23
DE69129118T2 (de) 1998-11-19
EP0556213A1 (fr) 1993-08-25
WO1992008799A1 (fr) 1992-05-29
ATE164185T1 (de) 1998-04-15

Similar Documents

Publication Publication Date Title
DK0556213T3 (da) Fremstilling af hyarulonsyre
KR850007983A (ko) 히알우론산 생산의 발효법
NZ504345A (en) Low pH lactic acid fermentation
JPS6437295A (en) Production of l-threonine by fermentation
IT1271001B (it) Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
AU6704196A (en) Industrial production process for a vaccine against Japanese encephalitis, and vaccine obtained
ES8606906A1 (es) Procedimiento para preparar productos que contienen oligosacaridos a partir de biomasa triturada.
FR2389673A1 (fr)
ES2188708T3 (es) Metodo de produccion de acido l-lactico con alta pureza optica utilizando cepas de bacillus.
MY109037A (en) Regioselective synthesis of 4-chloro-2- thiophenecarboxylic acid.
JPH0630593B2 (ja) 糖類の発酵によりポリオ−ルを工業的規模で製造する方法
ES2098372T3 (es) Microorganismo y procedimiento para la obtencion de acido antranilico.
CN108085317B (zh) 一种特异性靶向变异链球菌gtfB位点的CRISPR-B基因编辑方法及应用
GB2397819A (en) (R)-Hydroxycarboxylic acid producing recombinant microorganism and process for preparing (R)-hydroxycarboxylic acid using the same
AU634148B2 (en) Use of cellulase preparations in the cultivation and use of cellulose-producing microorganisms
KR910016916A (ko) 미생물 및 이를 이용한 바이오틴 바이타머의 생산방법
JPS5489088A (en) Preparation of d-alpha-amino acid
JPS6474999A (en) Production of optically active (r)-(-)-beta-hydroxylactic acid
DK1052289T3 (da) Fremgangsmåde til frembringelse af arabitol ved kontinuerlig fermentering
JPS5534047A (en) Preparation of alpha-amylase
JP3148342B2 (ja) レバン型フルクタンの製造に適した新規細菌
JPS578796A (en) Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt
JPS5452791A (en) Preparation of d-alpha-amino acid
JPS6463386A (en) Production of (r)-(+)-gamma-butyrolactone-gamma-3-propionic acid
JPS57163488A (en) Production of l-citrulline through fermentation process