DK0550631T3 - Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi - Google Patents
Forbindelser med blodtrykssænkende virkning og virkning mod iskæmiInfo
- Publication number
- DK0550631T3 DK0550631T3 DK91917927.5T DK91917927T DK0550631T3 DK 0550631 T3 DK0550631 T3 DK 0550631T3 DK 91917927 T DK91917927 T DK 91917927T DK 0550631 T3 DK0550631 T3 DK 0550631T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- antihypertensive
- ischemic effects
- ischemic
- adenosine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58788490A | 1990-09-25 | 1990-09-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0550631T3 true DK0550631T3 (da) | 1997-01-20 |
Family
ID=24351576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91917927.5T DK0550631T3 (da) | 1990-09-25 | 1991-09-25 | Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi |
Country Status (14)
Country | Link |
---|---|
US (1) | US5364862A (fr) |
EP (1) | EP0550631B1 (fr) |
JP (1) | JP2505085B2 (fr) |
AT (1) | ATE147074T1 (fr) |
AU (1) | AU654507B2 (fr) |
CA (1) | CA2092305C (fr) |
DE (1) | DE69123974T2 (fr) |
DK (1) | DK0550631T3 (fr) |
ES (1) | ES2095960T3 (fr) |
GR (1) | GR3022207T3 (fr) |
HK (1) | HK1002031A1 (fr) |
MX (1) | MX9203771A (fr) |
SG (1) | SG80526A1 (fr) |
WO (1) | WO1992005177A1 (fr) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679650A (en) * | 1993-11-24 | 1997-10-21 | Fukunaga; Atsuo F. | Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine |
US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
ATE147074T1 (de) * | 1990-09-25 | 1997-01-15 | Rhone Poulenc Rorer Int | Verbindungen welche antihypertensive und antiischemische eigenschaften besitzen |
FR2685918B1 (fr) * | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
EP0601322A3 (fr) * | 1992-10-27 | 1994-10-12 | Nippon Zoki Pharmaceutical Co | Inhibiteur de déaminase d'adénosine. |
DK155292D0 (da) * | 1992-12-23 | 1992-12-23 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
US5683989A (en) * | 1993-12-17 | 1997-11-04 | Novo Nordisk A/S | Treatment of ischemias by administration of 2,N6 -substituted adenosines |
FR2714907B1 (fr) * | 1994-01-07 | 1996-03-29 | Union Pharma Scient Appl | Nouveaux dérivés de l'Adénosine, leurs procédés de préparation, compositions pharmaceutiques les contenant. |
WO1995018817A1 (fr) * | 1994-01-07 | 1995-07-13 | Laboratoires Upsa | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant |
GB9414208D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
US5670649A (en) * | 1995-05-30 | 1997-09-23 | Rhone-Poulenc Rorer S.A. | Derivatives of 2-azabicyclo 2.2.1!heptane, their preparation and their application |
US5684159A (en) * | 1995-05-30 | 1997-11-04 | Rhone-Poulenc Rorer S.A. | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
FR2734822B1 (fr) * | 1995-05-30 | 1997-07-04 | Rhone Poulenc Rorer Sa | Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application |
ZA9756B (en) * | 1996-01-16 | 1997-07-17 | Warner Lambert Co | Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines |
US6376472B1 (en) | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
UA51716C2 (uk) * | 1996-07-08 | 2002-12-16 | Авентіс Фармасьютікалз Продактс Інк. | Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування |
US5747474A (en) * | 1996-07-29 | 1998-05-05 | Immune Modulation, Inc. | Immunosuppression by administration of N6,N6 -disubstituted cAMP's, analogues thereof, and related nucleosides |
SK26999A3 (en) * | 1996-09-12 | 1999-10-08 | Rhone Poulenc Rorer Pharma | Stereospecific preparation of chiral 1-aryl- and 1-heteroaryl-2- -substituted ethyl-2-amines |
EP0946550B1 (fr) * | 1996-12-11 | 2005-08-03 | Aventis Pharmaceuticals Inc. | PREPARATION DE [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-CHLORO-2-THIENYL)METHYL]PROPYL]AMINO]-3H-IMIDAZO[4,5-b]PYRIDIN-3-YL]-N-ETHYL-2,3-DIHYDROXYCYCLOPENTANECARBOXAMIDE |
TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
AU9790998A (en) | 1997-10-07 | 1999-04-27 | Regents Of The University Of California Corporation | Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine |
GB9723590D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
KR20010071591A (ko) | 1998-06-23 | 2001-07-28 | 그레이엄 브레레톤, 레슬리 에드워즈 | 2-(퓨린-9-일)-테트라히드로푸란-3,4-디올 유도체 |
JP3619017B2 (ja) | 1998-06-24 | 2005-02-09 | 日本臓器製薬株式会社 | 新規アラビノシルアデニン誘導体 |
PT1175420E (pt) * | 1998-12-21 | 2003-08-29 | Aventis Pharma Inc | Processo para a preparacao de derivados n6-substituidos da desaza-adenosina |
EP1140933B1 (fr) | 1998-12-31 | 2004-09-08 | Aventis Pharmaceuticals Inc. | Procede de preparation de derives de deaza-adenosine n6-substitues |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US6784165B1 (en) * | 1999-11-23 | 2004-08-31 | Aderis Pharmaceuticals, Inc. | Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines |
US20020045613A1 (en) * | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
HU228783B1 (en) * | 2001-07-26 | 2013-05-28 | Greenearth Cleaning | Dry cleaning apparatus and method capable of utilizing a siloxane solvent |
AU2002362443B2 (en) | 2001-10-01 | 2008-05-15 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
US7414036B2 (en) | 2002-01-25 | 2008-08-19 | Muscagen Limited | Compounds useful as A3 adenosine receptor agonists |
US7265111B2 (en) * | 2002-06-27 | 2007-09-04 | Sanofi-Aventis Deutschland Gmbh | Adenosine analogues and their use as pharmaceutical agents |
EP1589027A1 (fr) * | 2003-01-17 | 2005-10-26 | Ajinomoto Co., Inc. | Procedes de production de nucleosides |
AU2004238217A1 (en) * | 2003-04-24 | 2004-11-25 | Aderis Pharmaceuticals, Inc. | Method of treating atrial fibrillation or atrial flutter |
WO2005025545A2 (fr) * | 2003-09-17 | 2005-03-24 | Aderis Pharmaceuticals, Inc. | Formulation a liberation controlee |
EP1574508A1 (fr) * | 2004-01-30 | 2005-09-14 | Lonza AG | Procédé pour la préparation d acetals et cétals de 3-amino-5-(hydroxymethyl)-cyclopentane -1,2-diols et leur derivés sels |
AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
WO2006028618A1 (fr) | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | Analogues d'adenosine de propynyle 2-polycyclique presentant des groupes 5'-ribose modifies presentant une activite agoniste de a2a |
WO2006023272A1 (fr) | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | Analogues de 2-polycyclique propynyle adenosine presentant une activite agoniste de a2a |
US7605143B2 (en) | 2004-08-02 | 2009-10-20 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
WO2006068760A2 (fr) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Pyrazolopyrimidines anti-inflammatoires |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
WO2007120972A2 (fr) | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Procede permettant de traiter l'anemie a hematies falciformes |
PT2004654E (pt) | 2006-04-04 | 2013-08-27 | Univ California | Derivados de pirazolopirimidina para utilização como antagonistas da quinase |
ATE549337T1 (de) | 2006-04-21 | 2012-03-15 | Novartis Ag | Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten |
GB0607954D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
US8188063B2 (en) | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
EP1889846A1 (fr) | 2006-07-13 | 2008-02-20 | Novartis AG | Dérivés de purine comme agonistes du recepteur A2a |
EP1903044A1 (fr) | 2006-09-14 | 2008-03-26 | Novartis AG | Derivés de l'adénosine en tant qu' agonistes du récepteur A2A |
US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
JP5869222B2 (ja) | 2008-01-04 | 2016-02-24 | インテリカイン, エルエルシー | 特定の化学的実体、組成物および方法 |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
MX2011000216A (es) | 2008-07-08 | 2011-03-29 | Intellikine Inc | Inhibidores de cinasa y metodos para su uso. |
CA2738429C (fr) | 2008-09-26 | 2016-10-25 | Intellikine, Inc. | Inhibiteurs heterocycliques de kinases |
WO2010045542A2 (fr) | 2008-10-16 | 2010-04-22 | The Regents Of The University Of California | Inhibiteurs d'hétéroarylkinase à noyau fusionné |
US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
CA2760791C (fr) | 2009-05-07 | 2017-06-20 | Intellikine, Inc. | Composes heterocycliques et leurs utilisations |
US8980899B2 (en) | 2009-10-16 | 2015-03-17 | The Regents Of The University Of California | Methods of inhibiting Ire1 |
AU2011255218B2 (en) | 2010-05-21 | 2015-03-12 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環化合物及びその使用 |
WO2012087833A1 (fr) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Inhibiteurs de l'hépatite c et leurs utilisations |
CA2824197C (fr) | 2011-01-10 | 2020-02-25 | Michael Martin | Procedes de preparation d'isoquinolinones et de formes solides d'isoquinolinones |
JP6130305B2 (ja) | 2011-02-23 | 2017-05-17 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
CN103930422A (zh) | 2011-07-19 | 2014-07-16 | 无限药品股份有限公司 | 杂环化合物及其用途 |
CA2842190A1 (fr) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Composes heterocycliques et leurs utilisations |
AR091790A1 (es) | 2011-08-29 | 2015-03-04 | Infinity Pharmaceuticals Inc | Derivados de isoquinolin-1-ona y sus usos |
JP6342805B2 (ja) | 2011-09-02 | 2018-06-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 置換ピラゾロ[3,4−d]ピリミジンおよびその用途 |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
CA2886240A1 (fr) | 2012-09-26 | 2014-04-03 | The Regents Of The University Of California | Modulation de ire1 |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
WO2015051241A1 (fr) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
MX2016004340A (es) | 2013-10-04 | 2016-08-08 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
RU2695358C2 (ru) * | 2013-10-23 | 2019-07-23 | Академия Синика | Соединения для предотвращения и лечения нейродегенеративных заболеваний и боли |
PT3119397T (pt) | 2014-03-19 | 2022-04-11 | Infinity Pharmaceuticals Inc | Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama |
WO2015160975A2 (fr) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Polythérapies |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
US10160761B2 (en) | 2015-09-14 | 2018-12-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same |
WO2017161116A1 (fr) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues de composés isoquinolinone et quinazolinone et leurs utilisations comme inhibiteurs de la kinase pi3k |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
MX2018016227A (es) | 2016-06-24 | 2019-07-08 | Infinity Pharmaceuticals Inc | Terapias de combinacion. |
CN113015781B (zh) | 2018-11-20 | 2022-09-13 | 联合利华知识产权控股有限公司 | 洗涤剂组合物 |
WO2022135365A1 (fr) * | 2020-12-22 | 2022-06-30 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Inhibiteurs de kinase de cyclopentane disubstitués |
KR102308854B1 (ko) * | 2021-02-26 | 2021-10-05 | 퓨쳐메디신 주식회사 | 카보사이클릭 뉴클레오사이드 유도체를 포함하는 코로나바이러스감염증-19 예방 및 치료용 약학적 조성물 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL128629C (fr) * | 1966-05-07 | |||
BE768925A (fr) * | 1970-06-30 | 1971-11-03 | Takeda Chemical Industries Ltd | Derives d'adenosine et procede de preparation |
DE2059922A1 (de) * | 1970-12-05 | 1972-06-15 | Boehringer Mannheim Gmbh | Neue N(6)-Aralkyl-adenosin-Derivate und Verfahren zur Herstellung derselben |
DE2205002A1 (de) * | 1972-02-03 | 1973-08-09 | Merck Patent Gmbh | Adenosinderivate |
DE2136624A1 (de) * | 1971-07-22 | 1973-02-08 | Boehringer Mannheim Gmbh | N (6)-substituierte adenosin-derivate und verfahren zur herstellung derselben |
DE2139107A1 (de) * | 1971-08-04 | 1973-02-15 | Merck Patent Gmbh | Heterocyclisch substituierte adenosinverbindungen |
DE2151013C2 (de) * | 1971-10-08 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von in N↑6↑-Stellung gegebenenfalls substituierten 6-Amino- und 2,6-Diaminopurinnucleosiden |
US3914415A (en) * | 1973-06-14 | 1975-10-21 | Abbott Lab | Adenosine-5{40 -carboxylic acid amides |
US4167565A (en) * | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
JPS5921928A (ja) * | 1982-07-28 | 1984-02-04 | Haruo Kojima | 給湯装置 |
JPS59219284A (ja) * | 1983-05-27 | 1984-12-10 | Toyo Jozo Co Ltd | 3′−デオキシネプラノシンaおよびその製造法 |
US4501735A (en) * | 1983-12-05 | 1985-02-26 | Warner-Lambert Company | N6-(1- and 2-benzocycloalkyl) adenosines |
JPH0655756B2 (ja) * | 1984-04-18 | 1994-07-27 | ネルソン・リサ−チ・アンド・デベロツプメント・カンパニ− | 心臓血管拡張薬としてのn−6置換アデノシン誘導体 |
US4657897A (en) * | 1984-06-22 | 1987-04-14 | Warner-Lambert Company | N6 -substituted adenosines for treating pain |
US4657898A (en) * | 1984-06-22 | 1987-04-14 | Warner-Lambert Company | N6 -substituted adenosines and method of use |
US4683223A (en) * | 1985-09-09 | 1987-07-28 | Warner-Lambert Company | N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use |
US4663313A (en) * | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
US4593019A (en) * | 1984-10-26 | 1986-06-03 | Warner-Lambert Company | N6 -tricyclic adenosines |
AU575438B2 (en) * | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
US4600707A (en) * | 1985-01-25 | 1986-07-15 | Warner-Lambert Company | Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds |
US4636493A (en) * | 1985-01-25 | 1987-01-13 | Warner-Lambert Company | Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds |
DE3529497A1 (de) * | 1985-08-17 | 1987-02-26 | Boehringer Mannheim Gmbh | N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
US4738954A (en) * | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
US4755594A (en) * | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
US4780452A (en) * | 1986-09-08 | 1988-10-25 | Burroughs Wellcome Co. | F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof |
WO1988003147A1 (fr) * | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Adenosines a substitution n6 selectionees ayant une activite de liaison a2 selective |
AU8274187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
US5063233A (en) * | 1986-11-14 | 1991-11-05 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists |
US4954504A (en) * | 1986-11-14 | 1990-09-04 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity |
JPH0723394B2 (ja) * | 1986-11-27 | 1995-03-15 | 日本臓器製薬株式会社 | 新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
HU198950B (en) * | 1986-12-15 | 1989-12-28 | Sandoz Ag | Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds |
FI880405A (fi) * | 1987-02-04 | 1988-08-05 | Ciba Geigy Ag | Adenosin-5'-karboxamidderivat. |
US4968697A (en) * | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
CA1340361C (fr) * | 1987-04-24 | 1999-02-02 | Whitby Research, Inc. | Derives de substitution en n6 de 9-methyladenines : nouvelle classe d'antagonistes de recepteurs de l'adenosine |
GB8729994D0 (en) * | 1987-12-23 | 1988-02-03 | Glaxo Group Ltd | Chemical compounds |
US4977144A (en) * | 1988-08-02 | 1990-12-11 | Ciba-Geigy Corporation | Imidazo[4,5-b]pyridine derivatives as cardiovascular agents |
AU3820989A (en) * | 1988-08-02 | 1990-02-08 | Ciba-Geigy Ag | 7-amino-3-beta-d-ribofuranosyl-3h-imidazo(4,5-b) pyridin-5-amine derivatives |
GB2226027B (en) * | 1988-12-13 | 1992-05-20 | Sandoz Ltd | Adenosine derivatives,their production and use |
JPH0725785B2 (ja) * | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
GB8916480D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
ATE147074T1 (de) * | 1990-09-25 | 1997-01-15 | Rhone Poulenc Rorer Int | Verbindungen welche antihypertensive und antiischemische eigenschaften besitzen |
-
1991
- 1991-09-25 AT AT91917927T patent/ATE147074T1/de not_active IP Right Cessation
- 1991-09-25 SG SG9603118A patent/SG80526A1/en unknown
- 1991-09-25 DE DE69123974T patent/DE69123974T2/de not_active Expired - Fee Related
- 1991-09-25 WO PCT/US1991/006990 patent/WO1992005177A1/fr active IP Right Grant
- 1991-09-25 EP EP91917927A patent/EP0550631B1/fr not_active Expired - Lifetime
- 1991-09-25 AU AU87266/91A patent/AU654507B2/en not_active Ceased
- 1991-09-25 JP JP3516777A patent/JP2505085B2/ja not_active Expired - Fee Related
- 1991-09-25 DK DK91917927.5T patent/DK0550631T3/da active
- 1991-09-25 CA CA002092305A patent/CA2092305C/fr not_active Expired - Fee Related
- 1991-09-25 ES ES91917927T patent/ES2095960T3/es not_active Expired - Lifetime
-
1992
- 1992-06-29 MX MX9203771A patent/MX9203771A/es unknown
- 1992-10-02 US US07/955,783 patent/US5364862A/en not_active Expired - Fee Related
-
1997
- 1997-01-03 GR GR960402653T patent/GR3022207T3/el unknown
-
1998
- 1998-02-12 HK HK98101096A patent/HK1002031A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0550631A4 (en) | 1994-08-10 |
GR3022207T3 (en) | 1997-04-30 |
MX9203771A (es) | 1992-09-01 |
SG80526A1 (en) | 2001-05-22 |
JPH05508864A (ja) | 1993-12-09 |
CA2092305C (fr) | 2003-02-11 |
US5364862A (en) | 1994-11-15 |
DE69123974D1 (de) | 1997-02-13 |
AU8726691A (en) | 1992-04-15 |
WO1992005177A1 (fr) | 1992-04-02 |
ATE147074T1 (de) | 1997-01-15 |
HK1002031A1 (en) | 1998-07-24 |
EP0550631A1 (fr) | 1993-07-14 |
DE69123974T2 (de) | 1997-05-07 |
AU654507B2 (en) | 1994-11-10 |
JP2505085B2 (ja) | 1996-06-05 |
CA2092305A1 (fr) | 1992-03-26 |
ES2095960T3 (es) | 1997-03-01 |
EP0550631B1 (fr) | 1997-01-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0550631T3 (da) | Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi | |
BG60698B2 (en) | Pharmaceutical ACCEPTABLE SALTS | |
CA2188147A1 (fr) | Composes presentant des proprietes anti-hypertensives, cardioprotectrices, anti-ischemiques et antilipolytiques | |
EA200101203A1 (ru) | Производные пурина | |
CA2259538A1 (fr) | Composes presentant des proprietes anti-hypertensives, cardioprotectrices, anti-ischemiques et antilipolytiques | |
ATE286500T1 (de) | 1,2,3,4-tetrahydroisochinolin-derivate | |
ES2038613T3 (es) | Procedimiento para preparar derivados de 4,5,6,7-tetrahidro-1h-imidazo(4,5-c)piridina y analogos de los mismos que tienen actividad antihipertensiva. | |
DK0725782T3 (da) | A1-adenosin-receptor-agonister og antiagonister | |
DE69132141D1 (de) | Neuroprotective indolone und verwandte derivate | |
BG95705A (bg) | Аналози на 1,3-оксатиолан нуклеозида | |
ES2161418T3 (es) | Compuestos de piridilfurano y de piridiltiofeno y uso farmaceutico de los mismos. | |
FI840463A (fi) | Vissa bensazokinon- och bensazoninonderivat. | |
DK0630366T3 (da) | Substituerede heterocycliske derivater, der er nyttige som blodpladeaggregeringsinhibitorer | |
DK229187D0 (da) | 1-substituerede imidazolderivater, 2-thion-tautomere og ikke-toksiske, farmaceutisk acceptable salte deraf | |
HUP0103203A2 (hu) | Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények | |
FR2685918B1 (fr) | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. | |
ATE213233T1 (de) | Substituierte caprolactame und deren derivate verwendbar zur behandlung der hiv-krankheit | |
FI893163A (fi) | Menetelmä 19-hydroksylaasi-inhibiittoreina käyttökelpoisten 19-substituoitujen progesteronijohdannaisten valmistamiseksi | |
DE68919280D1 (de) | Alpha-adrenergische Rezeptorantagonisten. | |
FI970318A (fi) | Antiproliferatiivisina aineina ja Garft-inhibiitoreina käyttökelpoisia yhdisteitä | |
DE68919438D1 (de) | Alpha-adrenergische Rezeptorantagonisten. | |
DE68917217D1 (de) | Alpha-adrenergische Rezeptorantagonisten. |