DE951551T1 - Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie - Google Patents
Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilieInfo
- Publication number
- DE951551T1 DE951551T1 DE0951551T DE97952609T DE951551T1 DE 951551 T1 DE951551 T1 DE 951551T1 DE 0951551 T DE0951551 T DE 0951551T DE 97952609 T DE97952609 T DE 97952609T DE 951551 T1 DE951551 T1 DE 951551T1
- Authority
- DE
- Germany
- Prior art keywords
- ligand
- kappa
- receptor activator
- tnf superfamily
- receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5997896P | 1996-12-23 | 1996-12-23 | |
US7718197P | 1997-03-07 | 1997-03-07 | |
US6467197P | 1997-10-14 | 1997-10-14 | |
PCT/US1997/023775 WO1998028426A2 (en) | 1996-12-23 | 1997-12-22 | Ligand for receptor activator of nf-kappa b, ligand is member of tnf superfamily |
Publications (1)
Publication Number | Publication Date |
---|---|
DE951551T1 true DE951551T1 (de) | 2000-09-14 |
Family
ID=27369779
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69740107T Expired - Lifetime DE69740107D1 (de) | 1996-12-23 | 1997-12-22 | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
DE0951551T Pending DE951551T1 (de) | 1996-12-23 | 1997-12-22 | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
DE69738841T Expired - Lifetime DE69738841D1 (de) | 1996-12-23 | 1997-12-22 | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
DE122010000048C Pending DE122010000048I1 (de) | 1996-12-23 | 1997-12-22 | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69740107T Expired - Lifetime DE69740107D1 (de) | 1996-12-23 | 1997-12-22 | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69738841T Expired - Lifetime DE69738841D1 (de) | 1996-12-23 | 1997-12-22 | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
DE122010000048C Pending DE122010000048I1 (de) | 1996-12-23 | 1997-12-22 | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
Country Status (13)
Country | Link |
---|---|
US (21) | US6017729A (de) |
EP (5) | EP2003203A1 (de) |
JP (7) | JP4138013B2 (de) |
AT (2) | ATE497001T1 (de) |
AU (2) | AU713473B2 (de) |
CA (1) | CA2274987C (de) |
DE (4) | DE69740107D1 (de) |
DK (1) | DK0951551T4 (de) |
ES (1) | ES2144386T5 (de) |
IL (1) | IL130492A (de) |
LU (1) | LU91758I2 (de) |
PT (1) | PT951551E (de) |
WO (2) | WO1998028424A2 (de) |
Families Citing this family (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050060764A1 (en) * | 2003-09-17 | 2005-03-17 | Susan Gregory | Mouse model for bone metabolism |
US6919434B1 (en) | 1995-02-20 | 2005-07-19 | Sankyo Co., Ltd. | Monoclonal antibodies that bind OCIF |
IL117175A (en) * | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
US7632922B1 (en) * | 1995-12-22 | 2009-12-15 | Amgen, Inc. | Osteoprotegerin |
US20050147611A1 (en) * | 1995-12-22 | 2005-07-07 | Amgen Inc. | Combination therapy for conditions leading to bone loss |
US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
US6495520B2 (en) | 1996-03-22 | 2002-12-17 | Human Genome Sciences, Inc. | Apoptosis Inducing Molecule II and methods of use |
US6479254B2 (en) | 1996-03-22 | 2002-11-12 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II |
EP1114864B9 (de) * | 1996-12-13 | 2013-05-08 | Schering Corporation | Oberflächenantigene aus Säugern |
CA2274803C (en) * | 1996-12-23 | 2012-05-22 | Immunex Corporation | Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily |
EP2003203A1 (de) | 1996-12-23 | 2008-12-17 | Immunex Corporation | Ligand für den Rezeptorauslöser von NF-kappa b, wobei der Ligand Mitglied der TNF-Überfamilie ist |
AU2008200700C1 (en) * | 1997-04-15 | 2013-04-04 | Daiichi Sankyo Co., Ltd | Novel Protein and Process for Producing The Same |
DE122010000049I1 (de) | 1997-04-15 | 2011-05-05 | Daiichi Sankyo Co Ltd | Neues protein und verfahren zu dessen herstellung |
US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
ID23855A (id) * | 1997-04-16 | 2000-05-25 | Amgen Inc | Protein pengikat osteoprotegerin dan reseptor |
CA2229449A1 (en) * | 1997-04-25 | 1998-10-25 | Takeda Chemical Industries, Ltd. | Novel receptor protein and its use |
AU7705098A (en) * | 1997-05-29 | 1998-12-30 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like protein 8 |
CA2269114A1 (en) | 1997-09-24 | 1999-03-24 | Snow Brand Milk Products Co., Ltd. | Method for diagnosis of metabolic bone diseases |
WO1999029865A2 (en) * | 1997-12-12 | 1999-06-17 | The Rockefeller University | A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof |
US7063960B2 (en) | 1997-12-12 | 2006-06-20 | The Rockefeller University | Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof |
US7019119B2 (en) | 1997-12-12 | 2006-03-28 | The Rockefeller University | Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof |
EP2009025B1 (de) * | 1998-05-14 | 2011-07-27 | Immunex Corporation | Verfahren zur Hemmung der Wirkung der Osteoklasten |
US20020106728A1 (en) * | 2000-06-20 | 2002-08-08 | Genentech, Inc. | NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders |
SI1114166T1 (en) * | 1998-09-15 | 2005-10-31 | Pharmexa A/S | Method for down-regulating osteoprotegerin ligand activity |
CN1318105A (zh) * | 1998-09-15 | 2001-10-17 | M&E生物技术公司 | 负调节Osteoprotegerin配体活性的方法 |
EP1169448B1 (de) | 1999-04-12 | 2013-05-08 | Genentech, Inc. | Homologe des tumor-nekrosis-faktors und nucleinsäure die dafür kodiert |
US6492124B1 (en) | 1999-06-11 | 2002-12-10 | The Rockefeller University | Trance activated signal transduction pathways in osteoclasts |
US6872806B1 (en) * | 1999-06-25 | 2005-03-29 | The Governors Of The University Of Alberta | Polypeptide compositions formed using a coiled-coil template and methods of use |
IL147029A0 (en) | 1999-06-28 | 2002-08-14 | Genentech Inc | Method for making apo-2 ligand using divalent metal ions |
ATE448781T1 (de) * | 1999-07-28 | 2009-12-15 | Univ Pennsylvania | Methoden zur hemmung der aktivität der osteoklasten |
US6673771B1 (en) | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
AUPQ314799A0 (en) * | 1999-09-29 | 1999-10-21 | University Of Western Australia, The | Bone cell factor |
US6171860B1 (en) | 1999-11-05 | 2001-01-09 | Isis Pharmaceuticals, Inc. | Antisense inhibition of rank expression |
WO2001036637A1 (en) * | 1999-11-17 | 2001-05-25 | Immunex Corporation | Receptor activator of nf-kappa b |
GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
ES2267593T3 (es) | 2000-02-16 | 2007-03-16 | Genentech, Inc. | Anticuerpos anti-april y celulas hibridomas. |
DE60134459D1 (de) † | 2000-02-23 | 2008-07-31 | Amgen Inc | Antagonistische selektive bindungsagenzien des osteoprotegerin-bindungsproteins |
US20030103978A1 (en) * | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
ES2637801T3 (es) | 2000-04-11 | 2017-10-17 | Genentech, Inc. | Anticuerpos multivalentes y usos de los mismos |
WO2001091793A1 (en) * | 2000-05-26 | 2001-12-06 | Smithkline Beecham Corporation | Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders |
EP1303293B1 (de) | 2000-07-27 | 2008-12-03 | Genentech, Inc. | Sequentielle verabreichung von cpt-11 und apo-2l polypeptid |
AU2001286586A1 (en) * | 2000-08-18 | 2002-03-04 | University Of Massachusetts Medical Center | Trance regulation of chondrocyte differentiation |
AU2001288342A1 (en) * | 2000-08-21 | 2002-03-04 | Smith Kline Beecham Corporation | Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders |
US6884598B2 (en) * | 2000-09-22 | 2005-04-26 | Immunex Corporation | Screening assays for agonists and antagonists of receptor activator of NF-κB |
US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
US20040132971A1 (en) * | 2001-02-09 | 2004-07-08 | Haaning Jesper Mortensen | Rank ligand-binding polypeptides |
AU2002231602A1 (en) * | 2001-02-09 | 2002-08-28 | Maxygen Holdings Ltd. | Rank ligand-binding polypeptides |
US20030013651A1 (en) * | 2001-03-22 | 2003-01-16 | Barnes-Jewish Hospital | Stimulation of osteogenesis using rank ligand fusion proteins |
EA200301041A1 (ru) * | 2001-03-22 | 2004-08-26 | Барнс-Джуиш Хоспитал | Стимуляция остеогенеза с использованием гибридных белков лиганда для rank |
EP1412482A2 (de) * | 2001-03-23 | 2004-04-28 | Genentech, Inc. | Verwendung einer opg ligand, um immunreaktionenen zu modulieren |
CA2447431A1 (en) * | 2001-05-11 | 2002-11-21 | Research Development Foundation | Inhibitors of receptor activator of nf-kb and uses thereof |
US20040167072A1 (en) * | 2001-05-11 | 2004-08-26 | Aggarwal Bharat B. | Inhibitors of receptor activator of NF-kappaB and uses thereof |
DE02726901T1 (de) * | 2001-05-17 | 2004-07-15 | Immunex Corp., Seattle | Therapeutische verwendung von rang-antagonisten |
US20040213788A1 (en) * | 2001-05-18 | 2004-10-28 | Sweet Raymond W. | Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders |
CA2449658A1 (en) * | 2001-06-06 | 2002-12-12 | Immunex Corporation | Use of rank antagonists to treat cancer |
US6886964B2 (en) * | 2001-06-26 | 2005-05-03 | Allan Gardiner | Illuminator with filter array and bandwidth controller |
ES2674888T3 (es) | 2001-06-26 | 2018-07-04 | Amgen Inc. | Anticuerpos para OPGL |
EP2192130A1 (de) | 2001-07-03 | 2010-06-02 | Genentech, Inc. | Humane DR4-Antikörper und deren Anwendungen |
US20030050223A1 (en) * | 2001-08-09 | 2003-03-13 | Jonathan Lam | Crystal forms and mutants of RANK ligand |
IL161051A0 (en) | 2001-10-02 | 2004-08-31 | Genentech Inc | Apo-2 ligand variants and uses thereof |
US20030109444A1 (en) * | 2001-10-12 | 2003-06-12 | Jonathan Lam | Bone anti-resorptive compounds |
US20030100068A1 (en) * | 2001-10-12 | 2003-05-29 | Jonathan Lam | RANKL mimics and uses thereof |
AU2002365426A1 (en) * | 2001-10-12 | 2003-09-02 | Barnes-Jewish Hospital | Methods for screening osteogenic compounds |
WO2003033663A2 (en) * | 2001-10-15 | 2003-04-24 | Barnes-Jewish Hospital | Rankl mimics and uses thereof |
US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
DK1450847T3 (da) | 2001-11-13 | 2010-12-13 | Genentech Inc | Apo2-ligand/TRAIL-formuleringer og anvendelser deraf |
US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
WO2003059281A2 (en) * | 2002-01-04 | 2003-07-24 | Xencor | Novel variants of rankl protein |
US20040170602A1 (en) * | 2002-01-04 | 2004-09-02 | Desjarlais John R. | Dominant negative proteins and methods thereof |
US7381792B2 (en) * | 2002-01-04 | 2008-06-03 | Xencor, Inc. | Variants of RANKL protein |
US7399829B2 (en) * | 2002-01-04 | 2008-07-15 | Xencor, Inc. | Variants of RANKL protein |
AU2003210054A1 (en) * | 2002-03-21 | 2003-10-08 | Komed Co., Ltd. | Anti-rank monoclonal antibodies and pharmaceutical composition containing the same |
CA2481074A1 (en) | 2002-04-05 | 2003-10-23 | Amgen Inc. | Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors |
EP2500032A1 (de) | 2002-06-24 | 2012-09-19 | Genentech, Inc. | APO-2-Liganden-/Trailvarianten und Verwendungen dafür |
US20040138162A1 (en) * | 2002-08-30 | 2004-07-15 | Roodman G. David | Method of resisting osteoclast formation |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
CA2508773C (en) | 2002-12-10 | 2013-08-27 | Schering-Plough Ltd. | Canine rankl and methods for preparing and using the same |
CN1323164C (zh) * | 2003-01-10 | 2007-06-27 | 株式会社蛋白质晶体 | 蛋白质复合物及其制备方法以及其用途 |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US7700574B2 (en) * | 2003-09-17 | 2010-04-20 | Isis Pharmaceuticals, Inc. | Modulation of RANKL expression |
US7252833B2 (en) * | 2003-11-18 | 2007-08-07 | Skeletal Kinetics, Llc | Calcium phosphate cements comprising an osteoclastogenic agent |
WO2005063170A2 (en) * | 2003-12-29 | 2005-07-14 | Toudai Tlo, Ltd. | Methods of identifying immunoregulatory agents, immunoregulatory agents, and uses thereof |
KR20060132006A (ko) | 2004-03-23 | 2006-12-20 | 비오겐 아이덱 엠에이 아이엔씨. | 수용체 커플링제 및 이의 치료적 용도 |
BRPI0513826A2 (pt) | 2004-07-26 | 2010-06-22 | Dow Global Technologies Inc | processo para expressão de proteìna melhorada através de engenharia de cepa |
AU2005267722B2 (en) | 2004-08-04 | 2009-10-08 | Amgen Inc. | Antibodies to Dkk-1 |
ZA200701614B (en) | 2004-08-06 | 2008-10-29 | Genentech Inc | Assays and methods using biomarkers |
DK1774037T3 (da) | 2004-08-06 | 2011-08-15 | Genentech Inc | Analyser og fremgangsmåder, der anvender biomarkører |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
RU2007119989A (ru) * | 2004-12-02 | 2009-01-10 | Домантис Лимитед (Gb) | Композиции, слитые конструкции и конъюгаты plad домена |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
WO2007022157A2 (en) | 2005-08-16 | 2007-02-22 | Genentech, Inc. | Apoptosis sensitivity to ap02l/trail by testing for 'galnac-t14 expression in cells/tissues |
JP6088723B2 (ja) | 2005-11-23 | 2017-03-01 | ジェネンテック, インコーポレイテッド | B細胞アッセイに関する組成物及び方法。 |
US7795427B2 (en) * | 2006-02-14 | 2010-09-14 | New York University | Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass |
EP1854458A1 (de) * | 2006-05-08 | 2007-11-14 | IMBA-Institut für Molekulare Biotechnologie GmbH | Verwendung einer Verbindung mit RANKL Aktivität |
CA2651597C (en) | 2006-05-12 | 2013-02-05 | Keio University | Detection of inflammatory disease and composition for prevention or treatment of inflammatory disease |
WO2008044797A1 (fr) | 2006-10-11 | 2008-04-17 | Oriental Yeast Co., Ltd. | Animal modèle d'ostéopénie |
AU2007305855A1 (en) | 2006-10-11 | 2008-04-17 | Oriental Yeast Co., Ltd. | Agent containing fused protein of soluble RANKL with epitope tag |
WO2008044379A1 (fr) | 2006-10-11 | 2008-04-17 | Oriental Yeast Co., Ltd. | Modèle animal de perte osseuse |
CN101688213A (zh) | 2007-04-27 | 2010-03-31 | 陶氏环球技术公司 | 用于快速筛选微生物宿主以鉴定某些在表达异源蛋白质方面具有改善的产量和/或质量的菌株的方法 |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
EP2165716B1 (de) | 2007-06-05 | 2014-11-12 | Oriental Yeast Co., Ltd. | Neue mittel zur erhöhung der knochenmasse |
EP2171449A2 (de) * | 2007-06-20 | 2010-04-07 | Schering Corporation | Gelenkzerstörung-biomarker für die anti-il-17a-therapie von entzündlicher gelenkerkrankung |
SG10201500328QA (en) | 2007-08-21 | 2015-03-30 | Amgen Inc | Human c-fms antigen binding proteins |
KR100911852B1 (ko) | 2007-11-26 | 2009-08-11 | 고려대학교 산학협력단 | 유세포 분석기를 이용한 신규한 rank와 rank리간드의 결합 분석방법 |
WO2009105934A1 (zh) * | 2008-02-27 | 2009-09-03 | 上海先导药业有限公司 | 抗人rankl单克隆抗体 |
AR073072A1 (es) | 2008-08-19 | 2010-10-13 | Regeneron Pharma | Anticuerpos humanos para el ligando del activador del receptor de nf-kb (rankl) humano |
US8657662B2 (en) | 2008-09-04 | 2014-02-25 | Patent Investment & Licensing Company | Gaming device having variable speed of play |
JP5730018B2 (ja) | 2008-09-30 | 2015-06-03 | オリエンタル酵母工業株式会社 | 新しい軟骨細胞増殖及び分化誘導剤 |
CN101712964B (zh) * | 2008-10-08 | 2013-05-08 | 上海科新生物技术股份有限公司 | 抑制破骨细胞形成的融合蛋白、其制备方法及药物组合物 |
EA201190025A1 (ru) | 2008-11-25 | 2012-12-28 | Байоджен Айдек Ма Инк. | ПРИМЕНЕНИЕ АНТАГОНИСТОВ DR6 И p75 ДЛЯ ПРОМОТИРОВАНИЯ ВЫЖИВАНИЯ КЛЕТОК НЕРВНОЙ СИСТЕМЫ |
CN101514232B (zh) * | 2009-03-25 | 2013-06-19 | 上海科新生物技术股份有限公司 | 一种RANKL-Fc融合蛋白及其制备方法和用途 |
JP5746018B2 (ja) | 2009-04-16 | 2015-07-08 | 国立大学法人 東京大学 | 抗tmprss11e抗体を用いた癌の診断と治療 |
KR101153393B1 (ko) * | 2009-09-21 | 2012-06-07 | 고려대학교 산학협력단 | 점변이 이용한 수용성 재조합 인간 rank의 효능 향상 및 골 질환 치료용 조성물 |
EA201291482A1 (ru) | 2010-07-09 | 2013-10-30 | Байоджен Айдек Хемофилия Инк. | Химерные факторы коагуляции |
EP2434285A1 (de) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Brustkrebsdiagnose |
EP2433644A1 (de) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Brustkrebstherapeutika |
ES2911505T3 (es) | 2010-10-06 | 2022-05-19 | Inst Catalana Recerca Estudis Avancats | Método para el diagnóstico, pronóstico y tratamiento de la metástasis de cáncer de mama |
CA2831247C (en) | 2011-03-31 | 2020-07-21 | Oriental Yeast Co., Ltd. | Cancer immunopotentiating agent containing rankl antagonist |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
FR2980711A1 (fr) * | 2011-10-03 | 2013-04-05 | Centre Nat Rech Scient | Modulation du systeme immunitaire et des cellules stromales via rank |
EP2776066B1 (de) | 2011-11-07 | 2018-09-19 | Universite Laval | Rank-/rankl-antagonisten zur verwendung zur behandlung neuromuskulärer erkrankungen, genetischer myopathien und/oder nicht genetischer myopathien |
EP2650682A1 (de) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Asymmetrische Ester von als Schmiermittel geeigneten Fettsäuren |
JP6386450B2 (ja) | 2012-06-06 | 2018-09-05 | フンダシオ、インスティトゥト、デ、レセルカ、ビオメディカ(イエレベ、バルセロナ)Fundacio Institut De Recerca Biomedica (Irb Barcelona) | 肺がん転移の診断、予後診断および処置のための方法 |
US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
EP3553186B1 (de) | 2012-10-12 | 2021-11-17 | Inbiomotion, S.L. | Verfahren zur diagnose, prognose und behandlung von prostatakrebsmetastasen |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
WO2014184679A2 (en) | 2013-03-15 | 2014-11-20 | Inbiomotion S.L. | Method for the prognosis and treatment of renal cell carcinoma metastasis |
CA2899089C (en) | 2013-03-15 | 2021-10-26 | Biogen Ma Inc. | Factor ix polypeptide formulations |
CA2906394A1 (en) | 2013-03-15 | 2014-09-18 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
US9708375B2 (en) | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
CN105555291B (zh) | 2013-08-07 | 2021-08-24 | 助育公司 | 用于治疗雄性不育症的抗体、化合物及其衍生物 |
WO2015030701A1 (en) * | 2013-08-24 | 2015-03-05 | R-Pharm Overseas, Inc. | Fully human antibodies against human rankl |
TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
MX2016002870A (es) | 2013-09-05 | 2017-02-23 | Amgen Inc | Moleculas que contienen fc que presentan perfiles de glicoforma predecibles, consistentes y reproducibles. |
AU2014333513B2 (en) | 2013-10-09 | 2020-11-26 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of metastasizing cancer of the bone originating from breast cancer |
WO2015087187A1 (en) | 2013-12-10 | 2015-06-18 | Rinat Neuroscience Corp. | Anti-sclerostin antibodies |
MX2016014761A (es) | 2014-05-16 | 2017-05-25 | Amgen Inc | Ensayo para detectar poblaciones celulares linfocitos t colaboradores 1 (th1) y linfocitos t colaboradores (th2). |
WO2016092524A1 (en) | 2014-12-11 | 2016-06-16 | Inbiomotion S.L. | Binding members for human c-maf |
CN104829725A (zh) * | 2015-01-21 | 2015-08-12 | 武汉友芝友生物制药有限公司 | 一种双特异性抗体cd133×cd3的构建及应用 |
CN113288887A (zh) | 2015-04-29 | 2021-08-24 | 雷迪厄斯制药公司 | 用于治疗癌症的方法 |
CA2981115C (en) * | 2015-05-18 | 2022-05-31 | Eli Lilly And Company | Anti-dkk-1-anti-rankl bispecific antibody compounds |
EP3299382B1 (de) * | 2015-05-20 | 2023-04-26 | Osaka University | Oligopeptid mit proinflammatorischer zytokinsekretionshemmender wirkung |
EP3400003B1 (de) * | 2016-01-05 | 2023-05-03 | The Trustees of Columbia University in the City of New York | Zusammensetzungen zur regulierung der aktivität des inhibitors des dna-binding-2 (id2)-proteins |
WO2017123642A1 (en) * | 2016-01-12 | 2017-07-20 | The Trustees Of The University Of Pennsylvania | Methods and uses of osteoclast associated receptor (oscar) for prevention and treatment of osteoarthritis |
US11492386B2 (en) | 2016-02-01 | 2022-11-08 | Eli Lilly And Company | Parathyroid hormone-anti-RANKL antibody fusion compounds |
TWI742054B (zh) | 2016-03-08 | 2021-10-11 | 美商健生生物科技公司 | Gitr抗體,方法及用途 |
PT3458610T (pt) | 2016-05-25 | 2021-06-29 | Inbiomotion Sl | Tratamento terapêutico de cancro da mama baseado no estado de c-maf |
EA201990557A1 (ru) | 2016-10-28 | 2019-09-30 | Эли Лилли Энд Компани | Анти-rankl антитела и их применение |
CN110191707A (zh) | 2017-01-05 | 2019-08-30 | 雷迪厄斯制药公司 | Rad1901-2hcl的多晶型形式 |
JP2020513813A (ja) | 2017-03-14 | 2020-05-21 | アムジエン・インコーポレーテツド | 細胞培養において産生される抗体の総非フコシル化グリコフォームの調節 |
BR112020010192A2 (pt) | 2017-11-22 | 2020-10-13 | Inbiomotion S.L. | tratamento terapêutico de câncer de mama com base no status de c-maf |
SG11202009216YA (en) | 2018-03-26 | 2020-10-29 | Amgen Inc | Total afucosylated glycoforms of antibodies produced in cell culture |
JP7473486B2 (ja) | 2018-07-04 | 2024-04-23 | ラジウス ファーマシューティカルズ,インコーポレイテッド | Rad1901-2hclの多形形態 |
US20210355216A1 (en) | 2018-10-05 | 2021-11-18 | INSERM (Institut National de la Santé et de la Recherche Médicale | Methods and systems for controlling the agonistic properties of antibody variable domains by light |
US11279698B2 (en) | 2018-11-20 | 2022-03-22 | Cornell University | Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer |
EP4034556A1 (de) | 2019-09-26 | 2022-08-03 | Amgen Inc. | Verfahren zur herstellung von antikörperzusammensetzungen |
WO2021149012A1 (en) | 2020-01-24 | 2021-07-29 | Radius Health, Inc. | Methods of stimulating bone growth with abalopartide and denosumab |
CN111793135A (zh) * | 2020-05-11 | 2020-10-20 | 廊坊天光生物技术有限公司 | 一种用于检测血清中rankl含量的抗体对及其用途 |
US20230273126A1 (en) | 2020-06-04 | 2023-08-31 | Amgen Inc. | Assessment of cleaning procedures of a biotherapeutic manufacturing process |
JP2023548767A (ja) | 2020-10-15 | 2023-11-21 | アムジエン・インコーポレーテツド | 抗体製造方法における相対不対グリカン |
AU2022289365A1 (en) | 2021-06-07 | 2023-12-14 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
AU2022361382A1 (en) | 2021-10-05 | 2024-03-28 | Amgen Inc. | Fc-gamma receptor ii binding and glycan content |
WO2023179791A1 (en) * | 2022-03-24 | 2023-09-28 | Angitia Biomedicines Limited | Treatment of musculoskeletal disorders |
WO2023198851A1 (en) | 2022-04-14 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for controlling the tumor cell killing by light |
WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
Family Cites Families (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
US4710457A (en) | 1983-06-29 | 1987-12-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibody for human hematopoietic glycoproteins and method |
US4710473A (en) | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
EP0192658A4 (de) | 1984-07-30 | 1987-07-13 | Salk Inst For Biological Studi | Retrovirale gentransfervektoren. |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
DE3751997T2 (de) * | 1986-07-18 | 1997-07-10 | Univ Melbourne | Aktives protein in humoraler hyperkalzemia, durch bösartigkeit verursacht |
US5846534A (en) | 1988-02-12 | 1998-12-08 | British Technology Group Limited | Antibodies to the antigen campath-1 |
WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
AU648505B2 (en) | 1989-05-19 | 1994-04-28 | Amgen, Inc. | Metalloproteinase inhibitor |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
EP0513334A4 (en) | 1990-11-30 | 1993-08-04 | Celtrix Laboratories, Inc. | Use of a bone morphogenetic protein in synergistic combination with tgf--g(b) for bone repair |
US6121002A (en) * | 1990-12-26 | 2000-09-19 | The Rowett Research Institute | Method to detect bone and other connective tissue disorders in humans and animals |
US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
CA2068389A1 (en) | 1991-05-13 | 1992-11-14 | Masahiko Sato | Method for inhibiting bone resorption |
MX9204303A (es) | 1991-07-23 | 1993-11-01 | Rhone Poulenc Rorer Int | Factor regulador del crecimiento de osteoclasto. |
IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
US5961974A (en) | 1991-10-25 | 1999-10-05 | Immunex Corporation | Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same |
DK0822199T3 (da) * | 1991-10-25 | 2004-12-27 | Amgen Inc | N-terminalt monopegylerede polypeptider og fremgangsmåder til fremstilling heraf |
JPH07503132A (ja) | 1991-12-17 | 1995-04-06 | ジェンファーム インターナショナル,インコーポレイティド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
PT639079E (pt) | 1992-04-30 | 2000-04-28 | Amgen Inc | Composicao para tratamento de doencas mediadas por interleuquina-1 e factor de necrose tumoral |
US5585479A (en) | 1992-07-24 | 1996-12-17 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ELAM-I RNA |
WO1994010308A1 (en) | 1992-10-23 | 1994-05-11 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
US5578569A (en) | 1993-03-12 | 1996-11-26 | Tam; Cherk S. | Method of increasing bone growth |
US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
JPH09502614A (ja) | 1993-09-14 | 1997-03-18 | メルク エンド カンパニー インコーポレーテッド | 新規ヒト蛋白質チロシンホスファターゼをコードするcDNA |
US6268212B1 (en) | 1993-10-18 | 2001-07-31 | Amgen Inc. | Tissue specific transgene expression |
US5708142A (en) | 1994-05-27 | 1998-01-13 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
US5741667A (en) | 1994-05-27 | 1998-04-21 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
AU4440496A (en) | 1995-02-10 | 1996-08-22 | Smithkline Beecham Corporation | Use of src SH2 specific compounds to treat a bone resorption disease |
IL117175A (en) * | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
WO1996028546A1 (en) | 1995-03-15 | 1996-09-19 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
US7094564B1 (en) | 1995-03-15 | 2006-08-22 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
US20030166097A1 (en) | 1995-03-15 | 2003-09-04 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
WO1996034095A1 (en) | 1995-04-27 | 1996-10-31 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptors |
PT832229E (pt) | 1995-06-07 | 2004-06-30 | Immunex Corp | Muteina de cd40l |
WO1997000318A1 (en) | 1995-06-07 | 1997-01-03 | Osteosa Inc. | Osteoclast growth regulatory factor |
US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
WO1997000317A1 (en) | 1995-06-07 | 1997-01-03 | Osteosa Inc. | Osteoclast growth regulatory factor |
IL122408A0 (en) * | 1995-06-29 | 1998-06-15 | Immunex Corp | Dna encoding a trail polypeptide and its preparation |
ZA966663B (en) | 1995-08-17 | 1998-02-06 | Genentech Inc | Traf Inhibitors. |
JPH0997808A (ja) | 1995-09-29 | 1997-04-08 | Mitsumi Electric Co Ltd | ダイボンディング装置 |
JPH09151434A (ja) | 1995-11-24 | 1997-06-10 | Tootetsu:Kk | 角形蛇籠の変形防止枠及びその蛇籠の設置方法 |
US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
EP0873405B1 (de) | 1996-01-11 | 2004-09-08 | Immunex Corporation | Expressionssteigernde sequenzelemente (ease) für eukaryontische expressionssysteme |
JPH09217897A (ja) | 1996-02-14 | 1997-08-19 | Hitachi Ltd | Sf6貯蔵供給装置、その貯蔵方法及び供給方法 |
JPH09224803A (ja) | 1996-02-21 | 1997-09-02 | Nakajima Cafe Honsha:Kk | 蓋付きコーヒーカップ |
US5766223A (en) | 1996-03-21 | 1998-06-16 | Johnson; Deborah M. | Child's teething device |
US5710013A (en) | 1996-04-19 | 1998-01-20 | Tularik Inc. | Tumor necrosis factor receptor associated factor 6 (TRAF6) |
JPH1057071A (ja) | 1996-08-19 | 1998-03-03 | Snow Brand Milk Prod Co Ltd | 新規dna及びそれを用いた蛋白質の製造方法 |
EP1114864B9 (de) | 1996-12-13 | 2013-05-08 | Schering Corporation | Oberflächenantigene aus Säugern |
AU5901598A (en) * | 1996-12-20 | 1998-07-17 | Board Of Regents, The University Of Texas System | Compositions and methods of use for osteoclast inhibitory factors |
US6271349B1 (en) * | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
EP2003203A1 (de) * | 1996-12-23 | 2008-12-17 | Immunex Corporation | Ligand für den Rezeptorauslöser von NF-kappa b, wobei der Ligand Mitglied der TNF-Überfamilie ist |
DE122010000049I1 (de) | 1997-04-15 | 2011-05-05 | Daiichi Sankyo Co Ltd | Neues protein und verfahren zu dessen herstellung |
US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
US5843678A (en) | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
ID23855A (id) | 1997-04-16 | 2000-05-25 | Amgen Inc | Protein pengikat osteoprotegerin dan reseptor |
CA2229449A1 (en) * | 1997-04-25 | 1998-10-25 | Takeda Chemical Industries, Ltd. | Novel receptor protein and its use |
WO1998049305A1 (en) | 1997-05-01 | 1998-11-05 | Amgen Inc. | Chimeric opg polypeptides |
AU7705098A (en) | 1997-05-29 | 1998-12-30 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like protein 8 |
US6087555A (en) | 1997-10-15 | 2000-07-11 | Amgen Inc. | Mice lacking expression of osteoprotegerin |
WO1999029865A2 (en) | 1997-12-12 | 1999-06-17 | The Rockefeller University | A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof |
US7019119B2 (en) | 1997-12-12 | 2006-03-28 | The Rockefeller University | Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof |
US7063960B2 (en) | 1997-12-12 | 2006-06-20 | The Rockefeller University | Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof |
JPH11266872A (ja) * | 1998-03-20 | 1999-10-05 | Suntory Ltd | NF−κBの活性化を抑制する物質のスクリーニング方法 |
US6790823B1 (en) | 1998-04-23 | 2004-09-14 | Amgen Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
EP2009025B1 (de) | 1998-05-14 | 2011-07-27 | Immunex Corporation | Verfahren zur Hemmung der Wirkung der Osteoklasten |
HUP0102782A3 (en) | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
HUP0102492A2 (hu) | 1998-06-19 | 2001-11-28 | Smithkline Beecham Corp. | Amino-indanon származékok alkalmazása NF-kB transzkripciós faktor inhibitor hatású gyógyszerkészítmények előállítására |
AU6078500A (en) | 1999-07-09 | 2001-01-30 | Amgen, Inc. | Combination therapy for conditions leading to bone loss |
US6252180B1 (en) * | 1999-08-09 | 2001-06-26 | Lucent Technologies Inc. | Electromagnetic interference cover for a conduit and an electronic equipment chassis employing the same |
KR20010085996A (ko) | 1999-09-03 | 2001-09-07 | 스티븐 엠. 오드레 | 암 및 암관련 골손실을 예방 또는 치료하는 조성물 및 방법 |
US20030144187A1 (en) | 1999-09-03 | 2003-07-31 | Colin R. Dunstan | Opg fusion protein compositions and methods |
AUPQ314799A0 (en) | 1999-09-29 | 1999-10-21 | University Of Western Australia, The | Bone cell factor |
US20030103978A1 (en) | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
DE60134459D1 (de) | 2000-02-23 | 2008-07-31 | Amgen Inc | Antagonistische selektive bindungsagenzien des osteoprotegerin-bindungsproteins |
AU2001288342A1 (en) * | 2000-08-21 | 2002-03-04 | Smith Kline Beecham Corporation | Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders |
ES2674888T3 (es) | 2001-06-26 | 2018-07-04 | Amgen Inc. | Anticuerpos para OPGL |
CA2481074A1 (en) | 2002-04-05 | 2003-10-23 | Amgen Inc. | Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors |
US7157993B2 (en) | 2003-09-30 | 2007-01-02 | Rockwell Scientific Licensing, Llc | 1:N MEM switch module |
-
1997
- 1997-12-22 EP EP08010882A patent/EP2003203A1/de not_active Withdrawn
- 1997-12-22 AT AT97953438T patent/ATE497001T1/de active
- 1997-12-22 AU AU57184/98A patent/AU713473B2/en not_active Ceased
- 1997-12-22 AT AT97952609T patent/ATE401404T1/de active
- 1997-12-22 DE DE69740107T patent/DE69740107D1/de not_active Expired - Lifetime
- 1997-12-22 IL IL130492A patent/IL130492A/en not_active IP Right Cessation
- 1997-12-22 WO PCT/US1997/023866 patent/WO1998028424A2/en active IP Right Grant
- 1997-12-22 WO PCT/US1997/023775 patent/WO1998028426A2/en active Application Filing
- 1997-12-22 EP EP10182863A patent/EP2314695A3/de not_active Withdrawn
- 1997-12-22 PT PT97952609T patent/PT951551E/pt unknown
- 1997-12-22 CA CA2274987A patent/CA2274987C/en not_active Expired - Lifetime
- 1997-12-22 EP EP97952609A patent/EP0951551B9/de not_active Expired - Lifetime
- 1997-12-22 EP EP97953438A patent/EP0946725B1/de not_active Expired - Lifetime
- 1997-12-22 DK DK97952609.2T patent/DK0951551T4/da active
- 1997-12-22 DE DE0951551T patent/DE951551T1/de active Pending
- 1997-12-22 JP JP52904598A patent/JP4138013B2/ja not_active Expired - Lifetime
- 1997-12-22 US US08/996,139 patent/US6017729A/en not_active Expired - Lifetime
- 1997-12-22 JP JP52906898A patent/JP2002509431A/ja not_active Withdrawn
- 1997-12-22 US US08/995,659 patent/US6242213B1/en not_active Expired - Lifetime
- 1997-12-22 EP EP10182860A patent/EP2371962A3/de not_active Withdrawn
- 1997-12-22 ES ES97952609T patent/ES2144386T5/es not_active Expired - Lifetime
- 1997-12-22 DE DE69738841T patent/DE69738841D1/de not_active Expired - Lifetime
- 1997-12-22 AU AU56180/98A patent/AU713471C/en not_active Expired
- 1997-12-22 DE DE122010000048C patent/DE122010000048I1/de active Pending
-
1999
- 1999-12-17 US US09/466,496 patent/US6528482B1/en not_active Expired - Lifetime
-
2000
- 2000-05-24 US US09/577,800 patent/US6479635B1/en not_active Expired - Lifetime
- 2000-05-24 US US09/577,780 patent/US6419929B1/en not_active Expired - Lifetime
- 2000-10-13 US US09/688,459 patent/US6838262B1/en not_active Expired - Lifetime
-
2001
- 2001-05-25 US US09/865,363 patent/US6740522B2/en not_active Expired - Lifetime
- 2001-05-30 US US09/871,291 patent/US6562948B2/en not_active Expired - Fee Related
- 2001-05-31 US US09/871,856 patent/US6537763B2/en not_active Expired - Fee Related
- 2001-06-08 US US09/877,650 patent/US6649164B2/en not_active Expired - Lifetime
-
2003
- 2003-04-01 US US10/405,878 patent/US7262274B2/en not_active Expired - Fee Related
-
2004
- 2004-03-16 US US10/802,133 patent/US7411050B2/en not_active Expired - Fee Related
-
2006
- 2006-07-26 JP JP2006203204A patent/JP4054354B2/ja not_active Expired - Lifetime
-
2007
- 2007-07-30 US US11/881,911 patent/US7932375B2/en not_active Expired - Fee Related
- 2007-10-12 JP JP2007266393A patent/JP4203105B2/ja not_active Expired - Lifetime
-
2008
- 2008-02-25 JP JP2008043360A patent/JP4242913B2/ja not_active Expired - Lifetime
- 2008-06-24 US US12/214,914 patent/US7744886B2/en not_active Expired - Fee Related
- 2008-11-11 JP JP2008288844A patent/JP2009051862A/ja not_active Withdrawn
-
2010
- 2010-06-15 US US12/802,801 patent/US8377690B2/en not_active Expired - Fee Related
- 2010-07-02 JP JP2010152282A patent/JP5096527B2/ja not_active Expired - Lifetime
- 2010-08-04 US US12/850,368 patent/US8333963B2/en not_active Expired - Fee Related
- 2010-11-24 LU LU91758C patent/LU91758I2/fr unknown
-
2011
- 2011-04-22 US US13/092,718 patent/US8153775B2/en not_active Expired - Fee Related
-
2012
- 2012-03-19 US US13/424,179 patent/US8569456B2/en not_active Expired - Fee Related
-
2013
- 2013-02-12 US US13/765,597 patent/US8715683B2/en not_active Expired - Fee Related
- 2013-10-28 US US14/065,133 patent/US20140186887A1/en not_active Abandoned
-
2014
- 2014-05-02 US US14/268,858 patent/US20140235832A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE401404T1 (de) | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie | |
ATE187982T1 (de) | Cytokine antagoniste | |
DK0817847T4 (da) | IL-17-receptor | |
DK0760857T5 (da) | Receptor for onkostatin M | |
DE3482107D1 (de) | Zementzusammensetzungen und zementierungsverfahren in oelgebieten. | |
ATE114724T1 (de) | Antikörper gegen tnf-bindungsprotein i und deren f(ab)-fragmente. | |
DE69207351D1 (de) | Fibrinogen-Rezeptor-Antagoniste | |
DE69032963T2 (de) | (Modifiziertes) hydriertes Dien-Blockcopolymer und dieses enthaltende Zusammensetzung | |
DE69327720T2 (de) | Endothelin rezeptor antagonisten | |
DE69331175T2 (de) | Interleukin-2 Rezeptor Gamma-Kette | |
IT1228211B (it) | Agglomerato combustibile resistente all'acqua, procedimento per la sua preparazione e composizione di materiali usata in tale procedimento. | |
FR2695475B1 (fr) | Conductivimètre pour mesurer en régime transitoire la conductivité d'un matériau injectable ou non. | |
NO179550C (no) | Tachykinin reseptorantagonister | |
DE58907320D1 (de) | Bituminöse Masse und deren Verwendung. | |
IT1223336B (it) | Composizione bituminosa e suo impiego nel settore dell'impermeabilizzazione | |
IT8948295A0 (it) | Procedimento ed apparecchio per la cernita di materiali particellari mediante attrito | |
DE69003364D1 (de) | Einrichtung zum Einfahren von Gewindeverbindungen für Rohrstränge durch Festschrauben und Losdrehen. | |
ITRM920415A0 (it) | Composizione per uso chirurgico e sua applicazine per irrigazioni chirurgiche. | |
ES295315U (es) | Dispositivo de anclaje a barandillas perfeccionado, para porta-jardineras y similares | |
DK410789D0 (da) | Indretning til sneplov | |
IT1161553B (it) | Materiali minerali granulari stabilizzati per impieghi in mantichiari e riflettenti per strade,piste e simili,e procedimento per ottenerli |