DE69942799D1 - Polyhydroxyalkanoatbiopolymere - Google Patents

Polyhydroxyalkanoatbiopolymere

Info

Publication number
DE69942799D1
DE69942799D1 DE69942799T DE69942799T DE69942799D1 DE 69942799 D1 DE69942799 D1 DE 69942799D1 DE 69942799 T DE69942799 T DE 69942799T DE 69942799 T DE69942799 T DE 69942799T DE 69942799 D1 DE69942799 D1 DE 69942799D1
Authority
DE
Germany
Prior art keywords
group
biological system
hydroxyvalerate
hydroxypropionate
coa transferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69942799T
Other languages
German (de)
English (en)
Inventor
Frank A Skraly
Oliver P Peoples
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yield10 Bioscience Inc
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Application granted granted Critical
Publication of DE69942799D1 publication Critical patent/DE69942799D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
DE69942799T 1998-05-22 1999-05-21 Polyhydroxyalkanoatbiopolymere Expired - Lifetime DE69942799D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8639698P 1998-05-22 1998-05-22
PCT/US1999/011417 WO1999061624A2 (en) 1998-05-22 1999-05-21 Polyhydroxyalkanoate biopolymer compositions

Publications (1)

Publication Number Publication Date
DE69942799D1 true DE69942799D1 (en) 2010-11-11

Family

ID=22198310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69942799T Expired - Lifetime DE69942799D1 (en) 1998-05-22 1999-05-21 Polyhydroxyalkanoatbiopolymere

Country Status (9)

Country Link
US (3) US6323010B1 (enExample)
EP (2) EP1078068B1 (enExample)
JP (2) JP2002516384A (enExample)
AT (1) ATE483023T1 (enExample)
AU (1) AU4199599A (enExample)
CA (2) CA2726139A1 (enExample)
DE (1) DE69942799D1 (enExample)
MX (1) MXPA00011401A (enExample)
WO (1) WO1999061624A2 (enExample)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
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JP3684150B2 (ja) 1999-12-27 2005-08-17 キヤノン株式会社 ポリヒドロキシアルカノエート
US6225438B1 (en) * 2000-01-31 2001-05-01 The Procter & Gamble Company Medium chain length PHA copolymer and process for producing same
ATE329048T1 (de) * 2000-07-21 2006-06-15 Metabolix Inc Herstellung von polyhydroxyalkanoaten aus polyolen
JP4490628B2 (ja) * 2000-11-20 2010-06-30 カーギル インコーポレイテッド ３−ヒドロキシプロピオン酸および他の有機化合物
US6897338B2 (en) 2001-12-18 2005-05-24 Metabolix, Inc. Methods of making intermediates from polyhydroxyalkanoates
KR100482776B1 (ko) 2003-04-23 2005-04-14 한국과학기술원 ＭａｏＣ 단백질을 이용한 폴리히드록시알칸산의 제조방법
ES2527857T3 (es) 2003-05-08 2015-01-30 Tepha, Inc. Tejidos y fibras médicas de polihidroxialcanoato
US7353020B2 (en) * 2003-11-17 2008-04-01 Hitachi Communication Technologies, Ltd. Radio access point testing apparatus and method of testing radio access point
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
DK1778305T3 (da) 2004-08-03 2010-10-18 Tepha Inc Ikke-krøllende polyhydroxyalkanoatsuturer
KR100979694B1 (ko) 2005-05-24 2010-09-02 한국과학기술원 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
US8637126B2 (en) * 2006-02-06 2014-01-28 International Paper Co. Biodegradable paper-based laminate with oxygen and moisture barrier properties and method for making biodegradable paper-based laminate
US8016883B2 (en) * 2006-02-07 2011-09-13 Tepha, Inc. Methods and devices for rotator cuff repair
US8979921B2 (en) * 2006-02-07 2015-03-17 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
JP5508720B2 (ja) * 2006-02-07 2014-06-04 テファ， インコーポレイテッド 重合体分解性薬物溶出ステントおよび被膜
US9592325B2 (en) * 2006-02-07 2017-03-14 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US9089627B2 (en) 2006-07-11 2015-07-28 Abbott Cardiovascular Systems Inc. Stent fabricated from polymer composite toughened by a dispersed phase
US20080071018A1 (en) * 2006-09-19 2008-03-20 E. I. Du Pont De Nemours And Company Toughened Poly(hydroxyalkanoic acid) Compositions
EP4047033A1 (en) 2006-11-21 2022-08-24 LG Chem, Ltd. Copolymer comprising 4-hydroxybutyrate unit and lactate unit and its manufacturing method
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
AU2008213973A1 (en) * 2007-02-02 2008-08-14 Tornier, Inc. System and method for repairing tendons and ligaments
AU2008268150A1 (en) * 2007-06-27 2008-12-31 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Reagents and methods for cyanobacterial production of bioplastics and biomaterials
ES2415104T3 (es) * 2007-12-19 2013-07-24 Tepha, Inc. Dispositivos médicos que contienen no-tejidos fundidos-soplados de poli-4-hidroxibutirato y copolímeros
US20110086398A1 (en) * 2008-04-04 2011-04-14 Collin Hunter Martin Cellular production of hydroxyvalerates from levulinate
KR20160025043A (ko) 2008-12-12 2016-03-07 메타볼릭스 인코포레이티드 폴리（5ｈｖ）및 5 탄소 화학물질의 생산을 위한 녹색 공정 및 조성물
US20110028622A1 (en) 2009-07-28 2011-02-03 E. I. Du Pont De Nemours And Company Poly(hydroxyalkanoic acid) blown film
US20120174253A1 (en) 2009-09-15 2012-07-05 Nii Patterson Generation of high polyhydroxybutrate producing oilseeds
US8349955B2 (en) 2009-09-24 2013-01-08 E I Du Pont De Nemours And Company Poly(hydroxyalkanoic acid) plasticized with poly(trimethylene ether) glycol
CA2788811A1 (en) 2010-02-11 2011-08-18 Metabolix, Inc. Process for gamma-butyrolactone production
PT2558133T (pt) 2010-03-26 2020-04-23 Tepha Inc Revestimentos para o fabrico e aplicação de dispositivos médicos de polihidroxialcanqato
CA2802212C (en) 2010-06-15 2015-03-24 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers
US9511169B2 (en) 2010-06-15 2016-12-06 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
WO2012064526A1 (en) 2010-11-09 2012-05-18 Tepha, Inc. Drug eluting cochlear implants
CN103476937A (zh) 2010-11-29 2013-12-25 迈克罗麦达斯有限公司 产pha细菌
KR101575585B1 (ko) 2011-03-11 2015-12-21 한국과학기술원 글루코오스로부터〔락테이트­ｃｏ­글리콜레이트〕공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 〔락테이트­ｃｏ­글리콜레이트〕공중합체의 제조방법
KR101328567B1 (ko) * 2011-03-11 2013-11-13 한국화학연구원 ２­하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트를 생산하는 능력을 가지는 재조합 미생물 및 이를 이용한 ２­하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트의 제조방법
EP2760911B1 (en) 2011-09-27 2017-11-22 Tepha, Inc. Controlled hydrolysis of poly-4-hydroxybutyrate and copolymers
EP2771183B1 (en) 2011-10-26 2021-08-11 Performance Materials NA, Inc. Multilayer film structure comprising renewably sourced materials
KR101630003B1 (ko) * 2011-11-28 2016-06-13 주식회사 엘지화학 2-하이드록시알카노에이트 중합체의 제조방법
ES2822000T3 (es) 2012-05-21 2021-04-28 Tepha Inc Composiciones biocerámicas reabsorbibles de poli-4-hidroxibutirato y copolímeros
MY185155A (en) 2012-05-31 2021-04-30 Micromidas Inc Polyhydroxyalkanoate derivatives, preparation and uses thereof
WO2013185009A1 (en) 2012-06-08 2013-12-12 Metabolix, Inc. Renewable acrylic acid production and products made therefrom
EP2945655B1 (en) 2013-01-15 2019-09-25 Tepha, Inc. Implants for soft and hard tissue regeneration
WO2014127053A2 (en) 2013-02-13 2014-08-21 Metabolix, Inc. Process for ultra pure chemical production from biobased raw starting materials
US10201640B2 (en) 2013-03-13 2019-02-12 Tepha, Inc. Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof
US10689498B2 (en) 2013-08-20 2020-06-23 Tepha, Inc. Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof
US9687585B2 (en) 2013-08-20 2017-06-27 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
US9302029B2 (en) 2013-10-31 2016-04-05 Tepha, Inc. Pultrusion of poly-4-hydroxybutyrate and copolymers thereof
WO2015069556A1 (en) 2013-11-05 2015-05-14 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
ES2834498T3 (es) 2013-12-26 2021-06-17 Tepha Inc Implantes médicos que incluyen laminados de poli-4-hidroxibutirato y copolímeros del mismo
EP3119930B1 (en) 2014-03-18 2018-06-13 Tepha, Inc. Micro-fiber webs of poly-4-hydroxybutyrate and copolymers thereof produced by centrifugal spinning
ES2911675T3 (es) 2014-04-30 2022-05-20 Tepha Inc Implantes tridimensionales reabsorbibles para el refuerzo de tejidos y la reparación de hernias
EP3142716B1 (en) 2014-05-16 2018-04-25 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
EP3183012B1 (en) 2014-08-20 2017-12-20 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
EP3197512B1 (en) 2014-09-22 2020-05-06 Tepha, Inc. Oriented p4hb implants containing antimicrobial agents
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
EP4591894A3 (en) 2014-12-11 2025-08-27 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof cross-reference to related applications
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KR101774431B1 (ko) 2016-01-28 2017-09-05 한국과학기술원 자일로즈로부터 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체의 제조방법
WO2017171260A1 (ko) * 2016-03-28 2017-10-05 주식회사 엘지화학 액상의 바이오폴리머, 이의 용도 및 제조방법
WO2018159965A1 (ko) 2017-02-28 2018-09-07 한국과학기술원 2-하이드록시이소카프로에이트-CoA 전이효소를 이용한 폴리하이드록시알카노에이트의 제조방법
KR102036828B1 (ko) 2017-02-28 2019-10-25 한국과학기술원 2-하이드록시이소카프로에이트-CoA 전이효소를 이용한 폴리하이드록시알카노에이트의 제조방법
EP3630445B1 (en) 2017-05-25 2022-11-30 Tepha, Inc. Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof
CA3074733C (en) 2017-09-06 2022-06-21 Tepha, Inc. Calendered surgical meshes comprising polyhydroxyalkanoates
ES2916298T3 (es) 2017-12-04 2022-06-29 Tepha Inc Implantes médicos de poli-4-hidroxibutirato termoformado con membrana al vacío
EP4442767A3 (en) 2018-06-11 2025-01-22 Tepha, Inc. Methods for 3d printing of poly-4-hydroxybutyrate
WO2020092065A1 (en) 2018-10-29 2020-05-07 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
CN109913510B (zh) * 2019-03-29 2021-04-13 长春理工大学 一种聚羟基脂肪酸酯的体外合成方法
US20230087393A1 (en) * 2020-02-28 2023-03-23 National University Corporation Hokkaido University Block copolymer and method for producing same
MX2023010639A (es) 2021-03-11 2023-11-28 Tepha Inc Implante para la reconstrucción de la mama.

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Also Published As

Publication number Publication date
EP2267133A2 (en) 2010-12-29
WO1999061624A3 (en) 2000-02-17
US20080275208A1 (en) 2008-11-06
US6323010B1 (en) 2001-11-27
JP2010213700A (ja) 2010-09-30
EP1078068B1 (en) 2010-09-29
EP2267133B1 (en) 2017-07-12
MXPA00011401A (es) 2003-04-22
US8093022B2 (en) 2012-01-10
EP2267133A3 (en) 2011-09-14
US20040033572A1 (en) 2004-02-19
US7202064B2 (en) 2007-04-10
ATE483023T1 (de) 2010-10-15
AU4199599A (en) 1999-12-13
CA2328471A1 (en) 1999-12-02
JP2002516384A (ja) 2002-06-04
CA2328471C (en) 2013-09-17
EP1078068A2 (en) 2001-02-28
WO1999061624A2 (en) 1999-12-02
CA2726139A1 (en) 1999-12-02

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