DE69934308T2 - Il-6-antagonist peptide - Google Patents
Il-6-antagonist peptide Download PDFInfo
- Publication number
- DE69934308T2 DE69934308T2 DE69934308T DE69934308T DE69934308T2 DE 69934308 T2 DE69934308 T2 DE 69934308T2 DE 69934308 T DE69934308 T DE 69934308T DE 69934308 T DE69934308 T DE 69934308T DE 69934308 T2 DE69934308 T2 DE 69934308T2
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- Prior art keywords
- peptide
- seq
- peptides
- protein
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108997 | 1998-05-18 | ||
| EP98108997A EP0972780A1 (en) | 1998-05-18 | 1998-05-18 | Il-6 antagonist peptides |
| PCT/EP1999/003421 WO1999060013A2 (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69934308D1 DE69934308D1 (de) | 2007-01-18 |
| DE69934308T2 true DE69934308T2 (de) | 2007-03-29 |
Family
ID=8231951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69934308T Expired - Lifetime DE69934308T2 (de) | 1998-05-18 | 1999-05-18 | Il-6-antagonist peptide |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6599875B1 (https=) |
| EP (2) | EP0972780A1 (https=) |
| JP (1) | JP4468578B2 (https=) |
| AT (1) | ATE347563T1 (https=) |
| AU (1) | AU749616B2 (https=) |
| CA (2) | CA2690399C (https=) |
| CY (1) | CY1105865T1 (https=) |
| DE (1) | DE69934308T2 (https=) |
| DK (1) | DK1078001T3 (https=) |
| ES (1) | ES2273492T3 (https=) |
| IL (2) | IL139575A0 (https=) |
| PT (1) | PT1078001E (https=) |
| SI (1) | SI1078001T1 (https=) |
| WO (1) | WO1999060013A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| MEP42108A (en) | 1998-10-23 | 2011-02-10 | Kiren Amgen Inc | Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| US8143380B2 (en) | 2004-07-08 | 2012-03-27 | Amgen Inc. | Therapeutic peptides |
| US20070036788A1 (en) * | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| WO2006036834A2 (en) | 2004-09-24 | 2006-04-06 | Amgen Inc. | MODIFIED Fc MOLECULES |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| TWI438208B (zh) | 2007-01-23 | 2014-05-21 | 中外製藥股份有限公司 | 抑制慢性排斥反應之藥劑 |
| CA2728243C (en) | 2008-06-05 | 2020-03-10 | Chugai Seiyaku Kabushiki Kaisha | Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer |
| KR20110112307A (ko) | 2008-11-25 | 2011-10-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | 알부민을 상승시키고 및／또는 ｃｒｐ를 낮추는 ｉｌ６의 길항제 |
| WO2011149051A1 (ja) | 2010-05-28 | 2011-12-01 | 中外製薬株式会社 | 抗腫瘍t細胞応答増強剤 |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| EP2665486B1 (en) | 2011-01-18 | 2019-12-25 | Bioniz, LLC | Compositions for modulating gamma-c-cytokine activity |
| US9327023B2 (en) | 2011-10-25 | 2016-05-03 | The Regents Of The University Of Michigan | HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| CN103923182A (zh) * | 2014-01-17 | 2014-07-16 | 南通诚信氨基酸有限公司 | 白介素-6多肽抑制剂及其应用 |
| WO2017062685A1 (en) | 2015-10-09 | 2017-04-13 | Bioniz, Llc | Modulating gamma - c -cytokine activity |
| US12600757B2 (en) | 2017-04-07 | 2026-04-14 | Bioniz Therapeutics, Inc. | Peptides inhibiting gamma-c-cytokine activity and methods of use |
| WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| JP7235249B2 (ja) | 2017-10-20 | 2023-03-08 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| WO2019151418A1 (ja) | 2018-01-31 | 2019-08-08 | 元一 加藤 | Ｉｌ－６阻害剤を含有する喘息の治療剤 |
| EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| EP3957324A4 (en) | 2019-04-17 | 2023-02-08 | Hiroshima University | THERAPEUTIC FOR UROLOGICAL ONCOLOGY CHARACTERIZED BY BEING ADMINISTRATED IN COMBINATION WITH IL-6 INHIBITOR AND CCR2 INHIBITOR |
| CA3137971A1 (en) | 2019-05-03 | 2020-11-12 | Bioniz, Llc | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| CN116003530B (zh) * | 2022-12-27 | 2023-12-15 | 西湖大学 | 一种针对白细胞介素-6的d-蛋白抑制剂及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4420782C1 (de) * | 1994-06-15 | 1995-08-17 | Fluegge Ulf Ingo Prof Dr | DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter |
| DE69526665T2 (de) * | 1994-09-21 | 2002-11-21 | Cytogen Corp., Princeton | Antigen bindende peptide (abtides) aus peptidbibliotheken |
| WO1996023899A1 (en) * | 1995-02-01 | 1996-08-08 | University Of Massachusetts Medical Center | Methods of selecting a random peptide that binds to a target protein |
| ATE271128T1 (de) * | 1995-05-11 | 2004-07-15 | Applied Research Systems | Inhibitoren der il-6 aktivitaet |
| DE19628873A1 (de) * | 1995-07-17 | 1997-01-23 | Fraunhofer Ges Forschung | Cyclitol |
| CA2230949C (en) * | 1995-09-28 | 2009-11-17 | Judith Chebath | Synthetic peptides that inhibit il-6 activity |
| EP0928293A1 (en) * | 1996-06-20 | 1999-07-14 | Koster, Henk W. | Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity |
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
-
1998
- 1998-05-18 EP EP98108997A patent/EP0972780A1/en not_active Withdrawn
-
1999
- 1999-05-18 DK DK99926326T patent/DK1078001T3/da active
- 1999-05-18 PT PT99926326T patent/PT1078001E/pt unknown
- 1999-05-18 AT AT99926326T patent/ATE347563T1/de active
- 1999-05-18 CA CA2690399A patent/CA2690399C/en not_active Expired - Fee Related
- 1999-05-18 DE DE69934308T patent/DE69934308T2/de not_active Expired - Lifetime
- 1999-05-18 ES ES99926326T patent/ES2273492T3/es not_active Expired - Lifetime
- 1999-05-18 EP EP99926326A patent/EP1078001B1/en not_active Expired - Lifetime
- 1999-05-18 WO PCT/EP1999/003421 patent/WO1999060013A2/en not_active Ceased
- 1999-05-18 JP JP2000549631A patent/JP4468578B2/ja not_active Expired - Fee Related
- 1999-05-18 SI SI9930940T patent/SI1078001T1/sl unknown
- 1999-05-18 AU AU43627/99A patent/AU749616B2/en not_active Ceased
- 1999-05-18 CA CA2332817A patent/CA2332817C/en not_active Expired - Fee Related
- 1999-05-18 IL IL13957599A patent/IL139575A0/xx active IP Right Grant
-
2000
- 2000-11-09 IL IL139575A patent/IL139575A/en not_active IP Right Cessation
- 2000-11-20 US US09/715,923 patent/US6599875B1/en not_active Expired - Lifetime
-
2003
- 2003-02-04 US US10/357,479 patent/US6838433B2/en not_active Expired - Lifetime
-
2006
- 2006-12-20 CY CY20061101820T patent/CY1105865T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1105865T1 (el) | 2011-02-02 |
| EP1078001A2 (en) | 2001-02-28 |
| CA2332817A1 (en) | 1999-11-25 |
| EP0972780A1 (en) | 2000-01-19 |
| IL139575A (en) | 2008-03-20 |
| US6599875B1 (en) | 2003-07-29 |
| JP2002527354A (ja) | 2002-08-27 |
| CA2690399C (en) | 2015-01-20 |
| CA2690399A1 (en) | 1999-11-25 |
| US20030186876A1 (en) | 2003-10-02 |
| AU4362799A (en) | 1999-12-06 |
| ATE347563T1 (de) | 2006-12-15 |
| DE69934308D1 (de) | 2007-01-18 |
| EP1078001B1 (en) | 2006-12-06 |
| AU749616B2 (en) | 2002-06-27 |
| SI1078001T1 (sl) | 2007-04-30 |
| IL139575A0 (en) | 2002-02-10 |
| WO1999060013A2 (en) | 1999-11-25 |
| ES2273492T3 (es) | 2007-05-01 |
| DK1078001T3 (da) | 2007-02-19 |
| CA2332817C (en) | 2010-08-31 |
| WO1999060013A3 (en) | 2000-03-09 |
| JP4468578B2 (ja) | 2010-05-26 |
| US6838433B2 (en) | 2005-01-04 |
| PT1078001E (pt) | 2007-01-31 |
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Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH |