JP4468578B2 - Ｉｌ−６アンタゴニストペプチド - Google Patents

Ｉｌ−６アンタゴニストペプチド Download PDF

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Publication number
JP4468578B2
JP4468578B2 JP2000549631A JP2000549631A JP4468578B2 JP 4468578 B2 JP4468578 B2 JP 4468578B2 JP 2000549631 A JP2000549631 A JP 2000549631A JP 2000549631 A JP2000549631 A JP 2000549631A JP 4468578 B2 JP4468578 B2 JP 4468578B2
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JP
Japan
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seq
peptide
protein
domain
yeast
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Expired - Fee Related
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JP2000549631A
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Japanese (ja)
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JP2002527354A (ja
JP2002527354A5 (https=
Inventor
セルルピ−クレスチェンツィ，オッタビアーノ
ブレッサン，アレッサンドロ
ピエトラ，リンダ デッラ
リタ ペツォッティ，アンナ
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メルク セローノ ソシエテ アノニム
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2000549631A 1998-05-18 1999-05-18 Ｉｌ−６アンタゴニストペプチド Expired - Fee Related JP4468578B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98108997A EP0972780A1 (en) 1998-05-18 1998-05-18 Il-6 antagonist peptides
EP98108997.2 1998-05-18
PCT/EP1999/003421 WO1999060013A2 (en) 1998-05-18 1999-05-18 Il-6 antagonist peptides

Publications (3)

Publication Number Publication Date
JP2002527354A JP2002527354A (ja) 2002-08-27
JP2002527354A5 JP2002527354A5 (https=) 2006-05-18
JP4468578B2 true JP4468578B2 (ja) 2010-05-26

Family

ID=8231951

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000549631A Expired - Fee Related JP4468578B2 (ja) 1998-05-18 1999-05-18 Ｉｌ−６アンタゴニストペプチド

Country Status (14)

Country Link
US (2) US6599875B1 (https=)
EP (2) EP0972780A1 (https=)
JP (1) JP4468578B2 (https=)
AT (1) ATE347563T1 (https=)
AU (1) AU749616B2 (https=)
CA (2) CA2690399C (https=)
CY (1) CY1105865T1 (https=)
DE (1) DE69934308T2 (https=)
DK (1) DK1078001T3 (https=)
ES (1) ES2273492T3 (https=)
IL (2) IL139575A0 (https=)
PT (1) PT1078001E (https=)
SI (1) SI1078001T1 (https=)
WO (1) WO1999060013A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9260516B2 (en) 2006-04-07 2016-02-16 Osaka University Method for promoting muscle regeneration by administering an antibody to the IL-6 receptor
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
US12583918B2 (en) 2019-04-17 2026-03-24 Tokyo Women's Medical University Therapeutic agent for urological cancer which is characterized by being administered with IL-6 inhibitor and CCR2 inhibitor in combination
US12600772B2 (en) 2018-01-31 2026-04-14 Motokazu Kato Therapeutic agent for asthma containing IL-6 inhibitor

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0972780A1 (en) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
PT1783222E (pt) 1998-10-23 2012-07-26 Kirin Amgen Inc Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética
WO2006010057A2 (en) 2004-07-08 2006-01-26 Amgen Inc. Therapeutic peptides
US20070036788A1 (en) * 2004-09-22 2007-02-15 Ahmed Sheriff Use of a compound for reducing the biological effectiveness of il-6
EA011879B1 (ru) 2004-09-24 2009-06-30 Эмджин Инк. МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
WO2008090901A1 (ja) 2007-01-23 2008-07-31 Shinshu University 慢性拒絶反応抑制剤
TWI528973B (zh) 2008-06-05 2016-04-11 Chugai Pharmaceutical Co Ltd Nerve infiltration inhibitor
CA2744400C (en) 2008-11-25 2019-01-15 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
JP6051049B2 (ja) 2010-05-28 2016-12-21 中外製薬株式会社 抗腫瘍ｔ細胞応答増強剤
US9304134B2 (en) 2010-11-23 2016-04-05 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of anemia
HRP20200470T1 (hr) * 2011-01-18 2020-10-02 Bioniz, Llc Pripravci za modulaciju aktivnosti gama-c-citokina
WO2013063229A1 (en) 2011-10-25 2013-05-02 The Regents Of The University Of Michigan Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells
US9959384B2 (en) 2013-12-10 2018-05-01 Bioniz, Llc Methods of developing selective peptide antagonists
CN103923182A (zh) * 2014-01-17 2014-07-16 南通诚信氨基酸有限公司 白介素-6多肽抑制剂及其应用
CN119684428A (zh) 2015-10-09 2025-03-25 比奥尼斯治疗公司 调节γC-细胞因子活性
WO2018187499A1 (en) 2017-04-07 2018-10-11 Bioniz, Llc Stable modulators of gamma-c-cytokine activity
JP2022527972A (ja) 2019-04-02 2022-06-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 前悪性病変を有する患者において癌を予測及び予防する方法
EP3976182A4 (en) 2019-05-03 2023-01-18 Bioniz, LLC MODULATION OF THE EFFECTS OF GAMMA CYTOKINE SIGNALING FOR THE TREATMENT OF ALOPECIA AND ALOPECIA-ASSOCIATED DISORDERS
CN116003530B (zh) * 2022-12-27 2023-12-15 西湖大学 一种针对白细胞介素-6的d-蛋白抑制剂及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4420782C1 (de) * 1994-06-15 1995-08-17 Fluegge Ulf Ingo Prof Dr DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter
DE69526665T2 (de) * 1994-09-21 2002-11-21 Cytogen Corp., Princeton Antigen bindende peptide (abtides) aus peptidbibliotheken
AU3204895A (en) * 1995-02-01 1996-08-21 University Of Massachusetts Medical Center Methods of selecting a random peptide that binds to a target protein
JP4173539B2 (ja) * 1995-05-11 2008-10-29 ラボラトアール・セローノ・ソシエテ・アノニム Ｉｌ−６活性阻害剤
AU6731896A (en) * 1995-07-17 1997-02-18 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Cyclitol
DE69637845D1 (de) * 1995-09-28 2009-04-09 Yeda Res & Dev Synthetische peptide mit il-6 aktivitäthemmung
EP0928293A1 (en) * 1996-06-20 1999-07-14 Koster, Henk W. Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity
EP0972780A1 (en) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9260516B2 (en) 2006-04-07 2016-02-16 Osaka University Method for promoting muscle regeneration by administering an antibody to the IL-6 receptor
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
US12509511B2 (en) 2017-05-02 2025-12-30 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
US12600772B2 (en) 2018-01-31 2026-04-14 Motokazu Kato Therapeutic agent for asthma containing IL-6 inhibitor
US12583918B2 (en) 2019-04-17 2026-03-24 Tokyo Women's Medical University Therapeutic agent for urological cancer which is characterized by being administered with IL-6 inhibitor and CCR2 inhibitor in combination

Also Published As

Publication number Publication date
JP2002527354A (ja) 2002-08-27
EP1078001A2 (en) 2001-02-28
DK1078001T3 (da) 2007-02-19
AU4362799A (en) 1999-12-06
IL139575A (en) 2008-03-20
EP1078001B1 (en) 2006-12-06
CA2690399A1 (en) 1999-11-25
CA2690399C (en) 2015-01-20
CY1105865T1 (el) 2011-02-02
CA2332817A1 (en) 1999-11-25
US20030186876A1 (en) 2003-10-02
US6599875B1 (en) 2003-07-29
ATE347563T1 (de) 2006-12-15
ES2273492T3 (es) 2007-05-01
EP0972780A1 (en) 2000-01-19
WO1999060013A3 (en) 2000-03-09
WO1999060013A2 (en) 1999-11-25
SI1078001T1 (sl) 2007-04-30
PT1078001E (pt) 2007-01-31
DE69934308T2 (de) 2007-03-29
IL139575A0 (en) 2002-02-10
CA2332817C (en) 2010-08-31
DE69934308D1 (de) 2007-01-18
AU749616B2 (en) 2002-06-27
US6838433B2 (en) 2005-01-04

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