DK1078001T3 - IL-6 antagonost peptider - Google Patents

IL-6 antagonost peptider

Info

Publication number
DK1078001T3
DK1078001T3 DK99926326T DK99926326T DK1078001T3 DK 1078001 T3 DK1078001 T3 DK 1078001T3 DK 99926326 T DK99926326 T DK 99926326T DK 99926326 T DK99926326 T DK 99926326T DK 1078001 T3 DK1078001 T3 DK 1078001T3
Authority
DK
Denmark
Prior art keywords
seq
present
antagonist peptides
peptide
peptides
Prior art date
Application number
DK99926326T
Other languages
Danish (da)
English (en)
Inventor
Ottaviano Serlupi-Crescenzi
Pietra Linda Della
Alessandro Bressan
Anna Rita Pezzotti
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of DK1078001T3 publication Critical patent/DK1078001T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK99926326T 1998-05-18 1999-05-18 IL-6 antagonost peptider DK1078001T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98108997A EP0972780A1 (en) 1998-05-18 1998-05-18 Il-6 antagonist peptides
PCT/EP1999/003421 WO1999060013A2 (en) 1998-05-18 1999-05-18 Il-6 antagonist peptides

Publications (1)

Publication Number Publication Date
DK1078001T3 true DK1078001T3 (da) 2007-02-19

Family

ID=8231951

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99926326T DK1078001T3 (da) 1998-05-18 1999-05-18 IL-6 antagonost peptider

Country Status (14)

Country Link
US (2) US6599875B1 (https=)
EP (2) EP0972780A1 (https=)
JP (1) JP4468578B2 (https=)
AT (1) ATE347563T1 (https=)
AU (1) AU749616B2 (https=)
CA (2) CA2690399C (https=)
CY (1) CY1105865T1 (https=)
DE (1) DE69934308T2 (https=)
DK (1) DK1078001T3 (https=)
ES (1) ES2273492T3 (https=)
IL (2) IL139575A0 (https=)
PT (1) PT1078001E (https=)
SI (1) SI1078001T1 (https=)
WO (1) WO1999060013A2 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0972780A1 (en) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides
MEP42108A (en) 1998-10-23 2011-02-10 Kiren Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
US8143380B2 (en) 2004-07-08 2012-03-27 Amgen Inc. Therapeutic peptides
US20070036788A1 (en) * 2004-09-22 2007-02-15 Ahmed Sheriff Use of a compound for reducing the biological effectiveness of il-6
WO2006036834A2 (en) 2004-09-24 2006-04-06 Amgen Inc. MODIFIED Fc MOLECULES
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
JP5754875B2 (ja) 2006-04-07 2015-07-29 国立大学法人大阪大学 筋再生促進剤
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
TWI438208B (zh) 2007-01-23 2014-05-21 中外製藥股份有限公司 抑制慢性排斥反應之藥劑
CA2728243C (en) 2008-06-05 2020-03-10 Chugai Seiyaku Kabushiki Kaisha Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer
KR20110112307A (ko) 2008-11-25 2011-10-12 앨더 바이오파마슈티컬즈, 인코포레이티드 알부민을 상승시키고 및／또는 ｃｒｐ를 낮추는 ｉｌ­６의 길항제
WO2011149051A1 (ja) 2010-05-28 2011-12-01 中外製薬株式会社 抗腫瘍t細胞応答増強剤
CA2818813C (en) 2010-11-23 2020-10-06 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of oral mucositis
EP2665486B1 (en) 2011-01-18 2019-12-25 Bioniz, LLC Compositions for modulating gamma-c-cytokine activity
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
US9959384B2 (en) 2013-12-10 2018-05-01 Bioniz, Llc Methods of developing selective peptide antagonists
CN103923182A (zh) * 2014-01-17 2014-07-16 南通诚信氨基酸有限公司 白介素-6多肽抑制剂及其应用
WO2017062685A1 (en) 2015-10-09 2017-04-13 Bioniz, Llc Modulating gamma - c -cytokine activity
US12600757B2 (en) 2017-04-07 2026-04-14 Bioniz Therapeutics, Inc. Peptides inhibiting gamma-c-cytokine activity and methods of use
WO2018203545A1 (ja) 2017-05-02 2018-11-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
JP7235249B2 (ja) 2017-10-20 2023-03-08 学校法人兵庫医科大学 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
WO2019151418A1 (ja) 2018-01-31 2019-08-08 元一 加藤 Ｉｌ－６阻害剤を含有する喘息の治療剤
EP3947737A2 (en) 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
EP3957324A4 (en) 2019-04-17 2023-02-08 Hiroshima University THERAPEUTIC FOR UROLOGICAL ONCOLOGY CHARACTERIZED BY BEING ADMINISTRATED IN COMBINATION WITH IL-6 INHIBITOR AND CCR2 INHIBITOR
CA3137971A1 (en) 2019-05-03 2020-11-12 Bioniz, Llc Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders
CN116003530B (zh) * 2022-12-27 2023-12-15 西湖大学 一种针对白细胞介素-6的d-蛋白抑制剂及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4420782C1 (de) * 1994-06-15 1995-08-17 Fluegge Ulf Ingo Prof Dr DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter
DE69526665T2 (de) * 1994-09-21 2002-11-21 Cytogen Corp., Princeton Antigen bindende peptide (abtides) aus peptidbibliotheken
WO1996023899A1 (en) * 1995-02-01 1996-08-08 University Of Massachusetts Medical Center Methods of selecting a random peptide that binds to a target protein
ATE271128T1 (de) * 1995-05-11 2004-07-15 Applied Research Systems Inhibitoren der il-6 aktivitaet
DE19628873A1 (de) * 1995-07-17 1997-01-23 Fraunhofer Ges Forschung Cyclitol
CA2230949C (en) * 1995-09-28 2009-11-17 Judith Chebath Synthetic peptides that inhibit il-6 activity
EP0928293A1 (en) * 1996-06-20 1999-07-14 Koster, Henk W. Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity
EP0972780A1 (en) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides

Also Published As

Publication number Publication date
CY1105865T1 (el) 2011-02-02
EP1078001A2 (en) 2001-02-28
CA2332817A1 (en) 1999-11-25
EP0972780A1 (en) 2000-01-19
IL139575A (en) 2008-03-20
US6599875B1 (en) 2003-07-29
JP2002527354A (ja) 2002-08-27
CA2690399C (en) 2015-01-20
CA2690399A1 (en) 1999-11-25
US20030186876A1 (en) 2003-10-02
AU4362799A (en) 1999-12-06
DE69934308T2 (de) 2007-03-29
ATE347563T1 (de) 2006-12-15
DE69934308D1 (de) 2007-01-18
EP1078001B1 (en) 2006-12-06
AU749616B2 (en) 2002-06-27
SI1078001T1 (sl) 2007-04-30
IL139575A0 (en) 2002-02-10
WO1999060013A2 (en) 1999-11-25
ES2273492T3 (es) 2007-05-01
CA2332817C (en) 2010-08-31
WO1999060013A3 (en) 2000-03-09
JP4468578B2 (ja) 2010-05-26
US6838433B2 (en) 2005-01-04
PT1078001E (pt) 2007-01-31

Similar Documents

Publication Publication Date Title
ATE347563T1 (de) Il-6-antagonist peptide
BG98793A (bg) Нови производни на аминокиселините,методи за тяхното получаване и фармацевтични състави,съдържащи тези съединения
DK0894084T3 (da) Kanelsyrederivater og deres anvendelse som integrinantagonister
FI954609A0 (fi) 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina
IL123164A (en) Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
DK1086124T3 (da) Nye cyclosporiner
EP1093372A4 (en) CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF INHIBITING PEPTIDE RELEASE $ g (b) -AMYLOID AND / OR ITS SYNTHESIS USING THE SAME
IL104716A (en) 7-1-oxo-2- (substituted mercapto)-3- phenylpropyl) amino| octahydro-6-pyrido £2, 1-a| benzazepine- 4-carboxylic acid derivatives and analogs, their preparation and pharmaceutical compositions containing them for inhibiting enkephalinase and ace
TR200100889T2 (tr) Disfosfonik asit içeren terkipler
NO20000231L (no) Dolastatin-15-derivater
ES2120728T3 (es) Inhibidores de la agregacion de plaquetas.
DE3381282D1 (de) Peptidverbindungen.
ATE321543T1 (de) Pharmazeutische zusammensetzungen mit hydroximsäurederivaten
PT1079849E (pt) Utilizacao de proteinas hmg para a preparacao de medicamentos com actividade citotoxica
ES2110115T3 (es) Inhibidores de la agregacion de plaquetas.
DK1165544T3 (da) Substituerede 1,4-dihydroindeno[1,2-c]pyrazoler som inhibitorer af tyrosinkinase
ATE48001T1 (de) Cephemverbindungen, verfahren zu ihrer herstellung und ihre pharmazeutischen praeparate.
DK0804418T3 (da) Platelataggregationshæmmere
EP0952159A3 (en) Use of somatostatin derivatives and/or of phenylhydrazone derivatives as antinflammatory or analgetic agents
TNSN97092A1 (ar) مثبطات انزيم بروتيني فلزي وتركيبات صيدلانية تحتوي على تلك المثبتطات واستخدامها الصيدلاني وطرق ومركبات وسيطة مفيدة لتحضير التركيبات المذكورة.
EA199900551A1 (ru) Фармацевтическая композиция, содержащая ингибитор иммуноглобулин-рецепторного взаимодействия
NO974537L (no) Plateaggregeringsinhibitorer inneholdende C-terminale aminergiske sidekjedeaminosyrerester
EP0817643A4 (en) SUBSTANCES AND COMPOSITIONS FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES