CY1105865T1 - Ανταγωνιστικα πεπτιδια της il-6 - Google Patents

Ανταγωνιστικα πεπτιδια της il-6

Info

Publication number
CY1105865T1
CY1105865T1 CY20061101820T CY061101820T CY1105865T1 CY 1105865 T1 CY1105865 T1 CY 1105865T1 CY 20061101820 T CY20061101820 T CY 20061101820T CY 061101820 T CY061101820 T CY 061101820T CY 1105865 T1 CY1105865 T1 CY 1105865T1
Authority
CY
Cyprus
Prior art keywords
seq
present
peptides
antagonistic peptides
peptide
Prior art date
Application number
CY20061101820T
Other languages
English (en)
Inventor
Ottaviano Serlupi-Crescenzi
Alessandro Bressan
Linda Della Pietra
Anna Rita Pezzotti
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of CY1105865T1 publication Critical patent/CY1105865T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε ανταγωνιστικά πεπτίδια της IL-6, που μπορούν να απομονωθούν από μια βιβλιοθήκη πεπτιδίων μέσω του συστήματος δυο- υβριδίων μέσω της ικανότητας τους να προσδένονται στο ενδοκυττάριο τμήμα του gp130 και που περιέχουν τουλάχιστον 5 αμινοξέα. Συγκεκριμένα, τέτοια πεπτίδια περιλαμβάνουν μια αλληλουχία αμινοξέων, η οποία επιλέγεται από την ομάδα που περιλαμβάνει: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, καθώς επίσης άλατα, λειτουργικά παράγωγα, πρόδρομες ουσίες και ανάλογα εξ'αυτής. Ένα άλλο αντικείμενο της παρούσας εφεύρεσης είναι να παράσχει το πεπτίδιο σε σημαντικά καθαρμένη μορφή, προκειμένου να είναι κατάλληλο για χρήση σε φαρμακευτικές συνθέσεις, ως ένα ενεργό συστατικό, σε παθολογικές οντότητες οι οποίες απαιτούν την αναστολή της IL-6 δραστηριότητας.
CY20061101820T 1998-05-18 2006-12-20 Ανταγωνιστικα πεπτιδια της il-6 CY1105865T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98108997A EP0972780A1 (en) 1998-05-18 1998-05-18 Il-6 antagonist peptides
EP99926326A EP1078001B1 (en) 1998-05-18 1999-05-18 Il-6 antagonist peptides
PCT/EP1999/003421 WO1999060013A2 (en) 1998-05-18 1999-05-18 Il-6 antagonist peptides

Publications (1)

Publication Number Publication Date
CY1105865T1 true CY1105865T1 (el) 2011-02-02

Family

ID=8231951

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101820T CY1105865T1 (el) 1998-05-18 2006-12-20 Ανταγωνιστικα πεπτιδια της il-6

Country Status (14)

Country Link
US (2) US6599875B1 (el)
EP (2) EP0972780A1 (el)
JP (1) JP4468578B2 (el)
AT (1) ATE347563T1 (el)
AU (1) AU749616B2 (el)
CA (2) CA2690399C (el)
CY (1) CY1105865T1 (el)
DE (1) DE69934308T2 (el)
DK (1) DK1078001T3 (el)
ES (1) ES2273492T3 (el)
IL (2) IL139575A0 (el)
PT (1) PT1078001E (el)
SI (1) SI1078001T1 (el)
WO (1) WO1999060013A2 (el)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0972780A1 (en) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
HU228582B1 (en) 1998-10-23 2013-04-29 Kirin Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
CA2572765C (en) 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
US20070036788A1 (en) * 2004-09-22 2007-02-15 Ahmed Sheriff Use of a compound for reducing the biological effectiveness of il-6
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
JP5754875B2 (ja) 2006-04-07 2015-07-29 国立大学法人大阪大学 筋再生促進剤
JO3324B1 (ar) 2006-04-21 2019-03-13 Amgen Inc مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية
CA2675625C (en) 2007-01-23 2016-09-13 Shinshu University Chronic rejection inhibitor
CA2728243C (en) 2008-06-05 2020-03-10 National Cancer Center Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer
AU2009323002B2 (en) 2008-11-25 2016-01-28 Vitaeris Inc. Antagonists of IL-6 to raise albumin and/or lower CRP
ES2932398T3 (es) 2010-05-28 2023-01-18 Chugai Pharmaceutical Co Ltd Potenciador de la respuesta de las células T antitumorales
WO2012071561A2 (en) 2010-11-23 2012-05-31 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of anemia
CN109021069A (zh) 2011-01-18 2018-12-18 比奥尼斯有限责任公司 调节γ-C-细胞因子活性的组合物及方法
WO2013063229A1 (en) 2011-10-25 2013-05-02 The Regents Of The University Of Michigan Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells
US9959384B2 (en) 2013-12-10 2018-05-01 Bioniz, Llc Methods of developing selective peptide antagonists
CN103923182A (zh) * 2014-01-17 2014-07-16 南通诚信氨基酸有限公司 白介素-6多肽抑制剂及其应用
ES2884357T3 (es) 2015-10-09 2021-12-10 Bioniz Llc Modulación de la actividad de las citocinas gamma-c
WO2018203545A1 (ja) 2017-05-02 2018-11-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
EP3947737A2 (en) 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020227019A1 (en) 2019-05-03 2020-11-12 Bioniz, Llc Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders
CN116003530B (zh) * 2022-12-27 2023-12-15 西湖大学 一种针对白细胞介素-6的d-蛋白抑制剂及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4420782C1 (de) * 1994-06-15 1995-08-17 Fluegge Ulf Ingo Prof Dr DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter
ATE217344T1 (de) * 1994-09-21 2002-05-15 Cytogen Corp Antigen bindende peptide (abtides) aus peptidbibliotheken
WO1996023899A1 (en) * 1995-02-01 1996-08-08 University Of Massachusetts Medical Center Methods of selecting a random peptide that binds to a target protein
US6004813A (en) * 1995-05-11 1999-12-21 Applied Research Systems Ars Holding N.V. Il-6 activity inhibitor
AU6731896A (en) * 1995-07-17 1997-02-18 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Cyclitol
IL123815A (en) * 1995-09-28 2007-05-15 Yeda Res & Dev Synthetic peptides that inhibit il-6 activity
EP0928293A1 (en) * 1996-06-20 1999-07-14 Koster, Henk W. Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity
EP0972780A1 (en) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides

Also Published As

Publication number Publication date
EP1078001B1 (en) 2006-12-06
US20030186876A1 (en) 2003-10-02
IL139575A0 (en) 2002-02-10
ES2273492T3 (es) 2007-05-01
CA2332817A1 (en) 1999-11-25
PT1078001E (pt) 2007-01-31
US6599875B1 (en) 2003-07-29
DE69934308T2 (de) 2007-03-29
WO1999060013A2 (en) 1999-11-25
ATE347563T1 (de) 2006-12-15
CA2690399A1 (en) 1999-11-25
WO1999060013A3 (en) 2000-03-09
AU4362799A (en) 1999-12-06
CA2690399C (en) 2015-01-20
EP0972780A1 (en) 2000-01-19
EP1078001A2 (en) 2001-02-28
CA2332817C (en) 2010-08-31
JP2002527354A (ja) 2002-08-27
JP4468578B2 (ja) 2010-05-26
DK1078001T3 (da) 2007-02-19
US6838433B2 (en) 2005-01-04
IL139575A (en) 2008-03-20
SI1078001T1 (sl) 2007-04-30
AU749616B2 (en) 2002-06-27
DE69934308D1 (de) 2007-01-18

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