JP2002527354A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002527354A5 JP2002527354A5 JP2000549631A JP2000549631A JP2002527354A5 JP 2002527354 A5 JP2002527354 A5 JP 2002527354A5 JP 2000549631 A JP2000549631 A JP 2000549631A JP 2000549631 A JP2000549631 A JP 2000549631A JP 2002527354 A5 JP2002527354 A5 JP 2002527354A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide according
- diseases
- peptide
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 238000002054 transplantation Methods 0.000 description 4
- 108090001005 Interleukin-6 Proteins 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 208000020084 Bone disease Diseases 0.000 description 2
- 208000018084 Bone neoplasm Diseases 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 208000026278 immune system disease Diseases 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 108010067902 Peptide Library Proteins 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108997A EP0972780A1 (en) | 1998-05-18 | 1998-05-18 | Il-6 antagonist peptides |
| EP98108997.2 | 1998-05-18 | ||
| PCT/EP1999/003421 WO1999060013A2 (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002527354A JP2002527354A (ja) | 2002-08-27 |
| JP2002527354A5 true JP2002527354A5 (https=) | 2006-05-18 |
| JP4468578B2 JP4468578B2 (ja) | 2010-05-26 |
Family
ID=8231951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000549631A Expired - Fee Related JP4468578B2 (ja) | 1998-05-18 | 1999-05-18 | Ｉｌ−６アンタゴニストペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6599875B1 (https=) |
| EP (2) | EP0972780A1 (https=) |
| JP (1) | JP4468578B2 (https=) |
| AT (1) | ATE347563T1 (https=) |
| AU (1) | AU749616B2 (https=) |
| CA (2) | CA2690399C (https=) |
| CY (1) | CY1105865T1 (https=) |
| DE (1) | DE69934308T2 (https=) |
| DK (1) | DK1078001T3 (https=) |
| ES (1) | ES2273492T3 (https=) |
| IL (2) | IL139575A0 (https=) |
| PT (1) | PT1078001E (https=) |
| SI (1) | SI1078001T1 (https=) |
| WO (1) | WO1999060013A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| PT1783222E (pt) | 1998-10-23 | 2012-07-26 | Kirin Amgen Inc | Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética |
| WO2006010057A2 (en) | 2004-07-08 | 2006-01-26 | Amgen Inc. | Therapeutic peptides |
| US20070036788A1 (en) * | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| EA011879B1 (ru) | 2004-09-24 | 2009-06-30 | Эмджин Инк. | МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| EP2025346B1 (en) | 2006-04-07 | 2016-08-10 | Osaka University | Muscle regeneration promoter |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| WO2008090901A1 (ja) | 2007-01-23 | 2008-07-31 | Shinshu University | 慢性拒絶反応抑制剤 |
| TWI528973B (zh) | 2008-06-05 | 2016-04-11 | Chugai Pharmaceutical Co Ltd | Nerve infiltration inhibitor |
| CA2744400C (en) | 2008-11-25 | 2019-01-15 | Alder Biopharmaceuticals, Inc. | Antibodies to il-6 and use thereof |
| JP6051049B2 (ja) | 2010-05-28 | 2016-12-21 | 中外製薬株式会社 | 抗腫瘍ｔ細胞応答増強剤 |
| US9304134B2 (en) | 2010-11-23 | 2016-04-05 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of anemia |
| HRP20200470T1 (hr) * | 2011-01-18 | 2020-10-02 | Bioniz, Llc | Pripravci za modulaciju aktivnosti gama-c-citokina |
| WO2013063229A1 (en) | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| CN103923182A (zh) * | 2014-01-17 | 2014-07-16 | 南通诚信氨基酸有限公司 | 白介素-6多肽抑制剂及其应用 |
| CN119684428A (zh) | 2015-10-09 | 2025-03-25 | 比奥尼斯治疗公司 | 调节γC-细胞因子活性 |
| WO2018187499A1 (en) | 2017-04-07 | 2018-10-11 | Bioniz, Llc | Stable modulators of gamma-c-cytokine activity |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| EP3698808B1 (en) | 2017-10-20 | 2025-01-01 | Hyogo College Of Medicine | Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
| WO2019151418A1 (ja) | 2018-01-31 | 2019-08-08 | 元一 加藤 | Ｉｌ－６阻害剤を含有する喘息の治療剤 |
| JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
| IL287220B2 (en) | 2019-04-17 | 2026-03-01 | Univ Hiroshima | A therapeutic agent for urological cancer characterized by administering an IL-6 inhibitor in combination with a CCR2 inhibitor |
| EP3976182A4 (en) | 2019-05-03 | 2023-01-18 | Bioniz, LLC | MODULATION OF THE EFFECTS OF GAMMA CYTOKINE SIGNALING FOR THE TREATMENT OF ALOPECIA AND ALOPECIA-ASSOCIATED DISORDERS |
| CN116003530B (zh) * | 2022-12-27 | 2023-12-15 | 西湖大学 | 一种针对白细胞介素-6的d-蛋白抑制剂及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4420782C1 (de) * | 1994-06-15 | 1995-08-17 | Fluegge Ulf Ingo Prof Dr | DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter |
| DE69526665T2 (de) * | 1994-09-21 | 2002-11-21 | Cytogen Corp., Princeton | Antigen bindende peptide (abtides) aus peptidbibliotheken |
| AU3204895A (en) * | 1995-02-01 | 1996-08-21 | University Of Massachusetts Medical Center | Methods of selecting a random peptide that binds to a target protein |
| JP4173539B2 (ja) * | 1995-05-11 | 2008-10-29 | ラボラトアール・セローノ・ソシエテ・アノニム | Ｉｌ−６活性阻害剤 |
| AU6731896A (en) * | 1995-07-17 | 1997-02-18 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Cyclitol |
| DE69637845D1 (de) * | 1995-09-28 | 2009-04-09 | Yeda Res & Dev | Synthetische peptide mit il-6 aktivitäthemmung |
| EP0928293A1 (en) * | 1996-06-20 | 1999-07-14 | Koster, Henk W. | Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity |
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
-
1998
- 1998-05-18 EP EP98108997A patent/EP0972780A1/en not_active Withdrawn
-
1999
- 1999-05-18 CA CA2690399A patent/CA2690399C/en not_active Expired - Fee Related
- 1999-05-18 AU AU43627/99A patent/AU749616B2/en not_active Ceased
- 1999-05-18 JP JP2000549631A patent/JP4468578B2/ja not_active Expired - Fee Related
- 1999-05-18 AT AT99926326T patent/ATE347563T1/de active
- 1999-05-18 WO PCT/EP1999/003421 patent/WO1999060013A2/en not_active Ceased
- 1999-05-18 CA CA2332817A patent/CA2332817C/en not_active Expired - Fee Related
- 1999-05-18 DE DE69934308T patent/DE69934308T2/de not_active Expired - Lifetime
- 1999-05-18 SI SI9930940T patent/SI1078001T1/sl unknown
- 1999-05-18 PT PT99926326T patent/PT1078001E/pt unknown
- 1999-05-18 IL IL13957599A patent/IL139575A0/xx active IP Right Grant
- 1999-05-18 ES ES99926326T patent/ES2273492T3/es not_active Expired - Lifetime
- 1999-05-18 EP EP99926326A patent/EP1078001B1/en not_active Expired - Lifetime
- 1999-05-18 DK DK99926326T patent/DK1078001T3/da active
-
2000
- 2000-11-09 IL IL139575A patent/IL139575A/en not_active IP Right Cessation
- 2000-11-20 US US09/715,923 patent/US6599875B1/en not_active Expired - Lifetime
-
2003
- 2003-02-04 US US10/357,479 patent/US6838433B2/en not_active Expired - Lifetime
-
2006
- 2006-12-20 CY CY20061101820T patent/CY1105865T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002527354A5 (https=) | ||
| CA2332817A1 (en) | Il-6 antagonist peptides | |
| US11298403B2 (en) | Therapeutic agent for inflammatory bowel disease | |
| WO2023214576A1 (ja) | Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物 | |
| DE69631605T2 (de) | Verfahren zur verringerung und zur erhaltung von verringerten blutspiegeln von lipiden mittels zubereitungen von ob-proteinen | |
| JP2002539243A (ja) | 受精能を向上させるための組成物 | |
| JP2000507617A (ja) | ヘプタペプチドオキシトシン類似体 | |
| JP2001500893A (ja) | インスリンｃ―ペプチド | |
| JP2006506942A5 (https=) | ||
| JP2022513209A (ja) | オリゴペプチドを有効成分として含むがんの予防または治療用薬学的組成物 | |
| WO2005082395A1 (ja) | 新規な育毛剤、抗脱毛症剤 | |
| RU2398776C2 (ru) | Тимус-специфический белок | |
| JP5048372B2 (ja) | 育毛促進剤 | |
| JP2007500693A (ja) | 移植片拒絶反応を予防するための合成ペプチドコポリマーを含む併用療法 | |
| JPWO2001080891A1 (ja) | 間質性肺炎治療薬および当該疾病の動物モデルの作成方法並びにそれを用いるスクリーニング方法 | |
| WO2006041763A1 (en) | Renin inhibitors for treating transplantation induced diseases | |
| JP3059283B2 (ja) | 抗炎症剤 | |
| JP3517238B2 (ja) | レトロウイルス感染の阻害 | |
| JP3002725B2 (ja) | 線維芽細胞増殖因子関連ペプチドからなる医薬組成物 | |
| JP2000053580A (ja) | 全身性紅斑性狼そうの治療におけるペプチド化合物の使用方法 | |
| JP2001518062A (ja) | 肺繊維症の治療 | |
| JP2003527414A (ja) | Ｃ型肝炎を治療するための薬剤 | |
| US7728033B2 (en) | Mycophenolate mofetil in diabetic nephropathy | |
| JP2003531126A (ja) | 糸球体硬化症および腎不全に対する治療薬または予防薬としてのデス−アスパラギン酸塩−アンジオテンシンｉの使用 | |
| JP2009511510A (ja) | 肝不全の予防・治療用薬品の調製における効果の長いヒト組換え可溶性腫瘍壊死因子α受容体の使用 |