DE69912479T2 - 4- und 5-alkynyloxindole sowie 4- und 5-alkenyloxindole - Google Patents

4- und 5-alkynyloxindole sowie 4- und 5-alkenyloxindole Download PDF

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Publication number
DE69912479T2
DE69912479T2 DE69912479T DE69912479T DE69912479T2 DE 69912479 T2 DE69912479 T2 DE 69912479T2 DE 69912479 T DE69912479 T DE 69912479T DE 69912479 T DE69912479 T DE 69912479T DE 69912479 T2 DE69912479 T2 DE 69912479T2
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DE
Germany
Prior art keywords
dihydro
methylene
radical
pyrrol
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69912479T
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German (de)
English (en)
Other versions
DE69912479D1 (de
Inventor
Kin-Chun Luk
E. Paige MAHANEY
Steven Gregory Mischke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69912479D1 publication Critical patent/DE69912479D1/de
Publication of DE69912479T2 publication Critical patent/DE69912479T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69912479T 1998-12-17 1999-12-07 4- und 5-alkynyloxindole sowie 4- und 5-alkenyloxindole Expired - Fee Related DE69912479T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11258998P 1998-12-17 1998-12-17
US112589P 1998-12-17
US14148299P 1999-06-29 1999-06-29
US141482P 1999-06-29
PCT/EP1999/009578 WO2000035906A2 (en) 1998-12-17 1999-12-07 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles

Publications (2)

Publication Number Publication Date
DE69912479D1 DE69912479D1 (de) 2003-12-04
DE69912479T2 true DE69912479T2 (de) 2004-07-22

Family

ID=26810125

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69912479T Expired - Fee Related DE69912479T2 (de) 1998-12-17 1999-12-07 4- und 5-alkynyloxindole sowie 4- und 5-alkenyloxindole

Country Status (14)

Country Link
EP (1) EP1149092B1 (https=)
JP (1) JP2002532490A (https=)
KR (1) KR20010087421A (https=)
CN (1) CN1147486C (https=)
AT (1) ATE253062T1 (https=)
AU (1) AU771599B2 (https=)
BR (1) BR9916272A (https=)
CA (1) CA2354510A1 (https=)
DE (1) DE69912479T2 (https=)
DK (1) DK1149092T3 (https=)
ES (1) ES2209527T3 (https=)
PT (1) PT1149092E (https=)
TR (1) TR200101747T2 (https=)
WO (1) WO2000035906A2 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2003535847A (ja) 2000-06-02 2003-12-02 スージェン・インコーポレーテッド 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体
JP2004502686A (ja) 2000-06-30 2004-01-29 スージェン・インコーポレーテッド ４−ヘテロアリール−３−ヘテロアリーリデニル−２−インドリノンおよび蛋白質キナーゼ阻害剤としてのその使用
CN1300116C (zh) 2001-04-16 2007-02-14 卫材株式会社 1h－吲唑化合物
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
AU2002303892A1 (en) 2001-05-30 2002-12-09 Jingrong Cui 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
ES2318041T3 (es) 2001-07-23 2009-05-01 Laboratoires Serono Sa Derivados de arilsulfonamida como inhibidores de c-jun quinasas (jnk) n-terminales.
BR0213233A (pt) 2001-10-12 2005-01-04 Warner Lambert Co Alcinos inibidores de metaloproteinase de matriz
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
DE60332215D1 (de) 2002-02-28 2010-06-02 Eisai R&D Man Co Ltd Neue indazolverbindungen mit kondensiertem ring
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
CA2482838A1 (en) 2002-05-31 2003-12-11 Eisai Co., Ltd. Pyrazole compounds and pharmaceutical compositions containing the compound
EP1527070B1 (en) 2002-06-14 2013-01-09 Merck Serono SA Azole methylidene cyanide derivatives and their use as protein kinase modulators
JP2007509173A (ja) 2003-10-24 2007-04-12 シエーリング アクチエンゲゼルシャフト インドリノン誘導体類及び疾病状態、例えば癌の処理へのそれらの使用
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
US7803824B2 (en) 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
WO2006090698A1 (ja) * 2005-02-22 2006-08-31 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
CN1939922B (zh) * 2005-09-27 2010-10-13 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物
RU2008112691A (ru) 2005-10-03 2009-10-10 Оно Фармасьютикал Ко., Лтд. (Jp) Азотсодержащее гетероциклическое соединение и его фармацевтическое применение
FR2962733B1 (fr) 2010-07-13 2012-08-17 Michelin Soc Tech Polymere greffe par des molecules associatives azotees.
FR2962729B1 (fr) 2010-07-13 2012-09-21 Arkema France Molecules porteuses de groupes associatifs
WO2012178015A2 (en) * 2011-06-24 2012-12-27 Zenobia Therapeutics, Inc. Lrrk2 inhibitors
EP3828013B1 (en) 2019-11-27 2023-09-27 Industrial Technology Research Institute Self-powered sensing and transmitting device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9610964D0 (en) * 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
WO1998007695A1 (en) * 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
EP0984930B1 (en) * 1997-05-07 2005-04-06 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity

Also Published As

Publication number Publication date
ATE253062T1 (de) 2003-11-15
CA2354510A1 (en) 2000-06-22
AU771599B2 (en) 2004-03-25
BR9916272A (pt) 2001-09-04
KR20010087421A (ko) 2001-09-15
WO2000035906A3 (en) 2000-11-09
EP1149092B1 (en) 2003-10-29
ES2209527T3 (es) 2004-06-16
PT1149092E (pt) 2004-03-31
WO2000035906A2 (en) 2000-06-22
CN1331689A (zh) 2002-01-16
CN1147486C (zh) 2004-04-28
DK1149092T3 (da) 2004-02-23
JP2002532490A (ja) 2002-10-02
AU1507600A (en) 2000-07-03
EP1149092A2 (en) 2001-10-31
TR200101747T2 (tr) 2001-11-21
DE69912479D1 (de) 2003-12-04

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8339 Ceased/non-payment of the annual fee