BR9916272A - 4 e 5-alquiniloxindóis e 4 e 5-alqueniloxindóis - Google Patents

4 e 5-alquiniloxindóis e 4 e 5-alqueniloxindóis

Info

Publication number
BR9916272A
BR9916272A BR9916272-5A BR9916272A BR9916272A BR 9916272 A BR9916272 A BR 9916272A BR 9916272 A BR9916272 A BR 9916272A BR 9916272 A BR9916272 A BR 9916272A
Authority
BR
Brazil
Prior art keywords
alkynyloxindols
alkenyloxindols
protein kinases
alkynyloxindoles
alkenyloxindoles
Prior art date
Application number
BR9916272-5A
Other languages
English (en)
Inventor
Kin-Chun Luk
Paige E Mahaney
Steven Gregory Mischkemischke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9916272A publication Critical patent/BR9916272A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de invenção: <B>"4 E 5-ALQUINILOXINDóIS E 4 E 5-ALQUENILOXINDóIS"<D>. 4 e 5-alquiniloxindóis bem como 4 e 5-alqueniloxindóis tendo a fórmula (I) e (II), em que R¹, R², R³, R^ 11^, R^ 12^, X e z têm o significado indicado no relatório descritivo, inibem ou modulam cinases de proteína, em particular cinases de proteína de JNK e são úteis como agentes antiinflamatórios, particularmente no tratamento de artrite reumatóide.
BR9916272-5A 1998-12-17 1999-12-07 4 e 5-alquiniloxindóis e 4 e 5-alqueniloxindóis BR9916272A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11258998P 1998-12-17 1998-12-17
US14148299P 1999-06-29 1999-06-29
PCT/EP1999/009578 WO2000035906A2 (en) 1998-12-17 1999-12-07 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles

Publications (1)

Publication Number Publication Date
BR9916272A true BR9916272A (pt) 2001-09-04

Family

ID=26810125

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916272-5A BR9916272A (pt) 1998-12-17 1999-12-07 4 e 5-alquiniloxindóis e 4 e 5-alqueniloxindóis

Country Status (14)

Country Link
EP (1) EP1149092B1 (pt)
JP (1) JP2002532490A (pt)
KR (1) KR20010087421A (pt)
CN (1) CN1147486C (pt)
AT (1) ATE253062T1 (pt)
AU (1) AU771599B2 (pt)
BR (1) BR9916272A (pt)
CA (1) CA2354510A1 (pt)
DE (1) DE69912479T2 (pt)
DK (1) DK1149092T3 (pt)
ES (1) ES2209527T3 (pt)
PT (1) PT1149092E (pt)
TR (1) TR200101747T2 (pt)
WO (1) WO2000035906A2 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
CA2410509A1 (en) 2000-06-02 2001-12-13 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
US6635640B2 (en) 2000-06-30 2003-10-21 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
CN1300116C (zh) 2001-04-16 2007-02-14 卫材株式会社 1h－吲唑化合物
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
US6599902B2 (en) 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
EP1409483B1 (en) 2001-07-23 2008-12-31 Laboratoires Serono SA Arylsulfonamide derivatives as c-jun-n-terminal kinases (jnk's) inhibitors
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
CA2462442A1 (en) 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkyne matrix metalloproteinase inhibitors
US7390797B2 (en) 2002-02-28 2008-06-24 Eisai Co., Ltd. Fused indazole compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US7429609B2 (en) 2002-05-31 2008-09-30 Eisai R & D Management Co., Ltd. Pyrazole compound and medicinal composition containing the same
EP1527070B1 (en) 2002-06-14 2013-01-09 Merck Serono SA Azole methylidene cyanide derivatives and their use as protein kinase modulators
EP1680401A2 (en) 2003-10-24 2006-07-19 Schering Aktiengesellschaft Indolinone derivatives and their use in treating disease-states such as cancer
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
US7803824B2 (en) 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
WO2006090698A1 (ja) * 2005-02-22 2006-08-31 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
CN1939922B (zh) * 2005-09-27 2010-10-13 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物
US7968572B2 (en) 2005-10-03 2011-06-28 Ono Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
FR2962733B1 (fr) 2010-07-13 2012-08-17 Michelin Soc Tech Polymere greffe par des molecules associatives azotees.
FR2962729B1 (fr) 2010-07-13 2012-09-21 Arkema France Molecules porteuses de groupes associatifs
WO2012178015A2 (en) * 2011-06-24 2012-12-27 Zenobia Therapeutics, Inc. Lrrk2 inhibitors
EP3828013B1 (en) 2019-11-27 2023-09-27 Industrial Technology Research Institute Self-powered sensing and transmitting device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9610964D0 (en) * 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
EP0929520B1 (en) * 1996-08-23 2005-11-02 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
EP0984930B1 (en) * 1997-05-07 2005-04-06 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity

Also Published As

Publication number Publication date
AU771599B2 (en) 2004-03-25
CN1147486C (zh) 2004-04-28
DE69912479D1 (de) 2003-12-04
WO2000035906A3 (en) 2000-11-09
CN1331689A (zh) 2002-01-16
CA2354510A1 (en) 2000-06-22
JP2002532490A (ja) 2002-10-02
ATE253062T1 (de) 2003-11-15
TR200101747T2 (tr) 2001-11-21
PT1149092E (pt) 2004-03-31
EP1149092A2 (en) 2001-10-31
AU1507600A (en) 2000-07-03
DK1149092T3 (da) 2004-02-23
WO2000035906A2 (en) 2000-06-22
DE69912479T2 (de) 2004-07-22
KR20010087421A (ko) 2001-09-15
EP1149092B1 (en) 2003-10-29
ES2209527T3 (es) 2004-06-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DA(S) 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1986 DE 27/03/2009.