CN1147486C - 4-和5-炔基羟吲哚和4-和5-烯基羟吲哚 - Google Patents
4-和5-炔基羟吲哚和4-和5-烯基羟吲哚 Download PDFInfo
- Publication number
- CN1147486C CN1147486C CNB998146994A CN99814699A CN1147486C CN 1147486 C CN1147486 C CN 1147486C CN B998146994 A CNB998146994 A CN B998146994A CN 99814699 A CN99814699 A CN 99814699A CN 1147486 C CN1147486 C CN 1147486C
- Authority
- CN
- China
- Prior art keywords
- dihydro
- methylene
- indol
- pyrrol
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11258998P | 1998-12-17 | 1998-12-17 | |
| US14148299P | 1999-06-29 | 1999-06-29 | |
| US60/141,482 | 1999-06-29 | ||
| US60/112,589 | 1999-06-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1331689A CN1331689A (zh) | 2002-01-16 |
| CN1147486C true CN1147486C (zh) | 2004-04-28 |
Family
ID=26810125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB998146994A Expired - Fee Related CN1147486C (zh) | 1998-12-17 | 1999-12-07 | 4-和5-炔基羟吲哚和4-和5-烯基羟吲哚 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1149092B1 (https=) |
| JP (1) | JP2002532490A (https=) |
| KR (1) | KR20010087421A (https=) |
| CN (1) | CN1147486C (https=) |
| AT (1) | ATE253062T1 (https=) |
| AU (1) | AU771599B2 (https=) |
| BR (1) | BR9916272A (https=) |
| CA (1) | CA2354510A1 (https=) |
| DE (1) | DE69912479T2 (https=) |
| DK (1) | DK1149092T3 (https=) |
| ES (1) | ES2209527T3 (https=) |
| PT (1) | PT1149092E (https=) |
| TR (1) | TR200101747T2 (https=) |
| WO (1) | WO2000035906A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| JP2003535847A (ja) | 2000-06-02 | 2003-12-02 | スージェン・インコーポレーテッド | 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体 |
| JP2004502686A (ja) | 2000-06-30 | 2004-01-29 | スージェン・インコーポレーテッド | ４−ヘテロアリール−３−ヘテロアリーリデニル−２−インドリノンおよび蛋白質キナーゼ阻害剤としてのその使用 |
| CN1300116C (zh) | 2001-04-16 | 2007-02-14 | 卫材株式会社 | 1h－吲唑化合物 |
| US7018999B2 (en) | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
| AU2002303892A1 (en) | 2001-05-30 | 2002-12-09 | Jingrong Cui | 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| ES2318041T3 (es) | 2001-07-23 | 2009-05-01 | Laboratoires Serono Sa | Derivados de arilsulfonamida como inhibidores de c-jun quinasas (jnk) n-terminales. |
| BR0213233A (pt) | 2001-10-12 | 2005-01-04 | Warner Lambert Co | Alcinos inibidores de metaloproteinase de matriz |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| DE60332215D1 (de) | 2002-02-28 | 2010-06-02 | Eisai R&D Man Co Ltd | Neue indazolverbindungen mit kondensiertem ring |
| US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| CA2482838A1 (en) | 2002-05-31 | 2003-12-11 | Eisai Co., Ltd. | Pyrazole compounds and pharmaceutical compositions containing the compound |
| EP1527070B1 (en) | 2002-06-14 | 2013-01-09 | Merck Serono SA | Azole methylidene cyanide derivatives and their use as protein kinase modulators |
| JP2007509173A (ja) | 2003-10-24 | 2007-04-12 | シエーリング アクチエンゲゼルシャフト | インドリノン誘導体類及び疾病状態、例えば癌の処理へのそれらの使用 |
| DE102004012070A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
| US7803824B2 (en) | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20060094753A1 (en) | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| WO2006090698A1 (ja) * | 2005-02-22 | 2006-08-31 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| CN1939922B (zh) * | 2005-09-27 | 2010-10-13 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物 |
| RU2008112691A (ru) | 2005-10-03 | 2009-10-10 | Оно Фармасьютикал Ко., Лтд. (Jp) | Азотсодержащее гетероциклическое соединение и его фармацевтическое применение |
| FR2962733B1 (fr) | 2010-07-13 | 2012-08-17 | Michelin Soc Tech | Polymere greffe par des molecules associatives azotees. |
| FR2962729B1 (fr) | 2010-07-13 | 2012-09-21 | Arkema France | Molecules porteuses de groupes associatifs |
| WO2012178015A2 (en) * | 2011-06-24 | 2012-12-27 | Zenobia Therapeutics, Inc. | Lrrk2 inhibitors |
| EP3828013B1 (en) | 2019-11-27 | 2023-09-27 | Industrial Technology Research Institute | Self-powered sensing and transmitting device |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| GB9507298D0 (en) * | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB9610964D0 (en) * | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| WO1998007695A1 (en) * | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| EP0984930B1 (en) * | 1997-05-07 | 2005-04-06 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
-
1999
- 1999-12-07 PT PT99957341T patent/PT1149092E/pt unknown
- 1999-12-07 WO PCT/EP1999/009578 patent/WO2000035906A2/en not_active Ceased
- 1999-12-07 DK DK99957341T patent/DK1149092T3/da active
- 1999-12-07 CN CNB998146994A patent/CN1147486C/zh not_active Expired - Fee Related
- 1999-12-07 KR KR1020017007552A patent/KR20010087421A/ko not_active Ceased
- 1999-12-07 CA CA002354510A patent/CA2354510A1/en not_active Abandoned
- 1999-12-07 EP EP99957341A patent/EP1149092B1/en not_active Expired - Lifetime
- 1999-12-07 DE DE69912479T patent/DE69912479T2/de not_active Expired - Fee Related
- 1999-12-07 AU AU15076/00A patent/AU771599B2/en not_active Ceased
- 1999-12-07 AT AT99957341T patent/ATE253062T1/de not_active IP Right Cessation
- 1999-12-07 BR BR9916272-5A patent/BR9916272A/pt not_active IP Right Cessation
- 1999-12-07 JP JP2000588166A patent/JP2002532490A/ja active Pending
- 1999-12-07 TR TR2001/01747T patent/TR200101747T2/xx unknown
- 1999-12-07 ES ES99957341T patent/ES2209527T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE253062T1 (de) | 2003-11-15 |
| CA2354510A1 (en) | 2000-06-22 |
| AU771599B2 (en) | 2004-03-25 |
| BR9916272A (pt) | 2001-09-04 |
| KR20010087421A (ko) | 2001-09-15 |
| WO2000035906A3 (en) | 2000-11-09 |
| EP1149092B1 (en) | 2003-10-29 |
| ES2209527T3 (es) | 2004-06-16 |
| PT1149092E (pt) | 2004-03-31 |
| WO2000035906A2 (en) | 2000-06-22 |
| CN1331689A (zh) | 2002-01-16 |
| DK1149092T3 (da) | 2004-02-23 |
| DE69912479T2 (de) | 2004-07-22 |
| JP2002532490A (ja) | 2002-10-02 |
| AU1507600A (en) | 2000-07-03 |
| EP1149092A2 (en) | 2001-10-31 |
| TR200101747T2 (tr) | 2001-11-21 |
| DE69912479D1 (de) | 2003-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040428 Termination date: 20100107 |