JP2002532490A - ４−および５−アルキニルオキシンドールと４−および５−アルケニルオキシンドール - Google Patents

４−および５−アルキニルオキシンドールと４−および５−アルケニルオキシンドール

Info

Publication number
JP2002532490A
JP2002532490A JP2000588166A JP2000588166A JP2002532490A JP 2002532490 A JP2002532490 A JP 2002532490A JP 2000588166 A JP2000588166 A JP 2000588166A JP 2000588166 A JP2000588166 A JP 2000588166A JP 2002532490 A JP2002532490 A JP 2002532490A
Authority
JP
Japan
Prior art keywords
dihydro
methylene
pyrrol
indol
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000588166A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002532490A5 (https=
Inventor
ルーク，キン−チュン
イー． マハニー，ペイジ
グレゴリー ミスチュク，スティーブン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2002532490A publication Critical patent/JP2002532490A/ja
Publication of JP2002532490A5 publication Critical patent/JP2002532490A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2000588166A 1998-12-17 1999-12-07 ４−および５−アルキニルオキシンドールと４−および５−アルケニルオキシンドール Pending JP2002532490A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11258998P 1998-12-17 1998-12-17
US60/112,589 1998-12-17
US14148299P 1999-06-29 1999-06-29
US60/141,482 1999-06-29
PCT/EP1999/009578 WO2000035906A2 (en) 1998-12-17 1999-12-07 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles

Publications (2)

Publication Number Publication Date
JP2002532490A true JP2002532490A (ja) 2002-10-02
JP2002532490A5 JP2002532490A5 (https=) 2007-08-16

Family

ID=26810125

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000588166A Pending JP2002532490A (ja) 1998-12-17 1999-12-07 ４−および５−アルキニルオキシンドールと４−および５−アルケニルオキシンドール

Country Status (14)

Country Link
EP (1) EP1149092B1 (https=)
JP (1) JP2002532490A (https=)
KR (1) KR20010087421A (https=)
CN (1) CN1147486C (https=)
AT (1) ATE253062T1 (https=)
AU (1) AU771599B2 (https=)
BR (1) BR9916272A (https=)
CA (1) CA2354510A1 (https=)
DE (1) DE69912479T2 (https=)
DK (1) DK1149092T3 (https=)
ES (1) ES2209527T3 (https=)
PT (1) PT1149092E (https=)
TR (1) TR200101747T2 (https=)
WO (1) WO2000035906A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006090698A1 (ja) * 2005-02-22 2006-08-31 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
JP2007528884A (ja) * 2004-03-12 2007-10-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なシクロアルキル含有５−アシルインドリノン、その製法及びその医薬品としての使用

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2003535847A (ja) 2000-06-02 2003-12-02 スージェン・インコーポレーテッド 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体
WO2002002551A1 (en) * 2000-06-30 2002-01-10 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
CN1300116C (zh) 2001-04-16 2007-02-14 卫材株式会社 1h－吲唑化合物
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
US6599902B2 (en) 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
JP4414219B2 (ja) 2001-07-23 2010-02-10 メルク セローノ ソシエテ アノニム Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）インヒビターとしてのアリールスルホンアミド誘導体
EP1434585A1 (en) * 2001-10-12 2004-07-07 Warner-Lambert Company LLC Alkyne matrix metalloproteinase inhibitors
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
ATE465153T1 (de) 2002-02-28 2010-05-15 Eisai R&D Man Co Ltd Neue indazolverbindungen mit kondensiertem ring
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US7429609B2 (en) 2002-05-31 2008-09-30 Eisai R & D Management Co., Ltd. Pyrazole compound and medicinal composition containing the same
WO2003106455A1 (en) 2002-06-14 2003-12-24 Applied Research Systems Ars Holding N.V. Azole methylidene cyanide derivatives and their use as protein kinase modulators
RU2006117635A (ru) 2003-10-24 2007-12-10 Шеринг Акциенгезельшафт (De) Производные индолинона и их применение для лечения патологических состояний, таких как злокачественное новообразование
US7803824B2 (en) 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
CN1939922B (zh) * 2005-09-27 2010-10-13 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物
US7968572B2 (en) 2005-10-03 2011-06-28 Ono Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
FR2962729B1 (fr) 2010-07-13 2012-09-21 Arkema France Molecules porteuses de groupes associatifs
FR2962733B1 (fr) 2010-07-13 2012-08-17 Michelin Soc Tech Polymere greffe par des molecules associatives azotees.
US20140205537A1 (en) * 2011-06-24 2014-07-24 Zenobia Therapeutics, Inc. Lrrk2 inhibitors
CN214057141U (zh) 2019-11-27 2021-08-27 财团法人工业技术研究院 发电感测传输装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007695A1 (en) * 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
WO1998050356A1 (en) * 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9610964D0 (en) * 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007695A1 (en) * 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
WO1998050356A1 (en) * 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528884A (ja) * 2004-03-12 2007-10-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なシクロアルキル含有５−アシルインドリノン、その製法及びその医薬品としての使用
WO2006090698A1 (ja) * 2005-02-22 2006-08-31 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途

Also Published As

Publication number Publication date
EP1149092B1 (en) 2003-10-29
WO2000035906A2 (en) 2000-06-22
WO2000035906A3 (en) 2000-11-09
CN1147486C (zh) 2004-04-28
PT1149092E (pt) 2004-03-31
ATE253062T1 (de) 2003-11-15
ES2209527T3 (es) 2004-06-16
AU771599B2 (en) 2004-03-25
BR9916272A (pt) 2001-09-04
CN1331689A (zh) 2002-01-16
TR200101747T2 (tr) 2001-11-21
AU1507600A (en) 2000-07-03
EP1149092A2 (en) 2001-10-31
DE69912479D1 (de) 2003-12-04
KR20010087421A (ko) 2001-09-15
DK1149092T3 (da) 2004-02-23
DE69912479T2 (de) 2004-07-22
CA2354510A1 (en) 2000-06-22

Similar Documents

Publication Publication Date Title
JP2002532490A (ja) ４−および５−アルキニルオキシンドールと４−および５−アルケニルオキシンドール
US6307056B1 (en) 4-aryloxindoles
KR100738165B1 (ko) 헤테로방향족 카르복사미드 유도체 및 ｉｋｋ-2 효소억제제로서의 용도
JP3746680B2 (ja) Ｃｄｋ２阻害剤としてのピラゾロベンゾジアゼピン
US5874427A (en) Substituted heteroaromatic 5-HT1F agonists
US6252086B1 (en) 4-alkenyl-and 4-alkynyloxindoles
PL180027B1 (pl) Nowe zwiazki, skondensowane pirolokarboksyanilidy, bedace nowa klasa ligandów receptora mózgowego GABA PL PL PL PL PL PL PL PL
AU2007334416A1 (en) Imidazoles as aldosterone synthase inhibitors
JP2000509719A (ja) 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
CN110337433B (zh) 用于调节sgk活性的化合物和药物组合物及其方法
US5792766A (en) Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
US6221867B1 (en) 4,5-pyrazinoxindoles
KR20040047946A (ko) 2환식 화합물
KR20040104613A (ko) 인터루킨-4 유전자 발현 억제제로서의 3-치환된아미노-1η-인돌-2-카복실산 및 3-치환된아미노-벤조티오펜-2-카복실산 유도체
JP2006515355A (ja) 酵素ｉｋｋ−２阻害剤としてのチオフェンカルボキサミド
US6313310B1 (en) 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
MXPA01006049A (en) 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles
TW202417429A (zh) 用於抑制yap-tead交互作用的新穎雜雙環化合物及包含其之藥學組成物
ZA200104281B (en) 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles.
CN114276338B (zh) 2-吡唑-3-苯并咪唑衍生物及其制备方法和应用
MXPA01006141A (en) 4-aryloxindoles as inhibitors of jnk protein kinases
ZA200104320B (en) 4-Aryloxindoles as inhibitors of JNK protein kinases.

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20061207

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061207

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20070702

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100622

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20101130