DE69839071T2 - Adenovirale vektoren spezifisch für zellen, welche alpha-fetoprotein exprimieren, sowie methoden zu deren verwendung - Google Patents
Adenovirale vektoren spezifisch für zellen, welche alpha-fetoprotein exprimieren, sowie methoden zu deren verwendung Download PDFInfo
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- DE69839071T2 DE69839071T2 DE69839071T DE69839071T DE69839071T2 DE 69839071 T2 DE69839071 T2 DE 69839071T2 DE 69839071 T DE69839071 T DE 69839071T DE 69839071 T DE69839071 T DE 69839071T DE 69839071 T2 DE69839071 T2 DE 69839071T2
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| PCT/US1998/004084 WO1998039465A2 (en) | 1997-03-03 | 1998-03-03 | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
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| US5998205A (en) | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| US20020068049A1 (en) * | 1998-09-10 | 2002-06-06 | Henderson Daniel R. | Tissue specific adenoviral vectors |
| US7011976B1 (en) * | 1997-03-03 | 2006-03-14 | Calydon, Inc. | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| US7001764B2 (en) * | 1995-06-27 | 2006-02-21 | Cell Genesys, Inc. | Compositions comprising tissue specific adenoviral vectors |
| US6254862B1 (en) * | 1997-03-03 | 2001-07-03 | Calydon, Inc. | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| US6676935B2 (en) * | 1995-06-27 | 2004-01-13 | Cell Genesys, Inc. | Tissue specific adenoviral vectors |
| US20060165658A1 (en) * | 1997-03-03 | 2006-07-27 | Little Andrew S | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| ATE376062T1 (de) * | 1997-08-04 | 2007-11-15 | Cell Genesys Inc | Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung |
| US6900049B2 (en) * | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
| WO2000029599A1 (en) * | 1998-11-18 | 2000-05-25 | Canji, Inc. | Viral vectors with late transgene expression |
| US6495130B1 (en) * | 1998-12-30 | 2002-12-17 | Calydon, Inc. | Target cell-specific adenoviral vectors containing E3 and methods of use thereof |
| US20060024273A1 (en) * | 1998-12-30 | 2006-02-02 | Henderson Daniel R | Target cell-specific adenoviral vectors containing E3 and methods of use thereof |
| US7589069B1 (en) * | 1999-07-12 | 2009-09-15 | Saint Louis University | Replication-competent anti-cancer vectors |
| US6627190B2 (en) * | 1999-07-12 | 2003-09-30 | Saint Louis University | Recombinant adenovirus vectors that are replication-competent in tert-expressing cells |
| AU1071701A (en) | 1999-09-29 | 2001-04-30 | Trustees Of The University Of Pennsylvania, The | Methods for rapid peg-modification of viral vectors, compositions for enhanced gene transduction, compositions with enhanced physical stability, and uses therefor |
| CA2403795A1 (en) * | 2000-03-21 | 2001-09-27 | The University Of Virginia Patent Foundation | Osteocalcin promoter directed adenovirus replicaton for therapy |
| US6692736B2 (en) | 2000-03-24 | 2004-02-17 | Cell Genesys, Inc. | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
| ATE419338T1 (de) | 2000-03-24 | 2009-01-15 | Cell Genesys Inc | Menschliche zellspezifische urotheliale regulatorische sequenzen der transkription des uroplakins, dessen vektoren und verwendungsverfahren |
| US6911200B2 (en) * | 2000-03-24 | 2005-06-28 | Cell Genesys, Inc. | Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation |
| US7048920B2 (en) | 2000-03-24 | 2006-05-23 | Cell Genesys, Inc. | Recombinant oncolytic adenovirus for human melanoma |
| US6673614B2 (en) | 2000-06-27 | 2004-01-06 | Cell Genesys, Inc. | Rapid methods and kits for detection and semi-quantitation of anti-adenovirus antibody |
| AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| WO2002068627A2 (en) * | 2001-02-23 | 2002-09-06 | Novartis Ag | Vector constucts |
| CA2463816C (en) | 2001-10-19 | 2014-07-08 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
| US20030086903A1 (en) * | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
| EP1605053A1 (en) * | 2002-03-26 | 2005-12-14 | Oncolytics Biotech Inc. | Use of adenoviruses mutated in the VA genes for cancer treatment |
| US7364727B2 (en) * | 2002-07-22 | 2008-04-29 | Cell Genesys, Inc. | Metastatic colon cancer specific promoter and uses thereof |
| RU2393221C2 (ru) * | 2002-10-15 | 2010-06-27 | Пер Сонне ХОЛЬМ | Аденовирус с обращенной генной экспрессией и его применение |
| WO2005017149A1 (en) * | 2003-06-03 | 2005-02-24 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| US20050136035A1 (en) * | 2003-06-03 | 2005-06-23 | Derek Ko | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site |
| US20050186178A1 (en) * | 2003-08-28 | 2005-08-25 | Ennist David L. | Oncolytic adenoviral vectors encoding GM-CSF |
| CN100420742C (zh) * | 2003-09-29 | 2008-09-24 | 中国人民解放军军事医学科学院基础医学研究所 | 一种肝癌靶向性溶瘤腺病毒，其制备方法及用途 |
| US7482156B2 (en) | 2003-10-15 | 2009-01-27 | Cell Genesys, Inc. | Hepatocellular carcinoma specific promoter and uses thereof |
| DE602004025726D1 (de) * | 2003-11-14 | 2010-04-08 | Genvec Inc | Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc). |
| US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
| ES2292271B1 (es) * | 2004-05-20 | 2009-02-16 | Proyecto De Biomedicina Cima, S.L. | Un vector hibrido adenovirus-alfavirus para la administracion eficaz y expresion de genes terapeuticos en celulas tumorales. |
| TWI293307B (en) * | 2004-09-30 | 2008-02-11 | Ind Tech Res Inst | A liver-specific chimeric regulatory sequence and use thereof |
| DE102005055128B4 (de) * | 2005-11-15 | 2015-04-02 | Universität Rostock | Viraler Vektor, dessen Verwendung zur Therapie von Leberzellkarzinomen und pharmazeutische Mittel umfassend den Vektor |
| EP1900749A1 (en) * | 2006-09-12 | 2008-03-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nucleic acids for expressing a polynucleotide of interest in mammalian cancer cells |
| US20080089890A1 (en) * | 2006-09-29 | 2008-04-17 | Canji, Inc. | Methods of polypeptide production |
| CN102268457B (zh) * | 2007-04-23 | 2013-06-26 | 深圳益世康宁生物科技有限公司 | 一种afp重组腺相关病毒载体及其构建方法与应用 |
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| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
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| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9605844B2 (en) * | 2009-09-01 | 2017-03-28 | Cree, Inc. | Lighting device with heat dissipation elements |
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| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| JP2686819B2 (ja) | 1989-05-01 | 1997-12-08 | 雪印乳業株式会社 | α―フェトプロテイン遺伝子のエンハンサーに結合する蛋白質をコードするＤＮＡ |
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-
1998
- 1998-03-02 US US09/033,428 patent/US6254862B1/en not_active Expired - Fee Related
- 1998-03-03 AT AT98908871T patent/ATE385256T1/de not_active IP Right Cessation
- 1998-03-03 EP EP98908871A patent/EP0972063B1/en not_active Expired - Lifetime
- 1998-03-03 DE DE69839071T patent/DE69839071T2/de not_active Expired - Fee Related
- 1998-03-03 JP JP53867698A patent/JP2002516568A/ja not_active Ceased
- 1998-03-03 CN CNB988043890A patent/CN100390292C/zh not_active Expired - Fee Related
- 1998-03-03 AU AU66796/98A patent/AU745560B2/en not_active Ceased
- 1998-03-03 WO PCT/US1998/004084 patent/WO1998039465A2/en not_active Ceased
- 1998-03-03 KR KR1019997008005A patent/KR20000075924A/ko not_active Ceased
- 1998-03-03 CA CA002282706A patent/CA2282706C/en not_active Expired - Fee Related
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2001
- 2001-07-02 US US09/898,883 patent/US6585968B2/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CA2282706C (en) | 2008-07-22 |
| WO1998039465A3 (en) | 1998-12-10 |
| EP0972063A2 (en) | 2000-01-19 |
| AU745560B2 (en) | 2002-03-21 |
| US6254862B1 (en) | 2001-07-03 |
| EP0972063B1 (en) | 2008-01-30 |
| US20020164799A1 (en) | 2002-11-07 |
| US6585968B2 (en) | 2003-07-01 |
| WO1998039465A2 (en) | 1998-09-11 |
| CN1252840A (zh) | 2000-05-10 |
| CN100390292C (zh) | 2008-05-28 |
| DE69839071D1 (de) | 2008-03-20 |
| KR20000075924A (ko) | 2000-12-26 |
| JP2002516568A (ja) | 2002-06-04 |
| ATE385256T1 (de) | 2008-02-15 |
| CA2282706A1 (en) | 1998-09-11 |
| AU6679698A (en) | 1998-09-22 |
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