DE69837615D1 - Verfahren zur herstellung von oxazolidinonen - Google Patents

Verfahren zur herstellung von oxazolidinonen

Info

Publication number
DE69837615D1
DE69837615D1 DE69837615T DE69837615T DE69837615D1 DE 69837615 D1 DE69837615 D1 DE 69837615D1 DE 69837615 T DE69837615 T DE 69837615T DE 69837615 T DE69837615 T DE 69837615T DE 69837615 D1 DE69837615 D1 DE 69837615D1
Authority
DE
Germany
Prior art keywords
production
oxazolidinones
viiia
processes
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69837615T
Other languages
English (en)
Other versions
DE69837615T2 (de
Inventor
Bruce A Pearlman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22057971&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69837615(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of DE69837615D1 publication Critical patent/DE69837615D1/de
Application granted granted Critical
Publication of DE69837615T2 publication Critical patent/DE69837615T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE69837615T 1997-11-07 1998-10-13 Verfahren zur herstellung von oxazolidinonen Expired - Fee Related DE69837615T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6473897P 1997-11-07 1997-11-07
US64738P 1997-11-07
PCT/US1998/020934 WO1999024393A1 (en) 1997-11-07 1998-10-13 Process to produce oxazolidinones

Publications (2)

Publication Number Publication Date
DE69837615D1 true DE69837615D1 (de) 2007-05-31
DE69837615T2 DE69837615T2 (de) 2007-12-27

Family

ID=22057971

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69837615T Expired - Fee Related DE69837615T2 (de) 1997-11-07 1998-10-13 Verfahren zur herstellung von oxazolidinonen

Country Status (29)

Country Link
US (8) US6107519A (de)
EP (2) EP1028940B1 (de)
JP (1) JP2001522828A (de)
KR (2) KR100580408B1 (de)
CN (2) CN101353313A (de)
AT (1) ATE359994T1 (de)
AU (1) AU748128B2 (de)
BG (1) BG64794B1 (de)
BR (1) BR9813187A (de)
CA (2) CA2634657A1 (de)
CY (1) CY1106611T1 (de)
CZ (1) CZ20001613A3 (de)
DE (1) DE69837615T2 (de)
DK (1) DK1028940T3 (de)
EE (1) EE04370B1 (de)
ES (1) ES2284216T3 (de)
HK (1) HK1030938A1 (de)
HU (1) HUP0004388A3 (de)
IL (2) IL135912A (de)
IS (2) IS5431A (de)
NO (2) NO20002373L (de)
NZ (1) NZ504372A (de)
PL (1) PL199355B1 (de)
PT (1) PT1028940E (de)
RU (1) RU2205822C2 (de)
SK (1) SK286569B6 (de)
TR (1) TR200001199T2 (de)
TW (2) TWI250155B (de)
WO (1) WO1999024393A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK18362000A3 (sk) 1998-06-05 2001-06-11 Astrazeneca Ab Oxazolidinónové deriváty, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6444813B2 (en) 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
AR027261A1 (es) * 2000-02-02 2003-03-19 Upjohn Co Linezolid forma cristalina ii
US6514529B2 (en) 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
MY127336A (en) 2000-03-22 2006-11-30 Upjohn Co Container for linezolid iv solution
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6544991B2 (en) 2000-06-30 2003-04-08 Pharmacia & Upjohn Company Compositions and methods for treating bacterial infections
PE20020300A1 (es) 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
AU2002224421A1 (en) * 2000-10-17 2002-04-29 Pharmacia And Upjohn Company Methods of producing oxazolidinone compounds
EP1380121B1 (de) * 2001-04-20 2007-09-26 Pharmacia & Upjohn Company LLC Verfahren zur herstellung von oxazolidinonen
MXPA04008171A (es) 2002-02-22 2004-11-26 Pharmacia Corp Formulacion oftalmica con sistema de goma.
DE60303167T2 (de) 2002-09-25 2006-09-14 Daiso Co., Ltd. Verfahren zur Herstellung von Glycidylphthalimid
DE09163348T1 (de) 2003-10-16 2010-01-07 Symed Labs Ltd., Hyderabad Kristalline Form von Linezolid
US7186844B2 (en) * 2004-01-13 2007-03-06 Mitsubishi Gas Chemical Co., Inc. Method for producing cyclic carbamate ester
PL1737850T3 (pl) 2004-04-19 2008-02-29 Symed Labs Ltd Nowy sposób wytwarzania linezolidu i związków pokrewnych
PL1768967T3 (pl) 2004-07-20 2009-09-30 Symed Labs Ltd Nowe związki pośrednie do wytwarzania linezolidu oraz związki pokrewne
SE0402200D0 (sv) * 2004-09-13 2004-09-13 Astrazeneca Ab New process II
EP2007740A1 (de) * 2006-04-07 2008-12-31 Pfizer Products Incorporated Verfahren zur herstellung von linezolid
CA2697147A1 (en) * 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
EP2033960A3 (de) 2007-09-04 2009-04-29 Dipharma Francis S.r.l. Kristalline Linezolidhydratform und Linezolidsalze
ITMI20072359A1 (it) * 2007-12-18 2009-06-19 Dipharma Francis Srl Procedimento per la preparazione di derivati ossazolidinonici
EP2163547A1 (de) 2008-09-16 2010-03-17 Unión Químico Farmacéutica, S.A. (UQUIFA) Verfahren für die Herstellung eines antibakteriellen Oxazolidinon-Wirkstoffs und Zwischenprodukte davon
CN101774978B (zh) 2009-01-13 2011-09-21 联化科技股份有限公司 一种利奈唑胺的制备方法及其中间体
CA2785620A1 (en) 2009-12-26 2011-06-30 Alembic Pharmaceuticals Limited Process for the preparation of linezolid
US20110232588A1 (en) * 2010-03-26 2011-09-29 Msp Corporation Integrated system for vapor generation and thin film deposition
SG185103A1 (en) 2010-04-30 2012-12-28 Univ Indiana Res & Tech Corp Processes for preparing linezolid
CN103140487A (zh) 2010-08-11 2013-06-05 斯索恩有限公司 制备利奈唑胺的方法
EP2603506A1 (de) 2010-08-11 2013-06-19 Synthon BV Verfahren zur herstellung von linezolid
CA2816515A1 (en) 2010-11-03 2012-05-10 Wockhardt Limited Process for the preparation of phosphoric acid mono-(1-{4-[(s)-5-(acetylaminomethyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethylpiperidin-4-yl) ester
WO2012114354A1 (en) 2011-02-24 2012-08-30 Lee Pharma Limited Anhydrous linezolid crystalline form-ii
CN102731336B (zh) 2011-04-12 2014-05-07 浙江医药股份有限公司新昌制药厂 利奈唑胺中间体及合成利奈唑胺的方法
CN102731341A (zh) * 2011-04-13 2012-10-17 上海医药工业研究院 用于制备利奈唑胺的中间体及其制备方法
CN102267955A (zh) * 2011-06-02 2011-12-07 山东鲁抗医药股份有限公司 一种利奈唑胺的制备方法
WO2013072923A1 (en) 2011-09-19 2013-05-23 Cadila Healthcare Limited Process for the preparation of crystalline linezolid
US20150025236A1 (en) 2012-01-24 2015-01-22 Jubilant Life Sciences Limited Process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent
CN103254148B (zh) * 2012-02-15 2016-04-13 浙江海正药业股份有限公司 利奈唑胺中间体的制备方法
EP2838897A1 (de) 2012-04-16 2015-02-25 Ranbaxy Laboratories Limited Verfahren zur herstellung von rivaroxaban und zwischenprodukten davon
EP2855465A1 (de) 2012-05-24 2015-04-08 Ranbaxy Laboratories Limited Verfahren zur herstellung von rivaroxaban
CN103626712B (zh) * 2012-08-23 2016-06-01 重庆药友制药有限责任公司 一种用于制备利奈唑胺的中间体及其制备方法
ES2603252T3 (es) 2012-11-09 2017-02-24 Synthon Bv Proceso para preparar linezolid
WO2014141067A2 (en) 2013-03-14 2014-09-18 Benova Labs Pvt Limited Process for the preparation of oxazolidinone derivatives
CN103483294B (zh) * 2013-08-12 2015-01-28 四川大学 3-氨基-2-丙醇乙酰胺类化合物的盐、其制备方法和用途
IN2013MU03508A (de) 2013-11-06 2015-07-24 Unimark Remedies Ltd
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
WO2016150937A1 (en) 2015-03-25 2016-09-29 Lonza Ltd Method for preparation of thiophenecarbonyl chlorides
KR101880881B1 (ko) 2015-11-04 2018-07-20 론자 리미티드 옥살릴 클로라이드를 사용하는 티오펜-2-카보닐 클로라이드의 제조 방법
US9643939B1 (en) 2016-04-18 2017-05-09 Optimus Drugs Private Limited Process for the preparation of linezolid
USRE47606E1 (en) 2016-04-21 2019-09-17 Optimus Drugs Private Limited Process for the preparation of linezolid
RU2766082C9 (ru) 2016-04-21 2022-02-22 Оптимус Драгс Пвт Лтд Улучшенный процесс получения линезолида
CN108440382B (zh) * 2018-04-03 2020-02-21 浙江永太科技股份有限公司 一种s-n-缩水甘油邻苯二甲酰亚胺的制备方法
CN111574384B (zh) * 2020-06-12 2021-03-16 上海馨远医药科技有限公司 一种手性1-氨基-2-丙醇的制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2432905A (en) * 1943-01-04 1947-12-16 Lilly Co Eli N-substituted phthalimides and their synthesis
GB1180089A (en) * 1967-10-20 1970-02-04 Delalande Sa Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
DE2720915C2 (de) * 1977-05-10 1986-04-17 Kali-Chemie Pharma Gmbh, 3000 Hannover N↓1↓-Acyl-2-hydroxy-1,3-diaminopropane und Arzneimittel mit diesen Verbindungen als Wirkstoff
ES469020A1 (es) * 1977-05-10 1979-09-01 Kali Chemie Pharma Gmbh Procedimiento para la preparacion de nuevos 1-acil-2-hidroxi-1,3-diaminopropanos
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
JPS55133357A (en) * 1979-04-02 1980-10-17 Seitetsu Kagaku Co Ltd Preparation of 1-cyano-2-hydroxy-3-phthalimidopropane
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
US5182296A (en) * 1989-10-26 1993-01-26 Tanabe Seiyaky Co., Ltd. Naphthyloxazolidone derivatives
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
FR2678271B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
EP0610265B1 (de) * 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituierte aryl- und heteroaryl-phenyloxazolidinone
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
CA2146130C (en) * 1992-10-15 2004-06-08 Donald John Gerhart Antifouling coating composition and method
WO1994013649A1 (en) * 1992-12-08 1994-06-23 The Upjohn Company Tropone-substituted phenyloxazolidinone antibacterial agents
US5608110A (en) 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
FR2735475B1 (fr) * 1995-06-13 1997-07-11 Synthelabo Derives de n-((1,4-diazabicyclo(2.2.2)oct-2-yl)methyl) benzamide, leur preparation et leur application en therapeutique
DE19604223A1 (de) * 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone

Also Published As

Publication number Publication date
PL199355B1 (pl) 2008-09-30
EE200000210A (et) 2001-04-16
US20040006238A1 (en) 2004-01-08
US6613944B2 (en) 2003-09-02
US20030130509A1 (en) 2003-07-10
EP1028940B1 (de) 2007-04-18
TWI250155B (en) 2006-03-01
KR20010031859A (ko) 2001-04-16
TR200001199T2 (tr) 2000-08-21
KR100580408B1 (ko) 2006-05-16
HUP0004388A2 (hu) 2001-04-28
ATE359994T1 (de) 2007-05-15
NO20002373D0 (no) 2000-05-05
US6716980B2 (en) 2004-04-06
SK286569B6 (sk) 2009-01-07
US6563003B2 (en) 2003-05-13
IL135912A0 (en) 2001-05-20
BG64794B1 (bg) 2006-04-28
EP1028940A1 (de) 2000-08-23
TW555752B (en) 2003-10-01
NO20002373L (no) 2000-05-05
KR20050117589A (ko) 2005-12-14
US20020095054A1 (en) 2002-07-18
IS5431A (is) 2000-04-06
DE69837615T2 (de) 2007-12-27
EE04370B1 (et) 2004-10-15
NZ504372A (en) 2002-12-20
US6107519A (en) 2000-08-22
US6740754B2 (en) 2004-05-25
US6362334B1 (en) 2002-03-26
CN101353313A (zh) 2009-01-28
WO1999024393A1 (en) 1999-05-20
ES2284216T3 (es) 2007-11-01
IL159740A (en) 2006-06-11
IS8754A (is) 2008-07-29
US20030216572A1 (en) 2003-11-20
US6410788B1 (en) 2002-06-25
US6492555B2 (en) 2002-12-10
US20020032348A1 (en) 2002-03-14
PL340657A1 (en) 2001-02-12
CA2634657A1 (en) 1999-05-20
AU1067299A (en) 1999-05-31
AU748128B2 (en) 2002-05-30
KR100619639B1 (ko) 2006-09-06
SK6192000A3 (en) 2000-11-07
TW200304440A (en) 2003-10-01
HK1030938A1 (en) 2001-05-25
CA2304100A1 (en) 1999-05-20
PT1028940E (pt) 2007-06-25
US20030065219A1 (en) 2003-04-03
DK1028940T3 (da) 2007-07-30
CY1106611T1 (el) 2012-01-25
NO20084605L (no) 2000-05-05
BR9813187A (pt) 2000-08-22
CN100387581C (zh) 2008-05-14
IL135912A (en) 2004-12-15
CZ20001613A3 (cs) 2001-12-12
BG104377A (en) 2001-01-31
RU2205822C2 (ru) 2003-06-10
EP1772453A1 (de) 2007-04-11
JP2001522828A (ja) 2001-11-20
HUP0004388A3 (en) 2001-10-29
CN1275122A (zh) 2000-11-29

Similar Documents

Publication Publication Date Title
DE69837615D1 (de) Verfahren zur herstellung von oxazolidinonen
DE69322708T2 (de) Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinen
DE69621297T2 (de) Verfahren zur Herstellung wasserlöslicher organischer Silizium-Verbindungen
DE69418542D1 (de) Verfahren zur Herstellung funktioneller Beschichtungen
DE69407734T2 (de) Verfahren zur Herstellung diamantartiger Beschichtungen
DE69609244D1 (de) Verfahren zur Herstellung diamantartiger Beschichtungen
DE69705896T2 (de) Verfahren zur Herstellung amorphen Paroxetin-Hydrochlorids
DE69931493D1 (de) Verfahren zur herstellung von hydroxymethylthiobuttersäure
DE69939751D1 (de) Verfahren zur Herstellung von S-Aryl-Cystein
ATE234288T1 (de) Verfahren zur herstellung eines buthylthuio- isochinolinderivates und zwischenprodukte dafür
ATE161269T1 (de) Verfahren zur herstellung von peptiden und neue zwischenverbindungen dazu
DE59009951D1 (de) Verfahren zur Herstellung von Zwischenprodukten und zur Synthese von N-(2-Hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine.
ATE154022T1 (de) Verfahren zur herstellung von epibatidin
DE69820172D1 (de) Verfahren zur Herstellung von Zusammensetzungen und diese Zusammensetzungen
DE59502722D1 (de) Verfahren und Zwischenprodukte zur Herstellung von 5-Oxaspiro [2.4] heptan-6-on
DE69616801D1 (de) Eintopfverfahren zur herstellung von 2-oxazolidinonderivate
DE59405089D1 (de) Verfahren zur Herstellung von 4,5-Difluorbenzaldehyden
DE60028998T8 (de) Verfahren zur herstellung einer benzylamin-verbindung
DE69608512D1 (de) Verfahren zur Herstellung von benzylsubstituierten Rhodaninederivaten
DE59707484D1 (de) Verfahren zur Herstellung von 1.4 Bis(aminomethyl) cyclohexan

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee