DE69833106T2 - Antigene fusionsproteine, die gal-alpha-1,3-gal-epitope enthalten. - Google Patents
Antigene fusionsproteine, die gal-alpha-1,3-gal-epitope enthalten. Download PDFInfo
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- DE69833106T2 DE69833106T2 DE69833106T DE69833106T DE69833106T2 DE 69833106 T2 DE69833106 T2 DE 69833106T2 DE 69833106 T DE69833106 T DE 69833106T DE 69833106 T DE69833106 T DE 69833106T DE 69833106 T2 DE69833106 T2 DE 69833106T2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9701127A SE9701127D0 (sv) | 1997-03-26 | 1997-03-26 | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
| SE9701127 | 1997-03-26 | ||
| PCT/SE1998/000555 WO1998042750A1 (en) | 1997-03-26 | 1998-03-26 | ANTIGENIC FUSIONPROTEIN CARRYING GALα1,3GAL EPITOPES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69833106D1 DE69833106D1 (de) | 2006-03-30 |
| DE69833106T2 true DE69833106T2 (de) | 2006-08-31 |
Family
ID=20406335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69833106T Expired - Lifetime DE69833106T2 (de) | 1997-03-26 | 1998-03-26 | Antigene fusionsproteine, die gal-alpha-1,3-gal-epitope enthalten. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6943239B2 (https=) |
| EP (2) | EP0923606B1 (https=) |
| JP (1) | JP4099239B2 (https=) |
| AT (1) | ATE315047T1 (https=) |
| AU (1) | AU751760B2 (https=) |
| BR (1) | BR9804826A (https=) |
| CA (1) | CA2255765A1 (https=) |
| DE (1) | DE69833106T2 (https=) |
| DK (1) | DK0923606T3 (https=) |
| ES (1) | ES2258297T3 (https=) |
| SE (1) | SE9701127D0 (https=) |
| WO (1) | WO1998042750A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4421894B2 (ja) * | 2001-07-20 | 2010-02-24 | アブソーバー アクチボラゲット | 血液型抗原融合ポリペプチドおよびその使用方法 |
| WO2003089450A2 (en) * | 2002-04-22 | 2003-10-30 | Recopharma Ab | Fusion polypeptides and methods for inhibiting microbial adhesion |
| JP2005530493A (ja) * | 2002-04-22 | 2005-10-13 | レコファーマ アーベー | ムチン融合ポリペプチドワクチン、組成物およびそれらの使用方法 |
| JP5183010B2 (ja) * | 2002-05-16 | 2013-04-17 | グリコミメティクス， インコーポレイテッド | セレクチンによって媒介される機能を阻害するための化合物および方法 |
| CA2490703A1 (en) * | 2002-07-03 | 2004-01-15 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
| EP1534748A2 (en) * | 2002-08-09 | 2005-06-01 | Recopharma AB | Fusion proteins and methods of producing same |
| US20050076759A1 (en) * | 2003-10-08 | 2005-04-14 | Brian Westfall | Linear saw with stab-cut bevel capability |
| US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
| WO2005047320A2 (en) * | 2003-11-12 | 2005-05-26 | Wisconsin Alumni Research Foundation | Equine p-selection glycoprotein ligand-1 and uses thereof |
| US20050187171A1 (en) * | 2003-11-19 | 2005-08-25 | Glycomimetics, Inc. | Glycomimetic antagonists for both E-and P-selectins |
| WO2005051920A2 (en) * | 2003-11-19 | 2005-06-09 | Glycomimetics, Inc. | Specific antagonist for both e- and p-selectins |
| WO2006001348A1 (ja) * | 2004-06-23 | 2006-01-05 | Japan Science And Technology Agency | 浸潤抑制及び細胞殺傷剤 |
| US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
| US20090036386A1 (en) * | 2005-05-25 | 2009-02-05 | Glycomimetics, Inc | Heterobifunctional compounds for selectin inhibition |
| EP1928892B1 (en) * | 2005-08-09 | 2011-10-12 | GlycoMimetics, Inc. | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
| SI2264043T1 (en) | 2005-09-02 | 2018-01-31 | Glycomimetics, Inc. | HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS |
| US20070113297A1 (en) * | 2005-09-13 | 2007-05-17 | Yongguang Yang | Methods and compositions for inhibition of immune responses |
| EP2264060B1 (en) * | 2006-01-26 | 2014-04-23 | Recopharma AB | Compositions and methods for inhibiting viral adhesion |
| US20070178447A1 (en) * | 2006-01-31 | 2007-08-02 | Bethyl Laboratories, Inc. | Method for decreasing interference in results of immunochemical methods |
| WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
| WO2008060378A2 (en) | 2006-10-12 | 2008-05-22 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| US7998486B2 (en) | 2006-10-25 | 2011-08-16 | Newlink Genetics Corporation | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes |
| AU2008216794A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines |
| US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| WO2009126556A1 (en) * | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| CN102088983B (zh) * | 2008-06-13 | 2013-01-30 | 糖模拟物有限公司 | 利用选择的糖模拟化合物的血液癌症的治疗 |
| WO2010126888A1 (en) | 2009-05-01 | 2010-11-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| JP2014501748A (ja) * | 2010-12-21 | 2014-01-23 | リコファーマ アーベー | 涙代用物 |
| PT2794626T (pt) | 2011-12-22 | 2018-01-12 | Glycomimetics Inc | Compostos de antagonistas de e-selectina |
| CA2891514C (en) | 2012-12-07 | 2020-08-25 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
| ES2754549T3 (es) | 2014-12-03 | 2020-04-20 | Glycomimetics Inc | Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4 |
| JP2019502727A (ja) | 2016-01-22 | 2019-01-31 | グリコミメティクス， インコーポレイテッド | Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤 |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
| US11072625B2 (en) | 2016-10-07 | 2021-07-27 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| CN111566117A (zh) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
| WO2019173229A1 (en) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| WO2019241386A1 (en) * | 2018-06-12 | 2019-12-19 | Rush University Medical Center | Methods for enhanced endothelialization of implanted material |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69226871T3 (de) * | 1991-06-27 | 2009-09-24 | Bristol-Myers Squibb Co. | CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung |
| DE69333346T2 (de) * | 1992-10-23 | 2004-10-07 | Inst Genetics Llc | Neuartiges p- selectin ligandenprotein |
| JP4038236B2 (ja) * | 1993-03-16 | 2008-01-23 | オースチン・リサーチ・インスティテュート | 異種移植治療におけるブタＧａ１α（１，３）ガラクトシルトランスフェラーゼの使用 |
| GB9517758D0 (en) * | 1995-08-31 | 1995-11-01 | Imutran Ltd | Compositions and their uses |
-
1997
- 1997-03-26 SE SE9701127A patent/SE9701127D0/xx unknown
-
1998
- 1998-03-26 AU AU67551/98A patent/AU751760B2/en not_active Ceased
- 1998-03-26 AT AT98912863T patent/ATE315047T1/de not_active IP Right Cessation
- 1998-03-26 EP EP98912863A patent/EP0923606B1/en not_active Expired - Lifetime
- 1998-03-26 US US09/194,396 patent/US6943239B2/en not_active Expired - Fee Related
- 1998-03-26 ES ES98912863T patent/ES2258297T3/es not_active Expired - Lifetime
- 1998-03-26 DE DE69833106T patent/DE69833106T2/de not_active Expired - Lifetime
- 1998-03-26 EP EP06075010A patent/EP1700868A3/en not_active Withdrawn
- 1998-03-26 BR BR9804826-0A patent/BR9804826A/pt not_active Application Discontinuation
- 1998-03-26 WO PCT/SE1998/000555 patent/WO1998042750A1/en not_active Ceased
- 1998-03-26 JP JP54556998A patent/JP4099239B2/ja not_active Expired - Fee Related
- 1998-03-26 CA CA002255765A patent/CA2255765A1/en not_active Abandoned
- 1998-03-26 DK DK98912863T patent/DK0923606T3/da active
-
2005
- 2005-06-15 US US11/153,082 patent/US20050255099A1/en not_active Abandoned
-
2009
- 2009-07-22 US US12/507,626 patent/US20090286963A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR9804826A (pt) | 2000-01-25 |
| JP2000511782A (ja) | 2000-09-12 |
| EP1700868A3 (en) | 2007-12-12 |
| EP0923606B1 (en) | 2006-01-04 |
| US20050255099A1 (en) | 2005-11-17 |
| CA2255765A1 (en) | 1998-10-01 |
| US6943239B2 (en) | 2005-09-13 |
| DE69833106D1 (de) | 2006-03-30 |
| WO1998042750A1 (en) | 1998-10-01 |
| US20020028205A1 (en) | 2002-03-07 |
| EP0923606A1 (en) | 1999-06-23 |
| DK0923606T3 (da) | 2006-05-22 |
| US20090286963A1 (en) | 2009-11-19 |
| EP1700868A2 (en) | 2006-09-13 |
| ATE315047T1 (de) | 2006-02-15 |
| AU751760B2 (en) | 2002-08-29 |
| AU6755198A (en) | 1998-10-20 |
| JP4099239B2 (ja) | 2008-06-11 |
| SE9701127D0 (sv) | 1997-03-26 |
| ES2258297T3 (es) | 2006-08-16 |
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| 8364 | No opposition during term of opposition |