SE9701127D0 - Antigenic fusionprotein carrying GALal, 3GAL epitopes - Google Patents

Antigenic fusionprotein carrying GALal, 3GAL epitopes

Info

Publication number
SE9701127D0
SE9701127D0 SE9701127A SE9701127A SE9701127D0 SE 9701127 D0 SE9701127 D0 SE 9701127D0 SE 9701127 A SE9701127 A SE 9701127A SE 9701127 A SE9701127 A SE 9701127A SE 9701127 D0 SE9701127 D0 SE 9701127D0
Authority
SE
Sweden
Prior art keywords
polypeptide
galal
fusion protein
plasma
blood
Prior art date
Application number
SE9701127A
Other languages
English (en)
Swedish (sv)
Inventor
Jan Holgersson
Jining Liu
Original Assignee
Karolinska Innovations Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations Ab filed Critical Karolinska Innovations Ab
Priority to SE9701127A priority Critical patent/SE9701127D0/xx
Publication of SE9701127D0 publication Critical patent/SE9701127D0/xx
Priority to US09/194,396 priority patent/US6943239B2/en
Priority to ES98912863T priority patent/ES2258297T3/es
Priority to DK98912863T priority patent/DK0923606T3/da
Priority to CA002255765A priority patent/CA2255765A1/en
Priority to AT98912863T priority patent/ATE315047T1/de
Priority to PCT/SE1998/000555 priority patent/WO1998042750A1/en
Priority to AU67551/98A priority patent/AU751760B2/en
Priority to BR9804826-0A priority patent/BR9804826A/pt
Priority to JP54556998A priority patent/JP4099239B2/ja
Priority to EP98912863A priority patent/EP0923606B1/en
Priority to EP06075010A priority patent/EP1700868A3/en
Priority to DE69833106T priority patent/DE69833106T2/de
Priority to US11/153,082 priority patent/US20050255099A1/en
Priority to US12/507,626 priority patent/US20090286963A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SE9701127A 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes SE9701127D0 (sv)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes
DE69833106T DE69833106T2 (de) 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal-epitope enthalten.
PCT/SE1998/000555 WO1998042750A1 (en) 1997-03-26 1998-03-26 ANTIGENIC FUSIONPROTEIN CARRYING GALα1,3GAL EPITOPES
BR9804826-0A BR9804826A (pt) 1997-03-26 1998-03-26 Proteìna de fusão antigênica portando epìtopos galoc 1,3 gal
DK98912863T DK0923606T3 (da) 1997-03-26 1998-03-26 Antigent fusionsprotein med GALALPHA1,3GAL epitoper
CA002255765A CA2255765A1 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying gal.alpha.1,3gal epitopes
AT98912863T ATE315047T1 (de) 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.
US09/194,396 US6943239B2 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying Galα1,3Gal epitopes
AU67551/98A AU751760B2 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying galalpha1,3Gal epitopes
ES98912863T ES2258297T3 (es) 1997-03-26 1998-03-26 Proteina de fusion antigenica portadora de epitopos gal-alfa-1,3gal.
JP54556998A JP4099239B2 (ja) 1997-03-26 1998-03-26 ＧＡＬα１、３ＧＡＬエピトープを有する抗原性融合タンパク質
EP98912863A EP0923606B1 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying galalpha1,3gal epitopes
EP06075010A EP1700868A3 (en) 1997-03-26 1998-03-26 A method for removing an antibody from blood or plasma
US11/153,082 US20050255099A1 (en) 1997-03-26 2005-06-15 Antigenic fusion protein carrying Galalpha 1,3Gal epitopes
US12/507,626 US20090286963A1 (en) 1997-03-26 2009-07-22 Antigenic fusion protein carrying gal alpha1,3gal epitopes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes

Publications (1)

Publication Number Publication Date
SE9701127D0 true SE9701127D0 (sv) 1997-03-26

Family

ID=20406335

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes

Country Status (12)

Country Link
US (3) US6943239B2 (https=)
EP (2) EP0923606B1 (https=)
JP (1) JP4099239B2 (https=)
AT (1) ATE315047T1 (https=)
AU (1) AU751760B2 (https=)
BR (1) BR9804826A (https=)
CA (1) CA2255765A1 (https=)
DE (1) DE69833106T2 (https=)
DK (1) DK0923606T3 (https=)
ES (1) ES2258297T3 (https=)
SE (1) SE9701127D0 (https=)
WO (1) WO1998042750A1 (https=)

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JP4421894B2 (ja) * 2001-07-20 2010-02-24 アブソーバー アクチボラゲット 血液型抗原融合ポリペプチドおよびその使用方法
WO2003089450A2 (en) * 2002-04-22 2003-10-30 Recopharma Ab Fusion polypeptides and methods for inhibiting microbial adhesion
JP2005530493A (ja) * 2002-04-22 2005-10-13 レコファーマ アーベー ムチン融合ポリペプチドワクチン、組成物およびそれらの使用方法
JP5183010B2 (ja) * 2002-05-16 2013-04-17 グリコミメティクス， インコーポレイテッド セレクチンによって媒介される機能を阻害するための化合物および方法
CA2490703A1 (en) * 2002-07-03 2004-01-15 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
EP1534748A2 (en) * 2002-08-09 2005-06-01 Recopharma AB Fusion proteins and methods of producing same
US20050076759A1 (en) * 2003-10-08 2005-04-14 Brian Westfall Linear saw with stab-cut bevel capability
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
WO2005047320A2 (en) * 2003-11-12 2005-05-26 Wisconsin Alumni Research Foundation Equine p-selection glycoprotein ligand-1 and uses thereof
US20050187171A1 (en) * 2003-11-19 2005-08-25 Glycomimetics, Inc. Glycomimetic antagonists for both E-and P-selectins
WO2005051920A2 (en) * 2003-11-19 2005-06-09 Glycomimetics, Inc. Specific antagonist for both e- and p-selectins
WO2006001348A1 (ja) * 2004-06-23 2006-01-05 Japan Science And Technology Agency 浸潤抑制及び細胞殺傷剤
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
EP1928892B1 (en) * 2005-08-09 2011-10-12 GlycoMimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
SI2264043T1 (en) 2005-09-02 2018-01-31 Glycomimetics, Inc. HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS
US20070113297A1 (en) * 2005-09-13 2007-05-17 Yongguang Yang Methods and compositions for inhibition of immune responses
EP2264060B1 (en) * 2006-01-26 2014-04-23 Recopharma AB Compositions and methods for inhibiting viral adhesion
US20070178447A1 (en) * 2006-01-31 2007-08-02 Bethyl Laboratories, Inc. Method for decreasing interference in results of immunochemical methods
WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
WO2008060378A2 (en) 2006-10-12 2008-05-22 Glycomimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
US7998486B2 (en) 2006-10-25 2011-08-16 Newlink Genetics Corporation Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes
AU2008216794A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
WO2009126556A1 (en) * 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
CN102088983B (zh) * 2008-06-13 2013-01-30 糖模拟物有限公司 利用选择的糖模拟化合物的血液癌症的治疗
WO2010126888A1 (en) 2009-05-01 2010-11-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
JP2014501748A (ja) * 2010-12-21 2014-01-23 リコファーマ アーベー 涙代用物
PT2794626T (pt) 2011-12-22 2018-01-12 Glycomimetics Inc Compostos de antagonistas de e-selectina
CA2891514C (en) 2012-12-07 2020-08-25 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
ES2754549T3 (es) 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
JP2019502727A (ja) 2016-01-22 2019-01-31 グリコミメティクス， インコーポレイテッド Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2019241386A1 (en) * 2018-06-12 2019-12-19 Rush University Medical Center Methods for enhanced endothelialization of implanted material
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

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DE69226871T3 (de) * 1991-06-27 2009-09-24 Bristol-Myers Squibb Co. CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung
DE69333346T2 (de) * 1992-10-23 2004-10-07 Inst Genetics Llc Neuartiges p- selectin ligandenprotein
JP4038236B2 (ja) * 1993-03-16 2008-01-23 オースチン・リサーチ・インスティテュート 異種移植治療におけるブタＧａ１α（１，３）ガラクトシルトランスフェラーゼの使用
GB9517758D0 (en) * 1995-08-31 1995-11-01 Imutran Ltd Compositions and their uses

Also Published As

Publication number Publication date
BR9804826A (pt) 2000-01-25
JP2000511782A (ja) 2000-09-12
EP1700868A3 (en) 2007-12-12
EP0923606B1 (en) 2006-01-04
US20050255099A1 (en) 2005-11-17
CA2255765A1 (en) 1998-10-01
US6943239B2 (en) 2005-09-13
DE69833106D1 (de) 2006-03-30
WO1998042750A1 (en) 1998-10-01
US20020028205A1 (en) 2002-03-07
EP0923606A1 (en) 1999-06-23
DK0923606T3 (da) 2006-05-22
US20090286963A1 (en) 2009-11-19
EP1700868A2 (en) 2006-09-13
ATE315047T1 (de) 2006-02-15
DE69833106T2 (de) 2006-08-31
AU751760B2 (en) 2002-08-29
AU6755198A (en) 1998-10-20
JP4099239B2 (ja) 2008-06-11
ES2258297T3 (es) 2006-08-16

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