JP4099239B2 - ＧＡＬα１、３ＧＡＬエピトープを有する抗原性融合タンパク質 - Google Patents
ＧＡＬα１、３ＧＡＬエピトープを有する抗原性融合タンパク質 Download PDFInfo
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- JP4099239B2 JP4099239B2 JP54556998A JP54556998A JP4099239B2 JP 4099239 B2 JP4099239 B2 JP 4099239B2 JP 54556998 A JP54556998 A JP 54556998A JP 54556998 A JP54556998 A JP 54556998A JP 4099239 B2 JP4099239 B2 JP 4099239B2
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- galα1
- 3gal
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| SE9701127-4 | 1997-03-26 | ||
| SE9701127A SE9701127D0 (sv) | 1997-03-26 | 1997-03-26 | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
| PCT/SE1998/000555 WO1998042750A1 (en) | 1997-03-26 | 1998-03-26 | ANTIGENIC FUSIONPROTEIN CARRYING GALα1,3GAL EPITOPES |
Publications (3)
| Publication Number | Publication Date |
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| JP2000511782A JP2000511782A (ja) | 2000-09-12 |
| JP2000511782A5 JP2000511782A5 (https=) | 2005-11-10 |
| JP4099239B2 true JP4099239B2 (ja) | 2008-06-11 |
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| EP (2) | EP0923606B1 (https=) |
| JP (1) | JP4099239B2 (https=) |
| AT (1) | ATE315047T1 (https=) |
| AU (1) | AU751760B2 (https=) |
| BR (1) | BR9804826A (https=) |
| CA (1) | CA2255765A1 (https=) |
| DE (1) | DE69833106T2 (https=) |
| DK (1) | DK0923606T3 (https=) |
| ES (1) | ES2258297T3 (https=) |
| SE (1) | SE9701127D0 (https=) |
| WO (1) | WO1998042750A1 (https=) |
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| CA2454469A1 (en) * | 2001-07-20 | 2003-02-06 | Absorber, Ab | Blood group antigen fusion polypeptides and methods of use thereof |
| EP1517700B1 (en) * | 2002-04-22 | 2012-03-28 | Recopharma AB | Mucin fusion polypeptide vaccines, compositions and methods of use thereof |
| JP2005532793A (ja) * | 2002-04-22 | 2005-11-04 | レコファーマ アーベー | 微生物付着を阻害するための融合ポリペプチドおよび方法 |
| WO2003097658A2 (en) | 2002-05-16 | 2003-11-27 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| JP2006502986A (ja) * | 2002-07-03 | 2006-01-26 | グリコミメティクス， インコーポレイテッド | 新脈管形成に関与する医学的状態の診断および治療のための組成物および方法 |
| EP1534748A2 (en) * | 2002-08-09 | 2005-06-01 | Recopharma AB | Fusion proteins and methods of producing same |
| US20050076759A1 (en) * | 2003-10-08 | 2005-04-14 | Brian Westfall | Linear saw with stab-cut bevel capability |
| US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
| EP1689776A2 (en) * | 2003-11-12 | 2006-08-16 | Wisconsin Alumni Research Foundation | Equine p-selectin glycoprotein ligand-1 and uses thereof |
| EP1763533B1 (en) * | 2003-11-19 | 2008-01-09 | GlycoMimetics, Inc. | Specific antagonist for both e- and p-selectins |
| WO2005054264A2 (en) * | 2003-11-19 | 2005-06-16 | Glycomimetics, Inc. | Glycomimetic antagonists for both e- and p-selectins |
| US20080318297A1 (en) * | 2004-06-23 | 2008-12-25 | Mitsuru Nakamura | Inhibition of Infiltration, and Cell Killing Agent |
| US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
| US20090036386A1 (en) * | 2005-05-25 | 2009-02-05 | Glycomimetics, Inc | Heterobifunctional compounds for selectin inhibition |
| CN101291946B (zh) * | 2005-08-09 | 2011-06-29 | 糖模拟物有限公司 | 对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂 |
| PL2264043T3 (pl) | 2005-09-02 | 2018-04-30 | Glycomimetics, Inc. | Heterobifunkcyjne inhibitory pan-selektyny |
| WO2007033221A2 (en) * | 2005-09-13 | 2007-03-22 | The General Hospital Corporation | Methods and compositions for inhibition of immune responses |
| EP2264060B1 (en) * | 2006-01-26 | 2014-04-23 | Recopharma AB | Compositions and methods for inhibiting viral adhesion |
| US20070178447A1 (en) * | 2006-01-31 | 2007-08-02 | Bethyl Laboratories, Inc. | Method for decreasing interference in results of immunochemical methods |
| US20090176717A1 (en) * | 2006-06-01 | 2009-07-09 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
| EP2074132B1 (en) | 2006-10-12 | 2013-05-15 | GlycoMimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| US7998486B2 (en) | 2006-10-25 | 2011-08-16 | Newlink Genetics Corporation | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes |
| AU2008216794A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines |
| US8039442B2 (en) | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| CN102088983B (zh) * | 2008-06-13 | 2013-01-30 | 糖模拟物有限公司 | 利用选择的糖模拟化合物的血液癌症的治疗 |
| CA2760292A1 (en) | 2009-05-01 | 2010-11-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| AU2011347237A1 (en) * | 2010-12-21 | 2013-07-11 | Recopharma Ab | Tear substitutes |
| KR102055958B1 (ko) | 2011-12-22 | 2019-12-13 | 글리코미메틱스, 인크. | E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법 |
| US9867841B2 (en) | 2012-12-07 | 2018-01-16 | Glycomimetics, Inc. | Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells |
| JP6689854B2 (ja) | 2014-12-03 | 2020-04-28 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤 |
| JP2019502727A (ja) | 2016-01-22 | 2019-01-31 | グリコミメティクス， インコーポレイテッド | Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤 |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
| AU2017341065B2 (en) | 2016-10-07 | 2023-04-06 | Crescent Biopharma, Inc. | Highly potent multimeric E-selectin antagonists |
| EP3596096A1 (en) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| JP7275131B2 (ja) | 2017-11-30 | 2023-05-17 | グリコミメティクス， インコーポレイテッド | 骨髄浸潤リンパ球を動員する方法、およびその使用 |
| KR20200104889A (ko) | 2017-12-29 | 2020-09-04 | 글리코미메틱스, 인크. | E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제 |
| KR20200128025A (ko) | 2018-03-05 | 2020-11-11 | 글리코미메틱스, 인크. | 급성 골수성 백혈병 및 관련 병태의 치료 방법 |
| US20210260250A1 (en) * | 2018-06-12 | 2021-08-26 | Rush University Medical Center | Methods for Enhanced Endothelialization of Implanted Material |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
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| CA2580812A1 (en) * | 1991-06-27 | 1993-01-07 | Bristol-Myers Squibb Company | Ctla4 receptor, fusion proteins containing it and uses thereof |
| WO1994010309A1 (en) | 1992-10-23 | 1994-05-11 | Genetics Institute, Inc. | Novel p-selectin ligand protein |
| EP0689597A4 (en) * | 1993-03-16 | 1998-10-21 | Austin Research Inst | USE OF PIG GAL-g (a) (1,3) GALACTOSYL TRANSFERASE FOR XENOGENE THERAPIES |
| GB9517758D0 (en) * | 1995-08-31 | 1995-11-01 | Imutran Ltd | Compositions and their uses |
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1997
- 1997-03-26 SE SE9701127A patent/SE9701127D0/xx unknown
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1998
- 1998-03-26 AT AT98912863T patent/ATE315047T1/de not_active IP Right Cessation
- 1998-03-26 US US09/194,396 patent/US6943239B2/en not_active Expired - Fee Related
- 1998-03-26 DK DK98912863T patent/DK0923606T3/da active
- 1998-03-26 EP EP98912863A patent/EP0923606B1/en not_active Expired - Lifetime
- 1998-03-26 AU AU67551/98A patent/AU751760B2/en not_active Ceased
- 1998-03-26 BR BR9804826-0A patent/BR9804826A/pt not_active Application Discontinuation
- 1998-03-26 EP EP06075010A patent/EP1700868A3/en not_active Withdrawn
- 1998-03-26 ES ES98912863T patent/ES2258297T3/es not_active Expired - Lifetime
- 1998-03-26 WO PCT/SE1998/000555 patent/WO1998042750A1/en not_active Ceased
- 1998-03-26 JP JP54556998A patent/JP4099239B2/ja not_active Expired - Fee Related
- 1998-03-26 CA CA002255765A patent/CA2255765A1/en not_active Abandoned
- 1998-03-26 DE DE69833106T patent/DE69833106T2/de not_active Expired - Lifetime
-
2005
- 2005-06-15 US US11/153,082 patent/US20050255099A1/en not_active Abandoned
-
2009
- 2009-07-22 US US12/507,626 patent/US20090286963A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE315047T1 (de) | 2006-02-15 |
| EP0923606A1 (en) | 1999-06-23 |
| US20090286963A1 (en) | 2009-11-19 |
| BR9804826A (pt) | 2000-01-25 |
| US20050255099A1 (en) | 2005-11-17 |
| EP1700868A3 (en) | 2007-12-12 |
| DK0923606T3 (da) | 2006-05-22 |
| WO1998042750A1 (en) | 1998-10-01 |
| DE69833106T2 (de) | 2006-08-31 |
| CA2255765A1 (en) | 1998-10-01 |
| AU751760B2 (en) | 2002-08-29 |
| EP1700868A2 (en) | 2006-09-13 |
| SE9701127D0 (sv) | 1997-03-26 |
| JP2000511782A (ja) | 2000-09-12 |
| AU6755198A (en) | 1998-10-20 |
| US20020028205A1 (en) | 2002-03-07 |
| EP0923606B1 (en) | 2006-01-04 |
| ES2258297T3 (es) | 2006-08-16 |
| DE69833106D1 (de) | 2006-03-30 |
| US6943239B2 (en) | 2005-09-13 |
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