DE69821951T2 - Bernsteinsäure herstellung und reinigung - Google Patents
Bernsteinsäure herstellung und reinigung Download PDFInfo
- Publication number
- DE69821951T2 DE69821951T2 DE69821951T DE69821951T DE69821951T2 DE 69821951 T2 DE69821951 T2 DE 69821951T2 DE 69821951 T DE69821951 T DE 69821951T DE 69821951 T DE69821951 T DE 69821951T DE 69821951 T2 DE69821951 T2 DE 69821951T2
- Authority
- DE
- Germany
- Prior art keywords
- succinic acid
- ammonium
- succinate
- methanol
- sulfate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title claims description 277
- 239000001384 succinic acid Substances 0.000 title claims description 130
- 238000004519 manufacturing process Methods 0.000 title claims description 22
- 238000004140 cleaning Methods 0.000 title description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 205
- 238000000034 method Methods 0.000 claims description 66
- BIGPRXCJEDHCLP-UHFFFAOYSA-N ammonium bisulfate Chemical compound [NH4+].OS([O-])(=O)=O BIGPRXCJEDHCLP-UHFFFAOYSA-N 0.000 claims description 57
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 51
- 239000000243 solution Substances 0.000 claims description 48
- NHJPVZLSLOHJDM-UHFFFAOYSA-N azane;butanedioic acid Chemical compound [NH4+].[NH4+].[O-]C(=O)CCC([O-])=O NHJPVZLSLOHJDM-UHFFFAOYSA-N 0.000 claims description 41
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 38
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 38
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 38
- 230000008569 process Effects 0.000 claims description 30
- 239000002585 base Substances 0.000 claims description 27
- 229910021529 ammonia Inorganic materials 0.000 claims description 25
- 238000000855 fermentation Methods 0.000 claims description 25
- 230000004151 fermentation Effects 0.000 claims description 24
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 21
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 20
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 16
- 239000007864 aqueous solution Substances 0.000 claims description 14
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 12
- -1 ammonium ions Chemical class 0.000 claims description 11
- 150000003890 succinate salts Chemical class 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 10
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 10
- 239000001569 carbon dioxide Substances 0.000 claims description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 8
- 230000007935 neutral effect Effects 0.000 claims description 8
- 150000001720 carbohydrates Chemical class 0.000 claims description 7
- 150000001768 cations Chemical class 0.000 claims description 7
- 238000005336 cracking Methods 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000008020 evaporation Effects 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 4
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims description 2
- 229910001415 sodium ion Inorganic materials 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 229960005137 succinic acid Drugs 0.000 description 116
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 63
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 56
- 230000005611 electricity Effects 0.000 description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 239000000706 filtrate Substances 0.000 description 18
- 239000000047 product Substances 0.000 description 17
- 239000002002 slurry Substances 0.000 description 16
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 15
- 238000004227 thermal cracking Methods 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000000463 material Substances 0.000 description 12
- 239000006227 byproduct Substances 0.000 description 11
- 239000002253 acid Substances 0.000 description 10
- 238000002425 crystallisation Methods 0.000 description 9
- 230000008025 crystallization Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- 238000004064 recycling Methods 0.000 description 7
- 239000012141 concentrate Substances 0.000 description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 5
- 239000000908 ammonium hydroxide Substances 0.000 description 5
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000012736 aqueous medium Substances 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 238000010979 pH adjustment Methods 0.000 description 4
- 230000020477 pH reduction Effects 0.000 description 4
- 235000021395 porridge Nutrition 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
- 150000001735 carboxylic acids Chemical class 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 238000000909 electrodialysis Methods 0.000 description 3
- 229910052602 gypsum Inorganic materials 0.000 description 3
- 239000010440 gypsum Substances 0.000 description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
- 239000004097 EU approved flavor enhancer Substances 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 238000009621 Solvay process Methods 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021472 generally recognized as safe Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5601397P | 1997-08-18 | 1997-08-18 | |
| US56013P | 1997-08-18 | ||
| US09/134,061 US5958744A (en) | 1997-08-18 | 1998-08-13 | Succinic acid production and purification |
| US134061 | 1998-08-13 | ||
| PCT/US1998/017123 WO1999009196A1 (en) | 1997-08-18 | 1998-08-18 | Succinic acid production and purification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69821951D1 DE69821951D1 (de) | 2004-04-01 |
| DE69821951T2 true DE69821951T2 (de) | 2004-12-16 |
Family
ID=26734867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69821951T Expired - Lifetime DE69821951T2 (de) | 1997-08-18 | 1998-08-18 | Bernsteinsäure herstellung und reinigung |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5958744A (https=) |
| EP (1) | EP1005562B1 (https=) |
| JP (1) | JP4242558B2 (https=) |
| AR (1) | AR017255A1 (https=) |
| AT (1) | ATE260343T1 (https=) |
| AU (1) | AU9107598A (https=) |
| BR (1) | BR9815652A (https=) |
| CA (1) | CA2301177C (https=) |
| DE (1) | DE69821951T2 (https=) |
| IN (1) | IN190421B (https=) |
| WO (1) | WO1999009196A1 (https=) |
| ZA (1) | ZA987428B (https=) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010025167A1 (de) | 2010-06-25 | 2011-12-29 | Uhde Gmbh | Verfahren zur Abtrennung, Gewinnung und Reinigung von Bernsteinsäure |
| WO2013083229A1 (de) | 2011-12-09 | 2013-06-13 | Thyssenkrupp Uhde Gmbh | Verfahren zur aufreinigung von carbonsäuren aus fermentationsbrühen |
| EP2745905A1 (en) | 2012-12-21 | 2014-06-25 | ThyssenKrupp Uhde GmbH | Process for the purification of carboxylic acids by subcritical or supercritical fluid chromatography |
| DE102013000027A1 (de) | 2013-01-03 | 2014-07-03 | Thyssenkrupp Industrial Solutions Ag | Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen |
| WO2014108163A2 (de) | 2013-01-11 | 2014-07-17 | Thyssenkrupp Uhde Gmbh | Verfahren zur herstellung von dicarbonsäuren |
| DE102013225215A1 (de) * | 2013-12-06 | 2015-06-11 | Thyssenkrupp Ag | Verfahren zur Herstellung und Isolierung von Carbonsäureestern |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287480B1 (en) * | 2000-01-11 | 2001-09-11 | Applied Carbochemicals, Inc. | Deicing compositions and methods of use |
| US6635188B1 (en) * | 2002-04-18 | 2003-10-21 | Board Of Trustees Of Michigan State University | Windshield washer and deicer |
| MY137537A (en) * | 2002-05-10 | 2009-02-27 | Mitsubishi Chem Corp | Method for producing organic acid |
| JP4469568B2 (ja) * | 2003-07-09 | 2010-05-26 | 三菱化学株式会社 | 有機酸の製造方法 |
| CN100575496C (zh) * | 2003-08-28 | 2009-12-30 | 三菱化学株式会社 | 产生琥珀酸的方法 |
| CN1852978A (zh) * | 2003-09-17 | 2006-10-25 | 三菱化学株式会社 | 制备无－氨基有机酸的方法 |
| WO2005030973A1 (ja) * | 2003-09-30 | 2005-04-07 | Ajinomoto Co., Inc. | 発酵液からのコハク酸の精製方法 |
| JP2005295998A (ja) * | 2003-11-07 | 2005-10-27 | Mitsubishi Chemicals Corp | 有機酸アンモニウム溶液の製造方法 |
| EP1686183A1 (en) * | 2003-11-07 | 2006-08-02 | Mitsubishi Chemical Corporation | Method for producing organic acid ammonium solution |
| US6846431B1 (en) | 2003-12-26 | 2005-01-25 | Diversified Natural Products, Inc. | Environmentally benign, non-toxic, non-corrosive engine coolant/antifreeze |
| JP5572279B2 (ja) * | 2004-05-20 | 2014-08-13 | 味の素株式会社 | コハク酸生産菌及びコハク酸の製造方法 |
| BRPI0510919A (pt) * | 2004-05-20 | 2008-05-20 | Ajinomoto Kk | bactéria produtora de ácido succìnico e processo para produzir ácido succìnico |
| EP1831163B1 (de) * | 2004-12-21 | 2012-09-26 | Basf Se | Verfahren zur herstellung von pyrrolidonen aus succinaten aus fermentationsbrühen |
| JP4537862B2 (ja) * | 2005-01-18 | 2010-09-08 | 財団法人地球環境産業技術研究機構 | 好気性細菌による高効率な有機酸の製造方法 |
| KR100672813B1 (ko) * | 2005-01-18 | 2007-01-22 | 한국과학기술원 | 숙신산 정제 방법 |
| EP3919543A3 (en) | 2005-04-22 | 2022-03-16 | Mitsubishi Chemical Corporation | Biomass-resource-derived polyester and production process thereof |
| JP2006328380A (ja) * | 2005-04-26 | 2006-12-07 | Mitsubishi Chemicals Corp | ポリエステルの製造方法 |
| JP5088136B2 (ja) * | 2005-10-18 | 2012-12-05 | 味の素株式会社 | コハク酸の製造方法 |
| US20070122892A1 (en) * | 2005-11-30 | 2007-05-31 | Christian Andersson | Process for producing succinic acid from sucrose |
| CN101389752B (zh) * | 2006-02-24 | 2015-08-05 | 三菱化学株式会社 | 能够产生有机酸的细菌以及产生有机酸的方法 |
| EP2046709B1 (en) * | 2006-07-19 | 2017-08-09 | Showa Denko K.K. | A process for producing succinic acid |
| EP2157185B1 (en) * | 2007-05-18 | 2014-05-14 | Ajinomoto Co., Inc. | Process for production of succinic acid, and process for production of ammonium succinate solution |
| FR2925068B1 (fr) * | 2007-12-13 | 2010-01-08 | Roquette Freres | Procedes de production d'acide succinique |
| KR20090066958A (ko) * | 2007-12-20 | 2009-06-24 | 한국과학기술원 | 배양액의 결정화에 의한 숙신산 정제방법 |
| CN101215583B (zh) * | 2008-01-18 | 2010-11-10 | 南京工业大学 | 一种发酵与膜分离单元耦合制备丁二酸的方法 |
| US8865438B2 (en) | 2008-12-02 | 2014-10-21 | Purac Biochem B.V. | Process for the preparation of a monovalent succinate salt |
| US20120238722A1 (en) * | 2009-11-24 | 2012-09-20 | Roquette Freres Sa | Process for the crystallization of succinic acid |
| BR112012013158A2 (pt) | 2009-12-02 | 2016-03-01 | Univ Michigan State | método de produção de um éster alquílico de um ácido carboxílico e método para o isolamento de succinato de dietila |
| JP2013516180A (ja) * | 2009-12-31 | 2013-05-13 | ミリアント・コーポレイション | コハク酸アンモニウムを含有する発酵ブロスからのコハク酸の精製 |
| WO2011087062A1 (ja) * | 2010-01-15 | 2011-07-21 | 三菱化学株式会社 | 含窒素組成物およびその製造方法 |
| CN101748161B (zh) * | 2010-01-19 | 2012-06-06 | 南京工业大学 | 一种厌氧发酵纯化丁二酸的工艺 |
| BR112012023892B1 (pt) | 2010-03-16 | 2018-12-11 | Mitsubishi Chemical Corporation | processo para produzir ácido succínico |
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| FR3028864B1 (fr) | 2014-11-26 | 2018-05-18 | Roquette Freres | Procede de recuperation de cristaux d'acide succinique avec mise en œuvre de tensioactifs au cours de la cristallisation, cristaux obtenus et leurs utilisations |
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| DE102015216815A1 (de) * | 2015-09-02 | 2017-03-02 | Thyssenkrupp Ag | Verfahren und Anlage zur Gewinnung einer in einem Fermentationsprozess hergestellten Carbonsäure |
| EP3241820A1 (en) | 2016-05-02 | 2017-11-08 | Technische Universiteit Delft | Recovery of carboxylates from fermentation and production of esters using co2 expanded alcohols |
| KR20200009010A (ko) | 2017-05-19 | 2020-01-29 | 바스프 에스이 | 유기 화합물 제조 방법 |
| EP3502241A1 (en) | 2017-12-21 | 2019-06-26 | Basf Se | Modified microorganism for improved production of succinate |
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| WO2025250509A1 (en) * | 2024-05-31 | 2025-12-04 | Bioveritas, Llc | Systems and methods for direct acidification and distillation for recovery of carboxylic acids |
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| US4100188A (en) * | 1972-04-27 | 1978-07-11 | Ethyl Corporation | Chemical process |
| US5143834A (en) * | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| DE3783081T2 (de) * | 1986-06-11 | 1993-04-15 | Michigan Biotech Inst | Verfahren zur herstellung von bernsteinsaeure durch anaerobe fermentation. |
| US5168055A (en) * | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| US5034105A (en) * | 1989-07-27 | 1991-07-23 | Michigan Biotechnology Institute | Carboxylic acid purification and crystallization process |
| US5426219A (en) * | 1993-07-26 | 1995-06-20 | A.E. Staley Manufacturing Co. | Process for recovering organic acids |
| US5504004A (en) * | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5573931A (en) * | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
-
1998
- 1998-08-13 US US09/134,061 patent/US5958744A/en not_active Expired - Lifetime
- 1998-08-17 IN IN521BO1998 patent/IN190421B/en unknown
- 1998-08-18 AR ARP980104067A patent/AR017255A1/es unknown
- 1998-08-18 BR BR9815652-7A patent/BR9815652A/pt not_active Application Discontinuation
- 1998-08-18 AT AT98943239T patent/ATE260343T1/de active
- 1998-08-18 ZA ZA987428A patent/ZA987428B/xx unknown
- 1998-08-18 WO PCT/US1998/017123 patent/WO1999009196A1/en not_active Ceased
- 1998-08-18 CA CA002301177A patent/CA2301177C/en not_active Expired - Fee Related
- 1998-08-18 EP EP98943239A patent/EP1005562B1/en not_active Expired - Lifetime
- 1998-08-18 AU AU91075/98A patent/AU9107598A/en not_active Abandoned
- 1998-08-18 DE DE69821951T patent/DE69821951T2/de not_active Expired - Lifetime
- 1998-08-18 JP JP2000509858A patent/JP4242558B2/ja not_active Expired - Fee Related
-
1999
- 1999-09-02 US US09/389,641 patent/US6265190B1/en not_active Expired - Lifetime
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010025167A1 (de) | 2010-06-25 | 2011-12-29 | Uhde Gmbh | Verfahren zur Abtrennung, Gewinnung und Reinigung von Bernsteinsäure |
| WO2011160760A1 (de) | 2010-06-25 | 2011-12-29 | Uhde Gmbh | Verfahren zur abtrennung, gewinnung und reinigung von dicarbonsäuren |
| US8957249B2 (en) | 2010-06-25 | 2015-02-17 | Thyssenkrupp Uhde Gmbh | Process for removing, isolating and purifying dicarboxylic acids |
| DE102011120632A1 (de) | 2011-12-09 | 2013-06-13 | Thyssenkrupp Uhde Gmbh | Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen |
| WO2013083229A1 (de) | 2011-12-09 | 2013-06-13 | Thyssenkrupp Uhde Gmbh | Verfahren zur aufreinigung von carbonsäuren aus fermentationsbrühen |
| US9272976B2 (en) | 2011-12-09 | 2016-03-01 | Thyssenkrupp Industrial Solutions Ag | Method for purifying carboxylic acids from fermentation broths |
| EP2745905A1 (en) | 2012-12-21 | 2014-06-25 | ThyssenKrupp Uhde GmbH | Process for the purification of carboxylic acids by subcritical or supercritical fluid chromatography |
| WO2014095080A2 (en) | 2012-12-21 | 2014-06-26 | Thyssenkrupp Industrial Solutions Ag | Process for the purification of carboxylic acids |
| DE102013000027A1 (de) | 2013-01-03 | 2014-07-03 | Thyssenkrupp Industrial Solutions Ag | Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen |
| WO2014106532A2 (de) | 2013-01-03 | 2014-07-10 | Thyssenkrupp Industrial Solutions Ag | Verfahren zur aufreinigung von carbonsäuren aus fermentationsbrühen |
| WO2014108163A2 (de) | 2013-01-11 | 2014-07-17 | Thyssenkrupp Uhde Gmbh | Verfahren zur herstellung von dicarbonsäuren |
| DE102013225215A1 (de) * | 2013-12-06 | 2015-06-11 | Thyssenkrupp Ag | Verfahren zur Herstellung und Isolierung von Carbonsäureestern |
| US9963414B2 (en) | 2013-12-06 | 2018-05-08 | Thyssenkrupp Industrial Solutions Ag | Process for the preparation and isolation of carboxylic esters |
Also Published As
| Publication number | Publication date |
|---|---|
| US6265190B1 (en) | 2001-07-24 |
| AU9107598A (en) | 1999-03-08 |
| DE69821951D1 (de) | 2004-04-01 |
| EP1005562A4 (en) | 2002-05-22 |
| AR017255A1 (es) | 2001-09-05 |
| ZA987428B (en) | 1999-05-18 |
| CA2301177A1 (en) | 1999-02-25 |
| CA2301177C (en) | 2008-01-29 |
| JP4242558B2 (ja) | 2009-03-25 |
| ATE260343T1 (de) | 2004-03-15 |
| EP1005562B1 (en) | 2004-02-25 |
| JP2001514900A (ja) | 2001-09-18 |
| US5958744A (en) | 1999-09-28 |
| IN190421B (https=) | 2003-07-26 |
| WO1999009196A1 (en) | 1999-02-25 |
| BR9815652A (pt) | 2001-08-28 |
| EP1005562A1 (en) | 2000-06-07 |
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