DE69816082T2 - Phosphatbindende polymerzubereitungen - Google Patents

Phosphatbindende polymerzubereitungen Download PDF

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Publication number
DE69816082T2
DE69816082T2 DE69816082T DE69816082T DE69816082T2 DE 69816082 T2 DE69816082 T2 DE 69816082T2 DE 69816082 T DE69816082 T DE 69816082T DE 69816082 T DE69816082 T DE 69816082T DE 69816082 T2 DE69816082 T2 DE 69816082T2
Authority
DE
Germany
Prior art keywords
phosphate
binding polymer
less
tablet
particle size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69816082T
Other languages
German (de)
English (en)
Other versions
DE69816082D1 (de
Inventor
Katsuya Toshima-ku MATSUDA
Ryuji Kita-ku KUBOTA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE69816082D1 publication Critical patent/DE69816082D1/de
Application granted granted Critical
Publication of DE69816082T2 publication Critical patent/DE69816082T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69816082T 1997-04-04 1998-04-03 Phosphatbindende polymerzubereitungen Expired - Lifetime DE69816082T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8658197 1997-04-04
JP8658197 1997-04-04
PCT/JP1998/001536 WO1998044933A1 (en) 1997-04-04 1998-04-03 Phosphate-binding polymer preparations

Publications (2)

Publication Number Publication Date
DE69816082D1 DE69816082D1 (de) 2003-08-07
DE69816082T2 true DE69816082T2 (de) 2004-04-15

Family

ID=13890981

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69816082T Expired - Lifetime DE69816082T2 (de) 1997-04-04 1998-04-03 Phosphatbindende polymerzubereitungen
DE69837945T Expired - Lifetime DE69837945T2 (de) 1997-04-04 1998-04-03 Tablette, umfassend ein phosphatbindendes Polymer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69837945T Expired - Lifetime DE69837945T2 (de) 1997-04-04 1998-04-03 Tablette, umfassend ein phosphatbindendes Polymer

Country Status (15)

Country Link
US (2) US6383518B1 (https=)
EP (2) EP0997148B1 (https=)
JP (2) JP2009173687A (https=)
KR (1) KR100456202B1 (https=)
CN (1) CN1180782C (https=)
AT (2) ATE364377T1 (https=)
AU (1) AU726142B2 (https=)
CA (1) CA2286003C (https=)
CY (1) CY1106823T1 (https=)
DE (2) DE69816082T2 (https=)
DK (1) DK1304104T3 (https=)
ES (2) ES2287215T3 (https=)
PT (1) PT1304104E (https=)
TW (1) TW592727B (https=)
WO (1) WO1998044933A1 (https=)

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US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US6680069B1 (en) 1999-11-09 2004-01-20 Shin-Etsu Chemical Co., Ltd. Low-substituted hydroxypropyl cellulose and process for manufacturing the same
JP3552160B2 (ja) 2000-01-14 2004-08-11 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロース粒子の形成方法
US6710162B2 (en) 2001-02-16 2004-03-23 Genzyme Corporation Method of drying a material having a cohesive phase
AU2002252632B2 (en) 2001-04-18 2004-09-23 Genzyme Corporation Low salt forms of polyallylamine
CA2444046C (en) 2001-04-18 2011-06-07 Steven K. Burke Use of colesevelam in reducing serum glucose
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
FR2827771B1 (fr) * 2001-07-25 2003-10-24 Apis Spheromont Formulation et procede de preparation de spheroides pouvant etre fortement titres et a dispersion rapide
US6600011B2 (en) 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
TWI231760B (en) * 2001-12-20 2005-05-01 Chugai Pharmaceutical Co Ltd Coated lozenge and manufacturing method thereof
US7449605B2 (en) 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7459502B2 (en) 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
CA2601236A1 (en) * 2005-03-16 2006-09-21 Usv Limited An improved process for the preparation of crosslinked polyallylamine polymer
US8986669B2 (en) * 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
EP3000460A1 (en) 2005-09-15 2016-03-30 Genzyme Corporation Sachet formulation for amine polymers
GB0601899D0 (en) * 2006-01-31 2006-03-08 Ineos Silicas Ltd Compositions
MY157620A (en) 2006-01-31 2016-06-30 Cytochroma Dev Inc A granular material of a solid water-soluble mixed metal compound capable of binding phosphate
DK1818048T3 (da) * 2006-02-14 2009-04-20 Teva Pharma Farmaceutiske formuleringer af alifatiske aminpolymerer og metoder til deres fremstilling
CA2642255A1 (en) * 2006-02-14 2007-08-23 Teva Pharmaceutical Industries Ltd. Pharmaceutical formulations of aliphatic amine polymers and methods for their manufacture
EP2016114A2 (en) * 2006-05-05 2009-01-21 Genzyme Corporation Amine condensation polymers as phosphate sequestrants
AU2007275711A1 (en) * 2006-07-18 2008-01-24 Genzyme Corporation Amine dendrimers
CA2749074A1 (en) * 2006-09-01 2008-05-29 Usv Limited Process for the preparation of sevelamer hydrochloride and formulation thereof
US7964182B2 (en) * 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
EP2066293A2 (en) 2006-09-29 2009-06-10 Genzyme Corporation Amide dendrimer compositions
US8163799B2 (en) * 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
JP2010519298A (ja) * 2007-02-23 2010-06-03 ゲンズイメ コーポレーション アミンポリマー組成物
EP2131820A1 (en) * 2007-03-08 2009-12-16 Genzyme Corporation Sulfone polymer compositions
EP2152277A1 (en) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amine dendrimer compositions
GB0714670D0 (en) 2007-07-27 2007-09-05 Ineos Healthcare Ltd Use
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
GB0720220D0 (en) 2007-10-16 2007-11-28 Ineos Healthcare Ltd Compound
WO2009078958A1 (en) * 2007-12-14 2009-06-25 Genzyme Corporation Coated pharmaceutical compositions
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
DE102008030046A1 (de) 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
US20110081413A1 (en) * 2009-01-22 2011-04-07 Ashok Omray Pharmaceutical Compositions Comprising Phosphate-Binding Polymer
US20100330175A1 (en) * 2009-06-24 2010-12-30 Jobdevairakkam Christopher N Cross-linked polyallylamine tablet core
WO2010149794A2 (en) 2009-06-26 2010-12-29 Combino Pharm, S.L. Novel pharmaceutical composition comprising poly (allylamin-co-n,n'-diallyl- 1,3-diamino-2-hydroxypropane)
GB0913525D0 (en) 2009-08-03 2009-09-16 Ineos Healthcare Ltd Method
ES2720869T3 (es) * 2009-10-22 2019-07-25 Synthon Bv Composiciones farmacéuticas de sevelámero
GB201001779D0 (en) 2010-02-04 2010-03-24 Ineos Healthcare Ltd Composition
EP2545907A1 (en) 2011-07-15 2013-01-16 Combino Pharm, S.L. Aqueous wet granulation process for cross-linked polyallylamine polymers
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
EP3261624A1 (en) * 2015-02-23 2018-01-03 Amneal Pharmaceuticals Company GmbH Process for granulating sevelamer carbonate
BR112019013364A2 (pt) 2016-12-28 2020-04-14 Fujifilm Corp emulsão de polímero contendo átomo de nitrogênio ou sal do mesmo, método de produção para o mesmo e método de produção para partículas
TW201922268A (zh) * 2017-10-16 2019-06-16 日商富士軟片股份有限公司 高磷血症治療劑及粒子
CN111225674A (zh) 2017-10-16 2020-06-02 富士胶片株式会社 高磷血症治疗剂
JP2019182818A (ja) * 2018-04-17 2019-10-24 ライオン株式会社 舌苔除去用の口腔内崩壊錠及び舌苔除去方法

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JPS6090243A (ja) 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
US4631305A (en) * 1985-03-22 1986-12-23 The Upjohn Company Polymeric material as a disintegrant in a compressed tablet
EP0273209B1 (en) 1986-12-30 1992-01-15 American Cyanamid Company Composition of matter containing polycarbophil
US4956182A (en) * 1989-03-16 1990-09-11 Bristol-Myers Company Direct compression cholestyramine tablet and solvent-free coating therefor
JPH02286621A (ja) 1989-04-26 1990-11-26 Mitsubishi Kasei Corp 経口コレステロール低下剤
JPH0413627A (ja) 1990-04-27 1992-01-17 Mitsubishi Kasei Corp 経口コレステロール低下剤
JP2609022B2 (ja) 1990-11-29 1997-05-14 北陸製薬株式会社 ポリカルボフィルカルシウム含有製剤
JPH06157325A (ja) 1992-11-30 1994-06-03 Mitsubishi Kasei Corp 経口コレステロール低下剤
TW272942B (https=) 1993-02-10 1996-03-21 Takeda Pharm Industry Co Ltd
US5667775A (en) * 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
WO1996021454A1 (en) * 1995-01-12 1996-07-18 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
JP3836893B2 (ja) 1995-01-24 2006-10-25 アボットジャパン株式会社 ポリカルボフィルカルシウム含有製剤
TW438608B (en) 1995-08-02 2001-06-07 Hisamitsu Pharmaceutical Co A tablet containing anion exchange resin
JP3389493B2 (ja) * 1997-04-04 2003-03-24 中外製薬株式会社 リン酸結合性ポリマー製剤

Also Published As

Publication number Publication date
JP2009173687A (ja) 2009-08-06
EP1304104B1 (en) 2007-06-13
TW592727B (en) 2004-06-21
EP0997148A4 (en) 2000-05-03
DE69837945D1 (de) 2007-07-26
CY1106823T1 (el) 2012-05-23
WO1998044933A1 (en) 1998-10-15
PT1304104E (pt) 2007-07-27
KR20010005980A (ko) 2001-01-15
CN1254287A (zh) 2000-05-24
EP1304104A2 (en) 2003-04-23
HK1055387A1 (en) 2004-01-09
EP0997148B1 (en) 2003-07-02
HK1027506A1 (en) 2001-01-19
DE69837945T2 (de) 2008-02-21
ATE364377T1 (de) 2007-07-15
ES2287215T3 (es) 2007-12-16
US20020122786A1 (en) 2002-09-05
EP1304104A3 (en) 2003-11-12
JP2013010803A (ja) 2013-01-17
US6696087B2 (en) 2004-02-24
DE69816082D1 (de) 2003-08-07
CA2286003C (en) 2007-06-05
KR100456202B1 (ko) 2004-11-09
CN1180782C (zh) 2004-12-22
AU726142B2 (en) 2000-11-02
EP0997148A1 (en) 2000-05-03
CA2286003A1 (en) 1998-10-15
ATE244013T1 (de) 2003-07-15
AU6522398A (en) 1998-10-30
ES2201463T3 (es) 2004-03-16
US6383518B1 (en) 2002-05-07
JP5681156B2 (ja) 2015-03-04
DK1304104T3 (da) 2007-07-16

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8364 No opposition during term of opposition