TW592727B - Phosphate-binding polymer preparations - Google Patents

Phosphate-binding polymer preparations Download PDF

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Publication number
TW592727B
TW592727B TW087104092A TW87104092A TW592727B TW 592727 B TW592727 B TW 592727B TW 087104092 A TW087104092 A TW 087104092A TW 87104092 A TW87104092 A TW 87104092A TW 592727 B TW592727 B TW 592727B
Authority
TW
Taiwan
Prior art keywords
phosphate
binding polymer
less
particle size
tablet
Prior art date
Application number
TW087104092A
Other languages
English (en)
Inventor
Katsuya Matsuda
Ryuji Kubota
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of TW592727B publication Critical patent/TW592727B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Description

592727
8 888 ABCD 六、申請專利範圍2 係聚烯丙胺或此交聯後取得之磷酸結合性聚合物使粉碎胃 平均粒徑爲4 0 0 // m以下者，且粒徑5 〇 〇 μ m以下之 比例爲9 0%以上者’調濕含水量爲1〜1 4%後，配a 結晶性纖維素及/或低取代度羥基丙基纖維素後， 成者。 8 ·如申請專利範圍第7項之製造方法，其中該碟酸 結合性聚合物使粉碎爲平均粒徑爲2 5 0 以下，且粒 徑3 0 0 # m以下之比例爲9 0 %以上者。 9 .—種錠劑，其特徵爲，平均粒徑爲4 〇 〇μπι以 下’且粒徑5 0 0以下之比率爲9 0%以上，進而含有水 分含有量爲1〜1 4%之磷酸結合性聚合物，錠劑硬度爲 6 Κ Ρ以上且崩散時間爲1 5分鐘以內之錠劑者。 1 0 ·如申請專利範圍第9項之淀劑，其進而依磨損 度試驗之重量減少率爲1%以下者。 1 1 ·如申請專利範圍第9或1 0項之錠劑，其中前 述錠劑硬度係以錠劑硬度計所測定者。 1 2 ·如申請專利範圍第9或1 0項之錠劑，其中前 述崩散時間係以崩散試驗器（試驗液：水）所測定者。 1 3 ·如申請專利範圍第1 〇項之錠劑，其中依前述 磨損度試驗之重量減少率，係使用磨損度試驗器，以 1 00迴轉（25 r pm，4分鐘）所測定者。 1 4 .如申請專利範圍第9或1 〇項之錠劑，其中’ 結晶纖維素及/或低取代度羥基丙基纖維素之含有量’相 對於前述憐酸結合性聚合物之重量（1 0 0重量％ )，爲 本纸張尺度適用中國國家標準（CNS ) A4规格（210X297公釐） 請 先 閲 面 之 注
I 經濟部智慧財產局員工消費合作社印製 -2- 592727 Α8 Β8 C8 D8 六、申請專利乾園3 1 0〜2 0 0重量％之範圍者。 1 5 .如申請專利範圍第9或1 0項之錠劑，其中前 述磷酸結合性聚合物之平均粒徑爲2 5 Ομπι以下，且粒 徑3 0 0以下之比率爲9 0%以上者。 1 6 .如申請專利範圍第9或1 0項之錠劑，其中含 有經基丙氧基取代度爲5 ·0~1 6.0重量％之低取代經 基丙基纖維素者。 1 7 .如申請專利範圍第9或1 0項之錠劑，其中碟 酸結合性聚合物係環氧氯丙烷作用於聚烯丙胺中，交聯後 取得之聚合物者。 1 8 .如申請專利範圍第9或1 0項之錠劑，其進而 含有硬化油者。 1 9 ·如申請專利範圍第9或1 0項之錠劑’其進而 以水溶性薄膜基劑來塗佈錠劑表面者。 (請先閲部背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家擦準（CNS > Α4規格（210X297公釐） -3 -
TW087104092A 1997-04-04 1998-03-19 Phosphate-binding polymer preparations TW592727B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8658197 1997-04-04

Publications (1)

Publication Number Publication Date
TW592727B true TW592727B (en) 2004-06-21

Family

ID=13890981

Family Applications (1)

Application Number Title Priority Date Filing Date
TW087104092A TW592727B (en) 1997-04-04 1998-03-19 Phosphate-binding polymer preparations

Country Status (16)

Country Link
US (2) US6383518B1 (zh)
EP (2) EP1304104B1 (zh)
JP (2) JP2009173687A (zh)
KR (1) KR100456202B1 (zh)
CN (1) CN1180782C (zh)
AT (2) ATE364377T1 (zh)
AU (1) AU726142B2 (zh)
CA (1) CA2286003C (zh)
CY (1) CY1106823T1 (zh)
DE (2) DE69816082T2 (zh)
DK (1) DK1304104T3 (zh)
ES (2) ES2287215T3 (zh)
HK (2) HK1027506A1 (zh)
PT (1) PT1304104E (zh)
TW (1) TW592727B (zh)
WO (1) WO1998044933A1 (zh)

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Also Published As

Publication number Publication date
CA2286003C (en) 2007-06-05
DE69837945T2 (de) 2008-02-21
WO1998044933A1 (fr) 1998-10-15
ATE364377T1 (de) 2007-07-15
EP0997148A1 (en) 2000-05-03
EP0997148A4 (en) 2000-05-03
PT1304104E (pt) 2007-07-27
US20020122786A1 (en) 2002-09-05
AU6522398A (en) 1998-10-30
AU726142B2 (en) 2000-11-02
EP0997148B1 (en) 2003-07-02
JP2013010803A (ja) 2013-01-17
ATE244013T1 (de) 2003-07-15
ES2201463T3 (es) 2004-03-16
DK1304104T3 (da) 2007-07-16
EP1304104A3 (en) 2003-11-12
EP1304104A2 (en) 2003-04-23
JP2009173687A (ja) 2009-08-06
HK1055387A1 (en) 2004-01-09
CN1180782C (zh) 2004-12-22
DE69816082T2 (de) 2004-04-15
US6383518B1 (en) 2002-05-07
KR100456202B1 (ko) 2004-11-09
KR20010005980A (ko) 2001-01-15
DE69816082D1 (de) 2003-08-07
CA2286003A1 (en) 1998-10-15
CY1106823T1 (el) 2012-05-23
CN1254287A (zh) 2000-05-24
HK1027506A1 (en) 2001-01-19
EP1304104B1 (en) 2007-06-13
DE69837945D1 (de) 2007-07-26
ES2287215T3 (es) 2007-12-16
JP5681156B2 (ja) 2015-03-04
US6696087B2 (en) 2004-02-24

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