CN1180782C - 磷酸结合性聚合物制剂 - Google Patents

磷酸结合性聚合物制剂 Download PDF

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Publication number
CN1180782C
CN1180782C CNB988046245A CN98804624A CN1180782C CN 1180782 C CN1180782 C CN 1180782C CN B988046245 A CNB988046245 A CN B988046245A CN 98804624 A CN98804624 A CN 98804624A CN 1180782 C CN1180782 C CN 1180782C
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CN
China
Prior art keywords
tablet
record
binding polymer
phosphate
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB988046245A
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English (en)
Chinese (zh)
Other versions
CN1254287A (zh
Inventor
��ʤҲ
松田胜也
窪田隆二
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of CN1254287A publication Critical patent/CN1254287A/zh
Application granted granted Critical
Publication of CN1180782C publication Critical patent/CN1180782C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CNB988046245A 1997-04-04 1998-04-03 磷酸结合性聚合物制剂 Expired - Lifetime CN1180782C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP86581/1997 1997-04-04
JP8658197 1997-04-04

Publications (2)

Publication Number Publication Date
CN1254287A CN1254287A (zh) 2000-05-24
CN1180782C true CN1180782C (zh) 2004-12-22

Family

ID=13890981

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988046245A Expired - Lifetime CN1180782C (zh) 1997-04-04 1998-04-03 磷酸结合性聚合物制剂

Country Status (15)

Country Link
US (2) US6383518B1 (https=)
EP (2) EP0997148B1 (https=)
JP (2) JP2009173687A (https=)
KR (1) KR100456202B1 (https=)
CN (1) CN1180782C (https=)
AT (2) ATE364377T1 (https=)
AU (1) AU726142B2 (https=)
CA (1) CA2286003C (https=)
CY (1) CY1106823T1 (https=)
DE (2) DE69816082T2 (https=)
DK (1) DK1304104T3 (https=)
ES (2) ES2287215T3 (https=)
PT (1) PT1304104E (https=)
TW (1) TW592727B (https=)
WO (1) WO1998044933A1 (https=)

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US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
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US6710162B2 (en) 2001-02-16 2004-03-23 Genzyme Corporation Method of drying a material having a cohesive phase
AU2002252632B2 (en) 2001-04-18 2004-09-23 Genzyme Corporation Low salt forms of polyallylamine
CA2444046C (en) 2001-04-18 2011-06-07 Steven K. Burke Use of colesevelam in reducing serum glucose
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
FR2827771B1 (fr) * 2001-07-25 2003-10-24 Apis Spheromont Formulation et procede de preparation de spheroides pouvant etre fortement titres et a dispersion rapide
US6600011B2 (en) 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
TWI231760B (en) * 2001-12-20 2005-05-01 Chugai Pharmaceutical Co Ltd Coated lozenge and manufacturing method thereof
US7449605B2 (en) 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7459502B2 (en) 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
CA2601236A1 (en) * 2005-03-16 2006-09-21 Usv Limited An improved process for the preparation of crosslinked polyallylamine polymer
US8986669B2 (en) * 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
EP3000460A1 (en) 2005-09-15 2016-03-30 Genzyme Corporation Sachet formulation for amine polymers
GB0601899D0 (en) * 2006-01-31 2006-03-08 Ineos Silicas Ltd Compositions
MY157620A (en) 2006-01-31 2016-06-30 Cytochroma Dev Inc A granular material of a solid water-soluble mixed metal compound capable of binding phosphate
DK1818048T3 (da) * 2006-02-14 2009-04-20 Teva Pharma Farmaceutiske formuleringer af alifatiske aminpolymerer og metoder til deres fremstilling
CA2642255A1 (en) * 2006-02-14 2007-08-23 Teva Pharmaceutical Industries Ltd. Pharmaceutical formulations of aliphatic amine polymers and methods for their manufacture
EP2016114A2 (en) * 2006-05-05 2009-01-21 Genzyme Corporation Amine condensation polymers as phosphate sequestrants
AU2007275711A1 (en) * 2006-07-18 2008-01-24 Genzyme Corporation Amine dendrimers
CA2749074A1 (en) * 2006-09-01 2008-05-29 Usv Limited Process for the preparation of sevelamer hydrochloride and formulation thereof
US7964182B2 (en) * 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
EP2066293A2 (en) 2006-09-29 2009-06-10 Genzyme Corporation Amide dendrimer compositions
US8163799B2 (en) * 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
JP2010519298A (ja) * 2007-02-23 2010-06-03 ゲンズイメ コーポレーション アミンポリマー組成物
EP2131820A1 (en) * 2007-03-08 2009-12-16 Genzyme Corporation Sulfone polymer compositions
EP2152277A1 (en) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amine dendrimer compositions
GB0714670D0 (en) 2007-07-27 2007-09-05 Ineos Healthcare Ltd Use
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
GB0720220D0 (en) 2007-10-16 2007-11-28 Ineos Healthcare Ltd Compound
WO2009078958A1 (en) * 2007-12-14 2009-06-25 Genzyme Corporation Coated pharmaceutical compositions
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
DE102008030046A1 (de) 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
US20110081413A1 (en) * 2009-01-22 2011-04-07 Ashok Omray Pharmaceutical Compositions Comprising Phosphate-Binding Polymer
US20100330175A1 (en) * 2009-06-24 2010-12-30 Jobdevairakkam Christopher N Cross-linked polyallylamine tablet core
WO2010149794A2 (en) 2009-06-26 2010-12-29 Combino Pharm, S.L. Novel pharmaceutical composition comprising poly (allylamin-co-n,n'-diallyl- 1,3-diamino-2-hydroxypropane)
GB0913525D0 (en) 2009-08-03 2009-09-16 Ineos Healthcare Ltd Method
ES2720869T3 (es) * 2009-10-22 2019-07-25 Synthon Bv Composiciones farmacéuticas de sevelámero
GB201001779D0 (en) 2010-02-04 2010-03-24 Ineos Healthcare Ltd Composition
EP2545907A1 (en) 2011-07-15 2013-01-16 Combino Pharm, S.L. Aqueous wet granulation process for cross-linked polyallylamine polymers
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
EP3261624A1 (en) * 2015-02-23 2018-01-03 Amneal Pharmaceuticals Company GmbH Process for granulating sevelamer carbonate
BR112019013364A2 (pt) 2016-12-28 2020-04-14 Fujifilm Corp emulsão de polímero contendo átomo de nitrogênio ou sal do mesmo, método de produção para o mesmo e método de produção para partículas
TW201922268A (zh) * 2017-10-16 2019-06-16 日商富士軟片股份有限公司 高磷血症治療劑及粒子
CN111225674A (zh) 2017-10-16 2020-06-02 富士胶片株式会社 高磷血症治疗剂
JP2019182818A (ja) * 2018-04-17 2019-10-24 ライオン株式会社 舌苔除去用の口腔内崩壊錠及び舌苔除去方法

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JPS6090243A (ja) 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
US4631305A (en) * 1985-03-22 1986-12-23 The Upjohn Company Polymeric material as a disintegrant in a compressed tablet
EP0273209B1 (en) 1986-12-30 1992-01-15 American Cyanamid Company Composition of matter containing polycarbophil
US4956182A (en) * 1989-03-16 1990-09-11 Bristol-Myers Company Direct compression cholestyramine tablet and solvent-free coating therefor
JPH02286621A (ja) 1989-04-26 1990-11-26 Mitsubishi Kasei Corp 経口コレステロール低下剤
JPH0413627A (ja) 1990-04-27 1992-01-17 Mitsubishi Kasei Corp 経口コレステロール低下剤
JP2609022B2 (ja) 1990-11-29 1997-05-14 北陸製薬株式会社 ポリカルボフィルカルシウム含有製剤
JPH06157325A (ja) 1992-11-30 1994-06-03 Mitsubishi Kasei Corp 経口コレステロール低下剤
TW272942B (https=) 1993-02-10 1996-03-21 Takeda Pharm Industry Co Ltd
US5667775A (en) * 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
WO1996021454A1 (en) * 1995-01-12 1996-07-18 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
JP3836893B2 (ja) 1995-01-24 2006-10-25 アボットジャパン株式会社 ポリカルボフィルカルシウム含有製剤
TW438608B (en) 1995-08-02 2001-06-07 Hisamitsu Pharmaceutical Co A tablet containing anion exchange resin
JP3389493B2 (ja) * 1997-04-04 2003-03-24 中外製薬株式会社 リン酸結合性ポリマー製剤

Also Published As

Publication number Publication date
JP2009173687A (ja) 2009-08-06
EP1304104B1 (en) 2007-06-13
TW592727B (en) 2004-06-21
EP0997148A4 (en) 2000-05-03
DE69837945D1 (de) 2007-07-26
CY1106823T1 (el) 2012-05-23
WO1998044933A1 (en) 1998-10-15
PT1304104E (pt) 2007-07-27
KR20010005980A (ko) 2001-01-15
CN1254287A (zh) 2000-05-24
EP1304104A2 (en) 2003-04-23
HK1055387A1 (en) 2004-01-09
EP0997148B1 (en) 2003-07-02
HK1027506A1 (en) 2001-01-19
DE69837945T2 (de) 2008-02-21
ATE364377T1 (de) 2007-07-15
ES2287215T3 (es) 2007-12-16
US20020122786A1 (en) 2002-09-05
EP1304104A3 (en) 2003-11-12
JP2013010803A (ja) 2013-01-17
US6696087B2 (en) 2004-02-24
DE69816082D1 (de) 2003-08-07
CA2286003C (en) 2007-06-05
KR100456202B1 (ko) 2004-11-09
AU726142B2 (en) 2000-11-02
EP0997148A1 (en) 2000-05-03
CA2286003A1 (en) 1998-10-15
DE69816082T2 (de) 2004-04-15
ATE244013T1 (de) 2003-07-15
AU6522398A (en) 1998-10-30
ES2201463T3 (es) 2004-03-16
US6383518B1 (en) 2002-05-07
JP5681156B2 (ja) 2015-03-04
DK1304104T3 (da) 2007-07-16

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Granted publication date: 20041222