DE69813242D1 - Hemostatische verdichtungsmittel für gewebe - Google Patents

Hemostatische verdichtungsmittel für gewebe

Info

Publication number
DE69813242D1
DE69813242D1 DE69813242T DE69813242T DE69813242D1 DE 69813242 D1 DE69813242 D1 DE 69813242D1 DE 69813242 T DE69813242 T DE 69813242T DE 69813242 T DE69813242 T DE 69813242T DE 69813242 D1 DE69813242 D1 DE 69813242D1
Authority
DE
Germany
Prior art keywords
tissue
hemostatic
sealant
tissue sealant
sealants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69813242T
Other languages
English (en)
Other versions
DE69813242T2 (de
Inventor
Arthur J Coury
Amarpreet S Sawhney
Jeffrey A Hubbell
C Michael Philbrook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Focal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Focal Inc filed Critical Focal Inc
Application granted granted Critical
Publication of DE69813242D1 publication Critical patent/DE69813242D1/de
Publication of DE69813242T2 publication Critical patent/DE69813242T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/676—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
DE69813242T 1997-08-06 1998-08-06 Hemostatische verdichtungsmittel für gewebe Expired - Lifetime DE69813242T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5484997P 1997-08-06 1997-08-06
US54849P 1997-08-06
PCT/US1998/016410 WO1999007417A1 (en) 1997-08-06 1998-08-06 Hemostatic tissue sealants

Publications (2)

Publication Number Publication Date
DE69813242D1 true DE69813242D1 (de) 2003-05-15
DE69813242T2 DE69813242T2 (de) 2004-03-11

Family

ID=21993908

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69813242T Expired - Lifetime DE69813242T2 (de) 1997-08-06 1998-08-06 Hemostatische verdichtungsmittel für gewebe

Country Status (9)

Country Link
US (1) US6162241A (de)
EP (1) EP1003568B1 (de)
JP (7) JP2001513368A (de)
AT (1) ATE236666T1 (de)
AU (1) AU738784B2 (de)
CA (1) CA2299336A1 (de)
DE (1) DE69813242T2 (de)
WO (1) WO1999007417A1 (de)
ZA (1) ZA987019B (de)

Families Citing this family (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4193917B2 (ja) 1995-12-18 2008-12-10 アンジオデバイス インターナショナル ゲーエムベーハー 架橋ポリマー組成物およびその使用方法
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US6743248B2 (en) 1996-12-18 2004-06-01 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US20030191496A1 (en) 1997-03-12 2003-10-09 Neomend, Inc. Vascular sealing device with microwave antenna
US6162241A (en) * 1997-08-06 2000-12-19 Focal, Inc. Hemostatic tissue sealants
AU755051B2 (en) 1998-01-07 2002-12-05 Debio Recherche Pharmaceutique S.A. Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US7335220B2 (en) 2004-11-05 2008-02-26 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6458147B1 (en) 1998-11-06 2002-10-01 Neomend, Inc. Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
US6994686B2 (en) 1998-08-26 2006-02-07 Neomend, Inc. Systems for applying cross-linked mechanical barriers
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
US6949114B2 (en) 1998-11-06 2005-09-27 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US7279001B2 (en) * 1998-11-06 2007-10-09 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US6830756B2 (en) * 1998-11-06 2004-12-14 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US6899889B1 (en) * 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
EP1137373A4 (de) 1998-12-04 2004-05-19 Chandrashekhar P Pathak Biokompatible, vernetzte polymere
EP1146917A1 (de) * 1999-01-22 2001-10-24 St. Jude Medical, Inc. Medizinischer klebstoff
US6312725B1 (en) * 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
DE60042414D1 (de) 1999-08-27 2009-07-30 Angiodevice Internat Gmbh Interpenetrierende polymernetzwerke zur verwendung
US7008635B1 (en) 1999-09-10 2006-03-07 Genzyme Corporation Hydrogels for orthopedic repair
JP2001329183A (ja) * 2000-05-22 2001-11-27 Yuichi Mori ゲル化性組成物
US20050123583A1 (en) * 2000-12-18 2005-06-09 Hsing-Wen Sung Medical use of reuterin
US6632678B2 (en) * 2001-01-03 2003-10-14 Sienco, Inc. Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity
US20060094112A1 (en) * 2001-03-07 2006-05-04 Omotunde Babalola Biological scaffold
US7795218B2 (en) 2001-04-12 2010-09-14 Bioaxone Therapeutique Inc. ADP-ribosyl transferase fusion variant proteins
US7371403B2 (en) * 2002-06-14 2008-05-13 Providence Health System-Oregon Wound dressing and method for controlling severe, life-threatening bleeding
US8741335B2 (en) 2002-06-14 2014-06-03 Hemcon Medical Technologies, Inc. Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan
AU2002312493B2 (en) 2001-06-14 2007-08-09 Gregory, Kenton W Wound dressing and method for controlling severe, life-threatening bleeding
EP2462939A3 (de) * 2001-07-31 2012-08-15 Tyco Healthcare Group LP Bioabsorbierbare Klebeverbindungen und -zusammensetzungen
US6592608B2 (en) * 2001-12-07 2003-07-15 Biopsy Sciences, Llc Bioabsorbable sealant
US20030124118A1 (en) * 2001-11-27 2003-07-03 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and protein S inhibitors
US20080057059A1 (en) * 2001-11-09 2008-03-06 Novo Nordisk Healthcare A/G Pharmaceutical Composition Comprising Factor VII Polypeptides and Protein S Inhibitors
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
AU2002361902A1 (en) * 2001-12-31 2003-07-24 Ares Medical, Inc. Hemostatic compositions and methods for controlling bleeding
CA2484761C (en) 2002-05-24 2010-11-09 Angiotech International Ag Compositions and methods for coating medical implants
US20050137512A1 (en) * 2003-12-23 2005-06-23 Campbell Todd D. Wound dressing and method for controlling severe, life-threatening bleeding
US8269058B2 (en) 2002-06-14 2012-09-18 Hemcon Medical Technologies, Inc. Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US20040101546A1 (en) * 2002-11-26 2004-05-27 Gorman Anne Jessica Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents
US8349348B2 (en) * 2002-08-06 2013-01-08 Matrix Medical, Llc Biocompatible phase invertible proteinaceous compositions and methods for making and using the same
US9101536B2 (en) * 2002-08-06 2015-08-11 Matrix Medical Llc Biocompatible phase invertable proteinaceous compositions and methods for making and using the same
EP3915529A1 (de) * 2002-08-06 2021-12-01 BAXTER INTERNATIONAL INC. (a Delaware corporation) Biokompatible phasenumkehrbare proteinhaltige zusammensetzungen und verfahren zur herstellung und verwendung davon
US10098981B2 (en) 2002-08-06 2018-10-16 Baxter International Inc. Biocompatible phase invertable proteinaceous compositions and methods for making and using the same
DE10236152A1 (de) * 2002-08-07 2004-02-19 Marker Deutschland Gmbh Ski- und Skibindungs-Kombination
JP2006500978A (ja) * 2002-08-20 2006-01-12 イグザクテック・インコーポレイテッド 骨成長誘導物質の運搬および送達用組成物、およびその組成物の製造および適用方法
EP1556430B1 (de) * 2002-10-28 2009-06-24 Tyco Healthcare Group Lp Biologisch absorbierbare adhäsive verbindungen
EP1573295A2 (de) 2002-12-11 2005-09-14 Ferrosan A/S Tupfer aus gelatine basiertem material
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
US7931637B2 (en) * 2002-12-31 2011-04-26 Marine Polymer Technologies, Inc. Hemostatic compositions and uses therefor
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US20040151691A1 (en) * 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
US7331979B2 (en) * 2003-06-04 2008-02-19 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9289195B2 (en) 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
JP4709479B2 (ja) * 2003-07-03 2011-06-22 博 西田 高分子ミセルを有効成分とする組織接着剤
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
JP2005075815A (ja) * 2003-09-03 2005-03-24 Masao Tanihara 止血性組織修復材
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
JP5031367B2 (ja) * 2003-09-23 2012-09-19 オーソコン・インコーポレイテッド 吸収性のインプラントならびに止血および骨欠損の処置における、それらの使用
US20050125033A1 (en) * 2003-12-04 2005-06-09 Mcnally-Heintzelman Karen M. Wound closure apparatus
US20050125015A1 (en) * 2003-12-04 2005-06-09 Mcnally-Heintzelman Karen M. Tissue-handling apparatus, system and method
US7824711B2 (en) 2003-12-11 2010-11-02 Isto Technologies, Inc. Particulate cartilage system
US20050180957A1 (en) * 2004-01-16 2005-08-18 Scharp David W. Method of using fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
ATE475434T1 (de) 2004-01-30 2010-08-15 Ferrosan As Hämostatische sprays und zusammensetzungen
US20050203058A1 (en) * 2004-03-11 2005-09-15 Johnson Edwin L. Compositions of alpha- and beta-chitosan and methods of preparing them
EP1786480B1 (de) 2004-07-09 2016-09-21 Ferrosan Medical Devices A/S Hämostatische zusammensetzung mit hyaluronsäure
US8348971B2 (en) 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
CA2581093C (en) 2004-09-17 2014-11-18 Angiotech Biomaterials Corporation Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
CA2585215A1 (en) * 2004-10-28 2006-05-11 Surmodics, Inc. Pro-fibrotic coatings comprising collagen for medical implants
US8262693B2 (en) 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US8535709B2 (en) * 2004-12-13 2013-09-17 Southeastern Medical Technologies, Llc Agents for controlling biological fluids and methods of use thereof
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
US20070059350A1 (en) * 2004-12-13 2007-03-15 Kennedy John P Agents for controlling biological fluids and methods of use thereof
AU2006213822B2 (en) 2005-02-09 2011-05-26 Covidien Lp Synthetic sealants
US9204957B2 (en) 2005-03-17 2015-12-08 Hemcon Medical Technologies, Inc. Systems and methods for hemorrhage control and or tissue repair
US7806856B2 (en) * 2005-04-22 2010-10-05 Accessclosure, Inc. Apparatus and method for temporary hemostasis
US8002742B2 (en) * 2005-04-22 2011-08-23 Accessclosure, Inc. Apparatus and methods for sealing a puncture in tissue
US7468232B2 (en) * 2005-04-27 2008-12-23 Xerox Corporation Processes for forming latexes and toners, and latexes and toner formed thereby
US8044234B2 (en) * 2005-05-05 2011-10-25 Tyco Healthcare Group Lp Bioabsorbable surgical composition
US8304402B2 (en) 2005-05-05 2012-11-06 Binyarco, Llc Composition and method for treating nosebleeds
US20090177226A1 (en) * 2005-05-05 2009-07-09 Jon Reinprecht Bioabsorbable Surgical Compositions
US20100100124A1 (en) * 2005-05-05 2010-04-22 Tyco Healthcare Group Lp Bioabsorbable surgical composition
US8663686B2 (en) 2005-05-09 2014-03-04 University Of Washington Biodegradable chitosan-PEG compositions and methods of use
US20070031468A1 (en) * 2005-08-04 2007-02-08 Endomedix, Inc. Modified chitosan for vascular embolization
US20070031467A1 (en) * 2005-08-04 2007-02-08 Abrahams John M Composition and method for vascular embolization
JP5292533B2 (ja) 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド インプラントおよび関節疾患の治療、置換および治療方法
US7947263B2 (en) 2005-12-06 2011-05-24 Tyco Healthcare Group Lp Biocompatible surgical compositions
AU2006321915B2 (en) 2005-12-06 2012-04-26 Covidien Lp Bioabsorbable surgical composition
EP1957089A4 (de) 2005-12-06 2012-06-20 Tyco Healthcare Carbodimid-verneztung von funktionalisierten polyethylen-glykolen
WO2007067623A2 (en) 2005-12-06 2007-06-14 Tyco Healthcare Group Lp Biocompatible tissue sealants and adhesives
AU2006321914B2 (en) * 2005-12-06 2012-01-19 Covidien Lp Bioabsorbable compounds and compositions containing them
CA2630327C (en) 2005-12-08 2015-05-26 Tyco Healthcare Group Lp Biocompatible surgical compositons
GB0526505D0 (en) 2005-12-29 2006-02-08 Medtrade Products Ltd Hemostatic material
US8277837B2 (en) 2006-01-11 2012-10-02 Entegrion, Inc. Hemostatic textile
CA2573472A1 (en) * 2006-01-23 2007-07-23 Tyco Healthcare Group Lp Biodegradable hemostatic compositions
US8795709B2 (en) * 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US20070243130A1 (en) * 2006-04-18 2007-10-18 Weiliam Chen Biopolymer system for tissue sealing
US20080075657A1 (en) * 2006-04-18 2008-03-27 Abrahams John M Biopolymer system for tissue sealing
US7854923B2 (en) * 2006-04-18 2010-12-21 Endomedix, Inc. Biopolymer system for tissue sealing
EP2023941B1 (de) 2006-04-24 2016-12-21 Incept, LLC Proteinvernetzer, vernetzungsverfahren und ihre anwendungen
CA2653175A1 (en) 2006-05-23 2007-12-06 Providence Health System-Oregon D/B/A Providence St. Vincent Medical Cen Ter Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ
US8119780B2 (en) * 2006-06-02 2012-02-21 Synedgen, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
US20080248508A1 (en) * 2006-08-17 2008-10-09 Shenda Baker Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials
WO2008033964A2 (en) 2006-09-13 2008-03-20 Accessclosure, Inc. Apparatus for sealing a vascular puncture
CN102552967B (zh) 2006-12-15 2015-08-12 生命连结有限公司 明胶-转谷氨酰胺酶止血敷料和密封材料
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
JP2010518917A (ja) 2007-02-19 2010-06-03 マリン ポリマー テクノロジーズ，インコーポレーテッド 止血組成物及び治療法
MX2009009081A (es) * 2007-02-22 2009-10-30 Pluromed Inc Uso de polimeros termosensibles inversos para controlar el flujo de fluidos biologicos despues de un procedimiento medico.
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
EP2134297B1 (de) 2007-04-12 2017-03-08 Zimmer, Inc. Vorrichtung zur gewebereparatur
US20110123476A1 (en) * 2007-05-24 2011-05-26 Mbiya Kapiamba Adhesive Formulations
US7858835B2 (en) * 2007-06-27 2010-12-28 Tyco Healthcare Group Lp Foam control for synthetic adhesive/sealant
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US20090041858A1 (en) * 2007-08-06 2009-02-12 Cao Group, Inc. Haemostatic Compositions Thickened by Polymers Containing Nitrogen Moieties
US8067028B2 (en) 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
WO2009023745A1 (en) 2007-08-14 2009-02-19 The Regents Of The University Of California Mesocellular oxide foams as hemostatic compositions and methods of use
US7993367B2 (en) * 2007-09-28 2011-08-09 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
EP2209426A4 (de) 2007-11-02 2015-04-22 Incept Llc Gerät und verfahren zur abdichtung einer gefässpunktion
US8500947B2 (en) 2007-11-15 2013-08-06 Covidien Lp Speeding cure rate of bioadhesives
CA2706701C (en) 2007-12-03 2016-10-25 Tenaxis Medical, Inc. Biocompatible phase invertible proteinaceous compositions
US8299316B2 (en) 2007-12-18 2012-10-30 Ethicon, Inc. Hemostatic device
US8629314B2 (en) * 2007-12-18 2014-01-14 Ethicon, Inc. Surgical barriers having adhesion inhibiting properties
US8324292B2 (en) * 2008-02-29 2012-12-04 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
JP5569398B2 (ja) 2008-02-29 2014-08-13 フェッローサン メディカル ディバイス エー／エス 止血および／または創傷治癒を促進するための装置
US9364206B2 (en) 2008-04-04 2016-06-14 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8029533B2 (en) * 2008-04-04 2011-10-04 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
EP2269594B1 (de) 2008-04-16 2016-03-02 The Chemo-Sero-Therapeutic Research Institute Verfahren zur herstellung eines thrombin-immobilisierten biologisch absorbierbaren folienpräparats
EP2279012A4 (de) * 2008-05-02 2013-05-29 Providence Health Sys Oregon Wundverbände und verfahren
US20110086014A1 (en) * 2008-06-18 2011-04-14 Ishay Attar Method for enzymatic cross-linking of a protein
CA2728186A1 (en) * 2008-06-18 2009-12-23 Lifebond Ltd Methods and devices for use with sealants
CN104031393B (zh) 2008-06-18 2017-08-01 生命连结有限公司 改进的交联组合物
US9271706B2 (en) 2008-08-12 2016-03-01 Covidien Lp Medical device for wound closure and method of use
EP2340002B1 (de) 2008-10-06 2015-03-25 Providence Health System - Oregon Medizinische schaumvorrichtungen und verfahren
US9889230B2 (en) * 2008-10-17 2018-02-13 Covidien Lp Hemostatic implant
EP3821817A3 (de) 2008-11-12 2021-11-03 Access Closure, Inc. Vorrichtung zur versiegelung einer vaskulären punktur
US9827205B2 (en) * 2008-12-12 2017-11-28 Mallinckrodt Pharma Ip Trading D.A.C. Dry powder fibrin sealant
CN102395401B (zh) 2009-02-12 2015-08-19 因赛普特有限责任公司 经由水凝胶塞的药物递送
JP5936536B2 (ja) * 2009-03-16 2016-06-22 ユニバーシティー オブ メンフィス リサーチ ファウンデーション 傷に剤を届けるための組成物および方法
US9155815B2 (en) 2009-04-17 2015-10-13 Tenaxis Medical, Inc. Biocompatible phase invertible proteinaceous compositions and methods for making and using the same
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
CA2977830C (en) 2009-05-04 2019-09-17 Incept, Llc Biomaterials for track and puncture closure
US8470355B2 (en) * 2009-10-01 2013-06-25 Covidien Lp Mesh implant
CN102695500A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 多糖基水凝胶
CA2780274C (en) 2009-11-09 2018-06-26 Spotlight Technology Partners Llc Fragmented hydrogels
WO2011060390A2 (en) 2009-11-13 2011-05-19 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
ES2551388T3 (es) 2009-12-22 2015-11-18 Lifebond Ltd Modificación de agentes de entrecruzamiento enzimáticos para controlar las propiedades de las matrices entrecruzadas
CA2796068C (en) 2010-04-15 2022-07-19 Marine Polymer Technologies, Inc. Anti-bacterial applications of poly-n-acetylglucosamine nanofibers
AU2011287215B2 (en) 2010-08-05 2015-09-10 Lifebond Ltd. Dry composition wound dressings and adhesives
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
EP3821820A1 (de) 2011-01-19 2021-05-19 Access Closure, Inc. Vorrichtung und verfahren zur herstellung einer versiegelung einer gefässpunktion
US9820728B2 (en) 2011-01-19 2017-11-21 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9084602B2 (en) 2011-01-26 2015-07-21 Covidien Lp Buttress film with hemostatic action for surgical stapling apparatus
US9447169B2 (en) * 2011-03-04 2016-09-20 Orthovita, Inc. Flowable collagen-based hemostat and methods of use
US20140127310A1 (en) 2011-04-15 2014-05-08 Marine Polymer Technologies, Inc. Treatment of disease with poly-n-acetylglucosamine nanofibers
US9386968B2 (en) 2011-05-11 2016-07-12 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
WO2013020094A2 (en) * 2011-08-03 2013-02-07 Avant Garde Therapeutics Inc. Novel hemostatic patch and uses thereof
EP2755676B1 (de) * 2011-09-12 2019-08-14 Protege Biomedical, LLC Zusammensetzung und verband zur wundbehandlung
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US20130202675A1 (en) 2012-02-03 2013-08-08 Dynasil Biomedical Corporation Systems and methods for the fabrication of tissue patches
CN104159527B (zh) 2012-03-06 2017-04-12 弗罗桑医疗设备公司 包含止血糊剂的压力容器
US8721680B2 (en) 2012-03-23 2014-05-13 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9757105B2 (en) 2012-03-23 2017-09-12 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
JP6394916B2 (ja) 2012-06-12 2018-09-26 フェロサン メディカル デバイシーズ エイ／エス 乾燥止血組成物
US10016454B2 (en) 2012-12-04 2018-07-10 Cohera Medical, Inc. Silane-containing moisture-curable tissue sealant
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9040093B2 (en) 2013-03-13 2015-05-26 Orthovita, Inc. Bone graft materials containing calcium phosphate and chitosan
US9616088B2 (en) 2013-03-13 2017-04-11 Gel-E, Inc. Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
US11071805B2 (en) 2013-04-22 2021-07-27 Sealantium Medical Ltd. Fibrinogen-based tissue adhesive patches
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
EP3470094B1 (de) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Trockenzusammensetzung mit extrusionsverstärker
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
CN107206165B (zh) 2014-12-24 2020-10-23 弗罗桑医疗设备公司 用于保持并混合第一和第二物质的注射器
US11382731B2 (en) 2015-02-27 2022-07-12 Covidien Lp Medical devices with sealing properties
EP3316930B1 (de) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Spritze zum mischen zweier komponenten und zum aufrechterhalten eines vakuums im lagerzustand
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
EP3331577A4 (de) 2015-08-07 2019-07-17 Xcede Technologies, Inc. Klebstoffzusammensetzungen und zugehörige verfahren
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
WO2017033941A1 (ja) * 2015-08-24 2017-03-02 株式会社スリー・ディー・マトリックス 生分解性インジェクタブルゲル
WO2017037178A1 (en) * 2015-09-01 2017-03-09 Trauma Care Consult Traumatologische Forschung Gemeinnützige Gesellschaft Mbh Hemostatic material
JP6816135B2 (ja) 2015-10-19 2021-01-20 シーレーンチウム メディカル リミテッド フィブリノーゲンに基づく改善された組織接着剤パッチ
US11471556B2 (en) 2015-10-19 2022-10-18 Sealantium Medical Ltd. Fibrinogen-based tissue adhesive patch
EP3370783B1 (de) 2015-11-06 2023-06-07 Ethicon, Inc. Verdichtete hämostatische cellulosische aggregate
EP3373840B1 (de) 2015-11-11 2021-04-07 Devicor Medical Products, Inc. Markerfreisetzungsvorrichtung
US10335124B1 (en) 2016-02-29 2019-07-02 Devicor Medical Products, Inc. Marker delivery device with adaptor for biopsy site marking and method of use thereof
US10610841B1 (en) 2016-06-30 2020-04-07 Devicor Medical Products, Inc. Marker having enhanced ultrasound visibility and method of manufacturing the same
US11413335B2 (en) 2018-02-13 2022-08-16 Guangzhou Bioseal Biotech Co. Ltd Hemostatic compositions and methods of making thereof
CN107754005B (zh) 2016-08-15 2021-06-15 广州倍绣生物技术有限公司 止血组合物及其制造方法
US11090132B2 (en) 2017-09-15 2021-08-17 Devicor Medical Products, Inc. Method for manufacturing marker with aerated hydrogel
US11191610B2 (en) 2017-09-26 2021-12-07 Devicor Medical Products, Inc. Biopsy site marker with microsphere coating
WO2019180713A1 (en) 2018-03-22 2019-09-26 Sealantium Medical Ltd Method for determining the adhesive force of a hemostatic tissue sealant patch
US11639416B2 (en) 2018-04-19 2023-05-02 Poly-Med, Inc. Macromers and compositions for photocuring processes
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법
WO2019231763A1 (en) 2018-05-27 2019-12-05 Christos Angeletakis Tissue adhesives and sealants using naturally derived aldehydes
US10517988B1 (en) 2018-11-19 2019-12-31 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
JP2022512149A (ja) 2018-12-10 2022-02-02 デビコー・メディカル・プロダクツ・インコーポレイテッド 端部展開針付き生検システム
EP3876849A1 (de) 2018-12-17 2021-09-15 Devicor Medical Products, Inc. Vorrichtung zur freisetzung von biopsiehohlraummarkern
WO2020168026A1 (en) 2019-02-15 2020-08-20 Devicor Medical Products, Inc. Marker delivery device with sterile guide
CA3135980A1 (en) * 2019-03-05 2020-09-10 Medcura, Inc. System and method to reduce tissue or organ adhesion
WO2020243386A1 (en) 2019-05-30 2020-12-03 Devicor Medical Products, Inc. Shape memory marker deployment device
EP4279015A3 (de) 2019-05-30 2023-12-27 Devicor Medical Products, Inc. Vorrichtung zur direkten markierung
CN113873963A (zh) 2019-05-30 2021-12-31 Devicor医疗产业收购公司 用于有限迁移的活检部位标记物
CN115135276A (zh) 2020-01-15 2022-09-30 Devicor医疗产业收购公司 带有具有致动特征件的推杆的标记物递送装置
JP2023518067A (ja) 2020-03-17 2023-04-27 デビコー・メディカル・プロダクツ・インコーポレイテッド 非転移生検部位識別子
EP4231957A1 (de) 2020-12-02 2023-08-30 Devicor Medical Products, Inc. Markerfreisetzungsvorrichtung zur entkopplung von kolben und schubstange
WO2023215090A1 (en) 2022-05-03 2023-11-09 Devicor Medical Products, Inc. Biopsy site marker with increased visualization and non-migration features
WO2023249760A1 (en) 2022-06-23 2023-12-28 Devicor Medical Products, Inc. Biopsy site marker with expandable mesh
WO2024039560A1 (en) 2022-08-16 2024-02-22 Devicor Medical Products, Inc. Biopsy site marker having expandable portion
WO2024039561A1 (en) 2022-08-16 2024-02-22 Devicor Medical Products, Inc. Biopsy site marker having movable portions
CN115671372B (zh) * 2022-10-12 2023-06-20 浙江大学 可制备双交联纤维蛋白粘合剂的原料组合物及方法
CN115920118B (zh) * 2022-10-12 2023-07-04 浙江大学 双交联纤维蛋白凝胶、试剂盒及其应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2642375A (en) * 1951-08-21 1953-06-16 Ethicon Suture Lab Inc Hemostatic compositions
US3483870A (en) * 1963-04-22 1969-12-16 Eastman Kodak Co Surgical use of adhesive compositions
US3438374A (en) * 1966-02-28 1969-04-15 Us Health Education & Welfare Method of bonding tissue surfaces and controlling hemorrhaging thereof using a tissue adhesive and hemostatic composition
US4532134A (en) * 1981-04-06 1985-07-30 Malette William Graham Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
JPS5982864A (ja) * 1982-09-28 1984-05-14 ジヨンソン・アンド・ジヨンソン・プロダクツ・インコ−ポレイテツド ゲル包帯およびその製造方法
US4443430A (en) * 1982-11-16 1984-04-17 Ethicon, Inc. Synthetic absorbable hemostatic agent
US4511478A (en) * 1983-11-10 1985-04-16 Genetic Systems Corporation Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
US4741872A (en) * 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US5160745A (en) * 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US4716203A (en) * 1986-09-05 1987-12-29 American Cyanamid Company Diblock and triblock copolymers
IL82834A (en) * 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4888413A (en) * 1988-01-11 1989-12-19 Domb Abraham J Poly(propylene glycol fumarate) compositions for biomedical applications
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
IL90193A (en) * 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5595735A (en) * 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
NZ240214A (en) * 1990-10-16 1993-02-25 Takeda Chemical Industries Ltd Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
US5690675A (en) * 1991-02-13 1997-11-25 Fusion Medical Technologies, Inc. Methods for sealing of staples and other fasteners in tissue
JPH04265542A (ja) * 1991-02-20 1992-09-21 Dainippon Ink & Chem Inc 光ディスク用基板
US5714232A (en) * 1991-05-01 1998-02-03 E. R. Squibb & Sons, Inc. Alginate fabric, its use in wound dressings and surgical haemostats and a process for its manufacture
US5575995A (en) * 1991-08-15 1996-11-19 Giovanoni; Richard L. Ferric subsulfate gel and methods of using same
JPH05228203A (ja) * 1992-02-19 1993-09-07 Nitto Denko Corp 創傷被覆材
BR9306038A (pt) * 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
DE69328228T2 (de) * 1992-04-21 2000-12-21 Ajinomoto Kk Wundheilmittel
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US5409703A (en) * 1993-06-24 1995-04-25 Carrington Laboratories, Inc. Dried hydrogel from hydrophilic-hygroscopic polymer
DE4322956C2 (de) * 1993-07-09 1995-12-21 Haack Karl Werner An Folie aus Chitosan zur Wundversiegelung
US5405953A (en) * 1993-08-03 1995-04-11 Biocontrol Incorporated Microfibrillated oxycellulose
DE69433939T2 (de) * 1993-11-03 2005-08-11 Clarion Pharmaceuticals, Inc., Madison Hämostatisches pflaster
CZ288792B6 (cs) * 1993-12-23 2001-09-12 Johnson & Johnson Medical, Inc. Bioabsorbovatelný chirurgický hemostat a způsob jeho výroby
EP0748215B1 (de) * 1994-02-17 2003-05-28 New York Blood Center, Inc. Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung
JP3107726B2 (ja) * 1994-05-13 2000-11-13 株式会社クラレ 水膨潤性高分子ゲル
JP2535785B2 (ja) * 1994-06-03 1996-09-18 工業技術院長 血管塞栓剤
US5583114A (en) * 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
AU700903B2 (en) * 1994-10-12 1999-01-14 Focal, Inc. Targeted delivery via biodegradable polymers
WO1996029370A2 (en) * 1995-03-23 1996-09-26 Focal, Inc. Redox and photoinitiator systems for priming for improved adherence of gels to substrates
US5658588A (en) * 1995-03-31 1997-08-19 University Of Cincinnati Fibrinogen-coated liposomes
US5641502A (en) * 1995-06-07 1997-06-24 United States Surgical Corporation Biodegradable moldable surgical material
WO1996041818A1 (en) * 1995-06-09 1996-12-27 Drohan William N Chitin hydrogels, methods of their production and use
US5527864A (en) * 1995-08-08 1996-06-18 Suggs; Laura J. Poly(propylene fumarate-co-ethylene oxide)
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5800372A (en) * 1996-01-09 1998-09-01 Aerojet-General Corporation Field dressing for control of exsanguination
US5696101A (en) * 1996-04-16 1997-12-09 Eastman Chemical Company Oxidized cellulose and vitamin E blend for topical hemostatic applications
EP0927214B2 (de) * 1996-09-23 2014-03-12 Genzyme Corporation Polymerisierbare biologisch abbaubare polymere mit carbonat-oder dioxanonbindungen
US6162241A (en) * 1997-08-06 2000-12-19 Focal, Inc. Hemostatic tissue sealants

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JP2014141509A (ja) 2014-08-07
AU8695598A (en) 1999-03-01
JP2012140463A (ja) 2012-07-26
JP5843243B2 (ja) 2016-01-13
US6162241A (en) 2000-12-19
ZA987019B (en) 1999-06-04
JP2012139542A (ja) 2012-07-26
JP2015187140A (ja) 2015-10-29
JP2016094472A (ja) 2016-05-26
CA2299336A1 (en) 1999-02-18
JP2001513368A (ja) 2001-09-04
ATE236666T1 (de) 2003-04-15
JP2014208717A (ja) 2014-11-06
EP1003568B1 (de) 2003-04-09
WO1999007417A1 (en) 1999-02-18
JP5937257B2 (ja) 2016-06-22
AU738784B2 (en) 2001-09-27
EP1003568A1 (de) 2000-05-31

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