DE69739860D1 - Rekombinante AAV zur Herstellung eines Medikaments für die Gentherapie von Muskelzellen - Google Patents

Rekombinante AAV zur Herstellung eines Medikaments für die Gentherapie von Muskelzellen

Info

Publication number
DE69739860D1
DE69739860D1 DE69739860T DE69739860T DE69739860D1 DE 69739860 D1 DE69739860 D1 DE 69739860D1 DE 69739860 T DE69739860 T DE 69739860T DE 69739860 T DE69739860 T DE 69739860T DE 69739860 D1 DE69739860 D1 DE 69739860D1
Authority
DE
Germany
Prior art keywords
medicament
manufacture
gene therapy
muscle cells
recombinant aav
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739860T
Other languages
English (en)
Inventor
James M Wilson
Krishna J Fisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/708,188 external-priority patent/US5866552A/en
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Application granted granted Critical
Publication of DE69739860D1 publication Critical patent/DE69739860D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69739860T 1996-09-06 1997-09-04 Rekombinante AAV zur Herstellung eines Medikaments für die Gentherapie von Muskelzellen Expired - Lifetime DE69739860D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/708,188 US5866552A (en) 1996-09-06 1996-09-06 Method for expressing a gene in the absence of an immune response
US72906196A 1996-10-10 1996-10-10

Publications (1)

Publication Number Publication Date
DE69739860D1 true DE69739860D1 (de) 2010-06-02

Family

ID=27108032

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69739860T Expired - Lifetime DE69739860D1 (de) 1996-09-06 1997-09-04 Rekombinante AAV zur Herstellung eines Medikaments für die Gentherapie von Muskelzellen
DE69738351T Expired - Lifetime DE69738351T2 (de) 1996-09-06 1997-09-04 Verfaheren zur durch rekombinante adeno-assoziierte virus-gerichtete gentherapie

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69738351T Expired - Lifetime DE69738351T2 (de) 1996-09-06 1997-09-04 Verfaheren zur durch rekombinante adeno-assoziierte virus-gerichtete gentherapie

Country Status (11)

Country Link
EP (2) EP1696036B1 (de)
JP (1) JP2001500497A (de)
KR (1) KR20000068501A (de)
CN (1) CN1233291A (de)
AT (2) ATE380037T1 (de)
AU (1) AU723497C (de)
CA (1) CA2264483C (de)
DE (2) DE69739860D1 (de)
ES (1) ES2344660T3 (de)
IL (1) IL128779A0 (de)
WO (1) WO1998009657A2 (de)

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WO1998009657A2 (en) 1998-03-12
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AU723497B2 (en) 2000-08-31
IL128779A0 (en) 2000-01-31
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CN1233291A (zh) 1999-10-27
JP2001500497A (ja) 2001-01-16
EP1696036A1 (de) 2006-08-30
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ATE380037T1 (de) 2007-12-15
DE69738351D1 (de) 2008-01-17
CA2264483A1 (en) 1998-03-12
CA2264483C (en) 2011-03-22
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