DE69929600D1 - Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren - Google Patents
Konvektion-erhöhte verabreichung aadc-kodierende aav vektorenInfo
- Publication number
- DE69929600D1 DE69929600D1 DE69929600T DE69929600T DE69929600D1 DE 69929600 D1 DE69929600 D1 DE 69929600D1 DE 69929600 T DE69929600 T DE 69929600T DE 69929600 T DE69929600 T DE 69929600T DE 69929600 D1 DE69929600 D1 DE 69929600D1
- Authority
- DE
- Germany
- Prior art keywords
- convection
- aadc
- aav vectors
- increased administration
- encoding aav
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5184—Virus capsids or envelopes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01028—Aromatic-L-amino-acid decarboxylase (4.1.1.28), i.e. tryptophane-decarboxylase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Mycology (AREA)
- Nanotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8694998P | 1998-05-27 | 1998-05-27 | |
US86949P | 1998-05-27 | ||
US13474899P | 1999-05-18 | 1999-05-18 | |
US134748P | 1999-05-18 | ||
PCT/US1999/011687 WO1999061066A2 (en) | 1998-05-27 | 1999-05-26 | Convection-enhanced delivery of aav vectors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69929600D1 true DE69929600D1 (de) | 2006-04-13 |
DE69929600T2 DE69929600T2 (de) | 2006-09-07 |
Family
ID=26775343
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69940899T Expired - Lifetime DE69940899D1 (de) | 1998-05-27 | 1999-05-26 | AAV Vektoren zur Herstellung der Medikamente zur konvektion-erhöhten Verabreichung |
DE69929600T Expired - Lifetime DE69929600T2 (de) | 1998-05-27 | 1999-05-26 | Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren |
DE69941100T Expired - Lifetime DE69941100D1 (de) | 1998-05-27 | 1999-05-26 | AAV Vektoren zur Herstellung der Medikamente zur konvektion-erhöhten Verabreichung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69940899T Expired - Lifetime DE69940899D1 (de) | 1998-05-27 | 1999-05-26 | AAV Vektoren zur Herstellung der Medikamente zur konvektion-erhöhten Verabreichung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69941100T Expired - Lifetime DE69941100D1 (de) | 1998-05-27 | 1999-05-26 | AAV Vektoren zur Herstellung der Medikamente zur konvektion-erhöhten Verabreichung |
Country Status (9)
Country | Link |
---|---|
US (7) | US6309634B1 (de) |
EP (1) | EP1080202B1 (de) |
JP (2) | JP2002516295A (de) |
AT (3) | ATE316576T1 (de) |
CA (1) | CA2329259C (de) |
DE (3) | DE69940899D1 (de) |
ES (3) | ES2324540T3 (de) |
PT (1) | PT1080202E (de) |
WO (1) | WO1999061066A2 (de) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4645697A (en) | 1996-09-11 | 1998-04-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Aav4 vector and uses thereof |
ATE316576T1 (de) | 1998-05-27 | 2006-02-15 | Avigen Inc | Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren |
JP4060531B2 (ja) * | 1998-05-28 | 2008-03-12 | アメリカ合衆国 | Aav5ベクターおよびその使用 |
US6855314B1 (en) * | 2000-03-22 | 2005-02-15 | The United States Of America As Represented By The Department Of Health And Human Services | AAV5 vector for transducing brain cells and lung cells |
US7672712B2 (en) * | 2000-03-30 | 2010-03-02 | The Regents Of The University Of Michigan | Internal marker device for identification of biological substances |
US7098374B2 (en) | 2001-02-09 | 2006-08-29 | University Of Florida Research Foundation, Inc. | Human disease modeling using somatic gene transfer |
US7588757B2 (en) * | 2001-03-14 | 2009-09-15 | Genzyme Corporation | Methods of treating Parkinson's disease using recombinant adeno-associated virus virions |
US7182944B2 (en) * | 2001-04-25 | 2007-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of increasing distribution of nucleic acids |
US20050191638A1 (en) * | 2002-02-20 | 2005-09-01 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
US20030050273A1 (en) * | 2001-08-29 | 2003-03-13 | Keiya Ozawa | Compositions and methods for treating neurodegenerative diseases |
JP2005507927A (ja) * | 2001-10-30 | 2005-03-24 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | パーキンソン病を処置するための方法および組成物 |
US7419817B2 (en) * | 2002-05-17 | 2008-09-02 | The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. | Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography |
US7090836B2 (en) | 2002-06-21 | 2006-08-15 | Institut Pasteur | Vector for expressing α-L-iduronidase and method of treating MPS I by stereotactic injection into the brain of a mammal |
US20050143330A1 (en) * | 2002-09-30 | 2005-06-30 | Ron Mandel | Method for the treatment of Parkinson's Disease |
US7618948B2 (en) * | 2002-11-26 | 2009-11-17 | Medtronic, Inc. | Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA |
US7829694B2 (en) | 2002-11-26 | 2010-11-09 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
US7605249B2 (en) | 2002-11-26 | 2009-10-20 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
US7994149B2 (en) | 2003-02-03 | 2011-08-09 | Medtronic, Inc. | Method for treatment of Huntington's disease through intracranial delivery of sirna |
US7732591B2 (en) * | 2003-11-25 | 2010-06-08 | Medtronic, Inc. | Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna |
WO2004074439A2 (en) * | 2003-02-14 | 2004-09-02 | Biogen Idec Ma Inc. | An expression cassette and vector for transient or stable expression of exogenous molecules |
US8946151B2 (en) * | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
US7963956B2 (en) | 2003-04-22 | 2011-06-21 | Antisense Pharma Gmbh | Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique |
WO2005017101A2 (en) | 2003-05-19 | 2005-02-24 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH | Avian adenoassociated virus (aaav) and uses thereof |
US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
AU2004245175C1 (en) | 2003-06-10 | 2010-03-18 | Biogen Ma Inc. | Improved secretion of neublastin |
US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
BRPI0415563A (pt) | 2003-10-20 | 2007-01-02 | Nsgene As | método para o tratamento do mal de parkinson, uso de um vetor viral, vetor de expressão viral, composição farmacêutica, célula hospedeira isolada, linhagem de células de empacotamento, mamìfero não humano quimérico, dispositivo de cultura celular implantável, cápsula biocompatìvel, método para tratamento de uma doença do sistema nervoso, célula de mamìfero, e, método para produzir neurturin ou um seu equivalente funcional |
WO2005056807A2 (en) * | 2003-12-04 | 2005-06-23 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health | Bovine adeno-associated viral (baav) vector and uses thereof |
US20050208090A1 (en) * | 2004-03-18 | 2005-09-22 | Medtronic, Inc. | Methods and systems for treatment of neurological diseases of the central nervous system |
DE602005014354D1 (de) | 2004-03-30 | 2009-06-18 | Nsgene As | Therapeutische verwendung des wachstumsfaktors nsg33 |
JP2008503590A (ja) * | 2004-06-21 | 2008-02-07 | メドトロニック・インコーポレーテッド | 組成物を細胞にデリバリーするための医学用システム及び方法 |
WO2006013462A2 (en) * | 2004-07-30 | 2006-02-09 | Nsgene A/S | Growth factors nsg28, nsg30, and nsg32 |
US20080188431A1 (en) * | 2004-09-08 | 2008-08-07 | Chiorini John A | Transcytosis of Adeno-Associated Viruses |
CN102626336A (zh) | 2004-10-05 | 2012-08-08 | 建新公司 | 台阶式插管 |
US20060253068A1 (en) * | 2005-04-20 | 2006-11-09 | Van Bilsen Paul | Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart |
WO2006119432A2 (en) * | 2005-04-29 | 2006-11-09 | The Government Of The U.S.A., As Rep. By The Sec., Dept. Of Health & Human Services | Isolation, cloning and characterization of new adeno-associated virus (aav) serotypes |
WO2006121960A2 (en) * | 2005-05-06 | 2006-11-16 | Medtronic, Inc. | Methods and sequences to suppress primate huntington gene expression |
US7902352B2 (en) * | 2005-05-06 | 2011-03-08 | Medtronic, Inc. | Isolated nucleic acid duplex for reducing huntington gene expression |
EP2816118B1 (de) | 2005-05-31 | 2018-10-17 | The Regents of the University of Colorado, a body corporate | Verfahren zur Bereitstellung von Genen |
US20080280843A1 (en) * | 2006-05-24 | 2008-11-13 | Van Bilsen Paul | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
US9133517B2 (en) | 2005-06-28 | 2015-09-15 | Medtronics, Inc. | Methods and sequences to preferentially suppress expression of mutated huntingtin |
US9089667B2 (en) * | 2005-08-23 | 2015-07-28 | The Regents Of The University Of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
US20070132284A1 (en) * | 2005-12-06 | 2007-06-14 | Albert Ekladyous | Headliner mounted center high mount stop lamp (chmsl) |
CA2633468C (en) | 2005-12-14 | 2014-02-18 | Licentia Ltd | Novel neurotrophic factor protein and uses thereof |
EP2495327B1 (de) | 2006-03-03 | 2016-09-28 | ProMIS Neurosciences Inc. | Verfahren und Zusammensetzungen zum Behandeln und Erkennen von missgefaltetem SOD 1-herbeigeführte Erkrankungen |
ES2618787T5 (es) | 2006-04-25 | 2022-10-21 | Univ California | Administración de factores de crecimiento para el tratamiento de trastornos del SNC |
WO2007127839A2 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
US9273356B2 (en) | 2006-05-24 | 2016-03-01 | Medtronic, Inc. | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
JP5352452B2 (ja) * | 2006-06-06 | 2013-11-27 | メディシノバ, インコーポレイテッド | 置換ピラゾロ[1,5−a]ピリジン化合物およびその使用方法 |
US20080039415A1 (en) * | 2006-08-11 | 2008-02-14 | Gregory Robert Stewart | Retrograde transport of sirna and therapeutic uses to treat neurologic disorders |
WO2008033285A2 (en) * | 2006-09-15 | 2008-03-20 | The Trustees Of Culumbia University In The City Of New York | Delivery of double-stranded rna into the central nervous system |
US8324367B2 (en) | 2006-11-03 | 2012-12-04 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
US9375440B2 (en) * | 2006-11-03 | 2016-06-28 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
US7988668B2 (en) * | 2006-11-21 | 2011-08-02 | Medtronic, Inc. | Microsyringe for pre-packaged delivery of pharmaceuticals |
US7819842B2 (en) * | 2006-11-21 | 2010-10-26 | Medtronic, Inc. | Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites |
US20080171906A1 (en) * | 2007-01-16 | 2008-07-17 | Everaerts Frank J L | Tissue performance via hydrolysis and cross-linking |
US20080181876A1 (en) * | 2007-01-30 | 2008-07-31 | Johnson Kirk W | Methods for treating acute and subchronic pain |
EP1970001B1 (de) * | 2007-03-16 | 2014-07-23 | Brainlab AG | Katheter mit Drucksensorik |
US20090036395A1 (en) * | 2007-04-26 | 2009-02-05 | Davidson Beverly L | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
ES2557482T3 (es) * | 2007-05-17 | 2016-01-26 | Medgenesis Therapeutix Inc. | Catéter de entrega mejorada por convección con un miembro de rigidización eliminable |
DK2164967T3 (en) | 2007-05-31 | 2015-10-19 | Univ Iowa Res Found | Reduction of off-target rna interferenstoksicitet |
WO2009018275A1 (en) * | 2007-07-30 | 2009-02-05 | University Of Rochester | Adenosine and its mimetics, modulators, transport inhibitors, and receptor agonists as a therapeutic tool to replace or improve the efficacy of deep brain stimulation |
US8198257B2 (en) * | 2007-09-12 | 2012-06-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | CYP46A1 gene for the treatment of alzheimer's disease |
FI20070808A0 (fi) | 2007-10-25 | 2007-10-25 | Mart Saarma | GDNF:n silmukointivariantit ja niiden käytöt |
FI20080326A0 (fi) | 2008-04-30 | 2008-04-30 | Licentia Oy | Neurotroofinen tekijä MANF ja sen käytöt |
CN102027133A (zh) * | 2008-05-07 | 2011-04-20 | 温瑟瑞克斯有限公司 | 鉴定调节癌细胞中Wnt信号传导的化合物的方法 |
US20120021039A1 (en) | 2009-01-23 | 2012-01-26 | Nsgene A/S | Expression of neuropeptides in mammalian cells |
WO2010088560A1 (en) | 2009-01-29 | 2010-08-05 | University Of California, San Francisco | Methods for distributing high levels of therapeutic agent throughout the cortex to treat neurological disorders |
WO2010129021A1 (en) | 2009-05-02 | 2010-11-11 | Genzyme Corporation | Gene therapy for neurodegenerative disorders |
US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
US20120209110A1 (en) * | 2009-08-25 | 2012-08-16 | Bankiewicz Krystof S | Optimized Placement of Cannula for Delivery of Therapeutics to the Brain |
EP2498825B1 (de) | 2009-11-09 | 2017-03-29 | Genepod Therapeutics Ab | Neues virales vektorkonstrukt zur neuronenspezifischen kontinuierlichen dopa-synthese in vivo |
US10105485B2 (en) | 2010-04-16 | 2018-10-23 | MRI Interventions, Inc. | MRI surgical systems including MRI-compatible surgical cannulae for transferring a substance to and/or from a patient |
EP2621512B1 (de) | 2010-10-01 | 2016-04-06 | NsGene A/S | Verwendung von meteorin zur behandlung von allodynie, hyperalgesie, spontanen schmerzen und phantomschmerzen |
US10130687B2 (en) | 2011-01-05 | 2018-11-20 | Rhode Island Hospital | Compositions and methods for the treatment of orthopedic disease or injury |
EP2673286B1 (de) | 2011-02-12 | 2019-07-03 | University of Iowa Research Foundation | Therapeutische verbindungen |
US20120220648A1 (en) * | 2011-02-24 | 2012-08-30 | National Taiwan University Hospital | Method of Treating Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency Using Adeno-Associated Virus (AAV)-AADC Vector |
US9610354B2 (en) * | 2011-04-18 | 2017-04-04 | National Center Of Neurology And Psychiatry | Drug delivery particle and method for producing the same |
JP6230996B2 (ja) | 2011-08-01 | 2017-11-15 | アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. | 微小流体薬剤送達装置 |
JP6145667B2 (ja) | 2011-09-05 | 2017-06-14 | ホーバ セラピューティクス アンパルトセルスカブ | アロディニア、痛覚過敏、自発痛、及び幻痛の治療 |
RU2014144945A (ru) | 2012-04-10 | 2016-05-27 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Бис-полимерные липид-пептидные конъюгаты и наночастицы из них |
EP2884972A4 (de) * | 2012-08-17 | 2016-05-11 | Teva Pharma | Parenterale formulierung von rasagilin |
US8992458B2 (en) | 2012-12-18 | 2015-03-31 | Alcyone Lifesciences, Inc. | Systems and methods for reducing or preventing backflow in a delivery system |
WO2014172372A1 (en) | 2013-04-15 | 2014-10-23 | Northwestern University | Treatment for dopaminergic disorders |
CN115120746A (zh) | 2013-05-15 | 2022-09-30 | 明尼苏达大学董事会 | 腺相关病毒介导的基因向中枢神经系统转移 |
WO2014191630A2 (en) | 2013-05-28 | 2014-12-04 | Helsingin Yliopisto | Non-human animal model encoding a non-functional manf gene |
JP2016522069A (ja) | 2013-06-17 | 2016-07-28 | アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. | カテーテル先端部を保護する方法および装置ならびにマイクロカテーテル用の定位固定物 |
CA2920014C (en) | 2013-07-31 | 2021-11-09 | Alcyone Lifesciences, Inc. | Systems and methods for drug delivery, treatment, and monitoring |
US9891296B2 (en) | 2013-09-13 | 2018-02-13 | MRI Interventions, Inc. | Intrabody fluid transfer devices, systems and methods |
WO2015042252A1 (en) | 2013-09-19 | 2015-03-26 | The Regents Of The University Of California | Methods of treatment using bis-polymer lipid-peptide conjugates and nanoparticles thereof |
HUE054768T2 (hu) | 2014-05-02 | 2021-09-28 | Genzyme Corp | AAV vektorok retina és CNS génterápiára |
US9523093B2 (en) | 2014-05-20 | 2016-12-20 | University Of Iowa Research Foundation | Huntington's disease therapeutic compounds |
WO2016030748A1 (en) | 2014-08-25 | 2016-03-03 | Nippon Kayaku Kabushiki Kaisha | Ced of sn-38-loaded micelles against brain tumor |
CN107073051B (zh) * | 2014-10-21 | 2021-08-24 | 马萨诸塞大学 | 重组aav变体及其用途 |
MX2017005834A (es) * | 2014-11-05 | 2017-11-17 | Voyager Therapeutics Inc | Polinucleotidos aad para el tratamiento de la enfermedad de parkinson. |
US11242374B2 (en) | 2015-01-22 | 2022-02-08 | Brown University | Minimally-invasive and activity-dependent control of excitable cells |
US10806396B2 (en) | 2015-01-26 | 2020-10-20 | Alcyone Lifesciences, Inc. | Drug delivery methods with tracer |
SG10201907399RA (en) | 2015-02-10 | 2019-09-27 | Genzyme Corp | Enhanced delivery of viral particles to the striatum and cortex |
CN106190949B (zh) * | 2015-05-08 | 2020-04-10 | 上海微创心通医疗科技有限公司 | 一种干态动物源性胶原纤维组织材料及其制备方法和生物假体 |
CA2992511A1 (en) | 2015-08-03 | 2017-02-09 | Myodopa Limited | Systemic synthesis and regulation of l-dopa |
EA037993B1 (ru) | 2015-09-23 | 2021-06-21 | Сангамо Терапьютикс, Инк. | Репрессоры htt и их применение |
JP2019502473A (ja) | 2016-01-04 | 2019-01-31 | アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. | 脳卒中を治療するための方法および装置 |
WO2017142698A1 (en) | 2016-02-17 | 2017-08-24 | MRI Interventions, Inc. | Intrabody surgical fluid transfer assemblies with adjustable exposed cannula to needle tip length, related systems and methods |
JP7171439B2 (ja) | 2016-04-15 | 2022-11-15 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ムコ多糖症ii型を処置するための遺伝子療法 |
EP3458579B1 (de) | 2016-05-20 | 2023-07-05 | Braingene AB | Destabilisierung von domänen zur bedingten stabilisierung eines proteins |
US11298041B2 (en) | 2016-08-30 | 2022-04-12 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
US11578340B2 (en) | 2016-10-13 | 2023-02-14 | University Of Massachusetts | AAV capsid designs |
IL266862B2 (en) | 2016-12-01 | 2024-01-01 | Sangamo Therapeutics Inc | Tau modulators and methods and preparations for their administration |
WO2018191450A2 (en) | 2017-04-14 | 2018-10-18 | National Taiwan University Hospital | Gene therapy for aadc deficiency |
US11179411B2 (en) | 2017-05-18 | 2021-11-23 | Kyoto University | Composition for prevention or treatment of spinocerebellar ataxia type 36 |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
CN111132626B (zh) | 2017-07-17 | 2024-01-30 | 沃雅戈治疗公司 | 轨迹阵列引导系统 |
US11819539B2 (en) | 2017-09-22 | 2023-11-21 | The Trustees Of The University Of Pennsylvania | Gene therapy for treating Mucopolysaccharidosis type II |
AU2019208006A1 (en) | 2018-01-12 | 2020-07-23 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
US11253237B2 (en) | 2018-05-09 | 2022-02-22 | Clearpoint Neuro, Inc. | MRI compatible intrabody fluid transfer systems and related devices and methods |
US11022664B2 (en) | 2018-05-09 | 2021-06-01 | Clearpoint Neuro, Inc. | MRI compatible intrabody fluid transfer systems and related devices and methods |
SG11202011296VA (en) * | 2018-05-15 | 2020-12-30 | Voyager Therapeutics Inc | Compositions and methods for the treatment of parkinson's disease |
US11684750B2 (en) | 2019-10-08 | 2023-06-27 | Clearpoint Neuro, Inc. | Extension tube assembly and related medical fluid transfer systems and methods |
CA3217602A1 (en) | 2021-05-06 | 2022-11-10 | Kenneth Petersen | Prevention and treatment of chemotherapy-induced neuropathic pain |
WO2023104960A1 (en) | 2021-12-10 | 2023-06-15 | Hoba Therapeutics Aps | Treatment of nociceptive pain |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US4916151A (en) * | 1985-12-05 | 1990-04-10 | Merrell Dow Pharmaceuticals Inc. | Method of treating parkinson's syndrome |
JP2514913B2 (ja) * | 1987-10-19 | 1996-07-10 | 忠三 岸本 | ヒトbcdfを含有する神経系障害治療剤 |
DE3841955A1 (de) * | 1987-12-31 | 1989-07-13 | Asta Pharma Ag | Synergistische kombination von decarboxylasehemmern und l-dopa-pellets |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5766948A (en) * | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
AU7676894A (en) | 1993-08-27 | 1995-03-21 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Convection-enhanced drug delivery |
CA2187626C (en) * | 1994-04-13 | 2009-11-03 | Michael G. Kaplitt | Aav-mediated delivery of dna to cells of the nervous system |
US5658785A (en) | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
US6103226A (en) | 1994-08-12 | 2000-08-15 | Arch Development Corporation | Genetically engineered cells that produce produce L. Dopa |
US5599706A (en) * | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
US5667158A (en) | 1995-05-23 | 1997-09-16 | Glaxo Wellcome Inc. | Automated blend reclaim system for pharmaceutical tablet compression machine |
US5677158A (en) | 1995-06-07 | 1997-10-14 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
US6004797A (en) | 1995-11-09 | 1999-12-21 | Avigen, Inc. | Adenovirus helper-free recombinant AAV Virion production |
AU3591597A (en) * | 1996-06-28 | 1998-01-21 | Regents Of The University Of California, The | Transformation and genetherapy of cells of the inner ear |
JPH1113A (ja) | 1997-06-12 | 1999-01-06 | Mitsubishi Agricult Mach Co Ltd | 乗用農機 |
ATE316576T1 (de) * | 1998-05-27 | 2006-02-15 | Avigen Inc | Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren |
-
1999
- 1999-05-26 AT AT99925906T patent/ATE316576T1/de not_active IP Right Cessation
- 1999-05-26 AT AT05017045T patent/ATE435917T1/de not_active IP Right Cessation
- 1999-05-26 EP EP99925906A patent/EP1080202B1/de not_active Expired - Lifetime
- 1999-05-26 ES ES05016619T patent/ES2324540T3/es not_active Expired - Lifetime
- 1999-05-26 JP JP2000550525A patent/JP2002516295A/ja active Pending
- 1999-05-26 WO PCT/US1999/011687 patent/WO1999061066A2/en active IP Right Grant
- 1999-05-26 ES ES05017045T patent/ES2326893T3/es not_active Expired - Lifetime
- 1999-05-26 DE DE69940899T patent/DE69940899D1/de not_active Expired - Lifetime
- 1999-05-26 PT PT99925906T patent/PT1080202E/pt unknown
- 1999-05-26 CA CA002329259A patent/CA2329259C/en not_active Expired - Lifetime
- 1999-05-26 ES ES99925906T patent/ES2257051T3/es not_active Expired - Lifetime
- 1999-05-26 DE DE69929600T patent/DE69929600T2/de not_active Expired - Lifetime
- 1999-05-26 AT AT05016619T patent/ATE431418T1/de not_active IP Right Cessation
- 1999-05-26 DE DE69941100T patent/DE69941100D1/de not_active Expired - Lifetime
- 1999-06-26 US US09/320,171 patent/US6309634B1/en not_active Expired - Lifetime
-
2001
- 2001-06-21 US US09/887,854 patent/US6953575B2/en not_active Expired - Lifetime
-
2005
- 2005-04-08 US US11/102,521 patent/US7534613B2/en not_active Expired - Fee Related
-
2006
- 2006-05-19 JP JP2006140195A patent/JP2006298926A/ja active Pending
-
2009
- 2009-04-10 US US12/384,935 patent/US8309355B2/en not_active Expired - Fee Related
-
2012
- 2012-10-08 US US13/647,155 patent/US9492415B2/en not_active Expired - Fee Related
-
2016
- 2016-03-25 US US15/081,116 patent/US20160256534A1/en not_active Abandoned
-
2017
- 2017-10-10 US US15/728,570 patent/US20180243249A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20100104537A1 (en) | 2010-04-29 |
PT1080202E (pt) | 2006-05-31 |
WO1999061066A3 (en) | 2000-05-04 |
JP2002516295A (ja) | 2002-06-04 |
US9492415B2 (en) | 2016-11-15 |
US20020141980A1 (en) | 2002-10-03 |
ES2324540T3 (es) | 2009-08-10 |
EP1080202A2 (de) | 2001-03-07 |
US20160256534A1 (en) | 2016-09-08 |
US7534613B2 (en) | 2009-05-19 |
DE69929600T2 (de) | 2006-09-07 |
US20130101510A1 (en) | 2013-04-25 |
DE69941100D1 (de) | 2009-08-20 |
US6309634B1 (en) | 2001-10-30 |
ES2257051T3 (es) | 2006-07-16 |
US8309355B2 (en) | 2012-11-13 |
CA2329259C (en) | 2003-08-05 |
ATE316576T1 (de) | 2006-02-15 |
WO1999061066A2 (en) | 1999-12-02 |
CA2329259A1 (en) | 1999-12-02 |
US20180243249A1 (en) | 2018-08-30 |
US20050180955A1 (en) | 2005-08-18 |
ATE435917T1 (de) | 2009-07-15 |
DE69940899D1 (de) | 2009-06-25 |
ATE431418T1 (de) | 2009-05-15 |
JP2006298926A (ja) | 2006-11-02 |
US6953575B2 (en) | 2005-10-11 |
ES2326893T3 (es) | 2009-10-21 |
WO1999061066A9 (en) | 2000-03-30 |
EP1080202B1 (de) | 2006-01-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69929600D1 (de) | Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren | |
ATE380037T1 (de) | Verfaheren zur durch rekombinante adeno- assoziierte virus-gerichtete gentherapie | |
DK0764213T3 (da) | Vektorer der koder for rekombinante AAV-genomer | |
MX9800025A (es) | Virus mva recombinante, y su empleo. | |
HK1071518A1 (en) | Improved raav expression systems for genetic modification of specific capsid proteins | |
FI962990A (fi) | Menetelmä rekombinanttisten adenovirukseen assosioituvien virusten (AAV:iden) valmistamiseksi ja sen käyttöjä | |
PT1975235E (pt) | Vacina de poxvírus recombinante contra o circovírus porcino | |
MXPA02011545A (es) | Virus del sindrome respiratorio y reproductor porcino (peesv), vacuna recombinante para el virus de la viruela. | |
WO2000046246A8 (en) | Alpha-2-macroglobulin therapies and drug screening methods for alzheimer's disease | |
CL2020000295A1 (es) | Métodos de terapia génica del factor viii (fviii) | |
MX2022002961A (es) | Metodos para tratar enfermedades neovasculares oculares usando variantes de aav2 que codifican para aflibercept. | |
DE60129069D1 (de) | Hepatitis B Virus Vektoren für Gentherapie | |
MX2022002960A (es) | Metodos para tratar enfermedades neovasculares oculares usando variantes de aav2 que codifican para aflibercept. | |
EP1621625A3 (de) | AAV Vektoren zur Herstellung der Medikamenten zur konvektion-erhöten Verabreichung | |
UY38881A (es) | Métodos de tratamiento de enfermedades neovasculares oculares utilizando variantes de aav2 que codifican aflibercept | |
CA2425820A1 (en) | Convection-enhanced delivery of aav vectors | |
WO2002085287A3 (en) | Minimal adenoviral vectors for immunization | |
BR9907170A (pt) | Composições farmacêuticas e métodos para uso | |
WO2001090189A3 (en) | G-protein coupled receptor org3. | |
AR119955A1 (es) | Métodos de tratamiento de enfermedades neovasculares oculares utilizando variantes de aav2 que codifican aflibercept | |
WO2002088319A3 (en) | Mini-adenoviral vector and methods of using same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |