PT1975235E - Vacina de poxvírus recombinante contra o circovírus porcino - Google Patents
Vacina de poxvírus recombinante contra o circovírus porcino Download PDFInfo
- Publication number
- PT1975235E PT1975235E PT80055494T PT00005549T PT1975235E PT 1975235 E PT1975235 E PT 1975235E PT 80055494 T PT80055494 T PT 80055494T PT 00005549 T PT00005549 T PT 00005549T PT 1975235 E PT1975235 E PT 1975235E
- Authority
- PT
- Portugal
- Prior art keywords
- porcine circovirus
- recombinant poxvirus
- immunological
- circovirus vaccine
- animal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13847899P | 1999-06-10 | 1999-06-10 | |
US09/583,545 US6497883B1 (en) | 1999-06-10 | 2000-06-01 | Porcine circovirus recombinant poxvirus vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1975235E true PT1975235E (pt) | 2016-01-27 |
Family
ID=26836231
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00938971T PT1185660E (pt) | 1999-06-10 | 2000-06-09 | Vacina poxvírus recombinante contra o circovírus porcino |
PT80055494T PT1975235E (pt) | 1999-06-10 | 2000-06-09 | Vacina de poxvírus recombinante contra o circovírus porcino |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00938971T PT1185660E (pt) | 1999-06-10 | 2000-06-09 | Vacina poxvírus recombinante contra o circovírus porcino |
Country Status (17)
Country | Link |
---|---|
US (1) | US6497883B1 (pt) |
EP (2) | EP1975235B1 (pt) |
JP (1) | JP4859316B2 (pt) |
KR (1) | KR100837724B1 (pt) |
CN (1) | CN1195854C (pt) |
AT (1) | ATE476510T1 (pt) |
AU (1) | AU778520B2 (pt) |
BR (2) | BR0011737A (pt) |
CA (1) | CA2376600C (pt) |
DE (1) | DE60044778D1 (pt) |
DK (2) | DK1185660T3 (pt) |
ES (1) | ES2560513T3 (pt) |
HU (1) | HU229051B1 (pt) |
MX (1) | MXPA01012723A (pt) |
PL (1) | PL205032B1 (pt) |
PT (2) | PT1185660E (pt) |
WO (1) | WO2000077216A2 (pt) |
Families Citing this family (70)
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US6517843B1 (en) * | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
US7192594B2 (en) | 1997-10-03 | 2007-03-20 | Merial Limited | Postweaning multisystemic wasting syndrome and porcine circovirus from pigs |
US7211379B2 (en) * | 1997-10-03 | 2007-05-01 | Merial Sas | Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2 |
US20040062775A1 (en) * | 1997-12-05 | 2004-04-01 | Agence Francaise De Securite Sanitaire Des Aliments | Circovirus sequences associated with piglet weight loss disease (PWD) |
FR2772047B1 (fr) * | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
KR100879650B1 (ko) | 1997-12-11 | 2009-01-20 | 유니버시티 오브 사스카췌완 | 돼지로부터의 이유후 다기관계작용성 소모 증후군 바이러스 |
US6943152B1 (en) | 1999-06-10 | 2005-09-13 | Merial | DNA vaccine-PCV |
ES2170622B1 (es) * | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
HU230198B1 (hu) | 2000-11-23 | 2015-10-28 | Bavarian Nordic A/S | Módosított Vacciniavírus Ankara-variáns |
ATE430807T1 (de) | 2001-03-27 | 2009-05-15 | Univ Saskatchewan | Verfahren zur kultivierung von circovirus |
US6676958B2 (en) * | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
US7276353B2 (en) | 2001-12-12 | 2007-10-02 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
US7279166B2 (en) * | 2001-12-12 | 2007-10-09 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
US7906311B2 (en) | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
BRPI0313559B8 (pt) * | 2002-09-05 | 2021-05-25 | Bavarian Nordic As | método para o cultivo de células primárias e para a amplificação de vírus sob condições isentas de soro |
EP1606419A1 (en) | 2003-03-18 | 2005-12-21 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
ES2417019T3 (es) | 2003-11-13 | 2013-08-05 | University Of Georgia Research Foundation, Inc. | Procedimiento de caracterización del virus de la enfermedad de la bursitis infecciosa |
MXPA06009452A (es) | 2004-02-19 | 2007-03-15 | Univ Alberta | Polimorfismos del promotor de leptin y sus usos. |
US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
EP2460818A3 (en) * | 2004-12-30 | 2013-01-09 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
US7833707B2 (en) * | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
CN1328373C (zh) * | 2005-04-07 | 2007-07-25 | 南京农业大学 | 猪ⅱ型圆环病毒重组腺病毒 |
PL1881845T3 (pl) | 2005-04-25 | 2010-08-31 | Merial Ltd | Szczepionki przeciwko wirusowi Nipah |
WO2006132598A1 (en) * | 2005-06-07 | 2006-12-14 | Temasek Life Sciences Laboratory Limited | Porcine circovirus type 2 vaccines |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
EP1951751B1 (en) | 2005-11-14 | 2017-11-01 | Merial, Inc. | Gene therapy for renal failure |
US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
EP1792996A1 (en) * | 2005-12-01 | 2007-06-06 | Consejo Superior de Investigaciones Cientificas | Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV) |
MX338626B (es) | 2005-12-29 | 2016-04-26 | Boehringer Ingelheim Vetmed | Uso de una composicion inmunogenica de pcv2 para producir los sintomas clinicos en cerdos. |
TWI528970B (zh) * | 2005-12-29 | 2016-04-11 | 百靈佳殷格翰家畜藥品公司 | 多價第二型豬環狀病毒(pcv2)免疫組合物及製備該組合物之方法 |
US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
CN100489092C (zh) * | 2006-06-16 | 2009-05-20 | 中国农业科学院哈尔滨兽医研究所 | 一种猪圆环病毒2型遗传标记毒株及其应用 |
US20100129397A1 (en) | 2006-12-11 | 2010-05-27 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
PT2481420T (pt) * | 2006-12-15 | 2019-05-31 | Boehringer Ingelheim Animal Health Usa Inc | Vacina para porcos anti-pcv2 de dose única |
EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
US20080292663A1 (en) * | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
US7829274B2 (en) * | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
WO2009088950A2 (en) * | 2007-12-31 | 2009-07-16 | Boehringer Ingelheim Vetmedica, Inc. | Pcv2 orf2 virus like particle with foreign amino acid insertion |
CA2712006A1 (en) * | 2008-01-23 | 2009-10-15 | Boehringer Ingelheim Vetmedica, Inc. | Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions |
DK2998315T4 (da) | 2009-04-03 | 2022-02-07 | Boehringer Ingelheim Animal Health Usa Inc | Newcastle sygdomsvirus-bårne fuglevacciner |
AR078253A1 (es) * | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
CN101773667A (zh) * | 2010-01-28 | 2010-07-14 | 洛阳普莱柯生物工程有限公司 | 一种猪圆环病毒ii型疫苗制备 |
CA2809127C (en) | 2010-08-31 | 2019-04-02 | Merial Limited | Newcastle disease virus vectored herpesvirus vaccines |
TWI508974B (zh) | 2010-12-22 | 2015-11-21 | Sbc Virbac Ltd | 豬第二型環狀病毒(Porcine Circovirus Type 2)、含彼之免疫組合物、檢測套組及其應用 |
WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
CN102198268B (zh) * | 2011-03-29 | 2013-08-14 | 范红结 | 表达马链球菌兽疫亚种类m蛋白的重组猪痘病毒载体疫苗 |
US20140287931A1 (en) | 2011-04-04 | 2014-09-25 | Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
EP2694677A2 (en) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
AU2012245395A1 (en) | 2011-04-20 | 2013-11-14 | Merial, Inc. | Adjuvanted rabies vaccine with improved viscosity profile |
CN103945864A (zh) | 2011-04-25 | 2014-07-23 | 先进生物学实验室股份有限公司 | 截短的hiv包膜蛋白(env)、其相关方法和组合物 |
CA2837375C (en) | 2011-06-01 | 2019-07-16 | Merial Limited | Needle-free administration of prrsv vaccines |
EP2741740B1 (en) | 2011-08-12 | 2017-05-03 | Merial, Inc. | Vacuum-assisted preservation of biological products, in particular of vaccines |
WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
US9567606B2 (en) | 2012-02-14 | 2017-02-14 | Merial Inc. | Recombinant poxviral vectors expressing both rabies and OX40 proteins, and vaccines made therefrom |
WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
CN102861327B (zh) * | 2012-09-27 | 2015-01-21 | 郑州后羿制药有限公司 | 一种细胞灭活疫苗、卵黄抗体及卵黄抗体的注射液和冻干粉 |
EP2968514A1 (en) | 2013-03-12 | 2016-01-20 | Merial, Inc. | Reverse genetics schmallenberg virus vaccine compositions, and methods of use thereof |
ES2882374T3 (es) | 2013-05-08 | 2021-12-01 | Pharmgate Biologics Inc | Vacuna para PCV2 y micoplasma |
US20140348874A1 (en) * | 2013-05-22 | 2014-11-27 | Boehringer Ingelheim Espana, S.A. | Method for the reduction of pcv-2 in a herd of swine |
MX2016003855A (es) | 2013-09-25 | 2016-08-04 | Zoetis Services Llc | Composicion de vacuna de circovirus porcino tipo 2b divergente y procedimientos de uso. |
AU2014329524B2 (en) | 2013-10-02 | 2019-01-17 | Boehringer Ingelheim Animal Health USA Inc. | PCV2 ORF2 protein variant and virus like particles composed thereof |
US10010499B2 (en) | 2014-11-03 | 2018-07-03 | Merial Inc. | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
EP3294876A1 (en) | 2015-05-14 | 2018-03-21 | Merial, Inc. | Method for porcine circovirus production and pcv2 vaccines |
PL3313864T3 (pl) | 2015-06-23 | 2022-01-03 | Boehringer Ingelheim Animal Health USA Inc. | Rekombinowane wektory wirusowe zawierające drugorzędne białko prrsv oraz sposoby ich wytwarzania i zastosowania |
RU2771533C2 (ru) * | 2015-10-16 | 2022-05-05 | Канзас Стейт Юниверсити Рисерч Фаундейшн | Иммуногенные композиции для иммунизации свиней против цирковируса типа 3 и способы их получения и применения |
WO2018023473A1 (zh) * | 2016-08-03 | 2018-02-08 | 台湾生物制剂股份有限公司 | 以整体表现细胞作为抗原载体及其于制备疫苗或诊断试剂及筛选单株抗体的应用 |
CN111087452A (zh) * | 2019-12-18 | 2020-05-01 | 中国农业科学院兰州兽医研究所 | 一种猪圆环病毒2b亚型Cap蛋白的原核可溶性表达方法 |
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US6517843B1 (en) * | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
FR2769322B1 (fr) * | 1997-10-03 | 2002-03-08 | Merial Sas | Nouveaux circovirus porcins, vaccins et reactifs de diagnostic |
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-
2000
- 2000-06-01 US US09/583,545 patent/US6497883B1/en not_active Expired - Lifetime
- 2000-06-09 EP EP08005549.4A patent/EP1975235B1/en not_active Expired - Lifetime
- 2000-06-09 HU HU0201689A patent/HU229051B1/hu unknown
- 2000-06-09 BR BR0011737-4A patent/BR0011737A/pt active IP Right Grant
- 2000-06-09 DE DE60044778T patent/DE60044778D1/de not_active Expired - Lifetime
- 2000-06-09 PT PT00938971T patent/PT1185660E/pt unknown
- 2000-06-09 MX MXPA01012723A patent/MXPA01012723A/es active IP Right Grant
- 2000-06-09 BR BRPI0011737-4A patent/BRPI0011737B1/pt unknown
- 2000-06-09 DK DK00938971.9T patent/DK1185660T3/da active
- 2000-06-09 PT PT80055494T patent/PT1975235E/pt unknown
- 2000-06-09 JP JP2001503659A patent/JP4859316B2/ja not_active Expired - Lifetime
- 2000-06-09 DK DK08005549.4T patent/DK1975235T3/en active
- 2000-06-09 AU AU54189/00A patent/AU778520B2/en not_active Expired
- 2000-06-09 EP EP00938971A patent/EP1185660B1/en not_active Expired - Lifetime
- 2000-06-09 PL PL352201A patent/PL205032B1/pl unknown
- 2000-06-09 CA CA2376600A patent/CA2376600C/en not_active Expired - Lifetime
- 2000-06-09 WO PCT/IB2000/000882 patent/WO2000077216A2/en active IP Right Grant
- 2000-06-09 CN CNB00810560XA patent/CN1195854C/zh not_active Expired - Lifetime
- 2000-06-09 ES ES08005549.4T patent/ES2560513T3/es not_active Expired - Lifetime
- 2000-06-09 KR KR1020017015883A patent/KR100837724B1/ko active IP Right Grant
- 2000-06-09 AT AT00938971T patent/ATE476510T1/de active
Also Published As
Publication number | Publication date |
---|---|
EP1185660A2 (en) | 2002-03-13 |
ATE476510T1 (de) | 2010-08-15 |
CA2376600A1 (en) | 2000-12-21 |
JP4859316B2 (ja) | 2012-01-25 |
CN1361824A (zh) | 2002-07-31 |
WO2000077216A2 (en) | 2000-12-21 |
PL205032B1 (pl) | 2010-03-31 |
WO2000077216A3 (en) | 2001-08-09 |
US6497883B1 (en) | 2002-12-24 |
AU5418900A (en) | 2001-01-02 |
ES2560513T3 (es) | 2016-02-19 |
EP1975235A2 (en) | 2008-10-01 |
EP1185660B1 (en) | 2010-08-04 |
KR100837724B1 (ko) | 2008-06-13 |
PT1185660E (pt) | 2010-10-22 |
KR20020028896A (ko) | 2002-04-17 |
EP1975235A3 (en) | 2008-12-10 |
JP2003529323A (ja) | 2003-10-07 |
PL352201A1 (en) | 2003-08-11 |
DE60044778D1 (de) | 2010-09-16 |
HU229051B1 (en) | 2013-07-29 |
CA2376600C (en) | 2011-05-03 |
AU778520B2 (en) | 2004-12-09 |
DK1185660T3 (da) | 2010-10-04 |
BR0011737A (pt) | 2002-03-05 |
EP1975235B1 (en) | 2015-10-28 |
HUP0201689A2 (en) | 2002-09-28 |
MXPA01012723A (es) | 2002-07-22 |
DK1975235T3 (en) | 2015-11-16 |
HUP0201689A3 (en) | 2004-01-28 |
CN1195854C (zh) | 2005-04-06 |
BRPI0011737B1 (pt) | 2017-10-24 |
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