FR2870126A1 - Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin - Google Patents

Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin

Info

Publication number
FR2870126A1
FR2870126A1 FR0405366A FR0405366A FR2870126A1 FR 2870126 A1 FR2870126 A1 FR 2870126A1 FR 0405366 A FR0405366 A FR 0405366A FR 0405366 A FR0405366 A FR 0405366A FR 2870126 A1 FR2870126 A1 FR 2870126A1
Authority
FR
France
Prior art keywords
lentiviral vector
vaccine
expression
applications
recombinant lentiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR0405366A
Other languages
English (en)
Other versions
FR2870126B1 (fr
Inventor
Philippe Despres
Pierre Charneau
Frederic Tangy
Marie Pascale Frenkiel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Pasteur de Lille
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0405366A priority Critical patent/FR2870126B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Pasteur de Lille filed Critical Centre National de la Recherche Scientifique CNRS
Priority to CN200580015744XA priority patent/CN1981043B/zh
Priority to CA2564934A priority patent/CA2564934C/fr
Priority to BRPI0510016A priority patent/BRPI0510016B8/pt
Priority to JP2007517517A priority patent/JP2008508863A/ja
Priority to PCT/IB2005/001753 priority patent/WO2005111221A1/fr
Priority to EP05748053.5A priority patent/EP1751291B1/fr
Priority to US11/596,675 priority patent/US20090214589A1/en
Priority to EP11167507.0A priority patent/EP2371966B1/fr
Priority to MXPA06013388A priority patent/MXPA06013388A/es
Publication of FR2870126A1 publication Critical patent/FR2870126A1/fr
Application granted granted Critical
Publication of FR2870126B1 publication Critical patent/FR2870126B1/fr
Priority to US12/929,215 priority patent/US8716013B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Utilisation d'un vecteur lentiviral recombinant comprenant un fragment polynucléotidique codant pour au moins une protéine d'un virus de la famille des Flaviviridae ou un peptide immunogène d'au moins 8 acides aminés de ladite protéine, pour la préparation d'une composition pharmaceutique destinée à la prévention et/ou au traitement d'une infection à Flaviviridae chez une espèce sensible.
FR0405366A 2004-05-17 2004-05-17 Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin Expired - Lifetime FR2870126B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR0405366A FR2870126B1 (fr) 2004-05-17 2004-05-17 Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin
EP11167507.0A EP2371966B1 (fr) 2004-05-17 2005-05-16 Vecteur de lentivirus recombinant pour l'expression d'une protéine de Flaviviridés et applications associées en tant que vaccin
BRPI0510016A BRPI0510016B8 (pt) 2004-05-17 2005-05-16 vetor lentiviral recombinante, composição imunogênica e uso dos mesmos como vacina
JP2007517517A JP2008508863A (ja) 2004-05-17 2005-05-16 フラビウイルス科ウイルスタンパク質発現のための組換えレンチウイルスベクター、及びワクチンとしてのそれらの使用
PCT/IB2005/001753 WO2005111221A1 (fr) 2004-05-17 2005-05-16 Vecteur lentiviral recombine utilise dans l'expression d'une proteine flaviviridae et utilisations associees de ce vecteur sous forme de vaccin
EP05748053.5A EP1751291B1 (fr) 2004-05-17 2005-05-16 Vecteur lentiviral recombine utilise dans l'expression d'une proteine flaviviridae et utilisations associees de ce vecteur sous forme de vaccin
CN200580015744XA CN1981043B (zh) 2004-05-17 2005-05-16 用于表达黄病毒科蛋白的重组慢病毒载体及其作为疫苗的应用
CA2564934A CA2564934C (fr) 2004-05-17 2005-05-16 Vecteur lentiviral recombine utilise dans l'expression d'une proteine flaviviridae et utilisations associees de ce vecteur sous forme de vaccin
MXPA06013388A MXPA06013388A (es) 2004-05-17 2005-05-16 Vector lentiviral recombinante para la expresion de una proteina flaviviridae y sus aplicaciones como vacuna.
US11/596,675 US20090214589A1 (en) 2004-05-17 2005-05-16 Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine
US12/929,215 US8716013B2 (en) 2004-05-17 2011-01-07 Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0405366A FR2870126B1 (fr) 2004-05-17 2004-05-17 Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin

Publications (2)

Publication Number Publication Date
FR2870126A1 true FR2870126A1 (fr) 2005-11-18
FR2870126B1 FR2870126B1 (fr) 2009-07-17

Family

ID=34945000

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0405366A Expired - Lifetime FR2870126B1 (fr) 2004-05-17 2004-05-17 Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin

Country Status (9)

Country Link
US (2) US20090214589A1 (fr)
EP (2) EP2371966B1 (fr)
JP (1) JP2008508863A (fr)
CN (1) CN1981043B (fr)
BR (1) BRPI0510016B8 (fr)
CA (1) CA2564934C (fr)
FR (1) FR2870126B1 (fr)
MX (1) MXPA06013388A (fr)
WO (1) WO2005111221A1 (fr)

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DE60033045T2 (de) 1999-10-12 2007-11-08 Institut Pasteur Lentivirale triplex-dns, und vektoren und rekombinante zellen, die lentivirale triplex-dns enthalten
FR2870126B1 (fr) * 2004-05-17 2009-07-17 Pasteur Institut Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin
US8222029B2 (en) * 2005-05-16 2012-07-17 Institut Pasteur Lentiviral vector-based vaccine
CA2508266A1 (fr) 2005-06-20 2006-12-20 Institut Pasteur Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae
ES2423518T3 (es) 2006-12-22 2013-09-20 Institut Pasteur Células y metodología para generar virus de ARN de cadena de sentido negativo no segmentada
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
WO2009130261A1 (fr) * 2008-04-22 2009-10-29 Cytos Biotechnology Ag Compositions de vaccin pour le traitement de la dengue et leurs utilisations
EP2666477A1 (fr) 2012-05-23 2013-11-27 Theravectys Vecteurs lentiviraux contenant un promoteur du MHC classe I
EP2603799A4 (fr) * 2010-08-12 2014-02-12 Clontech Lab Inc Dosages à flux latéral pour analytes non diagnostiqués
EP3031923A1 (fr) 2014-12-11 2016-06-15 Institut Pasteur Composition immunogène contre l'encéphalite japonaise à base de vecteurs lentiviraux
MX2018005467A (es) 2015-11-09 2018-12-11 Immune Design Corp Composiciones que comprenden vectores lentivirales que expresan interleucina-12, y metodos de uso de las mismas.
EP3184119A1 (fr) 2015-12-23 2017-06-28 Themis Bioscience GmbH Chromatographie basée sur des stratégies de purification pour les virus de la rougeole basés sur un échafaudage
JP7225254B2 (ja) 2017-11-09 2023-02-20 アンスティテュ・パストゥール 非構造タンパク質を含むジカウイルスキメラポリエピトープ、及び免疫原性組成物におけるその使用

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WO2000075665A1 (fr) * 1999-06-09 2000-12-14 Institut Pasteur Detection precoce des flavivirus en utilisant la clycoproteine ns1
EP1092779A1 (fr) * 1999-10-11 2001-04-18 Institut Pasteur Vecteurs lentiviraux pour la préparation des compositions immunothérapeutiques
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CA2456873A1 (fr) * 2003-02-26 2004-08-26 Centre National De La Recherche Scientifique (C.N.R.S.) Proteines du virus du nil occidental, genes codant celles-ci et applications vaccinales, therapeutiques et diagnostiques a base de celles-ci

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Also Published As

Publication number Publication date
CA2564934C (fr) 2014-07-08
US20110206710A1 (en) 2011-08-25
MXPA06013388A (es) 2007-06-19
EP1751291A1 (fr) 2007-02-14
EP1751291B1 (fr) 2013-07-31
BRPI0510016B1 (pt) 2020-03-10
CN1981043B (zh) 2010-06-09
BRPI0510016B8 (pt) 2021-05-25
EP2371966A1 (fr) 2011-10-05
FR2870126B1 (fr) 2009-07-17
BRPI0510016A (pt) 2007-09-18
WO2005111221A1 (fr) 2005-11-24
CA2564934A1 (fr) 2005-11-24
US8716013B2 (en) 2014-05-06
CN1981043A (zh) 2007-06-13
EP2371966B1 (fr) 2015-11-25
JP2008508863A (ja) 2008-03-27
US20090214589A1 (en) 2009-08-27

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