BRPI0510016A - vetor lentiviral recombinante para expressão de uma proteìna de flaviviridae e aplicações do mesmo como vacina - Google Patents
vetor lentiviral recombinante para expressão de uma proteìna de flaviviridae e aplicações do mesmo como vacinaInfo
- Publication number
- BRPI0510016A BRPI0510016A BRPI0510016-0A BRPI0510016A BRPI0510016A BR PI0510016 A BRPI0510016 A BR PI0510016A BR PI0510016 A BRPI0510016 A BR PI0510016A BR PI0510016 A BRPI0510016 A BR PI0510016A
- Authority
- BR
- Brazil
- Prior art keywords
- lentiviral vector
- protein
- vaccine
- expression
- recombinant lentiviral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
VETOR LENTIVIRAL RECOMBINANTE PARA EX-PRESSãO DE UMA PROTEìNA DE FLAVIVIRIDAE E APLICAçõES DO MESMO COMO VACINA. A presente invenção refere-se ao uso de um vetor lentiviral recombinante que compreende um fragmento de polinucleotídeo que codifica pelo menos uma proteína de um vírus da família Flaviviridae ou um peptídeo imunogênico de pelo menos 8 aminoácidos dessa proteína, para preparação de uma composição farmacêutica pretendida para a prevenção e/ou o tratamento de uma infecção por Flaviviridae em uma espécie sensível.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0405366A FR2870126B1 (fr) | 2004-05-17 | 2004-05-17 | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
FR0405366 | 2004-05-17 | ||
PCT/IB2005/001753 WO2005111221A1 (en) | 2004-05-17 | 2005-05-16 | Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0510016A true BRPI0510016A (pt) | 2007-09-18 |
BRPI0510016B1 BRPI0510016B1 (pt) | 2020-03-10 |
BRPI0510016B8 BRPI0510016B8 (pt) | 2021-05-25 |
Family
ID=34945000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510016A BRPI0510016B8 (pt) | 2004-05-17 | 2005-05-16 | vetor lentiviral recombinante, composição imunogênica e uso dos mesmos como vacina |
Country Status (9)
Country | Link |
---|---|
US (2) | US20090214589A1 (pt) |
EP (2) | EP1751291B1 (pt) |
JP (1) | JP2008508863A (pt) |
CN (1) | CN1981043B (pt) |
BR (1) | BRPI0510016B8 (pt) |
CA (1) | CA2564934C (pt) |
FR (1) | FR2870126B1 (pt) |
MX (1) | MXPA06013388A (pt) |
WO (1) | WO2005111221A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1224314T3 (da) | 1999-10-12 | 2007-05-21 | Inst Nat Sante Rech Med | Lentiviralt triplex-DNA samt vektorer og rekombinante celler indeholder lentiviralt triplex-DNA |
FR2870126B1 (fr) * | 2004-05-17 | 2009-07-17 | Pasteur Institut | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
US8222029B2 (en) * | 2005-05-16 | 2012-07-17 | Institut Pasteur | Lentiviral vector-based vaccine |
CA2508266A1 (fr) | 2005-06-20 | 2006-12-20 | Institut Pasteur | Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae |
DK1939214T3 (da) | 2006-12-22 | 2013-10-14 | Pasteur Institut | Celler og metodik til at generere ikke-segmenterede negativstrengede RNA-vira |
GB0701253D0 (en) | 2007-01-23 | 2007-02-28 | Diagnostics For The Real World | Nucleic acid amplification and testing |
CA2721657A1 (en) * | 2008-04-22 | 2009-10-29 | Cytos Biotechnology Ag | Vaccine compositions for the treatment of dengue fever and uses thereof |
EP2666477A1 (en) | 2012-05-23 | 2013-11-27 | Theravectys | Lentiviral vectors containing an MHC class I promoter |
WO2012021741A2 (en) | 2010-08-12 | 2012-02-16 | Clontech Laboratories, Inc. | Lateral flow assays for non-diagnostic analytes |
EP3031923A1 (en) * | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentiviral vector-based japanese encephalitis immunogenic composition |
ES2785503T3 (es) | 2015-11-09 | 2020-10-07 | Immune Design Corp | Composiciones que comprenden vectores lentivíricos que expresan IL-12 y métodos de uso de los mismos |
EP3184119A1 (en) | 2015-12-23 | 2017-06-28 | Themis Bioscience GmbH | Chromatography based purification strategies for measles scaffold based viruses |
MX2020004833A (es) | 2017-11-09 | 2021-01-08 | Pasteur Institut | Un poliepitopo quimerico del virus del zika que comprende proteinas no estructurales y su uso en una composicion inmunogenica. |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69334328D1 (de) * | 1992-07-16 | 2010-06-10 | Advanced Life Science Inst Inc | Antigene Peptide zur Gruppierung des Hepatitis-C-Virus, Kit damit und Verfahren zur Gruppierung unter Verwendung dieses Kits |
US5883081A (en) * | 1995-07-26 | 1999-03-16 | The Regents Of The University Of California | Isolation of novel HIV-2 proviruses |
US5888767A (en) * | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
IL129017A0 (en) | 1996-10-17 | 2000-02-17 | Oxford Biomedica Ltd | Retroviral vectors |
CA2315269A1 (en) | 1997-12-22 | 1999-07-01 | Oxford Biomedica (Uk) Limited | Equine infectious anaemia virus (eiav) based |
CA2318575A1 (en) * | 1998-01-16 | 1999-07-22 | Chiron Corporation | Feline immunodeficiency virus gene therapy vectors |
FR2777909B1 (fr) * | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
AU4554899A (en) | 1998-06-09 | 1999-12-30 | Andrea D. Branch | Novel hepatitis c virus peptides and uses thereof |
US7052830B1 (en) * | 1998-06-09 | 2006-05-30 | Branch Andrea D | Hepatitis C virus peptides and uses thereof |
FR2794865B1 (fr) * | 1999-06-09 | 2003-04-18 | Pasteur Institut | Methode de detection precoce des flavivirus et ses applications |
ES2447115T3 (es) * | 1999-10-11 | 2014-03-11 | Institut Pasteur | Vectores para la preparación de composiciones inmunoterapéuticas |
DK1224314T3 (da) * | 1999-10-12 | 2007-05-21 | Inst Nat Sante Rech Med | Lentiviralt triplex-DNA samt vektorer og rekombinante celler indeholder lentiviralt triplex-DNA |
EP1092780A1 (en) | 1999-10-13 | 2001-04-18 | Boehringer Ingelheim International GmbH | Recombiant, replication defective CELO virus and CELO virus DNA |
DK1383796T3 (da) | 2001-04-04 | 2009-08-17 | Pasteur Institut | Neurovirulent stamme af viruset West Nile og anvendelser heraf |
US20040037848A1 (en) * | 2001-04-06 | 2004-02-26 | Audonnet Jean-Christophe Francis | Recombinant vaccine against West Nile Virus |
CN1935258B (zh) | 2001-07-27 | 2013-04-03 | 惠氏公司 | 西尼罗河疫苗 |
AU2003216046B2 (en) | 2002-01-10 | 2008-05-01 | The Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Construction of West Nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by West Nile virus |
NZ535690A (en) * | 2002-02-26 | 2009-04-30 | Maxygen Inc | Novel flavivirus antigens |
US20030194392A1 (en) * | 2002-04-10 | 2003-10-16 | Pierre Charneau | Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA |
DE10249594A1 (de) * | 2002-10-24 | 2004-05-13 | Jassoy, Christian, Dr. | Immunisierung gegen Bestandteile des Humanen Immunschwächevirus (HIV) |
CA2456873A1 (en) * | 2003-02-26 | 2004-08-26 | Centre National De La Recherche Scientifique (C.N.R.S.) | West nile virus proteins and genes coding the foregoing and their use in vaccinal, therapeutic and diagnostic applications |
CA2432738A1 (en) * | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
FR2870126B1 (fr) * | 2004-05-17 | 2009-07-17 | Pasteur Institut | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
US8158413B2 (en) * | 2005-10-17 | 2012-04-17 | Institut Pasteur | Lentiviral vector-based vaccine |
US8222029B2 (en) * | 2005-05-16 | 2012-07-17 | Institut Pasteur | Lentiviral vector-based vaccine |
-
2004
- 2004-05-17 FR FR0405366A patent/FR2870126B1/fr active Active
-
2005
- 2005-05-16 WO PCT/IB2005/001753 patent/WO2005111221A1/en active Application Filing
- 2005-05-16 CN CN200580015744XA patent/CN1981043B/zh active Active
- 2005-05-16 MX MXPA06013388A patent/MXPA06013388A/es active IP Right Grant
- 2005-05-16 US US11/596,675 patent/US20090214589A1/en not_active Abandoned
- 2005-05-16 CA CA2564934A patent/CA2564934C/en active Active
- 2005-05-16 EP EP05748053.5A patent/EP1751291B1/en active Active
- 2005-05-16 JP JP2007517517A patent/JP2008508863A/ja active Pending
- 2005-05-16 BR BRPI0510016A patent/BRPI0510016B8/pt active IP Right Grant
- 2005-05-16 EP EP11167507.0A patent/EP2371966B1/en active Active
-
2011
- 2011-01-07 US US12/929,215 patent/US8716013B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BRPI0510016B1 (pt) | 2020-03-10 |
CN1981043B (zh) | 2010-06-09 |
US8716013B2 (en) | 2014-05-06 |
EP1751291A1 (en) | 2007-02-14 |
EP2371966B1 (en) | 2015-11-25 |
FR2870126B1 (fr) | 2009-07-17 |
FR2870126A1 (fr) | 2005-11-18 |
CN1981043A (zh) | 2007-06-13 |
US20090214589A1 (en) | 2009-08-27 |
EP2371966A1 (en) | 2011-10-05 |
JP2008508863A (ja) | 2008-03-27 |
MXPA06013388A (es) | 2007-06-19 |
BRPI0510016B8 (pt) | 2021-05-25 |
US20110206710A1 (en) | 2011-08-25 |
EP1751291B1 (en) | 2013-07-31 |
WO2005111221A1 (en) | 2005-11-24 |
CA2564934C (en) | 2014-07-08 |
CA2564934A1 (en) | 2005-11-24 |
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Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12N 15/867 , C07K 14/18 Ipc: C12N 15/867 (2006.01), C07K 14/18 (2006.01), A61K |
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