BRPI0607097B8 - uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus - Google Patents
uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírusInfo
- Publication number
- BRPI0607097B8 BRPI0607097B8 BRPI0607097A BRPI0607097A BRPI0607097B8 BR PI0607097 B8 BRPI0607097 B8 BR PI0607097B8 BR PI0607097 A BRPI0607097 A BR PI0607097A BR PI0607097 A BRPI0607097 A BR PI0607097A BR PI0607097 B8 BRPI0607097 B8 BR PI0607097B8
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- peptide
- papillomavirus
- amino acids
- neutralizing antibodies
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
peptídeos de papiloma vírus l2 n-terminais para a indução de anticorpos de neutralização amplamente cruzada. a invenção compreende um método para induzir anticorpos de neutralização amplamente cruzada contra papiloma vírus tipos mucosa e cutâneo ou contra papiloma vírus tipos heterólogos em humanos, compreendendo administrar a um humano em necessidade do mesmo um peptídeo ou proteína imunogênicos (ou polinucleotídeo de codificação por essa razão), onde o peptídeo ou proteína imunogênícos é: (a) um peptídeo ou proteína de pelo menos 10 aminoácidos sobrando em comprimento tendo uma seqüência correspondente a tanto uma seqüência a partir dos aminoácidos n-terminal 1-200 de proteína l2 de papiloma vírus (para anticorpos de neutralização cruzada contra papiloma vírus tipos mucosa e cutâneo) quanto uma seqüência a partir de aminoácidos n-termínal 1-88 de proteína l2 papiloma vírus (para anticorpos de neutralização cruzada contra papiloma vírus tipos heterólogos), (b) um peptídeo ou proteína de pelo menos 10 aminoácidos sobrando em comprimento com pelo menos identidade de 55% com a seqüência a apartir de (a), ou (c) um peptídeo ou proteína como definido em tanto (a) quanto (b), o qual é conjugado ou fundido a uma proteína ou peptídeo diferente de peptídeo ou proteína l2 de papiloma vírus.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64924905P | 2005-02-01 | 2005-02-01 | |
US60/649,249 | 2005-02-01 | ||
US69765505P | 2005-07-07 | 2005-07-07 | |
US60/697,655 | 2005-07-07 | ||
US75226805P | 2005-12-21 | 2005-12-21 | |
US60/752,268 | 2005-12-21 | ||
PCT/US2006/003601 WO2006083984A1 (en) | 2005-02-01 | 2006-02-01 | Papillomavirus l2 n-terminal peptides for the induction of broadly cross-neutralizing antibodies |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0607097A2 BRPI0607097A2 (pt) | 2009-08-04 |
BRPI0607097B1 BRPI0607097B1 (pt) | 2020-09-24 |
BRPI0607097B8 true BRPI0607097B8 (pt) | 2021-05-25 |
Family
ID=36590144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0607097A BRPI0607097B8 (pt) | 2005-02-01 | 2006-02-01 | uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus |
Country Status (8)
Country | Link |
---|---|
US (2) | US8404244B2 (pt) |
EP (1) | EP1853307B1 (pt) |
JP (1) | JP5224821B2 (pt) |
CN (1) | CN101193653B (pt) |
AU (1) | AU2006210792B2 (pt) |
BR (1) | BRPI0607097B8 (pt) |
CA (1) | CA2596698C (pt) |
WO (1) | WO2006083984A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0607097B8 (pt) | 2005-02-01 | 2021-05-25 | The Gorvernment Of The United States Of America Repres By The Secretary Depart Of Health And Human S | uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus |
BRPI0714721A2 (pt) | 2006-07-14 | 2013-04-24 | Sanofi Pasteur Biologics Co | construÇço de vacinas de vÍrus recombinante por inserÇço direta mediada por transpàson de determinantes imunolàgicos estranhos em proteÍnas de vÍrus vetorial |
US20100239605A1 (en) | 2006-09-29 | 2010-09-23 | Sanofi Pasteur Biologics Co. | Recombinant Rhinovirus Vectors |
WO2008140474A1 (en) * | 2006-10-26 | 2008-11-20 | Johns Hopkins University | Recombinant adenovirus vaccines |
US8968995B2 (en) | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
US8278056B2 (en) * | 2008-06-13 | 2012-10-02 | Oncohealth Corp. | Detection of early stages and late stages HPV infection |
US8501907B2 (en) | 2007-08-10 | 2013-08-06 | Janssen Biotech, Inc. | Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such |
AP2010005284A0 (en) * | 2007-11-02 | 2010-06-30 | Univ Johns Hopkins | Multitype HPV peptide compositions and methods fortreatment or prevention of human papillomavirus i nfection |
ES2653251T3 (es) * | 2009-04-10 | 2018-02-06 | The Johns Hopkins University | Partículas de tipo papilomavirus (VLP) como vacunas de amplio espectro del virus del papiloma humano (VPH) |
EP2427763A4 (en) | 2009-05-07 | 2013-08-21 | Oncohealth Corp | IDENTIFICATION OF HIGH GRADE OR CIN2 FOR DETECTION, MONITORING AND DIAGNOSIS, AT EARLY STAGES AND ADVANCED STAGES, OF HUMAN PAPILLOMAVIRUS (HPV) AND HPV ASSOCIATED CANCERS |
WO2010149752A2 (en) | 2009-06-25 | 2010-12-29 | Glaxosmithline Biologicals S.A. | Novel compositions |
CN102574891A (zh) * | 2009-08-26 | 2012-07-11 | 西莱克塔生物科技公司 | 诱导t细胞辅助的组合物 |
CN102822672B (zh) | 2010-01-08 | 2015-12-09 | 安科健康公司 | 用于诊断和筛选与hpv有关的癌症的高通量细胞基hpv免疫测定 |
US9533057B2 (en) * | 2010-02-09 | 2017-01-03 | Stc.Unm | Immunogenic HPV L2-containing VLPs and related compositions, constructs, and therapeutic methods |
US9717783B2 (en) | 2010-02-09 | 2017-08-01 | Stc.Unm | Immunogenic HPV L2-containing VLPs and related compositions, constructs, and therapeutic methods |
EP2640414A4 (en) * | 2010-11-19 | 2016-06-15 | Janssen Biotech Inc | VACCINE COMPOSITIONS WITH IMMUNOGLOBULIN SPLITTING FRAGMENTS |
WO2015068101A1 (en) * | 2013-11-06 | 2015-05-14 | Shantha Biotechnics Private Limited | Papillomavirus vaccine formulations |
CN107188967B (zh) * | 2016-03-15 | 2020-03-31 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
CN107188966B (zh) * | 2016-03-15 | 2020-03-31 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3779175D1 (de) * | 1986-03-21 | 1992-06-25 | Pasteur Institut | Bestimmte, von einem papillomavirus-genom abgeleitete dns-sequenzen, deren anwendungen fuer in vitro-diagnostische zwecke und die herstellung von antigenzusammensetzungen. |
US5618536A (en) * | 1992-09-03 | 1997-04-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric papillomavirus-like particles |
GB9306731D0 (en) | 1993-03-31 | 1993-05-26 | Cancer Res Campaign Tech | Vaccines |
IL113817A (en) | 1994-06-30 | 2001-03-19 | Merck & Co Inc | Polynucleotide for vaccination against the umbilical cord virus |
GB9420146D0 (en) * | 1994-10-06 | 1994-11-23 | Cancer Res Campaign Tech | Papillomavirus vaccine |
GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
AU2003254585A1 (en) * | 2002-07-24 | 2004-02-16 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
WO2005108564A2 (en) * | 2004-03-25 | 2005-11-17 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusion |
BRPI0607097B8 (pt) | 2005-02-01 | 2021-05-25 | The Gorvernment Of The United States Of America Repres By The Secretary Depart Of Health And Human S | uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus |
-
2006
- 2006-02-01 BR BRPI0607097A patent/BRPI0607097B8/pt active IP Right Grant
- 2006-02-01 JP JP2007554194A patent/JP5224821B2/ja active Active
- 2006-02-01 EP EP06734177.6A patent/EP1853307B1/en active Active
- 2006-02-01 CN CN2006800110791A patent/CN101193653B/zh active Active
- 2006-02-01 WO PCT/US2006/003601 patent/WO2006083984A1/en active Application Filing
- 2006-02-01 US US11/883,495 patent/US8404244B2/en active Active
- 2006-02-01 CA CA2596698A patent/CA2596698C/en active Active
- 2006-02-01 AU AU2006210792A patent/AU2006210792B2/en active Active
-
2013
- 2013-02-21 US US13/772,893 patent/US9388221B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9388221B2 (en) | 2016-07-12 |
US20130177585A1 (en) | 2013-07-11 |
BRPI0607097B1 (pt) | 2020-09-24 |
EP1853307A1 (en) | 2007-11-14 |
CN101193653A (zh) | 2008-06-04 |
US20090047301A1 (en) | 2009-02-19 |
CN101193653B (zh) | 2013-03-27 |
JP5224821B2 (ja) | 2013-07-03 |
WO2006083984A9 (en) | 2006-10-26 |
JP2008530010A (ja) | 2008-08-07 |
CA2596698C (en) | 2017-05-16 |
WO2006083984A1 (en) | 2006-08-10 |
US8404244B2 (en) | 2013-03-26 |
AU2006210792A1 (en) | 2006-08-10 |
AU2006210792B2 (en) | 2012-07-26 |
EP1853307B1 (en) | 2016-12-14 |
BRPI0607097A2 (pt) | 2009-08-04 |
CA2596698A1 (en) | 2006-08-10 |
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