BRPI0607097A2 - peptìdeos de papiloma vìrus l2 n-terminais para a indução de anticorpos de neutralização amplamente cruzada - Google Patents
peptìdeos de papiloma vìrus l2 n-terminais para a indução de anticorpos de neutralização amplamente cruzadaInfo
- Publication number
- BRPI0607097A2 BRPI0607097A2 BRPI0607097-3A BRPI0607097A BRPI0607097A2 BR PI0607097 A2 BRPI0607097 A2 BR PI0607097A2 BR PI0607097 A BRPI0607097 A BR PI0607097A BR PI0607097 A2 BRPI0607097 A2 BR PI0607097A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- peptide
- papilloma virus
- neutralizing antibodies
- cross
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PEPTIDEOS DE PAPILOMA VìRUS L2 N-TERMINAIS PARA A INDUçãO DE ANTICORPOS DE NEUTRALIZAçãO AMPLAMENTE CRUZADA. A invenção compreende um método para induzir anticorpos de neutralização amplamente cruzada contra papíloma vírus tipos mucosa e cutâneo ou contra papiloma vírus tipos heterólogos em humanos, compreendendo administrar a um humano em necessidade do mesmo um peptídeo ou proteína imunogênicos (ou polínucleotídeo de codificação por essa razão), onde o peptideo ou proteína imunogênícos é: (a> um peptídeo ou proteína de pelo menos 10 amínoácidos sobrando em comprimento tendo uma seqUência correspondente a tanto uma seqUência a partir dos aminoácídos N-termínal 1-200 de proteína L2 de papiloma vírus (para anticorpos de neutralização cruzada contra papiloma vírus tipos mucosa e cutâneo) quanto uma seqUência a partir de aminoácídos N-termínal 1-88 de proteína L2 papiloma vírus (para anticorpos de neutralização cruzada contra papíloma vírus tipos heterólogos), (b) um peptideo ou proteína de pelo menos 10 aminoácídos sobrando em comprimento com pelo menos identidade de 55% com a seqUência a apartir de (a), ou (c> um peptideo ou proteína como definido em tanto (a) quanto (b), o qual é conjugado ou fundido a uma proteína ou peptídeo diferente de peptídeo ou proteína L2 de papíloma vírus.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64924905P | 2005-02-01 | 2005-02-01 | |
US60/649,249 | 2005-02-01 | ||
US69765505P | 2005-07-07 | 2005-07-07 | |
US60/697,655 | 2005-07-07 | ||
US75226805P | 2005-12-21 | 2005-12-21 | |
US60/752,268 | 2005-12-21 | ||
PCT/US2006/003601 WO2006083984A1 (en) | 2005-02-01 | 2006-02-01 | Papillomavirus l2 n-terminal peptides for the induction of broadly cross-neutralizing antibodies |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0607097A2 true BRPI0607097A2 (pt) | 2009-08-04 |
BRPI0607097B1 BRPI0607097B1 (pt) | 2020-09-24 |
BRPI0607097B8 BRPI0607097B8 (pt) | 2021-05-25 |
Family
ID=36590144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0607097A BRPI0607097B8 (pt) | 2005-02-01 | 2006-02-01 | uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus |
Country Status (8)
Country | Link |
---|---|
US (2) | US8404244B2 (pt) |
EP (1) | EP1853307B1 (pt) |
JP (1) | JP5224821B2 (pt) |
CN (1) | CN101193653B (pt) |
AU (1) | AU2006210792B2 (pt) |
BR (1) | BRPI0607097B8 (pt) |
CA (1) | CA2596698C (pt) |
WO (1) | WO2006083984A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2596698C (en) | 2005-02-01 | 2017-05-16 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Papillomavirus l2 n-terminal peptides for the induction of broadly cross-neutralizing antibodies |
AU2007297801A1 (en) | 2006-07-14 | 2008-03-27 | Sanofi Pasteur Biologics Co. | Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins |
JP2010504760A (ja) | 2006-09-29 | 2010-02-18 | サノフィ パスツール バイオロジクス カンパニー | 組換え型ライノウイルスベクター |
US20100272753A1 (en) * | 2006-10-26 | 2010-10-28 | The Johns Hopkins University | Recombinant Adenovirus Vaccines |
US8968995B2 (en) | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
US8278056B2 (en) | 2008-06-13 | 2012-10-02 | Oncohealth Corp. | Detection of early stages and late stages HPV infection |
WO2010129821A1 (en) | 2009-05-07 | 2010-11-11 | Oncohealth Corporation | Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers |
US8501907B2 (en) | 2007-08-10 | 2013-08-06 | Janssen Biotech, Inc. | Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such |
WO2009059325A2 (en) * | 2007-11-02 | 2009-05-07 | The Johns Hopkins University | Multitype hpv peptide compositions and methods for treatment or prevention of human papillomavirus infection |
CN102458440A (zh) | 2009-04-10 | 2012-05-16 | 约翰·霍普金斯大学 | 作为广谱人类乳头状瘤病毒(hpv)疫苗的乳头状瘤病毒样颗粒(vlp) |
EA022213B1 (ru) | 2009-06-25 | 2015-11-30 | Глаксосмитклайн Байолоджикалс С.А. | Новые конструкции белка вируса папилломы человека (hpv) и их применение в предупреждении заболевания, вызываемого hpv |
EP3311833A3 (en) * | 2009-08-26 | 2018-07-25 | Selecta Biosciences, Inc. | Compositions that induce t cell help |
US9128094B2 (en) | 2010-01-08 | 2015-09-08 | Oncohealth Corp. | High throughput cell-based HPV immunoassays for diagnosis and screening of HPV-associated cancers |
WO2011100234A2 (en) * | 2010-02-09 | 2011-08-18 | Stc.Unm | Immunogenic hpv l2-containing vlps and related compositions, constructs, and therapeutic methods |
US9717783B2 (en) | 2010-02-09 | 2017-08-01 | Stc.Unm | Immunogenic HPV L2-containing VLPs and related compositions, constructs, and therapeutic methods |
NZ610460A (en) * | 2010-11-19 | 2015-01-30 | Janssen Biotech Inc | Immunoglobulin cleavage fragments vaccine compositions |
WO2015068101A1 (en) * | 2013-11-06 | 2015-05-14 | Shantha Biotechnics Private Limited | Papillomavirus vaccine formulations |
CN107188967B (zh) * | 2016-03-15 | 2020-03-31 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
CN107188966B (zh) * | 2016-03-15 | 2020-03-31 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3779175D1 (de) * | 1986-03-21 | 1992-06-25 | Pasteur Institut | Bestimmte, von einem papillomavirus-genom abgeleitete dns-sequenzen, deren anwendungen fuer in vitro-diagnostische zwecke und die herstellung von antigenzusammensetzungen. |
US5618536A (en) | 1992-09-03 | 1997-04-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric papillomavirus-like particles |
GB9306731D0 (en) | 1993-03-31 | 1993-05-26 | Cancer Res Campaign Tech | Vaccines |
IL113817A (en) * | 1994-06-30 | 2001-03-19 | Merck & Co Inc | Polynucleotide for vaccination against the umbilical cord virus |
GB9420146D0 (en) * | 1994-10-06 | 1994-11-23 | Cancer Res Campaign Tech | Papillomavirus vaccine |
GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
JP2005533855A (ja) * | 2002-07-24 | 2005-11-10 | インターツェル・アクチェンゲゼルシャフト | 病原性ウイルスからの別のリーディングフレームによりコードされる抗原 |
EP1732615A4 (en) * | 2004-03-25 | 2009-09-16 | Kentucky Bioproc Llc | PRODUCTION OF PEPTIDES IN PLANTS IN THE FORM OF FUSION OF VIRAL ENVELOPE PROTEINS |
CA2596698C (en) | 2005-02-01 | 2017-05-16 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Papillomavirus l2 n-terminal peptides for the induction of broadly cross-neutralizing antibodies |
-
2006
- 2006-02-01 CA CA2596698A patent/CA2596698C/en active Active
- 2006-02-01 EP EP06734177.6A patent/EP1853307B1/en active Active
- 2006-02-01 BR BRPI0607097A patent/BRPI0607097B8/pt active IP Right Grant
- 2006-02-01 US US11/883,495 patent/US8404244B2/en active Active
- 2006-02-01 WO PCT/US2006/003601 patent/WO2006083984A1/en active Application Filing
- 2006-02-01 CN CN2006800110791A patent/CN101193653B/zh active Active
- 2006-02-01 JP JP2007554194A patent/JP5224821B2/ja active Active
- 2006-02-01 AU AU2006210792A patent/AU2006210792B2/en active Active
-
2013
- 2013-02-21 US US13/772,893 patent/US9388221B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2006083984A9 (en) | 2006-10-26 |
CN101193653A (zh) | 2008-06-04 |
CN101193653B (zh) | 2013-03-27 |
US20090047301A1 (en) | 2009-02-19 |
US9388221B2 (en) | 2016-07-12 |
EP1853307B1 (en) | 2016-12-14 |
EP1853307A1 (en) | 2007-11-14 |
AU2006210792A1 (en) | 2006-08-10 |
AU2006210792B2 (en) | 2012-07-26 |
WO2006083984A1 (en) | 2006-08-10 |
JP2008530010A (ja) | 2008-08-07 |
CA2596698A1 (en) | 2006-08-10 |
JP5224821B2 (ja) | 2013-07-03 |
US8404244B2 (en) | 2013-03-26 |
BRPI0607097B8 (pt) | 2021-05-25 |
US20130177585A1 (en) | 2013-07-11 |
BRPI0607097B1 (pt) | 2020-09-24 |
CA2596698C (en) | 2017-05-16 |
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