MX2022002961A - Metodos para tratar enfermedades neovasculares oculares usando variantes de aav2 que codifican para aflibercept. - Google Patents

Metodos para tratar enfermedades neovasculares oculares usando variantes de aav2 que codifican para aflibercept.

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Publication number
MX2022002961A
MX2022002961A MX2022002961A MX2022002961A MX2022002961A MX 2022002961 A MX2022002961 A MX 2022002961A MX 2022002961 A MX2022002961 A MX 2022002961A MX 2022002961 A MX2022002961 A MX 2022002961A MX 2022002961 A MX2022002961 A MX 2022002961A
Authority
MX
Mexico
Prior art keywords
aav2
amino acid
methods
ocular neovascular
acid sequence
Prior art date
Application number
MX2022002961A
Other languages
English (en)
Inventor
Mehdi Gasmi
Aaron Osborne
Szilard Kiss
Adam Turpcu
Original Assignee
Adverum Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/062066 external-priority patent/WO2021050094A1/en
Application filed by Adverum Biotechnologies Inc filed Critical Adverum Biotechnologies Inc
Publication of MX2022002961A publication Critical patent/MX2022002961A/es

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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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Abstract

Se proporcionan métodos para tratar una enfermedad neovascular ocular en un individuo, que comprenden administrar una dosis unitaria de partículas de virus adenoasociado recombinante (rAAV) a un ojo del individuo, en donde las partículas de rAAV comprenden: a) un ácido nucleico que codifica para un polipéptido que comprende una secuencia de aminoácidos con al menos aproximadamente 95% de identidad a la secuencia de aminoácidos de SEQ ID NO: 35 y flanqueado por repeticiones terminales invertidas (ITR) de AAV2 y b) una proteína de cápside de AAV2 que comprende una secuencia de aminoácidos LGETTRP (SEQ ID NO: 14) insertada entre las posiciones 587 y 588 de la proteína de cápside, en donde la numeración de residuos de aminoácidos corresponde a una proteína de cápside VP1 de AAV2.
MX2022002961A 2019-09-11 2020-09-10 Metodos para tratar enfermedades neovasculares oculares usando variantes de aav2 que codifican para aflibercept. MX2022002961A (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962899070P 2019-09-11 2019-09-11
US201962913648P 2019-10-10 2019-10-10
PCT/US2019/062066 WO2021050094A1 (en) 2019-09-11 2019-11-18 Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
US202062959784P 2020-01-10 2020-01-10
US202062971835P 2020-02-07 2020-02-07
US202063019190P 2020-05-01 2020-05-01
US202063030819P 2020-05-27 2020-05-27
US202063063203P 2020-08-07 2020-08-07
PCT/US2020/050079 WO2021050649A1 (en) 2019-09-11 2020-09-10 Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

Publications (1)

Publication Number Publication Date
MX2022002961A true MX2022002961A (es) 2022-04-06

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MX2022002961A MX2022002961A (es) 2019-09-11 2020-09-10 Metodos para tratar enfermedades neovasculares oculares usando variantes de aav2 que codifican para aflibercept.

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EP (1) EP4027983A1 (es)
JP (1) JP2022547541A (es)
KR (1) KR20220062353A (es)
CN (1) CN114375195A (es)
AU (1) AU2020345915A1 (es)
BR (1) BR112022004027A2 (es)
CA (1) CA3148376A1 (es)
IL (1) IL291182A (es)
MX (1) MX2022002961A (es)
WO (1) WO2021050649A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024515459A (ja) 2021-04-27 2024-04-10 アドヴェラム バイオテクノロジーズ， インコーポレイテッド アフリベルセプトをコードするａａｖ２バリアントを使用する眼疾患の治療方法
KR20240014477A (ko) * 2021-05-28 2024-02-01 상하이 레제네리드 테라피즈 컴퍼니 리미티드 변이체 캡시드를 갖는 재조합 아데노-연관 바이러스 및 이의 응용
WO2023028457A1 (en) * 2021-08-23 2023-03-02 Duke University Compositions for and methods of long-term integration of circuits using connexins
WO2023158990A1 (en) * 2022-02-16 2023-08-24 Adverum Biotechnologies, Inc. Method of reducing cst fluctuation in neovascular amd by a recombinant adeno-associated virus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3254703T3 (pl) 2011-04-22 2020-10-05 The Regents Of The University Of California Wiriony wirusa towarzyszącego adenowirusom z różnymi kapsydami i sposoby ich zastosowania
RS61311B1 (sr) * 2016-06-16 2021-02-26 Adverum Biotechnologies Inc Lečenje amd korišćenjem varijante aav2 sa afliberceptom
MX2019011040A (es) 2017-03-17 2020-01-20 Adverum Biotechnologies Inc Composiciones y metodos para potenciar la expresion genica.

Also Published As

Publication number Publication date
IL291182A (en) 2022-05-01
WO2021050649A1 (en) 2021-03-18
AU2020345915A1 (en) 2022-03-24
CN114375195A (zh) 2022-04-19
BR112022004027A2 (pt) 2022-05-31
KR20220062353A (ko) 2022-05-16
EP4027983A1 (en) 2022-07-20
JP2022547541A (ja) 2022-11-14
CA3148376A1 (en) 2021-03-18

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