MY186651A - Adeno-associated virus variant capsids and methods of use thereof - Google Patents

Adeno-associated virus variant capsids and methods of use thereof

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Publication number
MY186651A
MY186651A MYPI2018704186A MYPI2018704186A MY186651A MY 186651 A MY186651 A MY 186651A MY PI2018704186 A MYPI2018704186 A MY PI2018704186A MY PI2018704186 A MYPI2018704186 A MY PI2018704186A MY 186651 A MY186651 A MY 186651A
Authority
MY
Malaysia
Prior art keywords
aav
methods
virions
associated virus
adeno
Prior art date
Application number
MYPI2018704186A
Inventor
David H Kirn
Melissa Kotterman
David Schaffer
Original Assignee
4D Molecular Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4D Molecular Therapeutics Inc filed Critical 4D Molecular Therapeutics Inc
Priority claimed from PCT/US2017/032542 external-priority patent/WO2017197355A2/en
Publication of MY186651A publication Critical patent/MY186651A/en

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

[00214] Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and in clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more cells of the retina for the treatment of retinal disorders and diseases. (Figure 1)
MYPI2018704186A 2016-05-13 2017-05-12 Adeno-associated virus variant capsids and methods of use thereof MY186651A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662336441P 2016-05-13 2016-05-13
US201662378106P 2016-08-22 2016-08-22
US201662384590P 2016-09-07 2016-09-07
PCT/US2017/032542 WO2017197355A2 (en) 2016-05-13 2017-05-12 Adeno-associated virus variant capsids and methods of use thereof

Publications (1)

Publication Number Publication Date
MY186651A true MY186651A (en) 2021-08-03

Family

ID=81329687

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2018704186A MY186651A (en) 2016-05-13 2017-05-12 Adeno-associated virus variant capsids and methods of use thereof

Country Status (1)

Country Link
MY (1) MY186651A (en)

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