MY186651A - Adeno-associated virus variant capsids and methods of use thereof - Google Patents
Adeno-associated virus variant capsids and methods of use thereofInfo
- Publication number
- MY186651A MY186651A MYPI2018704186A MYPI2018704186A MY186651A MY 186651 A MY186651 A MY 186651A MY PI2018704186 A MYPI2018704186 A MY PI2018704186A MY PI2018704186 A MYPI2018704186 A MY PI2018704186A MY 186651 A MY186651 A MY 186651A
- Authority
- MY
- Malaysia
- Prior art keywords
- aav
- methods
- virions
- associated virus
- adeno
- Prior art date
Links
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
[00214] Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and in clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more cells of the retina for the treatment of retinal disorders and diseases. (Figure 1)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662336441P | 2016-05-13 | 2016-05-13 | |
US201662378106P | 2016-08-22 | 2016-08-22 | |
US201662384590P | 2016-09-07 | 2016-09-07 | |
PCT/US2017/032542 WO2017197355A2 (en) | 2016-05-13 | 2017-05-12 | Adeno-associated virus variant capsids and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MY186651A true MY186651A (en) | 2021-08-03 |
Family
ID=81329687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI2018704186A MY186651A (en) | 2016-05-13 | 2017-05-12 | Adeno-associated virus variant capsids and methods of use thereof |
Country Status (1)
Country | Link |
---|---|
MY (1) | MY186651A (en) |
-
2017
- 2017-05-12 MY MYPI2018704186A patent/MY186651A/en unknown
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