DE69733179T2 - Modifizierte chimäre superantigene und deren verwendung - Google Patents

Modifizierte chimäre superantigene und deren verwendung Download PDF

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Publication number
DE69733179T2
DE69733179T2 DE69733179T DE69733179T DE69733179T2 DE 69733179 T2 DE69733179 T2 DE 69733179T2 DE 69733179 T DE69733179 T DE 69733179T DE 69733179 T DE69733179 T DE 69733179T DE 69733179 T2 DE69733179 T2 DE 69733179T2
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Germany
Prior art keywords
region
superantigen
see
amino acid
sea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69733179T
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German (de)
English (en)
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DE69733179D1 (de
Inventor
Per Antonsson
Johan Hansson
Per Björk
Mikael Dohlsten
Terje Kalland
Lars Abrahmsen
Göran Forsberg
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Active Biotech AB
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Active Biotech AB
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Filing date
Publication date
Priority claimed from SE9601245A external-priority patent/SE9601245D0/xx
Application filed by Active Biotech AB filed Critical Active Biotech AB
Publication of DE69733179D1 publication Critical patent/DE69733179D1/de
Application granted granted Critical
Publication of DE69733179T2 publication Critical patent/DE69733179T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE69733179T 1996-03-29 1997-03-26 Modifizierte chimäre superantigene und deren verwendung Expired - Lifetime DE69733179T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9601245 1996-03-29
SE9601245A SE9601245D0 (sv) 1996-03-29 1996-03-29 Chimeric superantigens and their use
US08/695,692 US6514498B1 (en) 1996-03-19 1996-08-12 Modified/chimeric superantigens and their use
US695692 1996-08-12
PCT/SE1997/000537 WO1997036932A1 (en) 1996-03-29 1997-03-26 Modified/chimeric superantigens and their use

Publications (2)

Publication Number Publication Date
DE69733179D1 DE69733179D1 (de) 2005-06-09
DE69733179T2 true DE69733179T2 (de) 2005-10-06

Family

ID=26662565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69733179T Expired - Lifetime DE69733179T2 (de) 1996-03-29 1997-03-26 Modifizierte chimäre superantigene und deren verwendung

Country Status (20)

Country Link
US (1) US7226595B2 (https=)
EP (1) EP0835266B1 (https=)
JP (1) JP4114951B2 (https=)
AT (1) ATE294818T1 (https=)
AU (1) AU707827B2 (https=)
BR (1) BR9702179A (https=)
CA (1) CA2222757C (https=)
CZ (1) CZ294475B6 (https=)
DE (1) DE69733179T2 (https=)
ES (1) ES2242222T3 (https=)
HU (1) HU228185B1 (https=)
ID (1) ID16512A (https=)
IL (1) IL122211A (https=)
MX (1) MX9709265A (https=)
NO (1) NO321984B1 (https=)
NZ (1) NZ329145A (https=)
PL (1) PL189696B1 (https=)
PT (1) PT835266E (https=)
TW (1) TW517061B (https=)
WO (1) WO1997036932A1 (https=)

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Also Published As

Publication number Publication date
TW517061B (en) 2003-01-11
US7226595B2 (en) 2007-06-05
IL122211A (en) 2009-07-20
CZ371297A3 (cs) 1998-05-13
NZ329145A (en) 2000-06-23
MX9709265A (es) 1998-03-31
HUP9903444A2 (hu) 2000-02-28
DE69733179D1 (de) 2005-06-09
AU707827B2 (en) 1999-07-22
PL189696B1 (pl) 2005-09-30
IL122211A0 (en) 1998-04-05
PT835266E (pt) 2005-07-29
HUP9903444A3 (en) 2003-08-28
NO975435D0 (no) 1997-11-26
AU2525197A (en) 1997-10-22
EP0835266A1 (en) 1998-04-15
WO1997036932A1 (en) 1997-10-09
CA2222757C (en) 2011-07-26
CA2222757A1 (en) 1997-10-09
CZ294475B6 (cs) 2005-01-12
NO975435L (no) 1998-01-29
PL323626A1 (en) 1998-04-14
BR9702179A (pt) 1999-03-16
ID16512A (id) 1997-10-02
US20030092894A1 (en) 2003-05-15
NO321984B1 (no) 2006-07-31
EP0835266B1 (en) 2005-05-04
JP4114951B2 (ja) 2008-07-09
ES2242222T3 (es) 2005-11-01
HU228185B1 (en) 2013-01-28
ATE294818T1 (de) 2005-05-15
JP2002502363A (ja) 2002-01-22

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