JP2002502363A - 改変/キメラスーパー抗原およびその使用 - Google Patents
改変/キメラスーパー抗原およびその使用Info
- Publication number
- JP2002502363A JP2002502363A JP53519897A JP53519897A JP2002502363A JP 2002502363 A JP2002502363 A JP 2002502363A JP 53519897 A JP53519897 A JP 53519897A JP 53519897 A JP53519897 A JP 53519897A JP 2002502363 A JP2002502363 A JP 2002502363A
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- Prior art keywords
- superantigen
- wild
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- see
- amino acid
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.a)改変された野生型スーパー抗原と、 b)標的指向部分 とのコンジュゲートであって、該改変スーパー抗原が第一の野生型スーパー抗原 のアミノ酸配列を含み、 i)第一の野生型スーパー抗原のアミノ酸配列内に存在し、かつ ii)TCRへの結合およびT細胞のサブセットの活性化の決定において機能する 、 少なくとも1個の領域にある1個以上のアミノ酸残基が、異なるアミノ酸残基で 置換されており、該改変スーパー抗原がT細胞のサブセットを活性化する能力を 保持している、前記コンジュゲート。 2.少なくとも1個の領域が、TCRVβへの結合の決定において機能する、請 求項1に記載のコンジュゲート。 3.野生型スーパー抗原がSEA、SEDまたはSEEあるいは類似のスーパー 抗原である、請求項1〜2のいずれか一項に記載のコンジュゲート。 4.野生型スーパー抗原がSEEであり、少なくとも1個の領域が、配列番号8 で定義される領域A、C、FおよびHから成る群から選択される、請求項1〜3 のいずれか一項に記載のコンジュゲート。 5.野生型スーパー抗原がSEEであり、位置が図2の配列番号8で定義される 、R20G、N21T、S24GおよびR27Kのアミノ酸残基の置換を有する 、請求項1〜4のいずれか一項に記載のコンジュゲート。 6.改変スーパー抗原が、 a)第一の野生型スーパー抗原、および b)1個以上の別の野生型スーパー抗原 の間のキメラであり、第一の野生型スーパー抗原中の少なくとも1個の領域が、 1個以上の別の野生型スーパー抗原中の対応する領域に存在する対応するアミノ 酸残基で置換されている、請求項1〜5のいずれか一項に記載のコンジュゲート 。 7.第一および別の野生型スーパー抗原が、SEA、SED、SEEおよび類似 のスーパー抗原から選択される、請求項6に記載のコンジュゲート。 8.少なくとも1個の領域が、図2、配列番号7または8で定 義されるA、C、FおよびHに対応する領域から成る群から選択される、請求項 7に記載のコンジュゲート。 9.図2、配列番号7および8で定義される領域Aにおける20、21、24お よび27に対応する位置にある少なくとも1個のアミノ酸残基か、1個以上の別 の野生型スーパー抗原の領域A中の対応するアミノ酸残基で置換されている、請 求項8に記載のコンジュゲート。 10.第一の野生型スーパー抗原かSEEであり、1個以上の別の野生型スーパ ー抗原がSEAである、請求項6〜9のいずれか一項に記載のコンジュゲート。 11.1個以上のアミノ酸の置換が、図2、配列番号7および8で定義される、 20、21、24、27(領域Aについて)および/または60、62(領域C について)および/または111、114、115、117、118、124、 126(領域Fについて)および/または200、206、207(領域Hにつ いて)に対応する位置にあり、第一のスーパー抗原がSEEであり、1個以上の 別のスーパー抗原がSEAである場合は、領域Aにおける4個全ての位置の残基 が置換されているのが好ましい、請求項7〜10のいずれか一項に記載のコンジ ュ ゲート。 12.野生型スーパー抗原がMHOクラスII抗原への結合に対して亜鉛イオンを 必要とするものから選択され、第一の野生型スーパー抗原がコンジュゲートに存 在すると、亜鉛イオンへの結合に関与する位置、特に図2、配列番号7および8 で定義される225および/または227の位置のアミノ酸残基がこの結合能の 低下に効果があるように置換される、請求項1〜11のいずれか一項に記載のコ ンジュゲート。 13.標的指向部分が抗体、特に抗体活性断片である、請求項1〜12のいずれ か一項に記載のコンジュゲート。 14.標的指向部分がFabフラグメントである、請求項1〜13のいずれか一 項に記載のコンジュゲート。 15.i)第一の野生型スーパー抗原のアミノ酸配列内に存在し、かつ ii)TCRへの結合および続くT細胞のサブセットの活性化の決定において機能 する、 少なくとも1個の領域にある1個以上のアミノ酸残基の置換により改変されてい る第一の野生型スーパー抗原を含む、治療的に有効な量のスーパー抗原を哺乳類 に投与することを含む、哺 乳類の免疫系を活性化することによる哺乳類の病気の治療法。 16.改変スーパー抗原が第一の野生型スーパー抗原と1個以上の別の野生型ス ーパー抗原との間のキメラスーパー抗原であり、第一の野生型スーパー抗原の少 なくとも1個の領域にある1個以上のアミノ酸残基の各々が、1個以上の別の野 生型スーパー抗原の対応する領域に存在する対応するアミノ酸残基で置換されて いる、請求項16に記載の方法。 17.病気が、スーパー抗原の、TCRに結合するエピトープとは構造的に異な るエピトープに結合する表面標的構造を発現する細胞と関連し、表面結合構造へ の結合が、TCRへの結合および続くT細胞のサブセットの活性化を可能にする 、請求項15〜16のいずれか一項に記載の方法。 18.病気が、癌、ウイルス感染、寄生虫の外寄生および自己免疫疾患から成る 群から選択される、請求項15〜17のいすれか一項に記載の方法。 19.野生型スーパー抗原が、SEA、SED、SEEおよび類似のスーパー抗 原から成る群から選択される、請求項15〜18のいずれか一項に記載の方法。 20.少なくとも1個の領域が、図2、配列番号7および8で 定義される領域A、C、FおよびHに対応する領域から成る群から選択される、 請求項19に記載方法。 21.第一の野生型スーパー抗原がSEEであり、少なくとも1個の領域が、図 2、配列番号8で定義される領域A、C、FおよびHから成る群から選択される 、請求項15〜20のいずれか一項に記載の方法。 22.少なくとも1個の領域が領域Aであり、位置が図2の配列番号8で定義さ れる、R20G、N21T、S24GおよびR27Kのアミノ酸残基の置換を有 する、請求項21に記載の方法。 23.少なくとも1個の別の野生型スーパー抗原がSEAである、請求項15〜 22のいずれか一項に記載の方法。 24.スーパー抗原が請求項1〜14のいずれか一項に記載のコンジュゲートで ある、請求項15〜23のいずれか一項に記載の方法。 25.野生型スーパー抗原が、MHCクラスII抗原への結合に対して亜鉛イオン への結合を必要とするものから選択され、第一の野生型スーパー抗原の配列にお けるアミノ酸残基が、MHCクラスII抗原能を低下させるために、亜鉛への結合 に関 与する位置で置換されている、請求項24に記載の方法。 26.該位置が、図2、配列番号7および8で定義される227に対応し、特に 突然変異D227Aである、請求項25に記載の方法。 27.標的指向部分が、鎖間を結合させるシステイン残基の各々が、鎖間を結合 させないアミノ酸残基で置換されているFabフラグメントであり、好ましくは 、置換アミノ酸残基がセリンである、請求項24〜26のいずれか一項に記載の 方法。 28.天然の抗体において鎖間のシステイン結合を付与するシステインが、シス テインの形成を阻害するように置換されている改変抗体を含む薬剤組成物。 29.置換残基がセリン残基である、請求項28に記載の薬剤組成物。 30.抗体がFabフラグメントである、請求項29に記載の薬剤組成物。 31.抗体が、Vβ特異的にT細胞を活性化させるペプチド部分に融合した、請 求項30に記載の薬剤組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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SE9601245A SE9601245D0 (sv) | 1996-03-29 | 1996-03-29 | Chimeric superantigens and their use |
US9601245-5 | 1996-08-12 | ||
US08/695,692 | 1996-08-12 | ||
US08/695,692 US6514498B1 (en) | 1996-03-19 | 1996-08-12 | Modified/chimeric superantigens and their use |
PCT/SE1997/000537 WO1997036932A1 (en) | 1996-03-29 | 1997-03-26 | Modified/chimeric superantigens and their use |
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JP2002502363A true JP2002502363A (ja) | 2002-01-22 |
JP2002502363A5 JP2002502363A5 (ja) | 2004-12-09 |
JP4114951B2 JP4114951B2 (ja) | 2008-07-09 |
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JP53519897A Expired - Fee Related JP4114951B2 (ja) | 1996-03-29 | 1997-03-26 | 改変/キメラスーパー抗原およびその使用 |
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US (1) | US7226595B2 (ja) |
EP (1) | EP0835266B1 (ja) |
JP (1) | JP4114951B2 (ja) |
AT (1) | ATE294818T1 (ja) |
AU (1) | AU707827B2 (ja) |
BR (1) | BR9702179A (ja) |
CA (1) | CA2222757C (ja) |
CZ (1) | CZ294475B6 (ja) |
DE (1) | DE69733179T2 (ja) |
ES (1) | ES2242222T3 (ja) |
HU (1) | HU228185B1 (ja) |
ID (1) | ID16512A (ja) |
IL (1) | IL122211A (ja) |
MX (1) | MX9709265A (ja) |
NO (1) | NO321984B1 (ja) |
NZ (1) | NZ329145A (ja) |
PL (1) | PL189696B1 (ja) |
PT (1) | PT835266E (ja) |
TW (1) | TW517061B (ja) |
WO (1) | WO1997036932A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2016522259A (ja) * | 2013-06-19 | 2016-07-28 | インテグレイテッド バイオセラピューティクス,インコーポレイテッド | フェノール可溶性モジュリン、δ毒素、スーパー抗原に由来するトキソイドペプチド、およびその融合物 |
WO2020162203A1 (ja) * | 2019-02-08 | 2020-08-13 | 国立大学法人東京工業大学 | ホモジニアス免疫測定法に適した酵素変異体 |
JP2020537488A (ja) * | 2017-07-27 | 2020-12-24 | インテグレイテッド バイオセラピューティック ワクチンズ インコーポレイテッド | スーパー抗原トキソイドに由来する融合ペプチドを含む免疫原性組成物 |
Families Citing this family (47)
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SE9402430L (sv) * | 1994-07-11 | 1996-01-12 | Pharmacia Ab | Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten |
TW517061B (en) | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
US7276488B2 (en) | 1997-06-04 | 2007-10-02 | Oxford Biomedica (Uk) Limited | Vector system |
EP1012259B1 (en) | 1997-06-04 | 2009-09-30 | Oxford Biomedica (UK) Limited | Tumor targeted vector |
US6713284B2 (en) | 1997-06-25 | 2004-03-30 | The United States Of America As Represented By The Secretary Of The Army | Bacterial superantigen vaccines |
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Cited By (6)
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JP2016522259A (ja) * | 2013-06-19 | 2016-07-28 | インテグレイテッド バイオセラピューティクス,インコーポレイテッド | フェノール可溶性モジュリン、δ毒素、スーパー抗原に由来するトキソイドペプチド、およびその融合物 |
JP2020537488A (ja) * | 2017-07-27 | 2020-12-24 | インテグレイテッド バイオセラピューティック ワクチンズ インコーポレイテッド | スーパー抗原トキソイドに由来する融合ペプチドを含む免疫原性組成物 |
US11260120B2 (en) | 2017-07-27 | 2022-03-01 | Integrated Biotherapeutic Vaccines, Inc. | Immunogenic composition comprising a fusion peptide derived from superantigen toxoids |
JP7303791B2 (ja) | 2017-07-27 | 2023-07-05 | アブヴァク インコーポレイテッド | スーパー抗原トキソイドに由来する融合ペプチドを含む免疫原性組成物 |
US11826412B2 (en) | 2017-07-27 | 2023-11-28 | Abvacc, Inc. | Immunogenic composition comprising a fusion peptide derived from superantigen toxoids |
WO2020162203A1 (ja) * | 2019-02-08 | 2020-08-13 | 国立大学法人東京工業大学 | ホモジニアス免疫測定法に適した酵素変異体 |
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CZ294475B6 (cs) | 2005-01-12 |
DE69733179T2 (de) | 2005-10-06 |
WO1997036932A1 (en) | 1997-10-09 |
CZ371297A3 (cs) | 1998-05-13 |
ES2242222T3 (es) | 2005-11-01 |
HUP9903444A3 (en) | 2003-08-28 |
TW517061B (en) | 2003-01-11 |
ATE294818T1 (de) | 2005-05-15 |
HU228185B1 (en) | 2013-01-28 |
NO321984B1 (no) | 2006-07-31 |
IL122211A0 (en) | 1998-04-05 |
BR9702179A (pt) | 1999-03-16 |
EP0835266A1 (en) | 1998-04-15 |
PT835266E (pt) | 2005-07-29 |
DE69733179D1 (de) | 2005-06-09 |
ID16512A (id) | 1997-10-02 |
HUP9903444A2 (hu) | 2000-02-28 |
NZ329145A (en) | 2000-06-23 |
MX9709265A (es) | 1998-03-31 |
CA2222757A1 (en) | 1997-10-09 |
CA2222757C (en) | 2011-07-26 |
PL189696B1 (pl) | 2005-09-30 |
AU2525197A (en) | 1997-10-22 |
NO975435L (no) | 1998-01-29 |
US20030092894A1 (en) | 2003-05-15 |
EP0835266B1 (en) | 2005-05-04 |
US7226595B2 (en) | 2007-06-05 |
PL323626A1 (en) | 1998-04-14 |
JP4114951B2 (ja) | 2008-07-09 |
IL122211A (en) | 2009-07-20 |
AU707827B2 (en) | 1999-07-22 |
NO975435D0 (no) | 1997-11-26 |
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