CA2222757C - Modified/chimeric superantigens and their use - Google Patents

Modified/chimeric superantigens and their use Download PDF

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Publication number
CA2222757C
CA2222757C CA2222757A CA2222757A CA2222757C CA 2222757 C CA2222757 C CA 2222757C CA 2222757 A CA2222757 A CA 2222757A CA 2222757 A CA2222757 A CA 2222757A CA 2222757 C CA2222757 C CA 2222757C
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CA
Canada
Prior art keywords
superantigen
see
sea
binding
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2222757A
Other languages
English (en)
French (fr)
Other versions
CA2222757A1 (en
Inventor
Per Antonsson
Johan Hansson
Per Bjork
Mikael Dohlsten
Terje Kalland
Lars Abrahmsen
Goran Forsberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Active Biotech AB
Original Assignee
Active Biotech AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9601245A external-priority patent/SE9601245D0/xx
Application filed by Active Biotech AB filed Critical Active Biotech AB
Publication of CA2222757A1 publication Critical patent/CA2222757A1/en
Application granted granted Critical
Publication of CA2222757C publication Critical patent/CA2222757C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Catalysts (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2222757A 1996-03-29 1997-03-26 Modified/chimeric superantigens and their use Expired - Fee Related CA2222757C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9601245-5 1996-03-29
SE9601245A SE9601245D0 (sv) 1996-03-29 1996-03-29 Chimeric superantigens and their use
US08/695,692 1996-08-12
US08/695,692 US6514498B1 (en) 1996-03-19 1996-08-12 Modified/chimeric superantigens and their use
PCT/SE1997/000537 WO1997036932A1 (en) 1996-03-29 1997-03-26 Modified/chimeric superantigens and their use

Publications (2)

Publication Number Publication Date
CA2222757A1 CA2222757A1 (en) 1997-10-09
CA2222757C true CA2222757C (en) 2011-07-26

Family

ID=26662565

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2222757A Expired - Fee Related CA2222757C (en) 1996-03-29 1997-03-26 Modified/chimeric superantigens and their use

Country Status (20)

Country Link
US (1) US7226595B2 (https=)
EP (1) EP0835266B1 (https=)
JP (1) JP4114951B2 (https=)
AT (1) ATE294818T1 (https=)
AU (1) AU707827B2 (https=)
BR (1) BR9702179A (https=)
CA (1) CA2222757C (https=)
CZ (1) CZ294475B6 (https=)
DE (1) DE69733179T2 (https=)
ES (1) ES2242222T3 (https=)
HU (1) HU228185B1 (https=)
ID (1) ID16512A (https=)
IL (1) IL122211A (https=)
MX (1) MX9709265A (https=)
NO (1) NO321984B1 (https=)
NZ (1) NZ329145A (https=)
PL (1) PL189696B1 (https=)
PT (1) PT835266E (https=)
TW (1) TW517061B (https=)
WO (1) WO1997036932A1 (https=)

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SE0102327D0 (sv) * 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy
US20060240044A1 (en) * 2002-05-09 2006-10-26 Fraser John D Streptococcal superantigens spe-l and spe-m
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DE19216461T1 (de) 2011-10-03 2021-10-07 Modernatx, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
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Also Published As

Publication number Publication date
DE69733179T2 (de) 2005-10-06
NO321984B1 (no) 2006-07-31
HU228185B1 (en) 2013-01-28
EP0835266A1 (en) 1998-04-15
IL122211A0 (en) 1998-04-05
ID16512A (id) 1997-10-02
US20030092894A1 (en) 2003-05-15
MX9709265A (es) 1998-03-31
AU2525197A (en) 1997-10-22
HUP9903444A3 (en) 2003-08-28
CZ371297A3 (cs) 1998-05-13
TW517061B (en) 2003-01-11
PL189696B1 (pl) 2005-09-30
PT835266E (pt) 2005-07-29
BR9702179A (pt) 1999-03-16
CZ294475B6 (cs) 2005-01-12
JP4114951B2 (ja) 2008-07-09
US7226595B2 (en) 2007-06-05
PL323626A1 (en) 1998-04-14
HUP9903444A2 (hu) 2000-02-28
IL122211A (en) 2009-07-20
NO975435D0 (no) 1997-11-26
CA2222757A1 (en) 1997-10-09
ATE294818T1 (de) 2005-05-15
ES2242222T3 (es) 2005-11-01
DE69733179D1 (de) 2005-06-09
NZ329145A (en) 2000-06-23
WO1997036932A1 (en) 1997-10-09
EP0835266B1 (en) 2005-05-04
AU707827B2 (en) 1999-07-22
JP2002502363A (ja) 2002-01-22
NO975435L (no) 1998-01-29

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