DE69029294T2 - Nichtmenschliche primaten CD4-Polypeptide und menschliche glykosilierbare CD4-Moleküle - Google Patents

Nichtmenschliche primaten CD4-Polypeptide und menschliche glykosilierbare CD4-Moleküle

Info

Publication number
DE69029294T2
DE69029294T2 DE69029294T DE69029294T DE69029294T2 DE 69029294 T2 DE69029294 T2 DE 69029294T2 DE 69029294 T DE69029294 T DE 69029294T DE 69029294 T DE69029294 T DE 69029294T DE 69029294 T2 DE69029294 T2 DE 69029294T2
Authority
DE
Germany
Prior art keywords
molecules
relates
fusion proteins
human
immunoglobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69029294T
Other languages
English (en)
Other versions
DE69029294D1 (de
Inventor
Brian Seed
David Camerini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of DE69029294D1 publication Critical patent/DE69029294D1/de
Application granted granted Critical
Publication of DE69029294T2 publication Critical patent/DE69029294T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69029294T 1989-08-23 1990-08-18 Nichtmenschliche primaten CD4-Polypeptide und menschliche glykosilierbare CD4-Moleküle Expired - Fee Related DE69029294T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39778289A 1989-08-23 1989-08-23

Publications (2)

Publication Number Publication Date
DE69029294D1 DE69029294D1 (de) 1997-01-16
DE69029294T2 true DE69029294T2 (de) 1997-05-22

Family

ID=23572610

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029294T Expired - Fee Related DE69029294T2 (de) 1989-08-23 1990-08-18 Nichtmenschliche primaten CD4-Polypeptide und menschliche glykosilierbare CD4-Moleküle

Country Status (16)

Country Link
US (1) US5420264A (de)
EP (1) EP0414178B1 (de)
JP (1) JPH05500611A (de)
KR (1) KR927003613A (de)
AT (1) ATE145938T1 (de)
AU (1) AU648041B2 (de)
CA (1) CA2065010A1 (de)
DE (1) DE69029294T2 (de)
DK (1) DK0414178T3 (de)
ES (1) ES2097121T3 (de)
FI (1) FI920658A0 (de)
GR (1) GR3022039T3 (de)
IE (1) IE903043A1 (de)
PT (1) PT95072A (de)
WO (1) WO1991002743A1 (de)
ZA (1) ZA906246B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
DK0417563T3 (da) 1989-09-12 2000-11-06 Hoffmann La Roche TNF-bindende proteiner
US7253264B1 (en) 1990-06-28 2007-08-07 Sanofi-Arentideutschland GmbH Immunoglobulin fusion proteins, their production and use
EP0464533B1 (de) * 1990-06-28 1998-07-29 Hoechst Aktiengesellschaft Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung
FR2696188A1 (fr) * 1992-09-25 1994-04-01 Curie Paris Vi Univ Pierre Mar Molécule CD4 de chat, séquence nucléique codant pour cette molécule et leurs applications.
ATE367827T1 (de) * 1992-11-16 2007-08-15 Centocor Inc Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US5874268A (en) 1996-09-23 1999-02-23 Duke University Method of introducing exogenous compounds into cells by electroporation and apparatus for same
WO2000043551A1 (en) * 1999-01-26 2000-07-27 Cornell Research Foundation, Inc. Determining viral load in double negative t cells
US8029803B2 (en) 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8025873B2 (en) * 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
EP1948802A4 (de) * 2005-10-13 2009-01-14 Virexx Medical Corp Chimäres antigen mit hepatitis-c-virus-polypeptid und fc-fragment zum hervorrufen einer immunantwort

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE25197T1 (de) * 1982-05-12 1987-02-15 Harvard College Hybridproteinekodierende fusionierte gene, sie enthaltende klonierungsvektoren und deren verwendung.
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) * 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
ATE135747T1 (de) * 1986-08-21 1996-04-15 Univ Columbia Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids
WO1989001940A1 (en) * 1987-09-04 1989-03-09 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins
AU618969B2 (en) * 1987-10-02 1992-01-16 Genentech Inc. Adheson variants
NZ226414A (en) * 1987-10-02 1992-07-28 Genentech Inc Cd4 peptide adhesion variants and their preparation and use
IL87902A0 (en) * 1987-10-08 1989-03-31 Dana Farber Cancer Inst Inc Soluble human cd4 fragments and applications thereof
PT89484B (pt) * 1988-01-22 1994-03-31 Gen Hospital Corp Genes clonados codificadores de proteinas de fusao ig-cd4 e sua utilizacao
DK172110B1 (da) * 1988-04-15 1997-10-27 Gen Hospital Corp Fremgangsmåde til isolation af mutanter af DNA-sekvenser og anvendelsen heraf til identifikation af celleoverfladeproteiner
CA2011299A1 (en) * 1989-03-03 1990-09-03 Franklin Volvovitz Aids therapy

Also Published As

Publication number Publication date
KR927003613A (ko) 1992-12-18
IE903043A1 (en) 1991-02-27
US5420264A (en) 1995-05-30
EP0414178A2 (de) 1991-02-27
GR3022039T3 (en) 1997-03-31
AU648041B2 (en) 1994-04-14
DK0414178T3 (da) 1997-05-26
WO1991002743A1 (en) 1991-03-07
JPH05500611A (ja) 1993-02-12
DE69029294D1 (de) 1997-01-16
ATE145938T1 (de) 1996-12-15
PT95072A (pt) 1991-05-22
CA2065010A1 (en) 1991-02-24
FI920658A0 (fi) 1992-02-14
EP0414178B1 (de) 1996-12-04
ES2097121T3 (es) 1997-04-01
EP0414178A3 (en) 1991-11-13
AU6429590A (en) 1991-04-03
ZA906246B (en) 1991-07-31

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DE69029294T2 (de) Nichtmenschliche primaten CD4-Polypeptide und menschliche glykosilierbare CD4-Moleküle
Marchesi et al. Selective solubilization of a protein component of the red cell membrane
Richardson et al. Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.
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ATE122394T1 (de) Pankreatische isletzellen-antigene, erhalten durch molekulare klonierung.
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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee