ATE367827T1 - Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern - Google Patents

Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern

Info

Publication number
ATE367827T1
ATE367827T1 AT94901552T AT94901552T ATE367827T1 AT E367827 T1 ATE367827 T1 AT E367827T1 AT 94901552 T AT94901552 T AT 94901552T AT 94901552 T AT94901552 T AT 94901552T AT E367827 T1 ATE367827 T1 AT E367827T1
Authority
AT
Austria
Prior art keywords
immunogenic
immunogenicity
reducing
disclosed
auto
Prior art date
Application number
AT94901552T
Other languages
English (en)
Inventor
Robert E Jordan
Carrie Lynne Wagner
David M Knight
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Application granted granted Critical
Publication of ATE367827T1 publication Critical patent/ATE367827T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94901552T 1992-11-16 1993-11-16 Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern ATE367827T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97770592A 1992-11-16 1992-11-16

Publications (1)

Publication Number Publication Date
ATE367827T1 true ATE367827T1 (de) 2007-08-15

Family

ID=25525432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94901552T ATE367827T1 (de) 1992-11-16 1993-11-16 Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern

Country Status (9)

Country Link
US (2) US6652863B1 (de)
EP (1) EP0676965B1 (de)
AT (1) ATE367827T1 (de)
AU (1) AU5610194A (de)
DE (1) DE69334156T2 (de)
DK (1) DK0676965T3 (de)
ES (1) ES2293635T3 (de)
PT (1) PT676965E (de)
WO (1) WO1994011028A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011028A1 (en) * 1992-11-16 1994-05-26 Centocor, Inc. Compounds having reduced immunogenicity and a method of reducing the immunogenicity of compounds
WO2005075647A1 (en) * 2004-02-06 2005-08-18 Nymox Corporation Humanized antibody
US7625549B2 (en) * 2004-03-19 2009-12-01 Amgen Fremont Inc. Determining the risk of human anti-human antibodies in transgenic mice
EP2078077A2 (de) * 2006-10-04 2009-07-15 Codon Devices, Inc Nukleinsäurebibliotheken und ihr entwurf und herstellung
US8501907B2 (en) * 2007-08-10 2013-08-06 Janssen Biotech, Inc. Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such
US20110160071A1 (en) * 2008-06-03 2011-06-30 Baynes Brian M Novel Proteins and Methods for Designing the Same
WO2013065343A1 (ja) * 2011-10-31 2013-05-10 株式会社 島津製作所 非ペプチドヒンジ部含有フレキシブル抗体様分子
AU2014373593B2 (en) * 2013-12-23 2020-07-16 Zymeworks Bc Inc. Antibodies comprising C-terminal light chain polypeptide extensions and conjugates and methods of use thereof
US11254734B2 (en) 2016-11-14 2022-02-22 Morphosys Ag Fab molecules with a rodent hinge region and a non-rodent CH1 region
CA3172530A1 (en) 2021-02-25 2022-09-01 Spencer PARK Ror1 targeting chimeric antigen receptor

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8430252D0 (en) 1984-11-30 1985-01-09 Beecham Group Plc Compounds
ZA89430B (en) 1988-01-22 1989-10-25 Gen Hospital Corp Cloned genes encoding ig-cd4 fusion proteins and the use thereof
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
KR940009084B1 (ko) 1988-05-18 1994-09-29 체크 포인트 시스템스, 인코오퍼레이티드 자기 및 공명회로 검출용 안테나 시스템
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
WO1991002743A1 (en) * 1989-08-23 1991-03-07 The General Hospital Corporation Non-human primate cd4 polypeptides, fusions thereof, dna encoding, and uses thereof
JPH05502586A (ja) * 1989-12-27 1993-05-13 セントカー・インコーポレーテツド Ｃｄ４受容体に対するキメラ免疫グロブリン
JPH07501451A (ja) 1991-11-25 1995-02-16 エンゾン・インコーポレイテッド 多価抗原結合タンパク質
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
WO1993013133A1 (en) * 1991-12-20 1993-07-08 Yamanouchi Pharmaceutical Co., Ltd. HUMAN TYPE ANTIBODY REACTIVE WITH GPIIb/IIIa
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
WO1994011028A1 (en) * 1992-11-16 1994-05-26 Centocor, Inc. Compounds having reduced immunogenicity and a method of reducing the immunogenicity of compounds

Also Published As

Publication number Publication date
EP0676965A1 (de) 1995-10-18
EP0676965A4 (de) 2002-08-07
DE69334156T2 (de) 2008-04-10
PT676965E (pt) 2007-10-29
US20050079183A1 (en) 2005-04-14
DE69334156D1 (de) 2007-09-06
WO1994011028A1 (en) 1994-05-26
DK0676965T3 (da) 2007-11-19
ES2293635T3 (es) 2008-03-16
AU5610194A (en) 1994-06-08
US6652863B1 (en) 2003-11-25
EP0676965B1 (de) 2007-07-25

Similar Documents

Publication Publication Date Title
ATE153332T1 (de) Verfahren zur herstellung von oxetanonen
DK1015587T3 (da) DcR3 polypeptid, en TNFR-homolog
IL111479A0 (en) Chimeric proteins comprising borrelia polypetides and uses therefor
DK0484787T3 (da) HCV-specifikke peptider, fremgangsmåde til opnåelse deraf og anvendelse deraf
DE59507342D1 (de) Verfahren zur herstellung von heterologen bispezifischen antikörpern
SE8601325L (sv) Sett att producera ett immunglobulinbindande protein samt medel for detta
ES8705521A1 (es) Un metodo de producir un polipetido similar a factor de necrosis de tumores (tnf) de mamiferos.
AR248044A1 (es) Una secuencia de adn que codifica anticuerpos monoclonales humanizados contra interleuquinas humanas, metodo de obtencion y de seleccion de dichos anticuerpos, vector recombinante y celula huesped.
FI943591A7 (fi) Synteettinen hemofilus-influenssa yhdistelmärokote
DE3786832D1 (de) Verfahren zur herstellung von immunoglobulinzubereitungen fuer intravenoese injektion.
ATE367827T1 (de) Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern
WO1995006735A3 (en) Nucleotide sequences for novel protein tyrosine phosphatases
DK346385A (da) Genetiske sekvenser, hermed kodede interferon-peptider af type i og organismer, der producerer disse
DE69433400D1 (de) Neue proteine von parasitischen würmern
DE3579136D1 (de) Verfahren zur herstellung von hochgereinigten, hepatitis-b-virus-infektionsfreien gammaglobulinen.
DK0500736T3 (da) Rekombinant vaccine mod porcin pleuropneumoni
FI930626A0 (fi) Proteinstruktur hos vaexttoxingelonin
DK38889D0 (da) Onkogen-indkodet polypeptid med vaekstfaktoraktivitet
DE69427990D1 (de) Tyrosinaseaktivator-tyrosinase-fusions-enzym
DE69109510D1 (de) Verfahren zur Herstellung von Glycin.
ATE351909T1 (de) Neue peptidfragmente zur reinigung von proteinen
ATE162533T1 (de) Verfahren zur herstellung von nativem, intravenös verabreichbarem, stabilisiertem immunglobulin

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0676965

Country of ref document: EP