ATE367827T1 - Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern - Google Patents

Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern

Info

Publication number
ATE367827T1
ATE367827T1 AT94901552T AT94901552T ATE367827T1 AT E367827 T1 ATE367827 T1 AT E367827T1 AT 94901552 T AT94901552 T AT 94901552T AT 94901552 T AT94901552 T AT 94901552T AT E367827 T1 ATE367827 T1 AT E367827T1
Authority
AT
Austria
Prior art keywords
immunogenic
immunogenicity
reducing
disclosed
auto
Prior art date
Application number
AT94901552T
Other languages
English (en)
Inventor
Robert E Jordan
Carrie Lynne Wagner
David M Knight
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Application granted granted Critical
Publication of ATE367827T1 publication Critical patent/ATE367827T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94901552T 1992-11-16 1993-11-16 Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern ATE367827T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97770592A 1992-11-16 1992-11-16

Publications (1)

Publication Number Publication Date
ATE367827T1 true ATE367827T1 (de) 2007-08-15

Family

ID=25525432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94901552T ATE367827T1 (de) 1992-11-16 1993-11-16 Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern

Country Status (9)

Country Link
US (2) US6652863B1 (de)
EP (1) EP0676965B1 (de)
AT (1) ATE367827T1 (de)
AU (1) AU5610194A (de)
DE (1) DE69334156T2 (de)
DK (1) DK0676965T3 (de)
ES (1) ES2293635T3 (de)
PT (1) PT676965E (de)
WO (1) WO1994011028A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6652863B1 (en) * 1992-11-16 2003-11-25 Centocor, Inc. Method of reducing the immunogenicity of compounds
EP1718749A4 (de) * 2004-02-06 2007-07-18 Nymox Corp Humanisierter antikörper
US7625549B2 (en) * 2004-03-19 2009-12-01 Amgen Fremont Inc. Determining the risk of human anti-human antibodies in transgenic mice
US20080287320A1 (en) * 2006-10-04 2008-11-20 Codon Devices Libraries and their design and assembly
US8501907B2 (en) * 2007-08-10 2013-08-06 Janssen Biotech, Inc. Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such
WO2009149218A2 (en) * 2008-06-03 2009-12-10 Codon Devices, Inc. Novel proteins and methods of designing and using same
EP2784080B1 (de) * 2011-10-31 2019-12-18 Shimadzu Corporation Peptidscharnierfreies flexibles antikörperähnliches molekül
AU2014373593B2 (en) * 2013-12-23 2020-07-16 Zymeworks Bc Inc. Antibodies comprising C-terminal light chain polypeptide extensions and conjugates and methods of use thereof
WO2018087349A1 (en) 2016-11-14 2018-05-17 Morphosys Ag Fab molecules with a rodent hinge region and a non-rodent ch1 region

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
PT89484B (pt) * 1988-01-22 1994-03-31 Gen Hospital Corp Genes clonados codificadores de proteinas de fusao ig-cd4 e sua utilizacao
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
KR940009084B1 (ko) 1988-05-18 1994-09-29 체크 포인트 시스템스, 인코오퍼레이티드 자기 및 공명회로 검출용 안테나 시스템
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
CA2065010A1 (en) * 1989-08-23 1991-02-24 Brian Seed Non-human primate cd4 polypeptides, fusions thereof, dna encoding, and uses thereof
WO1991010722A2 (en) * 1989-12-27 1991-07-25 Centocor, Inc. Chimeric immunoglobulin for cd4 receptors
EP1136556B1 (de) 1991-11-25 2005-06-08 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
ES2179824T3 (es) 1991-12-20 2003-02-01 Yamanouchi Pharma Co Ltd Anticuerpos humanizados reactivos contra el antigeno gpiib/iiia.
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US6652863B1 (en) * 1992-11-16 2003-11-25 Centocor, Inc. Method of reducing the immunogenicity of compounds

Also Published As

Publication number Publication date
DE69334156T2 (de) 2008-04-10
AU5610194A (en) 1994-06-08
PT676965E (pt) 2007-10-29
EP0676965A1 (de) 1995-10-18
EP0676965A4 (de) 2002-08-07
US20050079183A1 (en) 2005-04-14
DE69334156D1 (de) 2007-09-06
ES2293635T3 (es) 2008-03-16
WO1994011028A1 (en) 1994-05-26
DK0676965T3 (da) 2007-11-19
EP0676965B1 (de) 2007-07-25
US6652863B1 (en) 2003-11-25

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