DK0676965T3 - Fremgangsmåde til at reducere immunogeniciteten af variable regioner på antistoffer - Google Patents

Fremgangsmåde til at reducere immunogeniciteten af variable regioner på antistoffer

Info

Publication number
DK0676965T3
DK0676965T3 DK94901552T DK94901552T DK0676965T3 DK 0676965 T3 DK0676965 T3 DK 0676965T3 DK 94901552 T DK94901552 T DK 94901552T DK 94901552 T DK94901552 T DK 94901552T DK 0676965 T3 DK0676965 T3 DK 0676965T3
Authority
DK
Denmark
Prior art keywords
immunogenic
immunogenicity
reducing
disclosed
auto
Prior art date
Application number
DK94901552T
Other languages
English (en)
Inventor
Robert E Jordan
Carrie Lynne Wagner
David M Knight
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Application granted granted Critical
Publication of DK0676965T3 publication Critical patent/DK0676965T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK94901552T 1992-11-16 1993-11-16 Fremgangsmåde til at reducere immunogeniciteten af variable regioner på antistoffer DK0676965T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97770592A 1992-11-16 1992-11-16
PCT/US1993/011148 WO1994011028A1 (en) 1992-11-16 1993-11-16 Compounds having reduced immunogenicity and a method of reducing the immunogenicity of compounds

Publications (1)

Publication Number Publication Date
DK0676965T3 true DK0676965T3 (da) 2007-11-19

Family

ID=25525432

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94901552T DK0676965T3 (da) 1992-11-16 1993-11-16 Fremgangsmåde til at reducere immunogeniciteten af variable regioner på antistoffer

Country Status (9)

Country Link
US (2) US6652863B1 (da)
EP (1) EP0676965B1 (da)
AT (1) ATE367827T1 (da)
AU (1) AU5610194A (da)
DE (1) DE69334156T2 (da)
DK (1) DK0676965T3 (da)
ES (1) ES2293635T3 (da)
PT (1) PT676965E (da)
WO (1) WO1994011028A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE367827T1 (de) * 1992-11-16 2007-08-15 Centocor Inc Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern
CN1965082A (zh) * 2004-02-06 2007-05-16 尼莫克斯股份有限公司 人源化抗体
US7625549B2 (en) * 2004-03-19 2009-12-01 Amgen Fremont Inc. Determining the risk of human anti-human antibodies in transgenic mice
EP2078077A2 (en) * 2006-10-04 2009-07-15 Codon Devices, Inc Nucleic acid libraries and their design and assembly
US8501907B2 (en) * 2007-08-10 2013-08-06 Janssen Biotech, Inc. Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such
US20110160071A1 (en) * 2008-06-03 2011-06-30 Baynes Brian M Novel Proteins and Methods for Designing the Same
JP6158090B2 (ja) * 2011-10-31 2017-07-05 ダニエル・ジェイ・カポン 非ペプチドヒンジ部含有フレキシブル抗体様分子
RU2016129724A (ru) * 2013-12-23 2018-01-30 Займворкс Инк. Антитела, содержащие с-концевые удлинения полипептида легкой цепи, их конъюгаты и способы применения
EP3538552B1 (en) 2016-11-14 2023-09-13 MorphoSys AG Fab molecules with a rodent hinge region and a non-rodent ch1 region

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
PT89484B (pt) * 1988-01-22 1994-03-31 Gen Hospital Corp Genes clonados codificadores de proteinas de fusao ig-cd4 e sua utilizacao
KR940009084B1 (ko) 1988-05-18 1994-09-29 체크 포인트 시스템스, 인코오퍼레이티드 자기 및 공명회로 검출용 안테나 시스템
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
JPH05500611A (ja) * 1989-08-23 1993-02-12 ザ・ジェネラル・ホスピタル・コーポレーション 非ヒト霊長類ｃｄ４ポリペプチド、グリコシル化可能なヒトｃｄ４分子、その断片、その融合タンパク質、その遺伝子配列および使用
CA2070182C (en) * 1989-12-27 2002-12-24 John Ghrayeb Chimeric immunoglobulin for cd4 receptors
ES2241710T3 (es) 1991-11-25 2005-11-01 Enzon, Inc. Procedimiento para producir proteinas multivalentes de union a antigeno.
CA2126182C (en) * 1991-12-20 2001-07-17 Man S. Co Humanized antibodies reactive with gpiib/iiia
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
ATE367827T1 (de) * 1992-11-16 2007-08-15 Centocor Inc Verfahren zur reduzierung der immunogenizität der variablen regionen von antikörpern

Also Published As

Publication number Publication date
EP0676965A4 (en) 2002-08-07
US20050079183A1 (en) 2005-04-14
WO1994011028A1 (en) 1994-05-26
EP0676965A1 (en) 1995-10-18
ATE367827T1 (de) 2007-08-15
PT676965E (pt) 2007-10-29
DE69334156T2 (de) 2008-04-10
DE69334156D1 (de) 2007-09-06
ES2293635T3 (es) 2008-03-16
EP0676965B1 (en) 2007-07-25
US6652863B1 (en) 2003-11-25
AU5610194A (en) 1994-06-08

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