DE69709655D1 - Verfahren zur herstellung von 17-estern von 9alpha,21-dihalopregan-11beta,17alpha-diol-20-onen - Google Patents

Verfahren zur herstellung von 17-estern von 9alpha,21-dihalopregan-11beta,17alpha-diol-20-onen

Info

Publication number
DE69709655D1
DE69709655D1 DE69709655T DE69709655T DE69709655D1 DE 69709655 D1 DE69709655 D1 DE 69709655D1 DE 69709655 T DE69709655 T DE 69709655T DE 69709655 T DE69709655 T DE 69709655T DE 69709655 D1 DE69709655 D1 DE 69709655D1
Authority
DE
Germany
Prior art keywords
dihalopregan
9alpha
11beta
17alpha
diol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69709655T
Other languages
English (en)
Other versions
DE69709655T2 (de
Inventor
Albert Kwok
J Tsai
Chou-Hong Tann
Xiaoyong Fu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69709655D1 publication Critical patent/DE69709655D1/de
Publication of DE69709655T2 publication Critical patent/DE69709655T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
DE69709655T 1996-06-28 1997-06-25 Verfahren zur herstellung von 17-estern von 9alpha,21-dihalopregan-11beta,17alpha-diol-20-onen Expired - Lifetime DE69709655T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67286196A 1996-06-28 1996-06-28
PCT/US1997/010121 WO1998000437A1 (en) 1996-06-28 1997-06-25 PROCESS FOR THE PREPARATION OF 17-ESTERS OF 9α,21-DIHALO-PREGNANE-11β,17αDIOL-20-ONES

Publications (2)

Publication Number Publication Date
DE69709655D1 true DE69709655D1 (de) 2002-02-21
DE69709655T2 DE69709655T2 (de) 2002-09-12

Family

ID=24700321

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69709655T Expired - Lifetime DE69709655T2 (de) 1996-06-28 1997-06-25 Verfahren zur herstellung von 17-estern von 9alpha,21-dihalopregan-11beta,17alpha-diol-20-onen

Country Status (21)

Country Link
EP (1) EP0923599B1 (de)
JP (3) JP4269110B2 (de)
KR (1) KR100441187B1 (de)
CN (1) CN1158296C (de)
AR (1) AR007485A1 (de)
AT (1) ATE212035T1 (de)
AU (1) AU725606B2 (de)
BR (1) BR9710081A (de)
CA (1) CA2258681C (de)
CZ (1) CZ293944B6 (de)
DE (1) DE69709655T2 (de)
DK (1) DK0923599T3 (de)
ES (1) ES2166549T3 (de)
HK (1) HK1017899A1 (de)
IL (1) IL127782A (de)
NO (1) NO312367B1 (de)
NZ (1) NZ333410A (de)
PL (1) PL185637B1 (de)
PT (1) PT923599E (de)
SK (1) SK283666B6 (de)
WO (1) WO1998000437A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ500555A (en) * 1999-08-02 2000-11-24 Hovione Int Ltd Process for the preparation of mometasone furoate
PT102405A (pt) * 2000-01-20 2001-07-31 Hovione Farmaciencia Sa Processo para a preparacao de mometasona
CN100436473C (zh) * 2005-12-09 2008-11-26 天津药业集团有限公司 糠酸莫美他松中间体21-酯及制法
CN100389121C (zh) * 2005-12-09 2008-05-21 天津药业集团有限公司 糠酸莫美他松中间体21-羟的制备方法
CN105566437B (zh) * 2015-12-30 2018-07-20 山东京卫制药有限公司 一种8dm衍生物及利用其合成糠酸莫米松的方法
CN107266519B (zh) * 2016-04-08 2021-06-29 天津金耀集团有限公司 一种9β，11β-环氧-17α-羟基-16α-甲基-21-氯代-1，4孕甾二烯-3，20-二酮新晶型及其制备方法
CN107266518B (zh) * 2016-04-08 2021-03-30 天津金耀集团有限公司 一种糠酸莫米松晶型及其制备方法
CN106279340B (zh) * 2016-08-10 2018-07-20 山东京卫制药有限公司 一种合成糠酸莫米松或其一水合物的方法
CN107951893B (zh) * 2016-10-18 2022-04-26 天津金耀集团有限公司 一种糠酸莫米松粉吸入剂组合物
CN109206468B (zh) * 2017-06-30 2023-06-27 天津药业研究院股份有限公司 一种糠酸莫米松的制备方法
CN109206466B (zh) * 2017-06-30 2022-08-09 天津药业研究院股份有限公司 一种甾体21位羟基氯代或溴代方法
CN109517019B (zh) * 2017-09-18 2021-12-07 华东师范大学 一种3β-乙酰氧基雄甾-5-烯-17-酮加成反应副产物的再利用方法
CN112110975A (zh) * 2019-06-21 2020-12-22 河南利华制药有限公司 一种一勺烩工艺合成糠酸莫米松的方法
CN112110972B (zh) * 2019-06-21 2022-03-18 河南利华制药有限公司 一种氯倍他索丙酸酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2713587A (en) * 1952-03-08 1955-07-19 Searle & Co 11, 17-dihydroxy-4-pregnene-3, 20-dione
US2793207A (en) * 1954-11-01 1957-05-21 Searle & Co Steroidal thiazole derivatives
US3440252A (en) * 1965-06-23 1969-04-22 Glaxo Lab Ltd Preparation of 21-deoxy steroids
US3502700A (en) * 1967-01-19 1970-03-24 Squibb & Sons Inc 17-esters of 9alpha,21-dihalo-11beta,17alpha-dihydroxyprogesterones
DE3260474D1 (en) * 1981-02-02 1984-09-06 Schering Corp Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NO312367B1 (no) 2002-04-29
KR100441187B1 (ko) 2004-11-03
SK283666B6 (sk) 2003-11-04
PL185637B1 (pl) 2003-06-30
CN1158296C (zh) 2004-07-21
PT923599E (pt) 2002-06-28
JP5061061B2 (ja) 2012-10-31
ES2166549T3 (es) 2002-04-16
DK0923599T3 (da) 2002-04-22
PL330843A1 (en) 1999-06-07
CZ293944B6 (cs) 2004-08-18
SK177898A3 (en) 2000-04-10
EP0923599A1 (de) 1999-06-23
CN1228782A (zh) 1999-09-15
NZ333410A (en) 2000-06-23
DE69709655T2 (de) 2002-09-12
AU725606B2 (en) 2000-10-12
JP2009035552A (ja) 2009-02-19
CZ417798A3 (cs) 1999-05-12
AU3483597A (en) 1998-01-21
IL127782A0 (en) 1999-10-28
KR20000022547A (ko) 2000-04-25
HK1017899A1 (en) 1999-12-03
CA2258681A1 (en) 1998-01-08
CA2258681C (en) 2006-11-14
NO986086L (no) 1999-02-16
BR9710081A (pt) 1999-08-10
JP4269110B2 (ja) 2009-05-27
IL127782A (en) 2004-06-20
AR007485A1 (es) 1999-10-27
ATE212035T1 (de) 2002-02-15
JP2012149076A (ja) 2012-08-09
EP0923599B1 (de) 2002-01-16
WO1998000437A1 (en) 1998-01-08
JP2000514058A (ja) 2000-10-24
NO986086D0 (no) 1998-12-23

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