BR9710081A - Processo para a preparaçÃo de 17-ésteres de 9alpha,21-dihalo-pregnano-1beta, 17alpha-diol-20-onas - Google Patents

Processo para a preparaçÃo de 17-ésteres de 9alpha,21-dihalo-pregnano-1beta, 17alpha-diol-20-onas

Info

Publication number
BR9710081A
BR9710081A BR9710081A BR9710081A BR9710081A BR 9710081 A BR9710081 A BR 9710081A BR 9710081 A BR9710081 A BR 9710081A BR 9710081 A BR9710081 A BR 9710081A BR 9710081 A BR9710081 A BR 9710081A
Authority
BR
Brazil
Prior art keywords
pregnano
9alpha
17alpha
1beta
dihalo
Prior art date
Application number
BR9710081A
Other languages
English (en)
Inventor
Daw Long Albert Kwok
David J S Tsai
Chou Hong Tann
Xiaoyong Fu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9710081A publication Critical patent/BR9710081A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR9710081A 1996-06-28 1997-06-25 Processo para a preparaçÃo de 17-ésteres de 9alpha,21-dihalo-pregnano-1beta, 17alpha-diol-20-onas BR9710081A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67286196A 1996-06-28 1996-06-28
PCT/US1997/010121 WO1998000437A1 (en) 1996-06-28 1997-06-25 PROCESS FOR THE PREPARATION OF 17-ESTERS OF 9α,21-DIHALO-PREGNANE-11β,17αDIOL-20-ONES

Publications (1)

Publication Number Publication Date
BR9710081A true BR9710081A (pt) 1999-08-10

Family

ID=24700321

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9710081A BR9710081A (pt) 1996-06-28 1997-06-25 Processo para a preparaçÃo de 17-ésteres de 9alpha,21-dihalo-pregnano-1beta, 17alpha-diol-20-onas

Country Status (21)

Country Link
EP (1) EP0923599B1 (pt)
JP (3) JP4269110B2 (pt)
KR (1) KR100441187B1 (pt)
CN (1) CN1158296C (pt)
AR (1) AR007485A1 (pt)
AT (1) ATE212035T1 (pt)
AU (1) AU725606B2 (pt)
BR (1) BR9710081A (pt)
CA (1) CA2258681C (pt)
CZ (1) CZ293944B6 (pt)
DE (1) DE69709655T2 (pt)
DK (1) DK0923599T3 (pt)
ES (1) ES2166549T3 (pt)
HK (1) HK1017899A1 (pt)
IL (1) IL127782A (pt)
NO (1) NO312367B1 (pt)
NZ (1) NZ333410A (pt)
PL (1) PL185637B1 (pt)
PT (1) PT923599E (pt)
SK (1) SK283666B6 (pt)
WO (1) WO1998000437A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ500555A (en) * 1999-08-02 2000-11-24 Hovione Int Ltd Process for the preparation of mometasone furoate
PT102405A (pt) * 2000-01-20 2001-07-31 Hovione Farmaciencia Sa Processo para a preparacao de mometasona
CN100436473C (zh) * 2005-12-09 2008-11-26 天津药业集团有限公司 糠酸莫美他松中间体21-酯及制法
CN100389121C (zh) * 2005-12-09 2008-05-21 天津药业集团有限公司 糠酸莫美他松中间体21-羟的制备方法
CN105566437B (zh) * 2015-12-30 2018-07-20 山东京卫制药有限公司 一种8dm衍生物及利用其合成糠酸莫米松的方法
CN107266519B (zh) * 2016-04-08 2021-06-29 天津金耀集团有限公司 一种9β，11β-环氧-17α-羟基-16α-甲基-21-氯代-1，4孕甾二烯-3，20-二酮新晶型及其制备方法
CN107266518B (zh) * 2016-04-08 2021-03-30 天津金耀集团有限公司 一种糠酸莫米松晶型及其制备方法
CN106279340B (zh) * 2016-08-10 2018-07-20 山东京卫制药有限公司 一种合成糠酸莫米松或其一水合物的方法
CN107951893B (zh) * 2016-10-18 2022-04-26 天津金耀集团有限公司 一种糠酸莫米松粉吸入剂组合物
CN109206468B (zh) * 2017-06-30 2023-06-27 天津药业研究院股份有限公司 一种糠酸莫米松的制备方法
CN109206466B (zh) * 2017-06-30 2022-08-09 天津药业研究院股份有限公司 一种甾体21位羟基氯代或溴代方法
CN109517019B (zh) * 2017-09-18 2021-12-07 华东师范大学 一种3β-乙酰氧基雄甾-5-烯-17-酮加成反应副产物的再利用方法
CN112110975A (zh) * 2019-06-21 2020-12-22 河南利华制药有限公司 一种一勺烩工艺合成糠酸莫米松的方法
CN112110972B (zh) * 2019-06-21 2022-03-18 河南利华制药有限公司 一种氯倍他索丙酸酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2713587A (en) * 1952-03-08 1955-07-19 Searle & Co 11, 17-dihydroxy-4-pregnene-3, 20-dione
US2793207A (en) * 1954-11-01 1957-05-21 Searle & Co Steroidal thiazole derivatives
US3440252A (en) * 1965-06-23 1969-04-22 Glaxo Lab Ltd Preparation of 21-deoxy steroids
US3502700A (en) * 1967-01-19 1970-03-24 Squibb & Sons Inc 17-esters of 9alpha,21-dihalo-11beta,17alpha-dihydroxyprogesterones
ATE8790T1 (de) * 1981-02-02 1984-08-15 Schering Corporation Aromatische heterocyclische steroidester, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.

Also Published As

Publication number Publication date
DE69709655D1 (de) 2002-02-21
PT923599E (pt) 2002-06-28
EP0923599A1 (en) 1999-06-23
CA2258681A1 (en) 1998-01-08
SK283666B6 (sk) 2003-11-04
NZ333410A (en) 2000-06-23
HK1017899A1 (en) 1999-12-03
SK177898A3 (en) 2000-04-10
PL185637B1 (pl) 2003-06-30
DK0923599T3 (da) 2002-04-22
JP2000514058A (ja) 2000-10-24
NO986086L (no) 1999-02-16
CN1228782A (zh) 1999-09-15
EP0923599B1 (en) 2002-01-16
WO1998000437A1 (en) 1998-01-08
IL127782A (en) 2004-06-20
CA2258681C (en) 2006-11-14
NO986086D0 (no) 1998-12-23
AR007485A1 (es) 1999-10-27
IL127782A0 (en) 1999-10-28
AU3483597A (en) 1998-01-21
ATE212035T1 (de) 2002-02-15
ES2166549T3 (es) 2002-04-16
PL330843A1 (en) 1999-06-07
CZ293944B6 (cs) 2004-08-18
CN1158296C (zh) 2004-07-21
JP2012149076A (ja) 2012-08-09
JP2009035552A (ja) 2009-02-19
JP4269110B2 (ja) 2009-05-27
NO312367B1 (no) 2002-04-29
KR100441187B1 (ko) 2004-11-03
DE69709655T2 (de) 2002-09-12
JP5061061B2 (ja) 2012-10-31
AU725606B2 (en) 2000-10-12
KR20000022547A (ko) 2000-04-25
CZ417798A3 (cs) 1999-05-12

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Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/06/1997, OBSERVADAS AS CONDICOES LEGAIS.

B24C Patent annual fee: request for for restoration

Free format text: REFERENTE A 15A ANUIDADE(S).

B24H Lapse because of non-payment of annual fees (definitively: art 78 iv lpi)
B24F Patent annual fee: publication cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2607 DE 22-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.