DE69609772D1 - 3-Substituierte Oxindolderivate als Kaliumkanalmodulatoren - Google Patents

3-Substituierte Oxindolderivate als Kaliumkanalmodulatoren

Info

Publication number
DE69609772D1
DE69609772D1 DE69609772T DE69609772T DE69609772D1 DE 69609772 D1 DE69609772 D1 DE 69609772D1 DE 69609772 T DE69609772 T DE 69609772T DE 69609772 T DE69609772 T DE 69609772T DE 69609772 D1 DE69609772 D1 DE 69609772D1
Authority
DE
Germany
Prior art keywords
potassium channel
channel modulators
oxindole derivatives
substituted oxindole
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69609772T
Other languages
English (en)
Other versions
DE69609772T2 (de
Inventor
Piyasena Hewawasam
Nicholas A Meanwell
Valentin K Gribkoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE69609772D1 publication Critical patent/DE69609772D1/de
Publication of DE69609772T2 publication Critical patent/DE69609772T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE69609772T 1995-06-07 1996-06-06 3-Substituierte Oxindolderivate als Kaliumkanalmodulatoren Expired - Lifetime DE69609772T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/477,047 US5565483A (en) 1995-06-07 1995-06-07 3-substituted oxindole derivatives as potassium channel modulators

Publications (2)

Publication Number Publication Date
DE69609772D1 true DE69609772D1 (de) 2000-09-21
DE69609772T2 DE69609772T2 (de) 2001-04-12

Family

ID=23894292

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69609772T Expired - Lifetime DE69609772T2 (de) 1995-06-07 1996-06-06 3-Substituierte Oxindolderivate als Kaliumkanalmodulatoren

Country Status (26)

Country Link
US (2) US5565483A (de)
EP (1) EP0747354B1 (de)
JP (1) JP4011135B2 (de)
KR (1) KR100432157B1 (de)
CN (1) CN1076348C (de)
AR (1) AR004493A1 (de)
AT (1) ATE195515T1 (de)
AU (1) AU707760B2 (de)
BR (1) BR1100180A (de)
CA (1) CA2176183C (de)
CZ (1) CZ289248B6 (de)
DE (1) DE69609772T2 (de)
DK (1) DK0747354T3 (de)
ES (1) ES2148685T3 (de)
GR (1) GR3034523T3 (de)
HK (1) HK1003301A1 (de)
HU (1) HU222046B1 (de)
IL (1) IL118349A (de)
NO (1) NO304829B1 (de)
NZ (1) NZ286748A (de)
PL (1) PL184660B1 (de)
PT (1) PT747354E (de)
RU (1) RU2165925C2 (de)
SG (1) SG70572A1 (de)
TW (1) TW384284B (de)
ZA (1) ZA964327B (de)

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US5972961A (en) * 1997-08-28 1999-10-26 Bristol-Myers Squibb Company 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators
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ATE285769T1 (de) * 1998-12-04 2005-01-15 Neurosearch As Verwendung von isatinderivaten als ionenkanalaktivierende mittel
RU2240998C2 (ru) * 1998-12-04 2004-11-27 Бристол-Маерс Сквибб Компани Производные 3-замещенного 4-арилхинолин-2-она в качестве модуляторов калиевых каналов
US6509334B1 (en) * 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
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EP1198456B1 (de) * 1999-08-03 2007-09-19 Abbott Laboratories Kalium kanalaktivatoren
DE60124080T2 (de) * 2000-03-23 2007-03-01 Elan Pharmaceuticals, Inc., San Francisco Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
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ES2248356T3 (es) 2000-06-30 2006-03-16 Elan Pharmaceuticals, Inc. Compuestos para tratar la enfermedad de alzheimer.
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US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
JP2004511457A (ja) * 2000-10-13 2004-04-15 ブリストル−マイヤーズ　スクイブ　カンパニー 高い細胞内カルシウム濃度の条件下で機能する選択的マキシ−ｋカリウムチャネル・オープナー、その方法および用途
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IL157313A0 (en) 2001-02-20 2004-02-19 Bristol Myers Squibb Co Modulators of kcnq potassium channels and uses thereof
CA2438805A1 (en) * 2001-02-20 2002-08-29 Bristol-Myers Squibb Company Fluoro oxindole derivatives as modulators of kcnq potassium channels
AR033095A1 (es) * 2001-04-04 2003-12-03 Wyeth Corp Metodos para el tratamiento de motilidad gastrica hiperactiva
BR0210721A (pt) * 2001-06-27 2004-07-20 Elan Pharm Inc Composto, sal ou éster farmaceuticamente aceitável, método para fabricar um composto, e, método para tratar um paciente que tem, ou para evitar que o paciente adquira uma doença ou condição
BR0308737A (pt) * 2002-03-20 2005-01-11 Bristol Myers Squibb Co Pró-drogas de fosfato de fluoroxindóis
AU2003240427A1 (en) * 2002-06-26 2004-01-19 Poseidon Pharmaceuticals A/S Novel benzimidazol-2-one derivatives and their use
TWI271402B (en) * 2002-10-15 2007-01-21 Tanabe Seiyaku Co Large conductance calcium-activated K channel opener
US7632866B2 (en) * 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
JP2006513154A (ja) * 2002-10-21 2006-04-20 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド カリウムチャネルおよび／または皮質ニューロン活性モジュレーターとしての、ｎ−フェニルアントラニル酸および２−ベンズイミダゾロンの誘導体
KR100456679B1 (ko) * 2002-11-14 2004-11-10 현대모비스 주식회사 차량의 조수석 에어백의 장착구조
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WO2005035498A1 (ja) * 2003-10-08 2005-04-21 Dainippon Sumitomo Pharma Co., Ltd. 含窒素二環性化合物の摂食調節剤としての用途
US7671072B2 (en) * 2003-11-26 2010-03-02 Pfizer Inc. Aminopyrazole derivatives as GSK-3 inhibitors
US7169803B2 (en) * 2004-03-15 2007-01-30 Bristol-Myers Squibb Company N-substituted prodrugs of fluorooxindoles
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GT200500321A (es) 2004-11-09 2006-09-04 Compuestos y composiciones como inhibidores de proteina kinase.
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CA2604759A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
GT200600164A (es) * 2005-04-22 2007-03-14 Derivados de dihidrobenzofuranos y usos de los mismos
CN101203218A (zh) * 2005-04-22 2008-06-18 惠氏公司 苯并呋喃基链烷胺衍生物和其作为5－ht2c激动剂的用途
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US7576082B2 (en) * 2005-06-24 2009-08-18 Hoffman-La Roche Inc. Oxindole derivatives
AR054849A1 (es) * 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
PA8720801A1 (es) * 2006-03-24 2008-11-19 Wyeth Corp Nuevas combinaciones terapeuticas para el tratamiento de la depresion
CN101410118A (zh) * 2006-03-24 2009-04-15 惠氏公司 疼痛的治疗
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US8252559B2 (en) * 2006-08-04 2012-08-28 The California Institute Of Technology Methods and systems for selective fluorination of organic molecules
US8802401B2 (en) * 2007-06-18 2014-08-12 The California Institute Of Technology Methods and compositions for preparation of selectively protected carbohydrates
WO2009037707A2 (en) 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
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EP2205079A4 (de) * 2007-10-04 2010-10-27 Merck Sharp & Dohme N-substituierte oxindolinderivate als calciumkanalblocker
KR100985286B1 (ko) * 2007-12-28 2010-10-04 주식회사 포스코 내지연파괴 특성이 우수한 고강도 고망간강 및 제조방법
EP2540295A1 (de) * 2011-06-27 2013-01-02 Centre national de la recherche scientifique Zusammensetzungen zur Behandlung des Fragilen-X-Syndroms
EP3288940B9 (de) 2015-04-29 2021-07-21 Janssen Pharmaceutica NV Azabenimidazole und ihre verwendung als ampa-rezeptor-modulatoren
US10604484B2 (en) * 2015-04-29 2020-03-31 Janssen Pharmaceutica Nv Indolone compounds and their use as AMPA receptor modulators
KR20190119602A (ko) 2017-02-24 2019-10-22 오비드 테라퓨틱스 인크. 발작 장애들을 치료하는 방법들
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Also Published As

Publication number Publication date
AR004493A1 (es) 1998-12-16
US5565483A (en) 1996-10-15
RU2165925C2 (ru) 2001-04-27
ATE195515T1 (de) 2000-09-15
JPH08333336A (ja) 1996-12-17
CN1144800A (zh) 1997-03-12
CA2176183A1 (en) 1996-12-08
CZ161896A3 (en) 1997-03-12
HU9601547D0 (en) 1996-08-28
IL118349A0 (en) 1996-09-12
CZ289248B6 (cs) 2001-12-12
EP0747354A1 (de) 1996-12-11
DE69609772T2 (de) 2001-04-12
ZA964327B (en) 1997-11-28
KR970001324A (ko) 1997-01-24
DK0747354T3 (da) 2000-09-18
AU5475796A (en) 1996-12-19
HUP9601547A1 (en) 1997-09-29
EP0747354B1 (de) 2000-08-16
NZ286748A (en) 1998-08-26
TW384284B (en) 2000-03-11
CN1076348C (zh) 2001-12-19
BR1100180A (pt) 2000-03-14
NO962232L (no) 1996-12-09
HU222046B1 (hu) 2003-04-28
SG70572A1 (en) 2000-02-22
CA2176183C (en) 2010-03-30
GR3034523T3 (en) 2000-12-29
PL184660B1 (pl) 2002-11-29
KR100432157B1 (ko) 2004-10-06
AU707760B2 (en) 1999-07-22
IL118349A (en) 2000-07-26
NO304829B1 (no) 1999-02-22
ES2148685T3 (es) 2000-10-16
HK1003301A1 (en) 1998-10-23
JP4011135B2 (ja) 2007-11-21
NO962232D0 (no) 1996-05-31
PT747354E (pt) 2000-11-30
US5602169A (en) 1997-02-11
PL314672A1 (en) 1996-12-09

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