DK0747354T3 - 3-substituerede oxindolderivater som kaliumkanalmodulatorer - Google Patents

3-substituerede oxindolderivater som kaliumkanalmodulatorer

Info

Publication number
DK0747354T3
DK0747354T3 DK96304188T DK96304188T DK0747354T3 DK 0747354 T3 DK0747354 T3 DK 0747354T3 DK 96304188 T DK96304188 T DK 96304188T DK 96304188 T DK96304188 T DK 96304188T DK 0747354 T3 DK0747354 T3 DK 0747354T3
Authority
DK
Denmark
Prior art keywords
potassium channel
channel modulators
oxindole derivatives
substituted oxindole
substituted
Prior art date
Application number
DK96304188T
Other languages
Danish (da)
English (en)
Inventor
Piyasena Hewawasam
Nicholas A Meanwell
Valentin K Gribkoff
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK0747354T3 publication Critical patent/DK0747354T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DK96304188T 1995-06-07 1996-06-06 3-substituerede oxindolderivater som kaliumkanalmodulatorer DK0747354T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/477,047 US5565483A (en) 1995-06-07 1995-06-07 3-substituted oxindole derivatives as potassium channel modulators

Publications (1)

Publication Number Publication Date
DK0747354T3 true DK0747354T3 (da) 2000-09-18

Family

ID=23894292

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96304188T DK0747354T3 (da) 1995-06-07 1996-06-06 3-substituerede oxindolderivater som kaliumkanalmodulatorer

Country Status (26)

Country Link
US (2) US5565483A (de)
EP (1) EP0747354B1 (de)
JP (1) JP4011135B2 (de)
KR (1) KR100432157B1 (de)
CN (1) CN1076348C (de)
AR (1) AR004493A1 (de)
AT (1) ATE195515T1 (de)
AU (1) AU707760B2 (de)
BR (1) BR1100180A (de)
CA (1) CA2176183C (de)
CZ (1) CZ289248B6 (de)
DE (1) DE69609772T2 (de)
DK (1) DK0747354T3 (de)
ES (1) ES2148685T3 (de)
GR (1) GR3034523T3 (de)
HK (1) HK1003301A1 (de)
HU (1) HU222046B1 (de)
IL (1) IL118349A (de)
NO (1) NO304829B1 (de)
NZ (1) NZ286748A (de)
PL (1) PL184660B1 (de)
PT (1) PT747354E (de)
RU (1) RU2165925C2 (de)
SG (1) SG70572A1 (de)
TW (1) TW384284B (de)
ZA (1) ZA964327B (de)

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AU755202B2 (en) 1998-12-04 2002-12-05 Bristol-Myers Squibb Company 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators
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US7632866B2 (en) * 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
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Also Published As

Publication number Publication date
PL314672A1 (en) 1996-12-09
DE69609772T2 (de) 2001-04-12
ES2148685T3 (es) 2000-10-16
US5565483A (en) 1996-10-15
AR004493A1 (es) 1998-12-16
PL184660B1 (pl) 2002-11-29
PT747354E (pt) 2000-11-30
EP0747354A1 (de) 1996-12-11
GR3034523T3 (en) 2000-12-29
NO304829B1 (no) 1999-02-22
HUP9601547A1 (en) 1997-09-29
AU707760B2 (en) 1999-07-22
CZ289248B6 (cs) 2001-12-12
NZ286748A (en) 1998-08-26
CN1076348C (zh) 2001-12-19
AU5475796A (en) 1996-12-19
CZ161896A3 (en) 1997-03-12
CN1144800A (zh) 1997-03-12
IL118349A (en) 2000-07-26
TW384284B (en) 2000-03-11
HU222046B1 (hu) 2003-04-28
CA2176183C (en) 2010-03-30
JPH08333336A (ja) 1996-12-17
KR100432157B1 (ko) 2004-10-06
EP0747354B1 (de) 2000-08-16
NO962232L (no) 1996-12-09
IL118349A0 (en) 1996-09-12
ATE195515T1 (de) 2000-09-15
SG70572A1 (en) 2000-02-22
BR1100180A (pt) 2000-03-14
CA2176183A1 (en) 1996-12-08
DE69609772D1 (de) 2000-09-21
ZA964327B (en) 1997-11-28
RU2165925C2 (ru) 2001-04-27
HU9601547D0 (en) 1996-08-28
JP4011135B2 (ja) 2007-11-21
HK1003301A1 (en) 1998-10-23
NO962232D0 (no) 1996-05-31
KR970001324A (ko) 1997-01-24
US5602169A (en) 1997-02-11

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