HK1003301A1 - 3-substituted oxindole derivatives as potassium channel modulators - Google Patents

3-substituted oxindole derivatives as potassium channel modulators

Info

Publication number
HK1003301A1
HK1003301A1 HK98102434A HK98102434A HK1003301A1 HK 1003301 A1 HK1003301 A1 HK 1003301A1 HK 98102434 A HK98102434 A HK 98102434A HK 98102434 A HK98102434 A HK 98102434A HK 1003301 A1 HK1003301 A1 HK 1003301A1
Authority
HK
Hong Kong
Prior art keywords
potassium channel
channel modulators
oxindole derivatives
substituted oxindole
substituted
Prior art date
Application number
HK98102434A
Other languages
English (en)
Inventor
Piyasena Hewawasam
Nicholas A Meanwell
Valentin K Gribkoff
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HK1003301A1 publication Critical patent/HK1003301A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
HK98102434A 1995-06-07 1998-03-23 3-substituted oxindole derivatives as potassium channel modulators HK1003301A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/477,047 US5565483A (en) 1995-06-07 1995-06-07 3-substituted oxindole derivatives as potassium channel modulators

Publications (1)

Publication Number Publication Date
HK1003301A1 true HK1003301A1 (en) 1998-10-23

Family

ID=23894292

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98102434A HK1003301A1 (en) 1995-06-07 1998-03-23 3-substituted oxindole derivatives as potassium channel modulators

Country Status (26)

Country Link
US (2) US5565483A (de)
EP (1) EP0747354B1 (de)
JP (1) JP4011135B2 (de)
KR (1) KR100432157B1 (de)
CN (1) CN1076348C (de)
AR (1) AR004493A1 (de)
AT (1) ATE195515T1 (de)
AU (1) AU707760B2 (de)
BR (1) BR1100180A (de)
CA (1) CA2176183C (de)
CZ (1) CZ289248B6 (de)
DE (1) DE69609772T2 (de)
DK (1) DK0747354T3 (de)
ES (1) ES2148685T3 (de)
GR (1) GR3034523T3 (de)
HK (1) HK1003301A1 (de)
HU (1) HU222046B1 (de)
IL (1) IL118349A (de)
NO (1) NO304829B1 (de)
NZ (1) NZ286748A (de)
PL (1) PL184660B1 (de)
PT (1) PT747354E (de)
RU (1) RU2165925C2 (de)
SG (1) SG70572A1 (de)
TW (1) TW384284B (de)
ZA (1) ZA964327B (de)

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EP2540295A1 (de) * 2011-06-27 2013-01-02 Centre national de la recherche scientifique Zusammensetzungen zur Behandlung des Fragilen-X-Syndroms
EP3288935B1 (de) * 2015-04-29 2019-10-30 Janssen Pharmaceutica NV Indolonverbindungen und ihre verwendung als ampa-rezeptormodulatoren
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Also Published As

Publication number Publication date
AU5475796A (en) 1996-12-19
IL118349A0 (en) 1996-09-12
BR1100180A (pt) 2000-03-14
DK0747354T3 (da) 2000-09-18
CZ289248B6 (cs) 2001-12-12
ES2148685T3 (es) 2000-10-16
KR970001324A (ko) 1997-01-24
PL314672A1 (en) 1996-12-09
JPH08333336A (ja) 1996-12-17
CA2176183C (en) 2010-03-30
JP4011135B2 (ja) 2007-11-21
RU2165925C2 (ru) 2001-04-27
IL118349A (en) 2000-07-26
CZ161896A3 (en) 1997-03-12
NZ286748A (en) 1998-08-26
EP0747354B1 (de) 2000-08-16
HU222046B1 (hu) 2003-04-28
AR004493A1 (es) 1998-12-16
GR3034523T3 (en) 2000-12-29
CN1076348C (zh) 2001-12-19
HU9601547D0 (en) 1996-08-28
DE69609772D1 (de) 2000-09-21
NO962232L (no) 1996-12-09
US5602169A (en) 1997-02-11
NO962232D0 (no) 1996-05-31
SG70572A1 (en) 2000-02-22
EP0747354A1 (de) 1996-12-11
NO304829B1 (no) 1999-02-22
ATE195515T1 (de) 2000-09-15
US5565483A (en) 1996-10-15
ZA964327B (en) 1997-11-28
AU707760B2 (en) 1999-07-22
CA2176183A1 (en) 1996-12-08
PL184660B1 (pl) 2002-11-29
DE69609772T2 (de) 2001-04-12
HUP9601547A1 (en) 1997-09-29
TW384284B (en) 2000-03-11
PT747354E (pt) 2000-11-30
KR100432157B1 (ko) 2004-10-06
CN1144800A (zh) 1997-03-12

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110606