DE69534164D1 - Tri-substituierte phenyl-derivate verwendbar als pde iv hemmer - Google Patents

Tri-substituierte phenyl-derivate verwendbar als pde iv hemmer

Info

Publication number
DE69534164D1
DE69534164D1 DE69534164T DE69534164T DE69534164D1 DE 69534164 D1 DE69534164 D1 DE 69534164D1 DE 69534164 T DE69534164 T DE 69534164T DE 69534164 T DE69534164 T DE 69534164T DE 69534164 D1 DE69534164 D1 DE 69534164D1
Authority
DE
Germany
Prior art keywords
group
optionally substituted
substituted alkyl
hydrogen atom
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69534164T
Other languages
English (en)
Other versions
DE69534164T2 (de
Inventor
John Warrellow
Campbell Boyd
Peter Alexander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
UCB Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9412386A external-priority patent/GB9412386D0/en
Priority claimed from GB9412384A external-priority patent/GB9412384D0/en
Priority claimed from GB9412493A external-priority patent/GB9412493D0/en
Priority claimed from GB9415836A external-priority patent/GB9415836D0/en
Application filed by Celltech R&D Ltd, UCB Celltech Ltd filed Critical Celltech R&D Ltd
Publication of DE69534164D1 publication Critical patent/DE69534164D1/de
Application granted granted Critical
Publication of DE69534164T2 publication Critical patent/DE69534164T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69534164T 1994-06-21 1995-06-21 Tri-substituierte phenyl-derivate verwendbar als pde iv hemmer Expired - Fee Related DE69534164T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB9412386 1994-06-21
GB9412386A GB9412386D0 (en) 1994-06-21 1994-06-21 Chemical compounds
GB9412384A GB9412384D0 (en) 1994-06-21 1994-06-21 Chemical compounds
GB9412384 1994-06-21
GB9412493 1994-06-22
GB9412493A GB9412493D0 (en) 1994-06-22 1994-06-22 Chemical compounds
GB9415836A GB9415836D0 (en) 1994-08-05 1994-08-05 Chemical compounds
GB9415836 1994-08-05
PCT/GB1995/001461 WO1995035283A1 (en) 1994-06-21 1995-06-21 Tri-substituted phenyl derivatives useful as pde iv inhibitors

Publications (2)

Publication Number Publication Date
DE69534164D1 true DE69534164D1 (de) 2005-05-25
DE69534164T2 DE69534164T2 (de) 2006-03-09

Family

ID=27451178

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69534164T Expired - Fee Related DE69534164T2 (de) 1994-06-21 1995-06-21 Tri-substituierte phenyl-derivate verwendbar als pde iv hemmer

Country Status (9)

Country Link
US (2) US6245774B1 (de)
EP (1) EP0766669B1 (de)
JP (1) JP3898757B2 (de)
AT (1) ATE293601T1 (de)
AU (1) AU707717B2 (de)
CA (1) CA2192645C (de)
DE (1) DE69534164T2 (de)
ES (1) ES2238681T3 (de)
WO (1) WO1995035283A1 (de)

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US6245774B1 (en) 2001-06-12
AU2746395A (en) 1996-01-15
CA2192645C (en) 2006-02-14
EP0766669A1 (de) 1997-04-09
AU707717B2 (en) 1999-07-15
ATE293601T1 (de) 2005-05-15
EP0766669B1 (de) 2005-04-20
JP3898757B2 (ja) 2007-03-28
DE69534164T2 (de) 2006-03-09
US20020143011A1 (en) 2002-10-03
ES2238681T3 (es) 2005-09-01
JPH10503174A (ja) 1998-03-24

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