MY111226A - Tri-substituted phenyl derivatives as phosphodiesterase inhibitors - Google Patents

Tri-substituted phenyl derivatives as phosphodiesterase inhibitors

Info

Publication number
MY111226A
MY111226A MYPI94001602A MYPI19941602A MY111226A MY 111226 A MY111226 A MY 111226A MY PI94001602 A MYPI94001602 A MY PI94001602A MY PI19941602 A MYPI19941602 A MY PI19941602A MY 111226 A MY111226 A MY 111226A
Authority
MY
Malaysia
Prior art keywords
group
optionally substituted
substituted alkyl
hydrogen atom
alkyl group
Prior art date
Application number
MYPI94001602A
Inventor
Campbell Boyd Ewan
Peter Alexander Rikki
John Warellow Graham
Original Assignee
Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Ltd filed Critical Celltech Ltd
Publication of MY111226A publication Critical patent/MY111226A/en

Links

Abstract

COMPOUNDS OF GENERAL FORMULA (1)(FORMULA 1)ARE DESRIBED WHEREIN Y IS A HALOGEN ATOM OR A GROUP -OR1, WHERE R1 IS AN OPTIONALLY SUBSTITUTED ALKYL GROUP; X IS -O-, -S- OR -N (R8)-, WHERE R8 IS A HYDROGEN ATOM OR AN ALKYL GROUP; R2 IS AN OPTIONALLY SUBSTITUTED ALKYL, ALKENYL, CYCLOALKYL OR CYCLOALKENYL GROUP; R3 IS A HYDROGEN OR HALOGEN ATOM OR AN -OR9 GROUP, WHERE R9 IS A HYDROGEN ATOM OR AN OPTIONALLY SUBSTITUTED ALKYL, ALKENYL, ALKOXYALKYL, OR ALKANOYL GROUP, OR A FORMYL, CARBOXAMIDO OR THIOCARBOXAMIDO GROUP; R4 AND R5, WHICH MAY BE THE SAME OR DIFFERENT, IS EACH A GROUP - (CH2)N AR, WHERE AR IS A MONOCYCLIC OR BICYCLIC ARYL GROUP OPTIONALLY CONTAINING ONE OR MORE HETEROATOMS SELECTED FROM OXYGEN, SULPHUR OR NITROGEN ATOMS AND N IS ZERO OR AN INTEGER 1, 2 OR 3; R6 IS A HYDROGEN ATOM OR AN OPTIONALLY SUBSTITUTED ALKYL GROUP; R7 IS A HYDROGEN ATOM OR AN OPTIONALLY SUBSTITUTED ALKYL GROUP; AND THE SALTS, SOLVATES, HYDRATES AND N-OXIDES THEREOF. COMPOUNDS ACCORDING TO THE INVENTION ARE POTENT, SELECTIVE AND ORALLY ACTIVE PDEIV INHIBITORS AND ARE USEFUL IN THE PROPHYLAXIS AND TREATMENT OF ASTHMA AND OTHER DISEASES.
MYPI94001602A 1993-08-02 1994-06-21 Tri-substituted phenyl derivatives as phosphodiesterase inhibitors MY111226A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939315966A GB9315966D0 (en) 1993-08-02 1993-08-02 Chemical compounds

Publications (1)

Publication Number Publication Date
MY111226A true MY111226A (en) 1999-09-30

Family

ID=10739823

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI94001602A MY111226A (en) 1993-08-02 1994-06-21 Tri-substituted phenyl derivatives as phosphodiesterase inhibitors

Country Status (2)

Country Link
GB (1) GB9315966D0 (en)
MY (1) MY111226A (en)

Also Published As

Publication number Publication date
GB9315966D0 (en) 1993-09-15

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