DE69435033D1 - Parathormonarzneizusammensetzung - Google Patents

Parathormonarzneizusammensetzung

Info

Publication number
DE69435033D1
DE69435033D1 DE69435033T DE69435033T DE69435033D1 DE 69435033 D1 DE69435033 D1 DE 69435033D1 DE 69435033 T DE69435033 T DE 69435033T DE 69435033 T DE69435033 T DE 69435033T DE 69435033 D1 DE69435033 D1 DE 69435033D1
Authority
DE
Germany
Prior art keywords
europe
drug composition
hormone drug
excipient
buffering agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69435033T
Other languages
English (en)
Other versions
DE69435033T2 (de
Inventor
Josephus Johannes Holthuis
Albert Mekking
Alwinus Antonius Voetman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
NPS Allelix Corp Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Allelix Corp Canada filed Critical NPS Allelix Corp Canada
Application granted granted Critical
Publication of DE69435033D1 publication Critical patent/DE69435033D1/de
Publication of DE69435033T2 publication Critical patent/DE69435033T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DE69435033T 1993-12-23 1994-12-16 Parathormonarzneizusammensetzung Expired - Lifetime DE69435033T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/172,206 US5496801A (en) 1993-12-23 1993-12-23 Parathyroid hormone formulation
US172206 1993-12-23
PCT/CA1994/000693 WO1995017207A1 (en) 1993-12-23 1994-12-16 Parathyroid hormone formulation

Publications (2)

Publication Number Publication Date
DE69435033D1 true DE69435033D1 (de) 2007-11-15
DE69435033T2 DE69435033T2 (de) 2008-05-29

Family

ID=22626763

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69435033T Expired - Lifetime DE69435033T2 (de) 1993-12-23 1994-12-16 Parathormonarzneizusammensetzung

Country Status (23)

Country Link
US (1) US5496801A (de)
EP (2) EP0735896B1 (de)
JP (1) JP3065662B2 (de)
KR (1) KR100398461B1 (de)
CN (1) CN1116897C (de)
AT (1) ATE374621T1 (de)
AU (1) AU681737B2 (de)
BR (1) BR9408398A (de)
CA (1) CA2179207C (de)
CZ (1) CZ184296A3 (de)
DE (1) DE69435033T2 (de)
DK (1) DK0735896T3 (de)
ES (1) ES2293637T3 (de)
FI (1) FI120291B (de)
HK (1) HK1010336A1 (de)
HU (1) HUT74381A (de)
LV (1) LV11731B (de)
NO (1) NO324905B1 (de)
NZ (1) NZ277463A (de)
PL (1) PL315158A1 (de)
PT (1) PT735896E (de)
SK (1) SK82896A3 (de)
WO (1) WO1995017207A1 (de)

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WO1999004808A1 (fr) * 1997-07-22 1999-02-04 Chugai Seiyaku Kabushiki Kaisha Medicaments dentaires contenant de la pth
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WO1999031137A1 (en) * 1997-12-18 1999-06-24 Eli Lilly And Company Crystalline teriparatide
SE9801495D0 (sv) * 1998-04-28 1998-04-28 Astra Ab Protein formulationa
AU1447600A (en) * 1998-10-22 2000-05-08 Thomas J. Gardella Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp)
AU4217299A (en) 1998-11-30 2000-06-19 General Hospital Corporation, The Pth1r and pth3r receptors, methods and uses thereof
US6689566B1 (en) 1999-01-14 2004-02-10 Scantibodies Laboratory, Inc. Methods, kits, and antibodies for detecting parathyroid hormone
US7820393B2 (en) * 1999-01-14 2010-10-26 Scantibodies Laboratory, Inc. Methods, kits and antibodies for detecting parathyroid hormone
US7893021B2 (en) * 1999-06-02 2011-02-22 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
CA2378949C (en) * 1999-07-12 2015-03-31 Grandis Biotech Gmbh Growth hormone formulations
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
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US6905886B2 (en) * 2000-08-11 2005-06-14 Quest Diagnostics Investments Incorporated Preservative solutions
US6387711B1 (en) * 2000-08-11 2002-05-14 Quest Diagnostics Investments Incorporated Liquid intact parathyroid hormone (PTH) standards
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JP4837888B2 (ja) 2001-07-23 2011-12-14 ザ ジェネラル ホスピタル コーポレイション コンホメーションが拘束された副甲状腺ホルモン（ｐｔｈ）類似体
US7497855B2 (en) * 2002-09-04 2009-03-03 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US20040067526A1 (en) * 2002-10-03 2004-04-08 Cantor Thomas L. Methods for diagnosing and guiding treatment of bone turnover disease
US7795220B2 (en) * 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
ES2437565T3 (es) * 2003-06-30 2014-01-13 Alza Corporation Formulaciones para microproyecciones revestidas que contienen contraiones no volátiles
KR100540659B1 (ko) * 2003-07-02 2006-01-10 삼성전자주식회사 이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체
WO2005014034A1 (en) * 2003-07-14 2005-02-17 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
EP1653985A4 (de) 2003-07-17 2009-08-05 Gen Hospital Corp Zwangsform-parathormon (pth)-analoga
US7459276B2 (en) * 2003-09-29 2008-12-02 Scantibodies Laboratory, Inc. Methods and controls for monitoring assay quality and accuracy in parathyroid hormone measurement
US20050119183A1 (en) * 2003-11-12 2005-06-02 Nps Allelix Corp. Method for treating bone loss using parathyroid hormone
AU2004292954A1 (en) * 2003-11-13 2005-06-09 Alza Corporation Composition and apparatus for transdermal delivery
CN100406059C (zh) * 2004-04-30 2008-07-30 陈新梅 甲状旁腺激素的新用途
ES2568259T3 (es) * 2004-05-13 2016-04-28 Alza Corporation Aparato y método para la administración transdérmica de agentes de hormona paratiroidea
US7541140B2 (en) * 2004-06-03 2009-06-02 Scantibodies Laboratory, Inc. Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
WO2006081279A2 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
KR100700869B1 (ko) 2005-06-03 2007-03-29 재단법인 목암생명공학연구소 Ｐｔｈ, 완충제 및 안정제를 포함하는 안정한 ｐｔｈ조성물
WO2007059470A2 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
WO2008019062A2 (en) * 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
EP1961765A1 (de) * 2006-12-08 2008-08-27 Zealand Pharma A/S Verkürzte PTH-Peptide mit zyklischer Konformation
AU2008282805B2 (en) 2007-08-01 2014-05-01 Chugai Pharmaceutical Co., Ltd. Screening methods using G-protein coupled receptors and related compositions
EP2173768B1 (de) * 2007-08-09 2014-03-05 USV Limited Neues orthogonales verfahren zur aufreinigung von rekombinantem humanem parathyroidhormon (rhpth)(1-34)
JP2009091363A (ja) * 2008-11-21 2009-04-30 Asahi Kasei Pharma Kk Ｐｔｈの安定化水溶液注射剤
JP2013512688A (ja) 2009-12-07 2013-04-18 ミシガン テクノロジカル ユニバーシティ クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法
BR112012028949B1 (pt) 2010-05-13 2020-11-17 Chugai Seiyaku Kabushiki Kaisha polipeptídeo análogo do hormônio paratireoideo, seu uso e método de produção, bem como ácido nucleico, vetor de expressão, célula e composição farmacêutica
BR112013023062B1 (pt) * 2011-03-10 2022-01-18 Xeris Pharmaceuticals, Inc Solução estável para a injeção parenteral e método de fabricação da mesma
CN103561757B (zh) 2011-06-07 2016-01-06 旭化成制药株式会社 高纯度含pth冷冻干燥制剂及其制造方法
CN105025928A (zh) * 2013-03-15 2015-11-04 普西维达公司 用于递送治疗剂的可生物蚀解的硅基组合物
CN103301058A (zh) * 2013-06-17 2013-09-18 深圳翰宇药业股份有限公司 一种特立帕肽注射用组合物及其制备方法和制剂
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CN110917150A (zh) * 2019-12-31 2020-03-27 北京博康健基因科技有限公司 一种pth冻干制剂及其制备方法
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Also Published As

Publication number Publication date
BR9408398A (pt) 1997-08-12
LV11731A (lv) 1997-04-20
EP0735896A1 (de) 1996-10-09
NO324905B1 (no) 2007-12-27
NO962634L (no) 1996-06-20
DK0735896T3 (da) 2008-02-04
FI962593A0 (fi) 1996-06-20
EP1880732A1 (de) 2008-01-23
CN1142772A (zh) 1997-02-12
ES2293637T3 (es) 2008-03-16
PL315158A1 (en) 1996-10-14
DE69435033T2 (de) 2008-05-29
FI962593A (fi) 1996-08-19
NO962634D0 (no) 1996-06-20
AU681737B2 (en) 1997-09-04
ATE374621T1 (de) 2007-10-15
JP3065662B2 (ja) 2000-07-17
HUT74381A (en) 1996-12-30
CZ184296A3 (en) 1997-01-15
CA2179207A1 (en) 1995-06-29
CA2179207C (en) 2000-11-14
PT735896E (pt) 2007-12-07
SK82896A3 (en) 1997-01-08
EP0735896B1 (de) 2007-10-03
NZ277463A (en) 1997-03-24
HU9601721D0 (en) 1996-08-28
CN1116897C (zh) 2003-08-06
HK1010336A1 (en) 1999-06-17
AU1269895A (en) 1995-07-10
FI120291B (fi) 2009-09-15
LV11731B (en) 1997-08-20
KR100398461B1 (ko) 2004-03-20
US5496801A (en) 1996-03-05
JPH09506869A (ja) 1997-07-08
WO1995017207A1 (en) 1995-06-29

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Owner name: NPS PHARMACEUTICALS,INC., BEDMINSTER, N.J., US

8380 Miscellaneous part iii

Free format text: DINGLICHES RECHT WURDE BESTELLT