DE69901487D1 - Eine didemnin verbindung enthaltende pharmazeutische formulierung - Google Patents

Eine didemnin verbindung enthaltende pharmazeutische formulierung

Info

Publication number
DE69901487D1
DE69901487D1 DE69901487T DE69901487T DE69901487D1 DE 69901487 D1 DE69901487 D1 DE 69901487D1 DE 69901487 T DE69901487 T DE 69901487T DE 69901487 T DE69901487 T DE 69901487T DE 69901487 D1 DE69901487 D1 DE 69901487D1
Authority
DE
Germany
Prior art keywords
didemnine
pharmaceutical formulation
formulation containing
didemnin
lyophilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69901487T
Other languages
English (en)
Other versions
DE69901487T2 (de
Inventor
Jacob Hendrik Beijnen
Bastiaan Nuyen
Roland E C Henrar
Andres Gomez
Jose Jimeno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10827213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69901487(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of DE69901487D1 publication Critical patent/DE69901487D1/de
Application granted granted Critical
Publication of DE69901487T2 publication Critical patent/DE69901487T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
DE69901487T 1998-02-18 1999-02-18 Eine didemnin verbindung enthaltende pharmazeutische formulierung Expired - Lifetime DE69901487T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9803448.1A GB9803448D0 (en) 1998-02-18 1998-02-18 Pharmaceutical formulation
PCT/GB1999/000511 WO1999042125A1 (en) 1998-02-18 1999-02-18 Pharmaceutical formulation of a didemnin compound

Publications (2)

Publication Number Publication Date
DE69901487D1 true DE69901487D1 (de) 2002-06-20
DE69901487T2 DE69901487T2 (de) 2002-12-19

Family

ID=10827213

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69901487T Expired - Lifetime DE69901487T2 (de) 1998-02-18 1999-02-18 Eine didemnin verbindung enthaltende pharmazeutische formulierung

Country Status (17)

Country Link
US (1) US8420130B1 (de)
EP (1) EP1054686B1 (de)
JP (2) JP4536255B2 (de)
KR (1) KR100595597B1 (de)
CN (1) CN1170586C (de)
AT (1) ATE217532T1 (de)
AU (1) AU754073B2 (de)
BR (1) BRPI9908088C1 (de)
CA (1) CA2321116C (de)
DE (1) DE69901487T2 (de)
DK (1) DK1054686T3 (de)
ES (1) ES2175940T3 (de)
GB (1) GB9803448D0 (de)
HK (1) HK1032538A1 (de)
IL (1) IL137911A (de)
PT (1) PT1054686E (de)
WO (1) WO1999042125A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
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US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
GB0002952D0 (en) 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
DE10008128A1 (de) * 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
NZ525196A (en) 2000-10-12 2004-09-24 Pharma Mar S Treatment of cancers by aplidine in conjunction with a myoprotector
AU1074902A (en) * 2000-10-31 2002-05-15 Pharma Mar Sa Kahalalide f
GB0304367D0 (en) 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
WO2004080421A2 (en) 2003-03-12 2004-09-23 Pharma Mar, S.A. Improved antitumoral treatments
MXPA05009742A (es) 2003-03-12 2006-05-25 Dana Farber Cancer Inst Inc Aplidina para tratamiento de mieloma multiple.
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
CN100335495C (zh) * 2006-01-23 2007-09-05 南方医科大学 一种海鞘多肽及其制备方法
CA2643238C (en) 2006-02-28 2016-05-03 Pharma Mar, S.A. Improved antitumoral treatments
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
ES2791690T3 (es) * 2011-02-09 2020-11-05 Glaxosmithkline Llc Formulaciones liofilizadas
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CA3169540A1 (en) 2020-03-02 2021-09-10 Pablo Aviles Marin Compounds for use in viral infections
JP2023517194A (ja) 2020-03-02 2023-04-24 ファルマ、マール、ソシエダード、アノニマ コロナウイルス感染の処置における組合せに使用するためのｐｌｄ
BR112022017008A2 (pt) 2020-03-02 2022-10-11 Pharma Mar Sa Compostos para uso no tratamento de infecção por coronavírus
US20230158104A1 (en) 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in autoimmune conditions
CN114085272B (zh) * 2022-01-10 2022-06-10 中山大学 一种isaridin类环酯肽衍生物及其制备方法和应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342744A (en) * 1979-07-19 1982-08-03 Lever Brothers Company Hair treatment products
US4493796A (en) 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
JPS5781413A (en) * 1980-09-12 1982-05-21 Univ Illinois Didemnin antibiotic
US4950649A (en) 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
DE3161556D1 (en) * 1980-09-12 1984-01-05 Univ Illinois Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
IT1153974B (it) 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en) 1989-04-10 1990-08-14 The Board Of Trustees Of The University Of Illinois Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en) 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
DE4120327A1 (de) 1991-06-20 1992-12-24 Basf Ag Neue peptide, ihre herstellung und verwendung
FR2698543B1 (fr) * 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
IL109350A (en) * 1993-05-12 2001-01-28 Genentech Inc Stable liquid preparations of gamma interferon
US5462726A (en) 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
EP0739210B1 (de) * 1993-12-29 2002-07-24 Matrix Pharmaceutical, Inc. Zusammensetzung für lokale freigabe von zytostatika
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
ES2102322B1 (es) 1995-07-13 1998-03-01 Pharma Mar Sa Procedimiento de preparacion de didemnina a.
US6365597B1 (en) * 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
US20020077461A1 (en) * 1996-04-24 2002-06-20 Soren Bjorn Pharmaceutical formulation
WO1997044026A1 (en) 1996-05-22 1997-11-27 Neuromedica, Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere
US6156724A (en) 1996-06-07 2000-12-05 Rinehart; Kenneth L. Uses of didemnins as immunomodulating agents
WO1998001353A1 (en) 1996-07-03 1998-01-15 Mckechnie Uk Limited Container
ES2202644T3 (es) 1996-10-24 2004-04-01 The Board Of Trustees Of The University Of Illinois Sintesis total del analogo hip amino de la didemnin a.
ATE321773T1 (de) 1996-10-24 2006-04-15 Univ Illinois Semisynthetisches verfahren zur herstellung von didemninanalogen
US6034058A (en) 1997-04-15 2000-03-07 Rinehart; Kenneth L. Semi-synthetic alanyl dilemnin analogs
EP0981352B8 (de) * 1997-05-07 2009-06-17 Pharma Mar, S.A. Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
WO2000006134A2 (en) 1998-07-30 2000-02-10 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of l-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
US20010021380A1 (en) 1999-04-19 2001-09-13 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
JP2003500360A (ja) 1999-05-25 2003-01-07 ポイント セラピューティクス， インコーポレイテッド ボロプロリン化合物類を含む抗癌剤
CN1423564A (zh) 1999-11-15 2003-06-11 法马马有限公司 癌症的aplidine治疗
US6509315B1 (en) 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
MXPA02009943A (es) 2000-04-07 2003-04-25 Univ Pennsylvania Analogos de tamandarin y didemnin y metodos para hacerlos y usarlos.
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
JP2004528008A (ja) 2000-10-05 2004-09-16 イミュネックス・コーポレーション ネクチンポリペプチド、ポリヌクレオチド、該ポリペプチドおよびポリヌクレオチドを作成し、そして使用する方法
WO2002030441A2 (en) 2000-10-12 2002-04-18 Pharma Mar, S.A. Treatment of cancers by aplidine in conjunction with a myoprotector
WO2002032374A2 (en) 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
DE60229414D1 (de) 2001-10-19 2008-11-27 Pharma Mar Sa Verwendung von aplidine in der behandlung von pankreaskrebs
WO2004080421A2 (en) 2003-03-12 2004-09-23 Pharma Mar, S.A. Improved antitumoral treatments

Also Published As

Publication number Publication date
EP1054686A1 (de) 2000-11-29
EP1054686B1 (de) 2002-05-15
JP2010163443A (ja) 2010-07-29
WO1999042125A1 (en) 1999-08-26
BR9908088B1 (pt) 2013-05-21
PT1054686E (pt) 2002-09-30
IL137911A (en) 2006-04-10
KR100595597B1 (ko) 2006-07-03
BRPI9908088C1 (pt) 2021-05-25
AU2538999A (en) 1999-09-06
CA2321116C (en) 2009-10-06
BR9908088A (pt) 2000-10-31
GB9803448D0 (en) 1998-04-15
CA2321116A1 (en) 1999-08-26
ATE217532T1 (de) 2002-06-15
AU754073B2 (en) 2002-11-07
CN1170586C (zh) 2004-10-13
IL137911A0 (en) 2001-10-31
JP2002503704A (ja) 2002-02-05
CN1330551A (zh) 2002-01-09
US8420130B1 (en) 2013-04-16
ES2175940T3 (es) 2002-11-16
KR20010040993A (ko) 2001-05-15
HK1032538A1 (en) 2001-07-27
DK1054686T3 (da) 2002-06-17
DE69901487T2 (de) 2002-12-19
BRPI9908088B8 (pt) 2017-03-07
JP4536255B2 (ja) 2010-09-01

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Legal Events

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